diff --git a/src/apps/ocioview/README.md b/src/apps/ocioview/README.md
index e62eb4516..a62465307 100644
--- a/src/apps/ocioview/README.md
+++ b/src/apps/ocioview/README.md
@@ -41,10 +41,10 @@ Dependencies
 
 * PyOpenColorIO
 * [OpenImageIO (Python bindings)](https://github.com/OpenImageIO/oiio)
-* [Imath (Python bindings)](https://github.com/AcademySoftwareFoundation/Imath)
 * ``pip install -r requirements.txt``
   * [numpy](https://pypi.org/project/numpy/)
   * [Pygments](https://pypi.org/project/Pygments/)
   * [PyOpenGL](https://pypi.org/project/PyOpenGL/)
-  * [PySide2](https://pypi.org/project/PySide2/)
+  * [PySide6](https://pypi.org/project/PySide6/)
   * [QtAwesome](https://pypi.org/project/QtAwesome/)
+  * [imageio](https://pypi.org/project/imageio/)
diff --git a/src/apps/ocioview/main.py b/src/apps/ocioview/main.py
index 85f657cab..609ef73d8 100644
--- a/src/apps/ocioview/main.py
+++ b/src/apps/ocioview/main.py
@@ -7,7 +7,7 @@
 from pathlib import Path
 
 import PyOpenColorIO as ocio
-from PySide2 import QtCore, QtWidgets, QtOpenGL
+from PySide6 import QtCore, QtGui, QtWidgets, QtOpenGL
 
 import ocioview.log_handlers  # Import to initialize logging
 from ocioview.main_window import OCIOView
@@ -30,12 +30,11 @@ def excepthook(exc_type, exc_value, exc_tb):
     sys.excepthook = excepthook
 
     # OpenGL core profile needed on macOS to access programmatic pipeline
-    gl_format = QtOpenGL.QGLFormat()
-    gl_format.setProfile(QtOpenGL.QGLFormat.CoreProfile)
-    gl_format.setSampleBuffers(True)
+    gl_format = QtGui.QSurfaceFormat()
+    gl_format.setProfile(QtGui.QSurfaceFormat.CoreProfile)
     gl_format.setSwapInterval(1)
     gl_format.setVersion(4, 0)
-    QtOpenGL.QGLFormat.setDefaultFormat(gl_format)
+    QtGui.QSurfaceFormat.setDefaultFormat(gl_format)
 
     # Create app
     app = QtWidgets.QApplication(sys.argv)
diff --git a/src/apps/ocioview/ocioview/config_dock.py b/src/apps/ocioview/ocioview/config_dock.py
index a47774fc1..33660b112 100644
--- a/src/apps/ocioview/ocioview/config_dock.py
+++ b/src/apps/ocioview/ocioview/config_dock.py
@@ -4,7 +4,7 @@
 from typing import Optional
 
 import PyOpenColorIO as ocio
-from PySide2 import QtCore, QtWidgets
+from PySide6 import QtCore, QtWidgets
 
 from .items import (
     ColorSpaceEdit,
diff --git a/src/apps/ocioview/ocioview/constants.py b/src/apps/ocioview/ocioview/constants.py
index a580e126f..18b7f0909 100644
--- a/src/apps/ocioview/ocioview/constants.py
+++ b/src/apps/ocioview/ocioview/constants.py
@@ -3,7 +3,7 @@
 
 from pathlib import Path
 
-from PySide2 import QtCore, QtGui
+from PySide6 import QtCore, QtGui
 
 
 # Root application directory
diff --git a/src/apps/ocioview/ocioview/inspect/code_inspector.py b/src/apps/ocioview/ocioview/inspect/code_inspector.py
index b812cbcb6..3fa1e81e3 100644
--- a/src/apps/ocioview/ocioview/inspect/code_inspector.py
+++ b/src/apps/ocioview/ocioview/inspect/code_inspector.py
@@ -6,7 +6,7 @@
 
 import PyOpenColorIO as ocio
 from pygments.formatters import HtmlFormatter
-from PySide2 import QtCore, QtGui, QtWidgets
+from PySide6 import QtCore, QtGui, QtWidgets
 
 from ..message_router import MessageRouter
 from ..utils import get_glyph_icon, processor_to_shader_html
@@ -40,9 +40,9 @@ def __init__(self, parent: Optional[QtCore.QObject] = None):
 
         html_css = HtmlFormatter(style="material").get_style_defs()
         # Update line number colors to match palette
-        html_css = html_css.replace("#263238", palette.color(palette.Base).name())
+        html_css = html_css.replace("#263238", palette.color(palette.ColorRole.Base).name())
         html_css = html_css.replace(
-            "#37474F", palette.color(palette.Text).darker(150).name()
+            "#37474F", palette.color(palette.ColorRole.Text).darker(150).name()
         )
 
         # Widgets
diff --git a/src/apps/ocioview/ocioview/inspect/curve_inspector.py b/src/apps/ocioview/ocioview/inspect/curve_inspector.py
index 6e5a078d6..9a483a1cc 100644
--- a/src/apps/ocioview/ocioview/inspect/curve_inspector.py
+++ b/src/apps/ocioview/ocioview/inspect/curve_inspector.py
@@ -8,7 +8,7 @@
 import numpy as np
 
 import PyOpenColorIO as ocio
-from PySide2 import QtCore, QtGui, QtWidgets
+from PySide6 import QtCore, QtGui, QtWidgets
 
 from ..constants import R_COLOR, G_COLOR, B_COLOR, GRAY_COLOR
 from ..message_router import MessageRouter
@@ -526,7 +526,7 @@ def drawForeground(self, painter: QtGui.QPainter, rect: QtCore.QRectF) -> None:
 
                 if color_name == GRAY_COLOR.name():
                     palette = self.palette()
-                    painter.setPen(palette.color(palette.Text))
+                    painter.setPen(palette.color(palette.ColorRole.Text))
                 else:
                     painter.setPen(QtGui.QColor(color_name))
 
@@ -635,7 +635,7 @@ def _on_cpu_processor_ready(self, cpu_proc: ocio.CPUProcessor) -> None:
             r_samples, b_samples, atol=self.EPSILON
         ):
             palette = self.palette()
-            color_name = palette.color(palette.Text).name()
+            color_name = palette.color(palette.ColorRole.Text).name()
 
             self._samples[color_name] = np.stack((self._x_lin, r_samples), axis=-1)
 
diff --git a/src/apps/ocioview/ocioview/inspect/log_inspector.py b/src/apps/ocioview/ocioview/inspect/log_inspector.py
index ac026899e..b2cf9fa63 100644
--- a/src/apps/ocioview/ocioview/inspect/log_inspector.py
+++ b/src/apps/ocioview/ocioview/inspect/log_inspector.py
@@ -4,7 +4,7 @@
 from typing import Optional
 
 import PyOpenColorIO as ocio
-from PySide2 import QtCore, QtGui, QtWidgets
+from PySide6 import QtCore, QtGui, QtWidgets
 
 from ..log_handlers import set_logging_level
 from ..message_router import MessageRouter
diff --git a/src/apps/ocioview/ocioview/inspect_dock.py b/src/apps/ocioview/ocioview/inspect_dock.py
index b68b36cd1..39c352cb1 100644
--- a/src/apps/ocioview/ocioview/inspect_dock.py
+++ b/src/apps/ocioview/ocioview/inspect_dock.py
@@ -3,7 +3,7 @@
 
 from typing import Optional
 
-from PySide2 import QtCore, QtWidgets
+from PySide6 import QtCore, QtWidgets
 
 from .inspect.curve_inspector import CurveInspector
 from .inspect import LogInspector, CodeInspector
diff --git a/src/apps/ocioview/ocioview/items/active_display_view_edit.py b/src/apps/ocioview/ocioview/items/active_display_view_edit.py
index 5d76b0b12..593a40d44 100644
--- a/src/apps/ocioview/ocioview/items/active_display_view_edit.py
+++ b/src/apps/ocioview/ocioview/items/active_display_view_edit.py
@@ -3,7 +3,7 @@
 
 from typing import Optional
 
-from PySide2 import QtCore, QtGui, QtWidgets
+from PySide6 import QtCore, QtGui, QtWidgets
 
 from ..widgets import ItemModelListWidget
 from ..utils import get_glyph_icon
diff --git a/src/apps/ocioview/ocioview/items/active_display_view_model.py b/src/apps/ocioview/ocioview/items/active_display_view_model.py
index 297a8e575..63f1d5fd3 100644
--- a/src/apps/ocioview/ocioview/items/active_display_view_model.py
+++ b/src/apps/ocioview/ocioview/items/active_display_view_model.py
@@ -5,7 +5,7 @@
 from typing import Any, Callable, Optional, Type
 
 import PyOpenColorIO as ocio
-from PySide2 import QtCore, QtGui, QtWidgets
+from PySide6 import QtCore, QtGui
 
 from ..config_cache import ConfigCache
 from ..undo import ConfigSnapshotUndoCommand
@@ -87,7 +87,7 @@ def get_item_names(self) -> list[str]:
 
     def _get_undo_command_type(
         self, column_desc: ColumnDesc
-    ) -> Type[QtWidgets.QUndoCommand]:
+    ) -> Type[QtGui.QUndoCommand]:
         if column_desc == self.ACTIVE:
             # Changing check state of the ACTIVE column has side effects related to
             # display/view order, so a config snapshot is needed to revert the change.
diff --git a/src/apps/ocioview/ocioview/items/color_space_edit.py b/src/apps/ocioview/ocioview/items/color_space_edit.py
index 5c3c9b2fa..4e5d659a3 100644
--- a/src/apps/ocioview/ocioview/items/color_space_edit.py
+++ b/src/apps/ocioview/ocioview/items/color_space_edit.py
@@ -4,7 +4,7 @@
 from functools import partial
 from typing import Optional
 
-from PySide2 import QtCore, QtWidgets
+from PySide6 import QtCore, QtWidgets
 import PyOpenColorIO as ocio
 
 from ..config_cache import ConfigCache
diff --git a/src/apps/ocioview/ocioview/items/color_space_model.py b/src/apps/ocioview/ocioview/items/color_space_model.py
index 80f34ee74..3b6c12d2c 100644
--- a/src/apps/ocioview/ocioview/items/color_space_model.py
+++ b/src/apps/ocioview/ocioview/items/color_space_model.py
@@ -5,7 +5,7 @@
 from typing import Any, Optional
 
 import PyOpenColorIO as ocio
-from PySide2 import QtCore, QtGui
+from PySide6 import QtCore, QtGui
 
 from ..config_cache import ConfigCache
 from ..ref_space_manager import ReferenceSpaceManager
diff --git a/src/apps/ocioview/ocioview/items/config_item_edit.py b/src/apps/ocioview/ocioview/items/config_item_edit.py
index 93aca0dc1..a49fbdc65 100644
--- a/src/apps/ocioview/ocioview/items/config_item_edit.py
+++ b/src/apps/ocioview/ocioview/items/config_item_edit.py
@@ -4,7 +4,7 @@
 from functools import partial
 from typing import Optional
 
-from PySide2 import QtCore, QtGui, QtWidgets
+from PySide6 import QtCore, QtGui, QtWidgets
 
 from ..constants import MARGIN_WIDTH
 from ..transform_manager import TransformManager
@@ -47,7 +47,7 @@ def __init__(self, parent: Optional[QtWidgets.QWidget] = None):
 
         if self.__has_transforms__:
             self.__has_tabs__ = True
-            no_tf_color = palette.color(palette.Disabled, palette.Text)
+            no_tf_color = palette.color(palette.ColorGroup.Disabled, palette.ColorRole.Text)
             self._from_ref_icon = get_glyph_icon("mdi6.layers-plus")
             self._no_from_ref_icon = get_glyph_icon(
                 "mdi6.layers-plus", color=no_tf_color
diff --git a/src/apps/ocioview/ocioview/items/config_item_model.py b/src/apps/ocioview/ocioview/items/config_item_model.py
index e06ac024c..15a11c9e1 100644
--- a/src/apps/ocioview/ocioview/items/config_item_model.py
+++ b/src/apps/ocioview/ocioview/items/config_item_model.py
@@ -6,7 +6,7 @@
 from typing import Any, Optional, Type, Union
 
 import PyOpenColorIO as ocio
-from PySide2 import QtCore, QtGui, QtWidgets
+from PySide6 import QtCore, QtGui, QtWidgets
 
 from ..config_cache import ConfigCache
 from ..transform_manager import TransformManager, TransformAgent
@@ -587,7 +587,7 @@ def _get_item_and_column(
 
     def _get_undo_command_type(
         self, column_desc: ColumnDesc
-    ) -> Type[QtWidgets.QUndoCommand]:
+    ) -> Type[QtGui.QUndoCommand]:
         """
         Support overriding the undo command type used to
         track data changes, per column.
diff --git a/src/apps/ocioview/ocioview/items/config_properties_edit.py b/src/apps/ocioview/ocioview/items/config_properties_edit.py
index 37b695a8c..58dddba8d 100644
--- a/src/apps/ocioview/ocioview/items/config_properties_edit.py
+++ b/src/apps/ocioview/ocioview/items/config_properties_edit.py
@@ -5,7 +5,7 @@
 from typing import Optional
 
 import PyOpenColorIO as ocio
-from PySide2 import QtWidgets
+from PySide6 import QtWidgets
 
 from ..constants import RGB
 from ..widgets import (
diff --git a/src/apps/ocioview/ocioview/items/config_properties_model.py b/src/apps/ocioview/ocioview/items/config_properties_model.py
index 895650802..247a7fb42 100644
--- a/src/apps/ocioview/ocioview/items/config_properties_model.py
+++ b/src/apps/ocioview/ocioview/items/config_properties_model.py
@@ -5,7 +5,7 @@
 from pathlib import Path
 from typing import Any, Optional
 
-from PySide2 import QtCore
+from PySide6 import QtCore
 import PyOpenColorIO as ocio
 
 from .config_item_model import ColumnDesc, BaseConfigItemModel
diff --git a/src/apps/ocioview/ocioview/items/delegates.py b/src/apps/ocioview/ocioview/items/delegates.py
index d11428b7f..75499e651 100644
--- a/src/apps/ocioview/ocioview/items/delegates.py
+++ b/src/apps/ocioview/ocioview/items/delegates.py
@@ -4,7 +4,7 @@
 from typing import Optional
 
 import PyOpenColorIO as ocio
-from PySide2 import QtCore, QtWidgets
+from PySide6 import QtCore, QtWidgets
 
 from ..config_cache import ConfigCache
 from ..widgets import CallbackComboBox
@@ -34,7 +34,6 @@ def createEditor(
         editor = CallbackComboBox(
             get_items=ConfigCache.get_color_space_names, editable=True, parent=parent
         )
-        editor.setAutoCompletion(True)
         editor.completer().setCompletionMode(QtWidgets.QCompleter.PopupCompletion)
         return editor
 
@@ -119,7 +118,6 @@ def createEditor(
             raise NotImplementedError
 
         widget = CallbackComboBox(get_items=get_items, editable=True, parent=parent)
-        widget.setAutoCompletion(True)
         widget.completer().setCompletionMode(QtWidgets.QCompleter.PopupCompletion)
         return widget
 
diff --git a/src/apps/ocioview/ocioview/items/display_model.py b/src/apps/ocioview/ocioview/items/display_model.py
index a12f08ff2..1f8c78213 100644
--- a/src/apps/ocioview/ocioview/items/display_model.py
+++ b/src/apps/ocioview/ocioview/items/display_model.py
@@ -5,7 +5,7 @@
 from typing import Any, Optional
 
 import PyOpenColorIO as ocio
-from PySide2 import QtCore
+from PySide6 import QtCore
 
 from ..config_cache import ConfigCache
 from ..utils import next_name
diff --git a/src/apps/ocioview/ocioview/items/display_view_edit.py b/src/apps/ocioview/ocioview/items/display_view_edit.py
index 0c5497a7f..059da4655 100644
--- a/src/apps/ocioview/ocioview/items/display_view_edit.py
+++ b/src/apps/ocioview/ocioview/items/display_view_edit.py
@@ -3,7 +3,7 @@
 
 from typing import Optional
 
-from PySide2 import QtCore, QtGui, QtWidgets
+from PySide6 import QtCore, QtGui, QtWidgets
 
 from ..utils import get_glyph_icon
 from .active_display_view_edit import ActiveDisplayViewEdit
diff --git a/src/apps/ocioview/ocioview/items/file_rule_edit.py b/src/apps/ocioview/ocioview/items/file_rule_edit.py
index ce8641bf0..0dd1b8a2f 100644
--- a/src/apps/ocioview/ocioview/items/file_rule_edit.py
+++ b/src/apps/ocioview/ocioview/items/file_rule_edit.py
@@ -3,7 +3,7 @@
 
 from typing import Optional
 
-from PySide2 import QtCore, QtWidgets
+from PySide6 import QtCore, QtWidgets
 
 from ..config_cache import ConfigCache
 from ..utils import get_glyph_icon
diff --git a/src/apps/ocioview/ocioview/items/file_rule_model.py b/src/apps/ocioview/ocioview/items/file_rule_model.py
index 0be470cd4..d73c76f5a 100644
--- a/src/apps/ocioview/ocioview/items/file_rule_model.py
+++ b/src/apps/ocioview/ocioview/items/file_rule_model.py
@@ -6,7 +6,7 @@
 from typing import Any, Optional, Union
 
 import PyOpenColorIO as ocio
-from PySide2 import QtCore, QtGui
+from PySide6 import QtCore, QtGui
 
 from ..config_cache import ConfigCache
 from ..undo import ConfigSnapshotUndoCommand
diff --git a/src/apps/ocioview/ocioview/items/look_edit.py b/src/apps/ocioview/ocioview/items/look_edit.py
index 0ae3e9015..630051c9c 100644
--- a/src/apps/ocioview/ocioview/items/look_edit.py
+++ b/src/apps/ocioview/ocioview/items/look_edit.py
@@ -5,7 +5,7 @@
 from typing import Optional
 
 import PyOpenColorIO as ocio
-from PySide2 import QtWidgets
+from PySide6 import QtWidgets
 
 from ..config_cache import ConfigCache
 from ..widgets import CallbackComboBox, TextEdit
diff --git a/src/apps/ocioview/ocioview/items/look_model.py b/src/apps/ocioview/ocioview/items/look_model.py
index ef4944692..d7d1a309e 100644
--- a/src/apps/ocioview/ocioview/items/look_model.py
+++ b/src/apps/ocioview/ocioview/items/look_model.py
@@ -5,7 +5,7 @@
 from typing import Any, Optional
 
 import PyOpenColorIO as ocio
-from PySide2 import QtCore, QtGui
+from PySide6 import QtCore, QtGui
 
 from ..config_cache import ConfigCache
 from ..ref_space_manager import ReferenceSpaceManager
diff --git a/src/apps/ocioview/ocioview/items/named_transform_edit.py b/src/apps/ocioview/ocioview/items/named_transform_edit.py
index 7364f0ef9..d2a7bc77a 100644
--- a/src/apps/ocioview/ocioview/items/named_transform_edit.py
+++ b/src/apps/ocioview/ocioview/items/named_transform_edit.py
@@ -3,7 +3,7 @@
 
 from typing import Optional
 
-from PySide2 import QtWidgets
+from PySide6 import QtWidgets
 
 from ..config_cache import ConfigCache
 from ..utils import get_glyph_icon
diff --git a/src/apps/ocioview/ocioview/items/named_transform_model.py b/src/apps/ocioview/ocioview/items/named_transform_model.py
index 656af6b11..2dc02acad 100644
--- a/src/apps/ocioview/ocioview/items/named_transform_model.py
+++ b/src/apps/ocioview/ocioview/items/named_transform_model.py
@@ -5,7 +5,7 @@
 from typing import Any, Optional, Union
 
 import PyOpenColorIO as ocio
-from PySide2 import QtCore, QtGui
+from PySide6 import QtCore, QtGui
 
 from ..config_cache import ConfigCache
 from ..utils import get_glyph_icon
diff --git a/src/apps/ocioview/ocioview/items/role_edit.py b/src/apps/ocioview/ocioview/items/role_edit.py
index af9138266..f527ceef1 100644
--- a/src/apps/ocioview/ocioview/items/role_edit.py
+++ b/src/apps/ocioview/ocioview/items/role_edit.py
@@ -3,7 +3,7 @@
 
 from typing import Optional
 
-from PySide2 import QtGui, QtWidgets
+from PySide6 import QtGui, QtWidgets
 
 from ..widgets import ItemModelTableWidget
 from .delegates import RoleDelegate
diff --git a/src/apps/ocioview/ocioview/items/role_model.py b/src/apps/ocioview/ocioview/items/role_model.py
index 6650c0c0b..fb5f78bbf 100644
--- a/src/apps/ocioview/ocioview/items/role_model.py
+++ b/src/apps/ocioview/ocioview/items/role_model.py
@@ -5,7 +5,7 @@
 from typing import Any
 
 import PyOpenColorIO as ocio
-from PySide2 import QtCore
+from PySide6 import QtCore
 
 from ..config_cache import ConfigCache
 from .config_item_model import ColumnDesc, BaseConfigItemModel
diff --git a/src/apps/ocioview/ocioview/items/rule_edit.py b/src/apps/ocioview/ocioview/items/rule_edit.py
index caef94723..cb60da1e8 100644
--- a/src/apps/ocioview/ocioview/items/rule_edit.py
+++ b/src/apps/ocioview/ocioview/items/rule_edit.py
@@ -3,7 +3,7 @@
 
 from typing import Optional
 
-from PySide2 import QtCore, QtGui, QtWidgets
+from PySide6 import QtCore, QtGui, QtWidgets
 
 from ..utils import get_glyph_icon
 from .file_rule_edit import FileRuleEdit
diff --git a/src/apps/ocioview/ocioview/items/shared_view_edit.py b/src/apps/ocioview/ocioview/items/shared_view_edit.py
index 527fffc5c..db474e531 100644
--- a/src/apps/ocioview/ocioview/items/shared_view_edit.py
+++ b/src/apps/ocioview/ocioview/items/shared_view_edit.py
@@ -5,7 +5,7 @@
 from typing import Optional
 
 import PyOpenColorIO as ocio
-from PySide2 import QtWidgets
+from PySide6 import QtWidgets
 
 from ..config_cache import ConfigCache
 from ..widgets import CallbackComboBox, LineEdit
diff --git a/src/apps/ocioview/ocioview/items/shared_view_model.py b/src/apps/ocioview/ocioview/items/shared_view_model.py
index b89f981fd..776912778 100644
--- a/src/apps/ocioview/ocioview/items/shared_view_model.py
+++ b/src/apps/ocioview/ocioview/items/shared_view_model.py
@@ -6,7 +6,7 @@
 from typing import Any, Optional
 
 import PyOpenColorIO as ocio
-from PySide2 import QtCore, QtGui
+from PySide6 import QtCore, QtGui
 
 from ..config_cache import ConfigCache
 from .config_item_model import ColumnDesc, BaseConfigItemModel
diff --git a/src/apps/ocioview/ocioview/items/view_edit.py b/src/apps/ocioview/ocioview/items/view_edit.py
index 349d401da..1172dbe75 100644
--- a/src/apps/ocioview/ocioview/items/view_edit.py
+++ b/src/apps/ocioview/ocioview/items/view_edit.py
@@ -5,7 +5,7 @@
 from typing import Optional
 
 import PyOpenColorIO as ocio
-from PySide2 import QtCore, QtWidgets
+from PySide6 import QtCore, QtWidgets
 
 from ..config_cache import ConfigCache
 from ..transform_manager import TransformManager
diff --git a/src/apps/ocioview/ocioview/items/view_model.py b/src/apps/ocioview/ocioview/items/view_model.py
index 064b46dff..7fd341263 100644
--- a/src/apps/ocioview/ocioview/items/view_model.py
+++ b/src/apps/ocioview/ocioview/items/view_model.py
@@ -4,7 +4,7 @@
 from typing import Any, Optional, Union
 
 import PyOpenColorIO as ocio
-from PySide2 import QtCore, QtGui
+from PySide6 import QtCore, QtGui
 
 from ..config_cache import ConfigCache
 from ..ref_space_manager import ReferenceSpaceManager
diff --git a/src/apps/ocioview/ocioview/items/view_transform_edit.py b/src/apps/ocioview/ocioview/items/view_transform_edit.py
index 50ffa0e78..c8a087359 100644
--- a/src/apps/ocioview/ocioview/items/view_transform_edit.py
+++ b/src/apps/ocioview/ocioview/items/view_transform_edit.py
@@ -4,7 +4,7 @@
 from functools import partial
 from typing import Optional
 
-from PySide2 import QtWidgets
+from PySide6 import QtWidgets
 import PyOpenColorIO as ocio
 
 from ..config_cache import ConfigCache
diff --git a/src/apps/ocioview/ocioview/items/view_transform_model.py b/src/apps/ocioview/ocioview/items/view_transform_model.py
index 63a954082..69595ecf6 100644
--- a/src/apps/ocioview/ocioview/items/view_transform_model.py
+++ b/src/apps/ocioview/ocioview/items/view_transform_model.py
@@ -5,7 +5,7 @@
 from typing import Any, Optional, Union
 
 import PyOpenColorIO as ocio
-from PySide2 import QtCore, QtGui
+from PySide6 import QtCore, QtGui
 
 from ..config_cache import ConfigCache
 from ..utils import get_enum_member, get_glyph_icon
diff --git a/src/apps/ocioview/ocioview/items/viewing_rule_edit.py b/src/apps/ocioview/ocioview/items/viewing_rule_edit.py
index 67c2ef83f..83c90a70b 100644
--- a/src/apps/ocioview/ocioview/items/viewing_rule_edit.py
+++ b/src/apps/ocioview/ocioview/items/viewing_rule_edit.py
@@ -3,7 +3,7 @@
 
 from typing import Optional
 
-from PySide2 import QtCore, QtWidgets
+from PySide6 import QtCore, QtWidgets
 
 from ..config_cache import ConfigCache
 from ..utils import get_glyph_icon
diff --git a/src/apps/ocioview/ocioview/items/viewing_rule_model.py b/src/apps/ocioview/ocioview/items/viewing_rule_model.py
index 381635ae8..7e04efa3d 100644
--- a/src/apps/ocioview/ocioview/items/viewing_rule_model.py
+++ b/src/apps/ocioview/ocioview/items/viewing_rule_model.py
@@ -7,7 +7,7 @@
 from typing import Any, Optional, Union
 
 import PyOpenColorIO as ocio
-from PySide2 import QtCore, QtGui
+from PySide6 import QtCore, QtGui
 
 from ..config_cache import ConfigCache
 from ..undo import ConfigSnapshotUndoCommand
diff --git a/src/apps/ocioview/ocioview/main_window.py b/src/apps/ocioview/ocioview/main_window.py
index e68b165f9..69646b266 100644
--- a/src/apps/ocioview/ocioview/main_window.py
+++ b/src/apps/ocioview/ocioview/main_window.py
@@ -7,7 +7,7 @@
 from typing import Optional
 
 import PyOpenColorIO as ocio
-from PySide2 import QtCore, QtGui, QtWidgets
+from PySide6 import QtCore, QtGui, QtWidgets
 
 from .config_cache import ConfigCache
 from .config_dock import ConfigDock
diff --git a/src/apps/ocioview/ocioview/message_router.py b/src/apps/ocioview/ocioview/message_router.py
index bbc3744a7..668cb219b 100644
--- a/src/apps/ocioview/ocioview/message_router.py
+++ b/src/apps/ocioview/ocioview/message_router.py
@@ -10,7 +10,7 @@
 from queue import Empty, SimpleQueue
 
 import PyOpenColorIO as ocio
-from PySide2 import QtCore, QtGui, QtWidgets
+from PySide6 import QtCore, QtGui, QtWidgets
 
 from .utils import config_to_html, processor_to_ctf_html, processor_to_shader_html
 
diff --git a/src/apps/ocioview/ocioview/settings.py b/src/apps/ocioview/ocioview/settings.py
index fded91dd5..9f2c5ac7b 100644
--- a/src/apps/ocioview/ocioview/settings.py
+++ b/src/apps/ocioview/ocioview/settings.py
@@ -1,7 +1,7 @@
 # SPDX-License-Identifier: BSD-3-Clause
 # Copyright Contributors to the OpenColorIO Project.
 
-from PySide2 import QtCore
+from PySide6 import QtCore
 
 
 settings = QtCore.QSettings(
diff --git a/src/apps/ocioview/ocioview/style.py b/src/apps/ocioview/ocioview/style.py
index 6acf1399a..1f35c1564 100644
--- a/src/apps/ocioview/ocioview/style.py
+++ b/src/apps/ocioview/ocioview/style.py
@@ -3,7 +3,7 @@
 
 from typing import Optional
 
-from PySide2 import QtGui, QtWidgets
+from PySide6 import QtGui, QtWidgets
 
 from .constants import (
     BORDER_COLOR_ROLE,
diff --git a/src/apps/ocioview/ocioview/transform_manager.py b/src/apps/ocioview/ocioview/transform_manager.py
index fb1078b10..65d72a248 100644
--- a/src/apps/ocioview/ocioview/transform_manager.py
+++ b/src/apps/ocioview/ocioview/transform_manager.py
@@ -7,7 +7,7 @@
 from typing import Callable, Optional
 
 import PyOpenColorIO as ocio
-from PySide2 import QtCore, QtGui
+from PySide6 import QtCore, QtGui
 
 from .utils import get_glyph_icon
 
diff --git a/src/apps/ocioview/ocioview/transforms/allocation_edit.py b/src/apps/ocioview/ocioview/transforms/allocation_edit.py
index 96885a9a5..2e7bde4a0 100644
--- a/src/apps/ocioview/ocioview/transforms/allocation_edit.py
+++ b/src/apps/ocioview/ocioview/transforms/allocation_edit.py
@@ -4,7 +4,7 @@
 from typing import Optional
 
 import PyOpenColorIO as ocio
-from PySide2 import QtCore
+from PySide6 import QtCore
 
 from ..widgets import EnumComboBox, FloatEdit, FloatEditArray
 from .transform_edit import BaseTransformEdit
diff --git a/src/apps/ocioview/ocioview/transforms/builtin_edit.py b/src/apps/ocioview/ocioview/transforms/builtin_edit.py
index 0813d33c9..2be865f24 100644
--- a/src/apps/ocioview/ocioview/transforms/builtin_edit.py
+++ b/src/apps/ocioview/ocioview/transforms/builtin_edit.py
@@ -4,7 +4,7 @@
 from typing import Optional
 
 import PyOpenColorIO as ocio
-from PySide2 import QtCore
+from PySide6 import QtCore
 
 from ..widgets import ComboBox
 from .transform_edit import BaseTransformEdit
diff --git a/src/apps/ocioview/ocioview/transforms/cdl_edit.py b/src/apps/ocioview/ocioview/transforms/cdl_edit.py
index 174b7cace..d411d16ae 100644
--- a/src/apps/ocioview/ocioview/transforms/cdl_edit.py
+++ b/src/apps/ocioview/ocioview/transforms/cdl_edit.py
@@ -4,7 +4,7 @@
 from typing import Optional
 
 import PyOpenColorIO as ocio
-from PySide2 import QtCore
+from PySide6 import QtCore
 
 from ..constants import RGB
 from ..widgets import EnumComboBox, FloatEdit, FloatEditArray
diff --git a/src/apps/ocioview/ocioview/transforms/color_space_edit.py b/src/apps/ocioview/ocioview/transforms/color_space_edit.py
index f297ded44..db83ec88b 100644
--- a/src/apps/ocioview/ocioview/transforms/color_space_edit.py
+++ b/src/apps/ocioview/ocioview/transforms/color_space_edit.py
@@ -4,7 +4,7 @@
 from typing import Optional
 
 import PyOpenColorIO as ocio
-from PySide2 import QtCore
+from PySide6 import QtCore
 
 from ..config_cache import ConfigCache
 from ..widgets import CheckBox, CallbackComboBox
diff --git a/src/apps/ocioview/ocioview/transforms/display_view_edit.py b/src/apps/ocioview/ocioview/transforms/display_view_edit.py
index 059dfc8f4..e5cb3bfae 100644
--- a/src/apps/ocioview/ocioview/transforms/display_view_edit.py
+++ b/src/apps/ocioview/ocioview/transforms/display_view_edit.py
@@ -4,7 +4,7 @@
 from typing import Optional
 
 import PyOpenColorIO as ocio
-from PySide2 import QtCore, QtWidgets
+from PySide6 import QtCore, QtWidgets
 
 from ..config_cache import ConfigCache
 from ..utils import SignalsBlocked
diff --git a/src/apps/ocioview/ocioview/transforms/exponent_edit.py b/src/apps/ocioview/ocioview/transforms/exponent_edit.py
index d7c294a7d..c5ed3dba2 100644
--- a/src/apps/ocioview/ocioview/transforms/exponent_edit.py
+++ b/src/apps/ocioview/ocioview/transforms/exponent_edit.py
@@ -4,7 +4,7 @@
 from typing import Optional
 
 import PyOpenColorIO as ocio
-from PySide2 import QtCore
+from PySide6 import QtCore
 
 from ..constants import RGBA
 from ..widgets import EnumComboBox, FloatEditArray
diff --git a/src/apps/ocioview/ocioview/transforms/exponent_with_linear_edit.py b/src/apps/ocioview/ocioview/transforms/exponent_with_linear_edit.py
index 2f78a68b6..004bdb02f 100644
--- a/src/apps/ocioview/ocioview/transforms/exponent_with_linear_edit.py
+++ b/src/apps/ocioview/ocioview/transforms/exponent_with_linear_edit.py
@@ -4,7 +4,7 @@
 from typing import Optional
 
 import PyOpenColorIO as ocio
-from PySide2 import QtCore
+from PySide6 import QtCore
 
 from ..constants import RGBA
 from ..widgets import EnumComboBox, FloatEditArray
diff --git a/src/apps/ocioview/ocioview/transforms/exposure_contrast_edit.py b/src/apps/ocioview/ocioview/transforms/exposure_contrast_edit.py
index eece95377..891eade24 100644
--- a/src/apps/ocioview/ocioview/transforms/exposure_contrast_edit.py
+++ b/src/apps/ocioview/ocioview/transforms/exposure_contrast_edit.py
@@ -4,7 +4,7 @@
 from typing import Optional
 
 import PyOpenColorIO as ocio
-from PySide2 import QtCore
+from PySide6 import QtCore
 
 from ..widgets import EnumComboBox, FloatEdit
 from .transform_edit import BaseTransformEdit
diff --git a/src/apps/ocioview/ocioview/transforms/file_edit.py b/src/apps/ocioview/ocioview/transforms/file_edit.py
index 68a633477..464eb0ca9 100644
--- a/src/apps/ocioview/ocioview/transforms/file_edit.py
+++ b/src/apps/ocioview/ocioview/transforms/file_edit.py
@@ -5,7 +5,7 @@
 from typing import Optional
 
 import PyOpenColorIO as ocio
-from PySide2 import QtCore
+from PySide6 import QtCore
 
 from ..widgets import EnumComboBox, LineEdit
 from .transform_edit import BaseTransformEdit
diff --git a/src/apps/ocioview/ocioview/transforms/fixed_function_edit.py b/src/apps/ocioview/ocioview/transforms/fixed_function_edit.py
index 35935fab2..ebf701908 100644
--- a/src/apps/ocioview/ocioview/transforms/fixed_function_edit.py
+++ b/src/apps/ocioview/ocioview/transforms/fixed_function_edit.py
@@ -4,7 +4,7 @@
 from typing import Optional
 
 import PyOpenColorIO as ocio
-from PySide2 import QtCore, QtWidgets
+from PySide6 import QtCore, QtWidgets
 
 from ..widgets import EnumComboBox, FloatEditArray, ExpandingStackedWidget
 from .transform_edit import BaseTransformEdit
diff --git a/src/apps/ocioview/ocioview/transforms/log_affine_edit.py b/src/apps/ocioview/ocioview/transforms/log_affine_edit.py
index 285f021e2..4190c9691 100644
--- a/src/apps/ocioview/ocioview/transforms/log_affine_edit.py
+++ b/src/apps/ocioview/ocioview/transforms/log_affine_edit.py
@@ -4,7 +4,7 @@
 from typing import Optional
 
 import PyOpenColorIO as ocio
-from PySide2 import QtCore
+from PySide6 import QtCore
 
 from ..constants import RGB
 from ..widgets import FloatEditArray
diff --git a/src/apps/ocioview/ocioview/transforms/log_camera_edit.py b/src/apps/ocioview/ocioview/transforms/log_camera_edit.py
index 03b4d605c..ddc865000 100644
--- a/src/apps/ocioview/ocioview/transforms/log_camera_edit.py
+++ b/src/apps/ocioview/ocioview/transforms/log_camera_edit.py
@@ -4,7 +4,7 @@
 from typing import Optional
 
 import PyOpenColorIO as ocio
-from PySide2 import QtCore
+from PySide6 import QtCore
 
 from ..constants import RGB
 from ..widgets import FloatEdit, FloatEditArray
diff --git a/src/apps/ocioview/ocioview/transforms/log_edit.py b/src/apps/ocioview/ocioview/transforms/log_edit.py
index f845571b7..638eb9417 100644
--- a/src/apps/ocioview/ocioview/transforms/log_edit.py
+++ b/src/apps/ocioview/ocioview/transforms/log_edit.py
@@ -4,7 +4,7 @@
 from typing import Optional
 
 import PyOpenColorIO as ocio
-from PySide2 import QtCore
+from PySide6 import QtCore
 
 from ..widgets import FloatEdit
 from .transform_edit import BaseTransformEdit
diff --git a/src/apps/ocioview/ocioview/transforms/look_edit.py b/src/apps/ocioview/ocioview/transforms/look_edit.py
index 396ee74d3..e6b0005a1 100644
--- a/src/apps/ocioview/ocioview/transforms/look_edit.py
+++ b/src/apps/ocioview/ocioview/transforms/look_edit.py
@@ -4,7 +4,7 @@
 from typing import Optional
 
 import PyOpenColorIO as ocio
-from PySide2 import QtCore
+from PySide6 import QtCore
 
 from ..config_cache import ConfigCache
 from ..widgets import CheckBox, CallbackComboBox, LineEdit
diff --git a/src/apps/ocioview/ocioview/transforms/matrix_edit.py b/src/apps/ocioview/ocioview/transforms/matrix_edit.py
index dad31c769..5cd48068b 100644
--- a/src/apps/ocioview/ocioview/transforms/matrix_edit.py
+++ b/src/apps/ocioview/ocioview/transforms/matrix_edit.py
@@ -4,7 +4,7 @@
 from typing import Optional
 
 import PyOpenColorIO as ocio
-from PySide2 import QtCore, QtGui, QtWidgets
+from PySide6 import QtCore, QtGui, QtWidgets
 
 from ..constants import RGB, RGBA
 from ..widgets import (
diff --git a/src/apps/ocioview/ocioview/transforms/range_edit.py b/src/apps/ocioview/ocioview/transforms/range_edit.py
index f0d6281dc..c6f4d058b 100644
--- a/src/apps/ocioview/ocioview/transforms/range_edit.py
+++ b/src/apps/ocioview/ocioview/transforms/range_edit.py
@@ -4,7 +4,7 @@
 from typing import Optional
 
 import PyOpenColorIO as ocio
-from PySide2 import QtCore, QtWidgets
+from PySide6 import QtCore, QtWidgets
 
 from ..widgets import CheckBox, EnumComboBox, FloatEdit
 from .transform_edit import BaseTransformEdit
diff --git a/src/apps/ocioview/ocioview/transforms/transform_edit.py b/src/apps/ocioview/ocioview/transforms/transform_edit.py
index 65821f2e1..9c297fa2a 100644
--- a/src/apps/ocioview/ocioview/transforms/transform_edit.py
+++ b/src/apps/ocioview/ocioview/transforms/transform_edit.py
@@ -7,7 +7,7 @@
 from typing import Optional
 
 import PyOpenColorIO as ocio
-from PySide2 import QtCore, QtGui, QtWidgets
+from PySide6 import QtCore, QtGui, QtWidgets
 
 from ..constants import ICON_SIZE_ITEM, BORDER_COLOR_ROLE
 from ..style import apply_top_tool_bar_style, apply_widget_with_top_tool_bar_style
diff --git a/src/apps/ocioview/ocioview/transforms/transform_edit_stack.py b/src/apps/ocioview/ocioview/transforms/transform_edit_stack.py
index b01b8edfb..1f7eaf10b 100644
--- a/src/apps/ocioview/ocioview/transforms/transform_edit_stack.py
+++ b/src/apps/ocioview/ocioview/transforms/transform_edit_stack.py
@@ -5,7 +5,7 @@
 from typing import Optional
 
 import PyOpenColorIO as ocio
-from PySide2 import QtCore, QtGui, QtWidgets
+from PySide6 import QtCore, QtGui, QtWidgets
 
 # Register all transform edit types
 from .. import transforms
@@ -48,7 +48,7 @@ def __init__(self, parent: Optional[QtCore.QObject] = None):
         self.add_tf_button.setToolButtonStyle(QtCore.Qt.ToolButtonTextBesideIcon)
         self.add_tf_button.setMenu(self.tf_menu)
 
-        self._start_collapsed_action = QtWidgets.QAction("Start Collapsed")
+        self._start_collapsed_action = QtGui.QAction("Start Collapsed")
         self._start_collapsed_action.setCheckable(True)
         self._start_collapsed_action.triggered[bool].connect(
             self._on_start_collapsed_changed
diff --git a/src/apps/ocioview/ocioview/undo.py b/src/apps/ocioview/ocioview/undo.py
index aee5ddef6..d8b0d14f9 100644
--- a/src/apps/ocioview/ocioview/undo.py
+++ b/src/apps/ocioview/ocioview/undo.py
@@ -6,16 +6,16 @@
 from typing import Any, Optional
 
 import PyOpenColorIO as ocio
-from PySide2 import QtCore, QtWidgets
+from PySide6 import QtCore, QtGui
 
 from .config_cache import ConfigCache
 
 
-undo_stack = QtWidgets.QUndoStack()
+undo_stack = QtGui.QUndoStack()
 """Global undo stack."""
 
 
-class ItemModelUndoCommand(QtWidgets.QUndoCommand):
+class ItemModelUndoCommand(QtGui.QUndoCommand):
     """
     Undo command for use in item model ``setData`` implementations.
 
@@ -31,7 +31,7 @@ def __init__(
         index: QtCore.QPersistentModelIndex,
         redo_value: Any,
         undo_value: Any,
-        parent: Optional[QtWidgets.QUndoCommand] = None,
+        parent: Optional[QtGui.QUndoCommand] = None,
     ):
         """
         :param text: Undo/redo command menu text
@@ -59,7 +59,7 @@ def undo(self) -> None:
             model.setData(self._index, self._undo_value)
 
 
-class ConfigSnapshotUndoCommand(QtWidgets.QUndoCommand):
+class ConfigSnapshotUndoCommand(QtGui.QUndoCommand):
     """
     Undo command for complex config changes like item adds, moves,
     and deletes, to be used as a content manager in which the entry
@@ -71,7 +71,7 @@ def __init__(
         text: str,
         model: Optional[QtCore.QAbstractItemModel] = None,
         item_name: Optional[str] = None,
-        parent: Optional[QtWidgets.QUndoCommand] = None,
+        parent: Optional[QtGui.QUndoCommand] = None,
     ):
         """
         :param text: Undo/redo command menu text
diff --git a/src/apps/ocioview/ocioview/utils.py b/src/apps/ocioview/ocioview/utils.py
index 23a02e088..31091a8fe 100644
--- a/src/apps/ocioview/ocioview/utils.py
+++ b/src/apps/ocioview/ocioview/utils.py
@@ -12,7 +12,7 @@
 from pygments import highlight
 from pygments.lexers import GLShaderLexer, HLSLShaderLexer, XmlLexer, YamlLexer
 from pygments.formatters import HtmlFormatter
-from PySide2 import QtCore, QtGui, QtWidgets
+from PySide6 import QtCore, QtGui, QtWidgets
 
 from .constants import ICON_SCALE_FACTOR, ICON_SIZE_BUTTON
 
diff --git a/src/apps/ocioview/ocioview/viewer/image_plane.py b/src/apps/ocioview/ocioview/viewer/image_plane.py
index b36c4cc4a..7b06fd4cb 100644
--- a/src/apps/ocioview/ocioview/viewer/image_plane.py
+++ b/src/apps/ocioview/ocioview/viewer/image_plane.py
@@ -11,13 +11,16 @@
 from functools import partial
 from pathlib import Path
 from typing import Any, Optional
+import sys
 
-import imath
 import numpy as np
 from OpenGL import GL
-import OpenImageIO as oiio
+try:
+    import OpenImageIO as oiio
+except:
+    import imageio as iio
 import PyOpenColorIO as ocio
-from PySide2 import QtCore, QtGui, QtWidgets, QtOpenGL
+from PySide6 import QtCore, QtGui, QtWidgets, QtOpenGLWidgets
 
 from ..log_handlers import message_queue
 from ..ref_space_manager import ReferenceSpaceManager
@@ -88,7 +91,7 @@
 """
 
 
-class ImagePlane(QtOpenGL.QGLWidget):
+class ImagePlane(QtOpenGLWidgets.QOpenGLWidget):
     """
     Qt-wrapped OpenGL window for drawing with PyOpenGL.
     """
@@ -125,8 +128,8 @@ def __init__(self, parent: Optional[QtWidgets.QWidget] = None):
         self._ocio_uniform_ids = {}
 
         # MVP matrix components
-        self._model_view_mat = imath.M44f()
-        self._proj_mat = imath.M44f()
+        self._model_view_mat = np.eye(4)
+        self._proj_mat = np.eye(4)
 
         # Keyboard shortcuts
         self._shortcuts = []
@@ -136,10 +139,10 @@ def __init__(self, parent: Optional[QtWidgets.QWidget] = None):
         self._mouse_last_pos = QtCore.QPointF()
 
         # Image texture
-        self._image_buf = None
+        self._image_array = None
         self._image_tex = None
-        self._image_pos = imath.V2f(0.0, 0.0)
-        self._image_size = imath.V2f(1.0, 1.0)
+        self._image_pos = np.array([0.0, 0.0])
+        self._image_size = np.array([1.0, 1.0])
         self._image_scale = 1.0
 
         # Image plane VAO
@@ -170,8 +173,8 @@ def initializeGL(self) -> None:
             GL.GL_TEXTURE_2D,
             0,
             GL.GL_RGBA32F,
-            self._image_size.x,
-            self._image_size.y,
+            self._image_size[0],
+            self._image_size[1],
             0,
             GL.GL_RGBA,
             GL.GL_FLOAT,
@@ -261,6 +264,31 @@ def initializeGL(self) -> None:
 
         self._build_program()
 
+    def _orthographicProjMatrix(self, near, far, left, right, top, bottom):
+        rightPlusLeft  = right + left
+        rightMinusLeft = right - left
+
+        topPlusBottom  = top + bottom
+        topMinusBottom = top - bottom
+
+        farPlusNear  = far + near
+        farMinusNear = far - near
+
+        tx = -rightPlusLeft / rightMinusLeft
+        ty = -topPlusBottom / topMinusBottom
+        tz = -farPlusNear / farMinusNear
+
+        A = 2 / rightMinusLeft
+        B = 2 / topMinusBottom
+        C = -2 / farMinusNear
+
+        return np.array([
+            [A, 0, 0, tx],
+            [0, B, 0, ty],
+            [0, 0, C, tz],
+            [0, 0, 0, 1 ]
+        ])
+
     def resizeGL(self, w: int, h: int) -> None:
         """
         Called whenever the widget is resized.
@@ -271,18 +299,15 @@ def resizeGL(self, w: int, h: int) -> None:
         GL.glViewport(0, 0, w, h)
 
         # Center image plane
-        # fmt: off
-        frustum = imath.Frustumf(
+        # fmt: on
+        self._proj_mat = self._orthographicProjMatrix(
                 -1.0,  # Near
                  1.0,  # Far
             -w / 2.0,  # Left
              w / 2.0,  # Right
              h / 2.0,  # Top
             -h / 2.0,  # Bottom
-            True,
         )
-        # fmt: on
-        self._proj_mat = frustum.projectionMatrix()
 
         self._update_model_view_mat()
 
@@ -301,10 +326,10 @@ def paintGL(self) -> None:
             self._use_ocio_uniforms()
 
             # Set uniforms
-            mvp_mat = self._proj_mat * self._model_view_mat
+            mvp_mat = self._proj_mat @ self._model_view_mat
             mvp_mat_loc = GL.glGetUniformLocation(self._shader_program, "mvpMat")
             GL.glUniformMatrix4fv(
-                mvp_mat_loc, 1, GL.GL_FALSE, self._m44f_to_ndarray(mvp_mat)
+                mvp_mat_loc, 1, GL.GL_FALSE, mvp_mat.T
             )
 
             image_tex_loc = GL.glGetUniformLocation(self._shader_program, "imageTex")
@@ -322,6 +347,55 @@ def paintGL(self) -> None:
 
             GL.glBindVertexArray(0)
 
+    def load_oiio(self, image_path: Path) -> np.ndarray:
+        image_buf = oiio.ImageBuf(image_path.as_posix())
+        spec = image_buf.spec()
+
+        # Convert to RGBA, filling missing color channels with 0.0, and a
+        # missing alpha with 1.0.
+        if spec.nchannels < 4:
+            image_buf = oiio.ImageBufAlgo.channels(
+                image_buf,
+                tuple(
+                    list(range(spec.nchannels))
+                    + ([0.0] * (4 - spec.nchannels - 1))
+                    + [1.0]
+                ),
+                newchannelnames=("R", "G", "B", "A"),
+            )
+        elif spec.nchannels > 4:
+            image_buf = oiio.ImageBufAlgo.channels(
+                image_buf, (0, 1, 2, 3), newchannelnames=("R", "G", "B", "A")
+            )
+
+        # Get pixels as 32-bit float NumPy array
+        return image_buf.get_pixels(oiio.FLOAT)
+
+    def load_iio(self, image_path: Path) -> np.ndarray:
+        data = iio.imread(image_path.as_posix())
+
+        # Convert to 32-bit float
+        if not np.issubdtype(data.dtype, np.floating):
+            data = data.astype(np.float32) / np.iinfo(data.dtype).max
+        if data.dtype != np.float32:
+            data = data.astype(np.float32)
+
+        # Convert to RGBA, filling missing color channels with 0.0, and a
+        # missing alpha with 1.0.
+        nchannels = 1
+        if len(data.shape) == 3:
+            nchannels = data.shape[-1]
+
+        while nchannels < 3:
+            data = np.dstack((data, np.zeros(data.shape[:2])))
+            nchannels += 1
+        if nchannels < 4:
+            data = np.dstack((data, np.ones(data.shape[:2])))
+        if nchannels > 4:
+            data = data[..., :4]
+
+        return data
+
     def load_image(self, image_path: Path) -> None:
         """
         Load an image into the image plane texture.
@@ -342,34 +416,18 @@ def load_image(self, image_path: Path) -> None:
                 color_space_name = ocio.ROLE_DEFAULT
         self._ocio_input_color_space = color_space_name
 
-        self._image_buf = oiio.ImageBuf(image_path.as_posix())
-        spec = self._image_buf.spec()
-
-        # Convert to RGBA, filling missing color channels with 0.0, and a
-        # missing alpha with 1.0.
-        if spec.nchannels < 4:
-            self._image_buf = oiio.ImageBufAlgo.channels(
-                self._image_buf,
-                tuple(
-                    list(range(spec.nchannels))
-                    + ([0.0] * (4 - spec.nchannels - 1))
-                    + [1.0]
-                ),
-                newchannelnames=("R", "G", "B", "A"),
-            )
-        elif spec.nchannels > 4:
-            self._image_buf = oiio.ImageBufAlgo.channels(
-                self._image_buf, (0, 1, 2, 3), newchannelnames=("R", "G", "B", "A")
-            )
+        if "OpenImageIO" in sys.modules:
+            self._image_array = self.load_oiio(image_path)
+        else:
+            self._image_array = self.load_iio(image_path)
 
-        # Get pixels as 32-bit float NumPy array
-        data = self._image_buf.get_pixels(oiio.FLOAT)
+        width = self._image_array.shape[1]
+        height = self._image_array.shape[0]
 
         # Stash image size for pan/zoom calculations
-        self._image_pos.x = spec.x
-        self._image_pos.y = spec.y
-        self._image_size.x = spec.width
-        self._image_size.y = spec.height
+
+        self._image_pos = np.array([0, 1], dtype=np.float64)
+        self._image_size = np.array([width, height], dtype=np.float64)
 
         # Load image data into texture
         self.makeCurrent()
@@ -379,16 +437,16 @@ def load_image(self, image_path: Path) -> None:
             GL.GL_TEXTURE_2D,
             0,
             GL.GL_RGBA32F,
-            spec.width,
-            spec.height,
+            width,
+            height,
             0,
             GL.GL_RGBA,
             GL.GL_FLOAT,
-            data.ravel(),
+            self._image_array.ravel(),
         )
 
         self.image_loaded.emit(
-            image_path, int(self._image_size.x), int(self._image_size.y)
+            image_path, int(self._image_size[0]), int(self._image_size[1])
         )
 
         self.update_ocio_proc(input_color_space=self._ocio_input_color_space)
@@ -628,7 +686,7 @@ def mouseMoveEvent(self, event: QtGui.QMouseEvent) -> None:
         pos = event.pos()
 
         if self._mouse_pressed:
-            offset = imath.V2f(*(pos - self._mouse_last_pos).toTuple())
+            offset = np.array([*(pos - self._mouse_last_pos).toTuple()])
             self._mouse_last_pos = pos
 
             self.pan(offset, update=True)
@@ -638,29 +696,24 @@ def mouseMoveEvent(self, event: QtGui.QMouseEvent) -> None:
 
             # Trace mouse position through the inverse MVP matrix to update sampled
             # pixel.
-            screen_pos = imath.V3f(
+            screen_pos = np.array([
                 pos.x() / widget_w * 2.0 - 1.0,
                 (widget_h - pos.y() - 1) / widget_h * 2.0 - 1.0,
                 0.0,
-            )
-            model_pos = (
-                (self._proj_mat * self._model_view_mat)
-                .inverse()
-                .multVecMatrix(screen_pos)
-            )
-            pixel_pos = (
-                imath.V2f(model_pos.x + 0.5, model_pos.y + 0.5) * self._image_size
-            )
+                1.0
+            ])
+            model_pos = np.linalg.inv(self._proj_mat @ self._model_view_mat) @ screen_pos
+            pixel_pos = np.array([model_pos[0] + 0.5, model_pos[1] + 0.5]) * self._image_size
 
             # Broadcast sample position
             if (
-                self._image_buf is not None
-                and 0 <= pixel_pos.x <= self._image_size.x
-                and 0 <= pixel_pos.y <= self._image_size.y
+                self._image_array is not None
+                and 0 <= pixel_pos[0] <= self._image_size[0]
+                and 0 <= pixel_pos[1] <= self._image_size[1]
             ):
-                pixel_x = math.floor(pixel_pos.x)
-                pixel_y = math.floor(pixel_pos.y)
-                pixel_input = list(self._image_buf.getpixel(pixel_x, pixel_y))
+                pixel_x = math.floor(pixel_pos[0])
+                pixel_y = math.floor(pixel_pos[1])
+                pixel_input = list(self._image_array[pixel_y, pixel_x])
                 if len(pixel_input) < 3:
                     pixel_input += [0.0] * (3 - len(pixel_input))
                 elif len(pixel_input) > 3:
@@ -685,9 +738,9 @@ def wheelEvent(self, event: QtGui.QWheelEvent) -> None:
 
         # Fit image to frame
         if h > w:
-            min_scale = w / self._image_size.x
+            min_scale = w / self._image_size[0]
         else:
-            min_scale = h / self._image_size.y
+            min_scale = h / self._image_size[1]
 
         # Fill frame with 1 pixel with 0.5 pixel overscan
         max_scale = max(w, h) * 1.5
@@ -712,7 +765,7 @@ def wheelEvent(self, event: QtGui.QWheelEvent) -> None:
         self.zoom(event.pos(), scale, update=True, absolute=True)
 
     def pan(
-        self, offset: imath.V2f, update: bool = True, absolute: bool = False
+        self, offset: np.ndarray, update: bool = True, absolute: bool = False
     ) -> None:
         """
         Pan the viewport by the specified offset in screen space.
@@ -746,7 +799,7 @@ def zoom(
         :param absolute: When True, amount will be treated as an
             absolute scale to set the viewport to.
         """
-        offset = imath.V2f(*(point - self.rect().center()).toTuple())
+        offset = np.array([*(point - self.rect().center()).toTuple()])
 
         self.pan(-offset, update=False)
 
@@ -759,7 +812,7 @@ def zoom(
 
         self.pan(offset, update=update)
 
-        if self._image_buf is not None:
+        if self._image_array is not None:
             self.scale_changed.emit(self._image_scale)
 
     def fit(self, update: bool = True) -> None:
@@ -773,12 +826,12 @@ def fit(self, update: bool = True) -> None:
 
         # Fit image to frame
         if h > w:
-            scale = w / self._image_size.x
+            scale = w / self._image_size[0]
         else:
-            scale = h / self._image_size.y
+            scale = h / self._image_size[1]
 
         self.zoom(QtCore.QPoint(), scale, update=False, absolute=True)
-        self.pan(imath.V2f(), update=update, absolute=True)
+        self.pan(np.array([0.0, 0.0]), update=update, absolute=True)
 
     def _install_shortcuts(self) -> None:
         """
@@ -787,7 +840,7 @@ def _install_shortcuts(self) -> None:
         # R,G,B,A = view channel
         # C = view color
         for i, key in enumerate(("R", "G", "B", "A", "C")):
-            channel_shortcut = QtWidgets.QShortcut(QtGui.QKeySequence(key), self)
+            channel_shortcut = QtGui.QShortcut(QtGui.QKeySequence(key), self)
             channel_shortcut.activated.connect(
                 partial(self.update_ocio_proc, channel=i)
             )
@@ -795,7 +848,7 @@ def _install_shortcuts(self) -> None:
 
         # Number keys = Subscribe to transform @ slot
         for i in range(10):
-            subscribe_shortcut = QtWidgets.QShortcut(QtGui.QKeySequence(str(i)), self)
+            subscribe_shortcut = QtGui.QShortcut(QtGui.QKeySequence(str(i)), self)
             subscribe_shortcut.activated.connect(
                 lambda slot=i: self.tf_subscription_requested.emit(slot)
             )
@@ -803,7 +856,7 @@ def _install_shortcuts(self) -> None:
 
         # Ctrl + Number keys = Power of 2 scale: 1 = x1, 2 = x2, 3 = x4, ...
         for i in range(9):
-            scale_shortcut = QtWidgets.QShortcut(
+            scale_shortcut = QtGui.QShortcut(
                 QtGui.QKeySequence(f"Ctrl+{i + 1}"), self
             )
             scale_shortcut.activated.connect(
@@ -814,7 +867,7 @@ def _install_shortcuts(self) -> None:
             self._shortcuts.append(scale_shortcut)
 
         # F = fit image to viewport
-        fit_shortcut = QtWidgets.QShortcut(QtGui.QKeySequence("F"), self)
+        fit_shortcut = QtGui.QShortcut(QtGui.QKeySequence("F"), self)
         fit_shortcut.activated.connect(self.fit)
         self._shortcuts.append(fit_shortcut)
 
@@ -912,18 +965,17 @@ def _update_model_view_mat(self, update: bool = True) -> None:
 
         :param bool update: Optionally redraw the window
         """
-        size = self._widget_size_to_v2f(self)
+        size = np.array([self.width(), self.height()])
 
-        self._model_view_mat.makeIdentity()
+        self._model_view_mat = np.eye(4)
 
         # Flip Y to account for different OIIO/OpenGL image origin
-        self._model_view_mat.scale(imath.V3f(1.0, -1.0, 1.0))
+        self._model_view_mat *= [1.0, -1.0, 1.0, 1.0]
 
-        self._model_view_mat.scale(imath.V3f(self._image_scale, self._image_scale, 1.0))
-        self._model_view_mat.translate(
-            self._v2f_to_v3f(self._image_pos / size * 2.0, 0.0)
-        )
-        self._model_view_mat.scale(self._v2f_to_v3f(self._image_size, 1.0))
+        self._model_view_mat *= [self._image_scale, self._image_scale, 1.0, 1.0]
+        self._model_view_mat[:2, -1] += self._image_pos / size * 2.0
+
+        self._model_view_mat *= self._image_size.tolist() + [1.0, 1.0]
 
         # Use nearest interpolation when scaling up to see pixels
         if self._image_scale > 1.0:
@@ -1138,43 +1190,3 @@ def _update_ocio_channel_hot(self, channel: int) -> None:
         else:
             for i in range(4):
                 self._ocio_channel_hot[i] = 1
-
-    def _m44f_to_ndarray(self, m44f: imath.M44f) -> np.ndarray:
-        """
-        Convert Imath.M44f matrix to a flat NumPy float32 array, so that it
-        can be passed to PyOpenGL functions.
-
-        :param m44f: 4x4 matrix
-        :return: NumPy array
-        """
-        # fmt: off
-        return np.array(
-            [
-                m44f[0][0], m44f[0][1], m44f[0][2], m44f[0][3],
-                m44f[1][0], m44f[1][1], m44f[1][2], m44f[1][3],
-                m44f[2][0], m44f[2][1], m44f[2][2], m44f[2][3],
-                m44f[3][0], m44f[3][1], m44f[3][2], m44f[3][3],
-            ],
-            dtype=np.float32,
-        )
-        # fmt: on
-
-    def _v2f_to_v3f(self, v2f: imath.V2f, z: float) -> imath.V3f:
-        """
-        Extend an Imath.V2f to an Imath.V3f by adding a Z dimension
-        value.
-
-        :param v2f: 2D float vector to extend
-        :param z: Z value to extend vector with
-        :return: 3D float vector
-        """
-        return imath.V3f(v2f.x, v2f.y, z)
-
-    def _widget_size_to_v2f(self, widget: QtWidgets.QWidget) -> imath.V2f:
-        """
-        Get QWidget dimensions as an Imath.V2f.
-
-        :param widget: Widget to get dimensions of
-        :return: 2D float vector
-        """
-        return imath.V2f(widget.width(), widget.height())
diff --git a/src/apps/ocioview/ocioview/viewer/image_viewer.py b/src/apps/ocioview/ocioview/viewer/image_viewer.py
index f687e7b13..11436a06c 100644
--- a/src/apps/ocioview/ocioview/viewer/image_viewer.py
+++ b/src/apps/ocioview/ocioview/viewer/image_viewer.py
@@ -6,7 +6,7 @@
 from typing import Generator, Optional
 
 import PyOpenColorIO as ocio
-from PySide2 import QtCore, QtGui, QtWidgets
+from PySide6 import QtCore, QtGui, QtWidgets
 
 from ..transform_manager import TransformManager
 from ..config_cache import ConfigCache
@@ -253,7 +253,7 @@ def __init__(self, parent: Optional[QtWidgets.QWidget] = None):
         self.image_plane.tf_subscription_requested.connect(
             self._on_tf_subscription_requested
         )
-        self.input_color_space_box.currentIndexChanged[str].connect(
+        self.input_color_space_box.currentTextChanged[str].connect(
             self._on_input_color_space_changed
         )
         self.tf_box.currentIndexChanged[int].connect(self._on_transform_changed)
diff --git a/src/apps/ocioview/ocioview/viewer_dock.py b/src/apps/ocioview/ocioview/viewer_dock.py
index 26cdb075f..b295fc35c 100644
--- a/src/apps/ocioview/ocioview/viewer_dock.py
+++ b/src/apps/ocioview/ocioview/viewer_dock.py
@@ -5,7 +5,7 @@
 from pathlib import Path
 from typing import Optional
 
-from PySide2 import QtCore, QtWidgets
+from PySide6 import QtCore, QtWidgets
 
 from .settings import settings
 from .transform_manager import TransformManager
diff --git a/src/apps/ocioview/ocioview/widgets/check_box.py b/src/apps/ocioview/ocioview/widgets/check_box.py
index eb2566a74..7dcdbc828 100644
--- a/src/apps/ocioview/ocioview/widgets/check_box.py
+++ b/src/apps/ocioview/ocioview/widgets/check_box.py
@@ -1,7 +1,7 @@
 # SPDX-License-Identifier: BSD-3-Clause
 # Copyright Contributors to the OpenColorIO Project.
 
-from PySide2 import QtCore, QtWidgets
+from PySide6 import QtCore, QtWidgets
 
 from ..utils import SignalsBlocked
 
diff --git a/src/apps/ocioview/ocioview/widgets/combo_box.py b/src/apps/ocioview/ocioview/widgets/combo_box.py
index 2f1f0f0c6..5ddc2b308 100644
--- a/src/apps/ocioview/ocioview/widgets/combo_box.py
+++ b/src/apps/ocioview/ocioview/widgets/combo_box.py
@@ -4,7 +4,7 @@
 import enum
 from typing import Callable, Optional
 
-from PySide2 import QtCore, QtGui, QtWidgets
+from PySide6 import QtCore, QtGui, QtWidgets
 
 from ..utils import SignalsBlocked
 
@@ -12,7 +12,7 @@
 class ComboBox(QtWidgets.QComboBox):
     def __init__(self, parent: Optional[QtCore.QObject] = None):
         super().__init__(parent=parent)
-        self.setSizeAdjustPolicy(QtWidgets.QComboBox.AdjustToMinimumContentsLength)
+        self.setSizeAdjustPolicy(QtWidgets.QComboBox.AdjustToMinimumContentsLengthWithIcon)
 
     # DataWidgetMapper user property interface
     @QtCore.Property(str, user=True)
@@ -103,7 +103,6 @@ def __init__(
         self._item_icon = item_icon
 
         self.setEditable(editable)
-        self.setAutoCompletion(True)
         self.setInsertPolicy(QtWidgets.QComboBox.NoInsert)
 
         completer = self.completer()
diff --git a/src/apps/ocioview/ocioview/widgets/item_view.py b/src/apps/ocioview/ocioview/widgets/item_view.py
index 2d81b5ec5..44d05fe18 100644
--- a/src/apps/ocioview/ocioview/widgets/item_view.py
+++ b/src/apps/ocioview/ocioview/widgets/item_view.py
@@ -3,7 +3,7 @@
 
 from typing import Callable, Optional
 
-from PySide2 import QtCore, QtGui, QtWidgets
+from PySide6 import QtCore, QtGui, QtWidgets
 
 from ..constants import ICON_SIZE_BUTTON, ICON_SIZE_ITEM
 from ..style import apply_top_tool_bar_style, apply_widget_with_top_tool_bar_style
@@ -241,6 +241,6 @@ def _on_preset_menu_requested(self) -> None:
                 else:
                     self.preset_menu.addAction(preset)
 
-    def _on_preset_triggered(self, action: QtWidgets.QAction) -> None:
+    def _on_preset_triggered(self, action: QtGui.QAction) -> None:
         """Add a new item from the triggered preset."""
         self.add_item(action.text())
diff --git a/src/apps/ocioview/ocioview/widgets/layout.py b/src/apps/ocioview/ocioview/widgets/layout.py
index e21cb71ea..331b057f2 100644
--- a/src/apps/ocioview/ocioview/widgets/layout.py
+++ b/src/apps/ocioview/ocioview/widgets/layout.py
@@ -3,7 +3,7 @@
 
 from typing import Optional
 
-from PySide2 import QtCore, QtWidgets
+from PySide6 import QtCore, QtWidgets
 
 
 class FormLayout(QtWidgets.QFormLayout):
diff --git a/src/apps/ocioview/ocioview/widgets/line_edit.py b/src/apps/ocioview/ocioview/widgets/line_edit.py
index 3588bd70e..0562cb549 100644
--- a/src/apps/ocioview/ocioview/widgets/line_edit.py
+++ b/src/apps/ocioview/ocioview/widgets/line_edit.py
@@ -5,7 +5,7 @@
 from pathlib import Path
 from typing import Any, Optional, Sequence
 
-from PySide2 import QtCore, QtGui, QtWidgets
+from PySide6 import QtCore, QtGui, QtWidgets
 
 from ..constants import R_COLOR, G_COLOR, B_COLOR
 from ..utils import SignalsBlocked, get_glyph_icon
@@ -50,7 +50,7 @@ class PathEdit(LineEdit):
         QtWidgets.QFileDialog.AnyFile: "ph.file",
         QtWidgets.QFileDialog.ExistingFile: "ph.file",
         QtWidgets.QFileDialog.Directory: "ph.folder",
-        QtWidgets.QFileDialog.DirectoryOnly: "ph.folder",
+        QtWidgets.QFileDialog.ShowDirsOnly: "ph.folder",
     }
 
     def __init__(
@@ -75,7 +75,7 @@ def __init__(
         if self._file_mode in self.BROWSE_GLYPHS:
             self._browse_action = self.addAction(
                 get_glyph_icon(self.BROWSE_GLYPHS[self._file_mode]),
-                self.TrailingPosition,
+                self.ActionPosition.TrailingPosition,
             )
             self._browse_action.triggered.connect(self._on_browse_action_triggered)
 
diff --git a/src/apps/ocioview/ocioview/widgets/list_widget.py b/src/apps/ocioview/ocioview/widgets/list_widget.py
index 88fc5159c..8fc686058 100644
--- a/src/apps/ocioview/ocioview/widgets/list_widget.py
+++ b/src/apps/ocioview/ocioview/widgets/list_widget.py
@@ -3,7 +3,7 @@
 
 from typing import Callable, Optional, TYPE_CHECKING, Union
 
-from PySide2 import QtCore, QtGui, QtWidgets
+from PySide6 import QtCore, QtGui, QtWidgets
 
 from ..utils import SignalsBlocked, next_name
 from .item_view import BaseItemView
diff --git a/src/apps/ocioview/ocioview/widgets/log_view.py b/src/apps/ocioview/ocioview/widgets/log_view.py
index 79cfd4ea6..91f79b8f4 100644
--- a/src/apps/ocioview/ocioview/widgets/log_view.py
+++ b/src/apps/ocioview/ocioview/widgets/log_view.py
@@ -3,7 +3,7 @@
 
 from typing import Any, Optional
 
-from PySide2 import QtCore, QtGui, QtWidgets
+from PySide6 import QtCore, QtGui, QtWidgets
 
 from ..constants import ICON_SIZE_BUTTON
 from ..style import (
diff --git a/src/apps/ocioview/ocioview/widgets/structure.py b/src/apps/ocioview/ocioview/widgets/structure.py
index b29571756..dc1492a2e 100644
--- a/src/apps/ocioview/ocioview/widgets/structure.py
+++ b/src/apps/ocioview/ocioview/widgets/structure.py
@@ -4,7 +4,7 @@
 from pathlib import Path
 from typing import Optional, Union
 
-from PySide2 import QtCore, QtGui, QtWidgets
+from PySide6 import QtCore, QtGui, QtWidgets
 
 from ..constants import ICON_SIZE_BUTTON, BORDER_COLOR_ROLE
 from ..style import apply_top_tool_bar_style
diff --git a/src/apps/ocioview/ocioview/widgets/table_widget.py b/src/apps/ocioview/ocioview/widgets/table_widget.py
index c0da4af86..fc6df1d5c 100644
--- a/src/apps/ocioview/ocioview/widgets/table_widget.py
+++ b/src/apps/ocioview/ocioview/widgets/table_widget.py
@@ -3,7 +3,7 @@
 
 from typing import Callable, Optional
 
-from PySide2 import QtCore, QtGui, QtWidgets
+from PySide6 import QtCore, QtGui, QtWidgets
 
 from ..constants import ICON_SIZE_ITEM
 from ..utils import SignalsBlocked, next_name
diff --git a/src/apps/ocioview/ocioview/widgets/text_edit.py b/src/apps/ocioview/ocioview/widgets/text_edit.py
index b1a18dd12..d654215ec 100644
--- a/src/apps/ocioview/ocioview/widgets/text_edit.py
+++ b/src/apps/ocioview/ocioview/widgets/text_edit.py
@@ -3,7 +3,7 @@
 
 from typing import Optional
 
-from PySide2 import QtCore, QtWidgets
+from PySide6 import QtCore, QtWidgets
 
 from ..utils import SignalsBlocked
 
diff --git a/src/apps/ocioview/requirements.txt b/src/apps/ocioview/requirements.txt
index 1a453b819..2da54714f 100644
--- a/src/apps/ocioview/requirements.txt
+++ b/src/apps/ocioview/requirements.txt
@@ -1,7 +1,7 @@
-# imath
+imageio
 numpy
-# OpenImageIO
 pygments
 PyOpenGL
-PySide2
+PySide6
 QtAwesome
+OpenColorIO
\ No newline at end of file
diff --git a/src/apps/pyociodisplay/pyociodisplay.py b/src/apps/pyociodisplay/pyociodisplay.py
index 1588001a7..3142f9ba9 100644
--- a/src/apps/pyociodisplay/pyociodisplay.py
+++ b/src/apps/pyociodisplay/pyociodisplay.py
@@ -11,11 +11,10 @@
 import logging
 import sys
 
-from PySide2 import QtCore, QtGui, QtWidgets, QtOpenGL
+from PySide6 import QtCore, QtGui, QtWidgets, QtOpenGL
 from OpenGL import GL
 import PyOpenColorIO as ocio
 import OpenImageIO as oiio
-import imath
 import numpy as np