-
Notifications
You must be signed in to change notification settings - Fork 0
Commit
This commit does not belong to any branch on this repository, and may belong to a fork outside of the repository.
Merge pull request #24 from Merck/baseline-characteristic-table-by-su…
…bgroup metalite.sl: baseline characteristic table by subgroup
- Loading branch information
Showing
12 changed files
with
1,304 additions
and
1 deletion.
There are no files selected for viewing
This file contains bidirectional Unicode text that may be interpreted or compiled differently than what appears below. To review, open the file in an editor that reveals hidden Unicode characters.
Learn more about bidirectional Unicode characters
This file contains bidirectional Unicode text that may be interpreted or compiled differently than what appears below. To review, open the file in an editor that reveals hidden Unicode characters.
Learn more about bidirectional Unicode characters
Original file line number | Diff line number | Diff line change |
---|---|---|
@@ -0,0 +1,98 @@ | ||
# Copyright (c) 2024 Merck & Co., Inc., Rahway, NJ, USA and its affiliates. | ||
# All rights reserved. | ||
# | ||
# This file is part of the metalite.sl program. | ||
# | ||
# metalite.sl is free software: you can redistribute it and/or modify | ||
# it under the terms of the GNU General Public License as published by | ||
# the Free Software Foundation, either version 3 of the License, or | ||
# (at your option) any later version. | ||
# | ||
# This program is distributed in the hope that it will be useful, | ||
# but WITHOUT ANY WARRANTY; without even the implied warranty of | ||
# MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the | ||
# GNU General Public License for more details. | ||
# | ||
# You should have received a copy of the GNU General Public License | ||
# along with this program. If not, see <http://www.gnu.org/licenses/>. | ||
|
||
#' Prepare data for Subgroup Analysis for Baseline Characteristic | ||
#' | ||
#' @param outdata A metadata object created by [prepare_base_char_subgroup()]. | ||
#' @param display Column wants to display on the table. | ||
#' The term could be selected from `c("n", "prop", "total")`. | ||
#' @param display_stat A vector of statistics term name. | ||
#' The term name could be selected from | ||
#' `c("mean", "sd", "se", "median", "q1 to q3", "range", "q1", "q3", "min", "max")`. | ||
#' | ||
#' @return A list of analysis raw datasets. | ||
#' @export | ||
#' | ||
#' @examples | ||
#' meta <- meta_sl_example() | ||
#' | ||
#' outdata <- prepare_base_char_subgroup( | ||
#' meta, | ||
#' population = "apat", | ||
#' parameter = "age", | ||
#' subgroup_var = "TRTA", | ||
#' subgroup_header = c("SEX","TRTA"), | ||
#' display_subgroup_total = TRUE | ||
#' ) | ||
#' | ||
#' outdata |> format_base_char_subgroup() | ||
|
||
format_base_char_subgroup <- function( | ||
outdata, | ||
display = c("n","prop","total"), | ||
display_stat = c("mean", "sd", "median", "range")) { | ||
|
||
out_all <- outdata$out_all | ||
|
||
outlst <- list() | ||
for (i in seq_along(out_all)) { | ||
tbl <- out_all[[i]] |> | ||
format_base_char( | ||
display_col = display, | ||
digits_prop = 1, | ||
display_stat = display_stat | ||
) | ||
|
||
#names(tbl$tbl)[-1] <- paste0(names(out_all[i]), names(tbl$tbl)[-1]) | ||
names(tbl$tbl)[-1] <- ifelse(grepl("_label",names(tbl$tbl)[-1]) %in% "FALSE", paste0(names(out_all[i]), names(tbl$tbl)[-1]),names(tbl$tbl)[-1]) | ||
|
||
tbl$tbl$order <- as.numeric(rownames(tbl$tbl)) | ||
|
||
outlst[[i]] <- tbl$tbl | ||
} | ||
|
||
names(outlst) <- names(out_all) | ||
outlst <- outlst[-length(outlst)] | ||
|
||
i <- 1 | ||
while (i < length(outlst)) { | ||
if (i == 1) { | ||
tbl <- merge(outlst[[i]], outlst[[i + 1]], by = c("name","var_label","order"), all = TRUE) | ||
} | ||
|
||
i <- i + 1 | ||
|
||
if (i > 1 && i < length(outlst)) { | ||
tbl <- merge(tbl, outlst[[i + 1]], by = c("name","var_label","order"), all = TRUE) | ||
} | ||
} | ||
|
||
|
||
# If outdata$display_subgroup_total = FALSE, remove that part | ||
#if (!outdata$display_subgroup_total) { | ||
# rm_tot <- names(outlst$Total) # Columns from Total Section | ||
# rm_tot <- rm_tot[!rm_tot %in% c("name", "order")] | ||
|
||
# tbl <- tbl[, -which(names(tbl) %in% rm_tot)] | ||
#} | ||
|
||
outdata$tbl <- tbl |> dplyr::arrange(order) | ||
outdata$display <- display | ||
outdata$display_stat <- display_stat | ||
outdata | ||
} |
This file contains bidirectional Unicode text that may be interpreted or compiled differently than what appears below. To review, open the file in an editor that reveals hidden Unicode characters.
Learn more about bidirectional Unicode characters
This file contains bidirectional Unicode text that may be interpreted or compiled differently than what appears below. To review, open the file in an editor that reveals hidden Unicode characters.
Learn more about bidirectional Unicode characters
Original file line number | Diff line number | Diff line change |
---|---|---|
@@ -0,0 +1,123 @@ | ||
# Copyright (c) 2024 Merck & Co., Inc., Rahway, NJ, USA and its affiliates. | ||
# All rights reserved. | ||
# | ||
# This file is part of the metalite.sl program. | ||
# | ||
# metalite.sl is free software: you can redistribute it and/or modify | ||
# it under the terms of the GNU General Public License as published by | ||
# the Free Software Foundation, either version 3 of the License, or | ||
# (at your option) any later version. | ||
# | ||
# This program is distributed in the hope that it will be useful, | ||
# but WITHOUT ANY WARRANTY; without even the implied warranty of | ||
# MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the | ||
# GNU General Public License for more details. | ||
# | ||
# You should have received a copy of the GNU General Public License | ||
# along with this program. If not, see <http://www.gnu.org/licenses/>. | ||
|
||
#' Prepare data for treatment compliance table | ||
#' | ||
#' @param meta A metadata object created by metalite. | ||
#' @param population A character value of population term name. | ||
#' The term name is used as key to link information. | ||
#' @param analysis A character value of analysis term name. | ||
#' The term name is used as key to link information. | ||
#' @param parameter A character value of parameter term name. | ||
#' The term name is used as key to link information. | ||
#' @param subgroup_var A character value of subgroup variable name in | ||
#' observation data saved in `meta$data_observation`. | ||
#' @param subgroup_header A character vector for column header hierarchy. | ||
#' The first element will be the first level header and the second element | ||
#' will be second level header. | ||
#' @param display_subgroup_total A logic value of displaying the total group. | ||
#' | ||
#' @return A list of analysis raw datasets. | ||
#' @export | ||
#' | ||
#' @examples | ||
#' meta <- meta_sl_example() | ||
#' outdata <- prepare_base_char_subgroup( | ||
#' meta, | ||
#' population = "apat", | ||
#' parameter = "age", | ||
#' subgroup_var = "TRTA", | ||
#' subgroup_header = c("SEX","TRTA"), | ||
#' display_subgroup_total = TRUE) | ||
|
||
|
||
prepare_base_char_subgroup <- function( | ||
meta, | ||
population, | ||
analysis = "base_char_subgroup", | ||
parameter, | ||
subgroup_var, | ||
subgroup_header = c(meta$population[[population]]$group, subgroup_var), | ||
display_subgroup_total = TRUE) { | ||
|
||
meta_original <- meta | ||
|
||
observation <- meta$plan[meta$plan$analysis==analysis,]$observation | ||
|
||
#Factor Level 1 Subgroup | ||
meta$data_population[[subgroup_header[1]]] <- factor( | ||
as.character(meta$data_population[[subgroup_header[1]]]), | ||
levels = sort(unique(meta$data_population[[subgroup_header[1]]])) | ||
) | ||
meta$data_observation[[subgroup_header[1]]] <- factor( | ||
as.character(meta$data_observation[[subgroup_header[1]]]), | ||
levels = sort(unique(meta$data_observation[[subgroup_header[1]]])) | ||
) | ||
|
||
#Factor Level 2 Subgroup | ||
meta$data_population[[subgroup_var]] <- factor( | ||
as.character(meta$data_population[[subgroup_var]]), | ||
levels = sort(unique(meta$data_population[[subgroup_var]])) | ||
) | ||
meta$data_observation[[subgroup_var]] <- factor( | ||
as.character(meta$data_observation[[subgroup_var]]), | ||
levels = sort(unique(meta$data_observation[[subgroup_var]])) | ||
) | ||
|
||
meta$observation[[observation]]$group <- subgroup_header[1] | ||
meta$population[[population]]$group <- subgroup_header[1] | ||
|
||
# Obtain variables | ||
par_var <- metalite::collect_adam_mapping(meta, parameter)$var | ||
|
||
meta_subgroup <- metalite::meta_split(meta, subgroup_header[2]) | ||
|
||
outdata_all <- prepare_sl_summary( | ||
meta, | ||
analysis = analysis, | ||
population = meta$plan[meta$plan$analysis==analysis,]$population, | ||
parameter = parameter | ||
) | ||
|
||
outdata_subgroup <- lapply( | ||
meta_subgroup, | ||
prepare_sl_summary, | ||
analysis = analysis, | ||
population = meta$plan[meta$plan$analysis==analysis,]$population, | ||
parameter = parameter | ||
) | ||
|
||
out_all <- outdata_subgroup | ||
out_all$Total <- outdata_all | ||
|
||
group <- as.character(outdata_subgroup[[1]]$group_label) | ||
group <- group[!group %in% "Total"] | ||
|
||
outdata <- list( | ||
group = group, | ||
subgroup = tools::toTitleCase(tolower(names(outdata_subgroup))), | ||
display_subgroup_total = display_subgroup_total, | ||
meta = meta_original, | ||
population = population, | ||
observation = observation, | ||
parameter = parameter, | ||
out_all = out_all | ||
) | ||
|
||
} | ||
|
Oops, something went wrong.