Validation of Noncompartmental Analysis Performed by NonCompart R package

Sungpil Han shan@acp.kr 2018-08-07

Introduction

NonCompart R package (Bae 2018; Kim et al. 2018) can conduct a noncompartmental analysis as similar as possible to the most widely used commercial software for pharmacokinetic analysis, i.e. Phoenix^® WinNonlin^® (Certara USA 2018). This document provides validation of noncompartmental analysis performed by NonCompart R package version 0.4.4 as compared to the results from the commercial software, WinNonlin^® version 6.3 and 7.0.

Results

A function, Equal() will return TRUE if there is no difference between results from NonCompart and WinNonlin.

# install.packages("NonCompart", repos="http://r.acr.kr")
library(NonCompart)
RptCfg = read.csv("RptCfg.csv", as.is=TRUE)

Equal = function(Wres, Rres, Tol=0.001)
{
  Wres[,"ID"] = as.character(Wres[,"Subject"])
  ColName0 = colnames(Rres)
  rownames(RptCfg) = RptCfg[,"PPTESTCD"]
  colnames(Rres) = c(ColName0[1], RptCfg[ColName0[-1],"WNL"])
  Inter = intersect(colnames(Wres), colnames(Rres))
  
  IsSame = TRUE
  for (i in 1:nrow(Wres)) {
    for (j in Inter) {
      R = as.numeric(Rres[i,j])
      W = as.numeric(Wres[i,j])
      if (W != 0) {
        if(abs((R - W)/W) > Tol) {
          print(Wres[i,j])
          print(Rres[i,j])
          IsSame = FALSE
        }
      }
    }
  }
  return(IsSame)
}

Eight comparison tests were performed using Theoph and Indometh default datasets. (Table 1) Detailed side-by-side comparison is in Appendix A.

No.	Dataset	Down	Route	Hyperlink
1	Theoph (n=12)	Linear	Extravascular	CSV
2	Theoph (n=12)	Log	Extravascular	CSV
3	Indometh (n=6)	Linear	IV Bolus	CSV
4	Indometh (n=6)	Log	IV Bolus	CSV
5	Indometh (n=6)	Linear	IV Infusion (0.25hr)	CSV
6	Indometh (n=6)	Log	IV Infusion (0.25hr)	CSV
7	Indometh (n=6)	Linear	Extravascular	CSV
8	Indometh (n=6)	Log	Extravascular	CSV

Description of settings for the noncompartmental analysis performed in WinNonlin and links to the raw data

Theoph[,"Subject"] = as.numeric(as.character(Theoph[,"Subject"]))
Indometh[,"Subject"] = as.numeric(as.character(Indometh[,"Subject"]))

Wres1 = read.csv("Final_Parameters_Pivoted_Theoph_Linear.csv")
Rres1 = tblNCA(Theoph, "Subject", "Time", "conc", dose=320, concUnit="mg/L")
Equal(Wres1, Rres1)

## [1] TRUE

Wres2 = read.csv("Final_Parameters_Pivoted_Theoph_Log.csv")
Rres2 = tblNCA(Theoph, "Subject", "Time", "conc", dose=320, down="Log", 
               concUnit="mg/L")
Equal(Wres2, Rres2)

## [1] TRUE

Wres3 = read.csv("Final_Parameters_Pivoted_Indometh_Linear.csv")
Rres3 = tblNCA(Indometh, "Subject", "time", "conc", dose=25, adm="Bolus", 
               concUnit="mg/L", R2ADJ=0.8)
Equal(Wres3, Rres3)

## [1] TRUE

Wres4 = read.csv("Final_Parameters_Pivoted_Indometh_Log.csv")
Rres4 = tblNCA(Indometh, "Subject", "time", "conc", dose=25, adm="Bolus", 
               down="Log", concUnit="mg/L", R2ADJ=0.8)
Equal(Wres4, Rres4)

## [1] TRUE

Wres5 = read.csv("Final_Parameters_Pivoted_Indometh_Linear_Infusion.csv")
Rres5 = tblNCA(Indometh, "Subject", "time", "conc", dose=25, adm="Infusion", 
               dur=0.25, concUnit="mg/L", R2ADJ=0.8)
Equal(Wres5, Rres5)

## [1] TRUE

Wres6 = read.csv("Final_Parameters_Pivoted_Indometh_Log_Infusion.csv")
Rres6 = tblNCA(Indometh, "Subject", "time", "conc", dose=25, adm="Infusion", 
               dur=0.25, down="Log", concUnit="mg/L", R2ADJ=0.8)
Equal(Wres6, Rres6)

## [1] TRUE

Wres7 = read.csv("Final_Parameters_Pivoted_Indometh_Linear_Wrong_Extravascular.csv")
Rres7 = tblNCA(Indometh, "Subject", "time", "conc", dose=25, concUnit="mg/L", 
               R2ADJ=0.8)
Equal(Wres7, Rres7)

## [1] TRUE

Wres8 = read.csv("Final_Parameters_Pivoted_Indometh_Log_Wrong_Extravascular.csv")
Rres8 = tblNCA(Indometh, "Subject", "time", "conc", dose=25, down="Log", 
               concUnit="mg/L", R2ADJ=0.8)
Equal(Wres8, Rres8)

## [1] TRUE

\pagebreak

Conclusion

There is no discrepancy between results from NonCompart and WinNonlin. We also performed multiple analyses with the real clinical trial datasets and have found no differences (data not shown: confidential). Noncompartmental analysis performed by the open-source R package, NonCompart can be qualified and validated enough to acquire the identical results of the commercial software, WinNonlin.

Please report issues regarding validation of the R package to https://github.com/asancpt/NonCompart-tests/issues.

Affiliation:
Sungpil Han
M.D/Ph.D, Resident
Department of Clinical Pharmacology and Therapeutics,
Asan Medical Center, University of Ulsan,
Seoul 05505, Republic of Korea
E-mail: shan@acp.kr
URL: www.github.com/shanmdphd

\pagebreak

(APPENDIX) Appendix

Side-by-side comparison of results

library(dplyr)
library(tidyr)

table_wres_rres <- function(wres, rres, Caption){
  wres %>% 
    gather(WNL, WinNonlin, -Subject) %>% 
    left_join(RptCfg %>% select(PPTESTCD, WNL), by = "WNL") %>% 
    left_join(rres %>% as.data.frame() %>% gather(PPTESTCD, NonCompart, -Subject),
              by = c("Subject", "PPTESTCD")) %>% 
    select(Subject, PPTESTCD, WNL, NonCompart, WinNonlin) %>% 
    mutate(NonCompart = as.numeric(NonCompart),
           WinNonlin = as.numeric(WinNonlin)) %>% 
    mutate(Difference = ifelse((NonCompart - WinNonlin) / WinNonlin < 0.001, 
                               yes = 0, no = 'Larger than tol.')) %>% 
    mutate(Difference = ifelse(is.na(Difference), 0, Difference)) %>% 
    filter(!is.na(WinNonlin) & !is.na(NonCompart)) %>% 
    knitr::kable(longtable = TRUE, booktabs = TRUE, # format = "latex", 
                 caption = Caption) %>% 
    add_header_above(c(" ", "Pharmacokinetic Parameters" = 2, "Values" = 2, " ")) %>% 
    kable_styling(latex_options = c("repeat_header"))
}

Test 1: Theoph (n=12), Linear, Extravascular

table_wres_rres(Wres1, Rres1, 
                Caption = 'Theoph (n=12), Linear, Extravascular')

Theoph (n=12), Linear, Extravascular

	Pharmacokinetic Parameters		Values
Subject	PPTESTCD	WNL	NonCompart	WinNonlin	Difference
1	R2	Rsq	0.9999997	0.9999997	0
2	R2	Rsq	0.9971954	0.9971954	0
3	R2	Rsq	0.9993250	0.9993250	0
4	R2	Rsq	0.9989241	0.9989241	0
5	R2	Rsq	0.9986472	0.9986472	0
6	R2	Rsq	0.9982413	0.9982413	0
7	R2	Rsq	0.9986702	0.9986702	0
8	R2	Rsq	0.9910124	0.9910124	0
9	R2	Rsq	0.9994437	0.9994437	0
10	R2	Rsq	0.9995087	0.9995087	0
11	R2	Rsq	0.9999983	0.9999983	0
12	R2	Rsq	0.9993968	0.9993968	0
1	R2ADJ	Rsq_adjusted	0.9999995	0.9999995	0
2	R2ADJ	Rsq_adjusted	0.9957931	0.9957931	0
3	R2ADJ	Rsq_adjusted	0.9986499	0.9986499	0
4	R2ADJ	Rsq_adjusted	0.9978483	0.9978483	0
5	R2ADJ	Rsq_adjusted	0.9979708	0.9979708	0
6	R2ADJ	Rsq_adjusted	0.9978896	0.9978896	0
7	R2ADJ	Rsq_adjusted	0.9980053	0.9980053	0
8	R2ADJ	Rsq_adjusted	0.9887655	0.9887655	0
9	R2ADJ	Rsq_adjusted	0.9988873	0.9988873	0
10	R2ADJ	Rsq_adjusted	0.9990174	0.9990174	0
11	R2ADJ	Rsq_adjusted	0.9999965	0.9999965	0
12	R2ADJ	Rsq_adjusted	0.9987936	0.9987936	0
1	CORRXY	Corr_XY	-0.9999999	-0.9999999	0
2	CORRXY	Corr_XY	-0.9985967	-0.9985967	0
3	CORRXY	Corr_XY	-0.9996624	-0.9996624	0
4	CORRXY	Corr_XY	-0.9994619	-0.9994619	0
5	CORRXY	Corr_XY	-0.9993234	-0.9993234	0
6	CORRXY	Corr_XY	-0.9991203	-0.9991203	0
7	CORRXY	Corr_XY	-0.9993349	-0.9993349	0
8	CORRXY	Corr_XY	-0.9954961	-0.9954961	0
9	CORRXY	Corr_XY	-0.9997218	-0.9997218	0
10	CORRXY	Corr_XY	-0.9997543	-0.9997543	0
11	CORRXY	Corr_XY	-0.9999991	-0.9999991	0
12	CORRXY	Corr_XY	-0.9996984	-0.9996984	0
1	LAMZNPT	No_points_lambda_z	3.0000000	3.0000000	0
2	LAMZNPT	No_points_lambda_z	4.0000000	4.0000000	0
3	LAMZNPT	No_points_lambda_z	3.0000000	3.0000000	0
4	LAMZNPT	No_points_lambda_z	3.0000000	3.0000000	0
5	LAMZNPT	No_points_lambda_z	4.0000000	4.0000000	0
6	LAMZNPT	No_points_lambda_z	7.0000000	7.0000000	0
7	LAMZNPT	No_points_lambda_z	4.0000000	4.0000000	0
8	LAMZNPT	No_points_lambda_z	6.0000000	6.0000000	0
9	LAMZNPT	No_points_lambda_z	3.0000000	3.0000000	0
10	LAMZNPT	No_points_lambda_z	3.0000000	3.0000000	0
11	LAMZNPT	No_points_lambda_z	3.0000000	3.0000000	0
12	LAMZNPT	No_points_lambda_z	3.0000000	3.0000000	0
1	LAMZ	Lambda_z	0.0484570	0.0484570	0
2	LAMZ	Lambda_z	0.1040864	0.1040864	0
3	LAMZ	Lambda_z	0.1024443	0.1024443	0
4	LAMZ	Lambda_z	0.0992870	0.0992870	0
5	LAMZ	Lambda_z	0.0866189	0.0866189	0
6	LAMZ	Lambda_z	0.0877957	0.0877957	0
7	LAMZ	Lambda_z	0.0883365	0.0883365	0
8	LAMZ	Lambda_z	0.0814505	0.0814505	0
9	LAMZ	Lambda_z	0.0824586	0.0824586	0
10	LAMZ	Lambda_z	0.0749598	0.0749598	0
11	LAMZ	Lambda_z	0.0954586	0.0954586	0
12	LAMZ	Lambda_z	0.1102595	0.1102595	0
1	LAMZLL	Lambda_z_lower	9.0500000	9.0500000	0
2	LAMZLL	Lambda_z_lower	7.0300000	7.0300000	0
3	LAMZLL	Lambda_z_lower	9.0000000	9.0000000	0
4	LAMZLL	Lambda_z_lower	9.0200000	9.0200000	0
5	LAMZLL	Lambda_z_lower	7.0200000	7.0200000	0
6	LAMZLL	Lambda_z_lower	2.0300000	2.0300000	0
7	LAMZLL	Lambda_z_lower	6.9800000	6.9800000	0
8	LAMZLL	Lambda_z_lower	3.5300000	3.5300000	0
9	LAMZLL	Lambda_z_lower	8.8000000	8.8000000	0
10	LAMZLL	Lambda_z_lower	9.3800000	9.3800000	0
11	LAMZLL	Lambda_z_lower	9.0300000	9.0300000	0
12	LAMZLL	Lambda_z_lower	9.0300000	9.0300000	0
1	LAMZUL	Lambda_z_upper	24.3700000	24.3700000	0
2	LAMZUL	Lambda_z_upper	24.3000000	24.3000000	0
3	LAMZUL	Lambda_z_upper	24.1700000	24.1700000	0
4	LAMZUL	Lambda_z_upper	24.6500000	24.6500000	0
5	LAMZUL	Lambda_z_upper	24.3500000	24.3500000	0
6	LAMZUL	Lambda_z_upper	23.8500000	23.8500000	0
7	LAMZUL	Lambda_z_upper	24.2200000	24.2200000	0
8	LAMZUL	Lambda_z_upper	24.1200000	24.1200000	0
9	LAMZUL	Lambda_z_upper	24.4300000	24.4300000	0
10	LAMZUL	Lambda_z_upper	23.7000000	23.7000000	0
11	LAMZUL	Lambda_z_upper	24.0800000	24.0800000	0
12	LAMZUL	Lambda_z_upper	24.1500000	24.1500000	0
1	LAMZHL	HL_Lambda_z	14.3043776	14.3043776	0
2	LAMZHL	HL_Lambda_z	6.6593416	6.6593416	0
3	LAMZHL	HL_Lambda_z	6.7660874	6.7660874	0
4	LAMZHL	HL_Lambda_z	6.9812467	6.9812467	0
5	LAMZHL	HL_Lambda_z	8.0022640	8.0022640	0
6	LAMZHL	HL_Lambda_z	7.8949979	7.8949979	0
7	LAMZHL	HL_Lambda_z	7.8466683	7.8466683	0
8	LAMZHL	HL_Lambda_z	8.5100379	8.5100379	0
9	LAMZHL	HL_Lambda_z	8.4059988	8.4059988	0
10	LAMZHL	HL_Lambda_z	9.2469158	9.2469158	0
11	LAMZHL	HL_Lambda_z	7.2612365	7.2612365	0
12	LAMZHL	HL_Lambda_z	6.2865082	6.2865082	0
1	TLAG	Tlag	0.0000000	0.0000000	0
2	TLAG	Tlag	0.0000000	0.0000000	0
3	TLAG	Tlag	0.0000000	0.0000000	0
4	TLAG	Tlag	0.0000000	0.0000000	0
5	TLAG	Tlag	0.0000000	0.0000000	0
6	TLAG	Tlag	0.0000000	0.0000000	0
7	TLAG	Tlag	0.0000000	0.0000000	0
8	TLAG	Tlag	0.0000000	0.0000000	0
9	TLAG	Tlag	0.0000000	0.0000000	0
10	TLAG	Tlag	0.0000000	0.0000000	0
11	TLAG	Tlag	0.0000000	0.0000000	0
12	TLAG	Tlag	0.0000000	0.0000000	0
1	TMAX	Tmax	1.1200000	1.1200000	0
2	TMAX	Tmax	1.9200000	1.9200000	0
3	TMAX	Tmax	1.0200000	1.0200000	0
4	TMAX	Tmax	1.0700000	1.0700000	0
5	TMAX	Tmax	1.0000000	1.0000000	0
6	TMAX	Tmax	1.1500000	1.1500000	0
7	TMAX	Tmax	3.4800000	3.4800000	0
8	TMAX	Tmax	2.0200000	2.0200000	0
9	TMAX	Tmax	0.6300000	0.6300000	0
10	TMAX	Tmax	3.5500000	3.5500000	0
11	TMAX	Tmax	0.9800000	0.9800000	0
12	TMAX	Tmax	3.5200000	3.5200000	0
1	CMAX	Cmax	10.5000000	10.5000000	0
2	CMAX	Cmax	8.3300000	8.3300000	0
3	CMAX	Cmax	8.2000000	8.2000000	0
4	CMAX	Cmax	8.6000000	8.6000000	0
5	CMAX	Cmax	11.4000000	11.4000000	0
6	CMAX	Cmax	6.4400000	6.4400000	0
7	CMAX	Cmax	7.0900000	7.0900000	0
8	CMAX	Cmax	7.5600000	7.5600000	0
9	CMAX	Cmax	9.0300000	9.0300000	0
10	CMAX	Cmax	10.2100000	10.2100000	0
11	CMAX	Cmax	8.0000000	8.0000000	0
12	CMAX	Cmax	9.7500000	9.7500000	0
1	CMAXD	Cmax_D	0.0328125	0.0328125	0
2	CMAXD	Cmax_D	0.0260312	0.0260312	0
3	CMAXD	Cmax_D	0.0256250	0.0256250	0
4	CMAXD	Cmax_D	0.0268750	0.0268750	0
5	CMAXD	Cmax_D	0.0356250	0.0356250	0
6	CMAXD	Cmax_D	0.0201250	0.0201250	0
7	CMAXD	Cmax_D	0.0221562	0.0221562	0
8	CMAXD	Cmax_D	0.0236250	0.0236250	0
9	CMAXD	Cmax_D	0.0282188	0.0282188	0
10	CMAXD	Cmax_D	0.0319063	0.0319062	0
11	CMAXD	Cmax_D	0.0250000	0.0250000	0
12	CMAXD	Cmax_D	0.0304688	0.0304688	0
1	TLST	Tlast	24.3700000	24.3700000	0
2	TLST	Tlast	24.3000000	24.3000000	0
3	TLST	Tlast	24.1700000	24.1700000	0
4	TLST	Tlast	24.6500000	24.6500000	0
5	TLST	Tlast	24.3500000	24.3500000	0
6	TLST	Tlast	23.8500000	23.8500000	0
7	TLST	Tlast	24.2200000	24.2200000	0
8	TLST	Tlast	24.1200000	24.1200000	0
9	TLST	Tlast	24.4300000	24.4300000	0
10	TLST	Tlast	23.7000000	23.7000000	0
11	TLST	Tlast	24.0800000	24.0800000	0
12	TLST	Tlast	24.1500000	24.1500000	0
1	CLST	Clast	3.2800000	3.2800000	0
2	CLST	Clast	0.9000000	0.9000000	0
3	CLST	Clast	1.0500000	1.0500000	0
4	CLST	Clast	1.1500000	1.1500000	0
5	CLST	Clast	1.5700000	1.5700000	0
6	CLST	Clast	0.9200000	0.9200000	0
7	CLST	Clast	1.1500000	1.1500000	0
8	CLST	Clast	1.2500000	1.2500000	0
9	CLST	Clast	1.1200000	1.1200000	0
10	CLST	Clast	2.4200000	2.4200000	0
11	CLST	Clast	0.8600000	0.8600000	0
12	CLST	Clast	1.1700000	1.1700000	0
1	AUCLST	AUClast	148.9230500	148.9230500	0
2	AUCLST	AUClast	91.5268000	91.5268000	0
3	AUCLST	AUClast	99.2865000	99.2865000	0
4	AUCLST	AUClast	106.7963000	106.7963000	0
5	AUCLST	AUClast	121.2944000	121.2944000	0
6	AUCLST	AUClast	73.7755500	73.7755500	0
7	AUCLST	AUClast	90.7534000	90.7534000	0
8	AUCLST	AUClast	88.5599500	88.5599500	0
9	AUCLST	AUClast	86.3261500	86.3261500	0
10	AUCLST	AUClast	138.3681000	138.3681000	0
11	AUCLST	AUClast	80.0936000	80.0936000	0
12	AUCLST	AUClast	119.9775000	119.9775000	0
1	AUCALL	AUCall	148.9230500	148.9230500	0
2	AUCALL	AUCall	91.5268000	91.5268000	0
3	AUCALL	AUCall	99.2865000	99.2865000	0
4	AUCALL	AUCall	106.7963000	106.7963000	0
5	AUCALL	AUCall	121.2944000	121.2944000	0
6	AUCALL	AUCall	73.7755500	73.7755500	0
7	AUCALL	AUCall	90.7534000	90.7534000	0
8	AUCALL	AUCall	88.5599500	88.5599500	0
9	AUCALL	AUCall	86.3261500	86.3261500	0
10	AUCALL	AUCall	138.3681000	138.3681000	0
11	AUCALL	AUCall	80.0936000	80.0936000	0
12	AUCALL	AUCall	119.9775000	119.9775000	0
1	AUCIFO	AUCINF_obs	216.6119330	216.6119330	0
2	AUCIFO	AUCINF_obs	100.1734591	100.1734591	0
3	AUCIFO	AUCINF_obs	109.5359707	109.5359707	0
4	AUCIFO	AUCINF_obs	118.3788814	118.3788814	0
5	AUCIFO	AUCINF_obs	139.4197778	139.4197778	0
6	AUCIFO	AUCINF_obs	84.2544183	84.2544183	0
7	AUCIFO	AUCINF_obs	103.7718018	103.7718018	0
8	AUCIFO	AUCINF_obs	103.9066868	103.9066868	0
9	AUCIFO	AUCINF_obs	99.9087179	99.9087179	0
10	AUCIFO	AUCINF_obs	170.6520606	170.6520606	0
11	AUCIFO	AUCINF_obs	89.1027449	89.1027449	0
12	AUCIFO	AUCINF_obs	130.5888316	130.5888316	0
1	AUCIFOD	AUCINF_D_obs	0.6769123	0.6769123	0
2	AUCIFOD	AUCINF_D_obs	0.3130421	0.3130421	0
3	AUCIFOD	AUCINF_D_obs	0.3422999	0.3422999	0
4	AUCIFOD	AUCINF_D_obs	0.3699340	0.3699340	0
5	AUCIFOD	AUCINF_D_obs	0.4356868	0.4356868	0
6	AUCIFOD	AUCINF_D_obs	0.2632951	0.2632951	0
7	AUCIFOD	AUCINF_D_obs	0.3242869	0.3242869	0
8	AUCIFOD	AUCINF_D_obs	0.3247084	0.3247084	0
9	AUCIFOD	AUCINF_D_obs	0.3122147	0.3122147	0
10	AUCIFOD	AUCINF_D_obs	0.5332877	0.5332877	0
11	AUCIFOD	AUCINF_D_obs	0.2784461	0.2784461	0
12	AUCIFOD	AUCINF_D_obs	0.4080901	0.4080901	0
1	AUCPEO	AUC_.Extrap_obs	31.2489169	31.2489169	0
2	AUCPEO	AUC_.Extrap_obs	8.6316867	8.6316867	0
3	AUCPEO	AUC_.Extrap_obs	9.3571734	9.3571734	0
4	AUCPEO	AUC_.Extrap_obs	9.7843309	9.7843309	0
5	AUCPEO	AUC_.Extrap_obs	13.0005786	13.0005786	0
6	AUCPEO	AUC_.Extrap_obs	12.4371737	12.4371737	0
7	AUCPEO	AUC_.Extrap_obs	12.5452209	12.5452209	0
8	AUCPEO	AUC_.Extrap_obs	14.7697297	14.7697297	0
9	AUCPEO	AUC_.Extrap_obs	13.5949777	13.5949777	0
10	AUCPEO	AUC_.Extrap_obs	18.9180022	18.9180022	0
11	AUCPEO	AUC_.Extrap_obs	10.1109623	10.1109623	0
12	AUCPEO	AUC_.Extrap_obs	8.1257573	8.1257573	0
1	VZFO	Vz_F_obs	30.4867482	30.4867482	0
2	VZFO	Vz_F_obs	30.6904416	30.6904416	0
3	VZFO	Vz_F_obs	28.5170999	28.5170999	0
4	VZFO	Vz_F_obs	27.2259641	27.2259641	0
5	VZFO	Vz_F_obs	26.4979947	26.4979946	0
6	VZFO	Vz_F_obs	43.2597345	43.2597345	0
7	VZFO	Vz_F_obs	34.9084408	34.9084408	0
8	VZFO	Vz_F_obs	37.8105081	37.8105081	0
9	VZFO	Vz_F_obs	38.8427934	38.8427934	0
10	VZFO	Vz_F_obs	25.0155401	25.0155401	0
11	VZFO	Vz_F_obs	37.6221852	37.6221852	0
12	VZFO	Vz_F_obs	22.2242936	22.2242936	0
1	CLFO	Cl_F_obs	1.4772963	1.4772963	0
2	CLFO	Cl_F_obs	3.1944589	3.1944589	0
3	CLFO	Cl_F_obs	2.9214147	2.9214147	0
4	CLFO	Cl_F_obs	2.7031849	2.7031849	0
5	CLFO	Cl_F_obs	2.2952267	2.2952267	0
6	CLFO	Cl_F_obs	3.7980204	3.7980204	0
7	CLFO	Cl_F_obs	3.0836893	3.0836894	0
8	CLFO	Cl_F_obs	3.0796863	3.0796863	0
9	CLFO	Cl_F_obs	3.2029237	3.2029237	0
10	CLFO	Cl_F_obs	1.8751605	1.8751605	0
11	CLFO	Cl_F_obs	3.5913596	3.5913596	0
12	CLFO	Cl_F_obs	2.4504393	2.4504393	0
1	AUCIFP	AUCINF_pred	216.6149558	216.6149558	0
2	AUCIFP	AUCINF_pred	100.0643176	100.0643176	0
3	AUCIFP	AUCINF_pred	109.5857218	109.5857218	0
4	AUCIFP	AUCINF_pred	118.4435586	118.4435586	0
5	AUCIFP	AUCINF_pred	139.2546304	139.2546304	0
6	AUCIFP	AUCINF_pred	84.4966986	84.4966986	0
7	AUCIFP	AUCINF_pred	103.8931470	103.8931470	0
8	AUCIFP	AUCINF_pred	103.6430515	103.6430515	0
9	AUCIFP	AUCINF_pred	99.8660677	99.8660677	0
10	AUCIFP	AUCINF_pred	170.5679125	170.5679125	0
11	AUCIFP	AUCINF_pred	89.1007190	89.1007190	0
12	AUCIFP	AUCINF_pred	130.6390680	130.6390680	0
1	AUCIFPD	AUCINF_D_pred	0.6769217	0.6769217	0
2	AUCIFPD	AUCINF_D_pred	0.3127010	0.3127010	0
3	AUCIFPD	AUCINF_D_pred	0.3424554	0.3424554	0
4	AUCIFPD	AUCINF_D_pred	0.3701361	0.3701361	0
5	AUCIFPD	AUCINF_D_pred	0.4351707	0.4351707	0
6	AUCIFPD	AUCINF_D_pred	0.2640522	0.2640522	0
7	AUCIFPD	AUCINF_D_pred	0.3246661	0.3246661	0
8	AUCIFPD	AUCINF_D_pred	0.3238845	0.3238845	0
9	AUCIFPD	AUCINF_D_pred	0.3120815	0.3120815	0
10	AUCIFPD	AUCINF_D_pred	0.5330247	0.5330247	0
11	AUCIFPD	AUCINF_D_pred	0.2784397	0.2784397	0
12	AUCIFPD	AUCINF_D_pred	0.4082471	0.4082471	0
1	AUCPEP	AUC_.Extrap_pred	31.2498763	31.2498763	0
2	AUCPEP	AUC_.Extrap_pred	8.5320300	8.5320300	0
3	AUCPEP	AUC_.Extrap_pred	9.3983245	9.3983245	0
4	AUCPEP	AUC_.Extrap_pred	9.8335939	9.8335939	0
5	AUCPEP	AUC_.Extrap_pred	12.8974027	12.8974027	0
6	AUCPEP	AUC_.Extrap_pred	12.6882455	12.6882455	0
7	AUCPEP	AUC_.Extrap_pred	12.6473665	12.6473664	0
8	AUCPEP	AUC_.Extrap_pred	14.5529307	14.5529307	0
9	AUCPEP	AUC_.Extrap_pred	13.5580763	13.5580763	0
10	AUCPEP	AUC_.Extrap_pred	18.8780012	18.8780012	0
11	AUCPEP	AUC_.Extrap_pred	10.1089184	10.1089184	0
12	AUCPEP	AUC_.Extrap_pred	8.1610870	8.1610870	0
1	VZFP	Vz_F_pred	30.4863228	30.4863228	0
2	VZFP	Vz_F_pred	30.7239161	30.7239161	0
3	VZFP	Vz_F_pred	28.5041534	28.5041534	0
4	VZFP	Vz_F_pred	27.2110972	27.2110972	0
5	VZFP	Vz_F_pred	26.5294196	26.5294196	0
6	VZFP	Vz_F_pred	43.1356944	43.1356944	0
7	VZFP	Vz_F_pred	34.8676684	34.8676684	0
8	VZFP	Vz_F_pred	37.9066862	37.9066862	0
9	VZFP	Vz_F_pred	38.8593822	38.8593822	0
10	VZFP	Vz_F_pred	25.0278813	25.0278813	0
11	VZFP	Vz_F_pred	37.6230406	37.6230406	0
12	VZFP	Vz_F_pred	22.2157473	22.2157473	0
1	CLFP	Cl_F_pred	1.4772757	1.4772757	0
2	CLFP	Cl_F_pred	3.1979432	3.1979432	0
3	CLFP	Cl_F_pred	2.9200884	2.9200884	0
4	CLFP	Cl_F_pred	2.7017088	2.7017088	0
5	CLFP	Cl_F_pred	2.2979487	2.2979487	0
6	CLFP	Cl_F_pred	3.7871302	3.7871302	0
7	CLFP	Cl_F_pred	3.0800877	3.0800877	0
8	CLFP	Cl_F_pred	3.0875201	3.0875201	0
9	CLFP	Cl_F_pred	3.2042916	3.2042916	0
10	CLFP	Cl_F_pred	1.8760856	1.8760856	0
11	CLFP	Cl_F_pred	3.5914413	3.5914413	0
12	CLFP	Cl_F_pred	2.4494970	2.4494970	0
1	AUMCLST	AUMClast	1459.0711035	1459.0711040	0
2	AUMCLST	AUMClast	706.5865660	706.5865660	0
3	AUMCLST	AUMClast	803.1858700	803.1858700	0
4	AUMCLST	AUMClast	901.0842105	901.0842105	0
5	AUMCLST	AUMClast	1017.1143165	1017.1143170	0
6	AUMCLST	AUMClast	609.1523875	609.1523875	0
7	AUMCLST	AUMClast	782.4198600	782.4198600	0
8	AUMCLST	AUMClast	739.5345980	739.5345980	0
9	AUMCLST	AUMClast	705.2296255	705.2296255	0
10	AUMCLST	AUMClast	1278.1800420	1278.1800420	0
11	AUMCLST	AUMClast	617.2422125	617.2422125	0
12	AUMCLST	AUMClast	977.8807235	977.8807235	0
1	AUMCIFO	AUMCINF_obs	4505.5348194	4505.5348190	0
2	AUMCIFO	AUMCINF_obs	999.7722880	999.7722880	0
3	AUMCIFO	AUMCINF_obs	1150.9647687	1150.9647690	0
4	AUMCIFO	AUMCINF_obs	1303.2524014	1303.2524010	0
5	AUMCIFO	AUMCINF_obs	1667.7216119	1667.7216120	0
6	AUMCIFO	AUMCINF_obs	978.4284857	978.4284857	0
7	AUMCIFO	AUMCINF_obs	1245.0984083	1245.0984080	0
8	AUMCIFO	AUMCINF_obs	1298.1157547	1298.1157550	0
9	AUMCIFO	AUMCINF_obs	1201.7715381	1201.7715380	0
10	AUMCIFO	AUMCINF_obs	2473.9934274	2473.9934270	0
11	AUMCIFO	AUMCINF_obs	928.5599714	928.5599714	0
12	AUMCIFO	AUMCINF_obs	1330.3840024	1330.3840020	0
1	AUMCPEO	AUMC_.Extrap_obs	67.6160287	67.6160287	0
2	AUMCPEO	AUMC_.Extrap_obs	29.3252499	29.3252499	0
3	AUMCPEO	AUMC_.Extrap_obs	30.2162940	30.2162940	0
4	AUMCPEO	AUMC_.Extrap_obs	30.8588107	30.8588107	0
5	AUMCPEO	AUMC_.Extrap_obs	39.0117446	39.0117446	0
6	AUMCPEO	AUMC_.Extrap_obs	37.7417567	37.7417567	0
7	AUMCPEO	AUMC_.Extrap_obs	37.1599984	37.1599984	0
8	AUMCPEO	AUMC_.Extrap_obs	43.0301500	43.0301500	0
9	AUMCPEO	AUMC_.Extrap_obs	41.3174965	41.3174965	0
10	AUMCPEO	AUMC_.Extrap_obs	48.3353501	48.3353501	0
11	AUMCPEO	AUMC_.Extrap_obs	33.5269416	33.5269415	0
12	AUMCPEO	AUMC_.Extrap_obs	26.4963558	26.4963558	0
1	AUMCIFP	AUMCINF_pred	4505.6708646	4505.6708650	0
2	AUMCIFP	AUMCINF_pred	996.0715835	996.0715835	0
3	AUMCIFP	AUMCINF_pred	1152.6528903	1152.6528900	0
4	AUMCIFP	AUMCINF_pred	1305.4981092	1305.4981090	0
5	AUMCIFP	AUMCINF_pred	1661.7936744	1661.7936740	0
6	AUMCIFP	AUMCINF_pred	986.9664597	986.9664597	0
7	AUMCIFP	AUMCINF_pred	1249.4110601	1249.4110600	0
8	AUMCIFP	AUMCINF_pred	1288.5201162	1288.5201160	0
9	AUMCIFP	AUMCINF_pred	1200.2123597	1200.2123600	0
10	AUMCIFP	AUMCINF_pred	2470.8765418	2470.8765420	0
11	AUMCIFP	AUMCINF_pred	928.4899636	928.4899636	0
12	AUMCIFP	AUMCINF_pred	1332.0528341	1332.0528340	0
1	AUMCPEP	AUMC_.Extrap_pred	67.6170065	67.6170065	0
2	AUMCPEP	AUMC_.Extrap_pred	29.0626720	29.0626720	0
3	AUMCPEP	AUMC_.Extrap_pred	30.3184960	30.3184960	0
4	AUMCPEP	AUMC_.Extrap_pred	30.9777468	30.9777468	0
5	AUMCPEP	AUMC_.Extrap_pred	38.7941877	38.7941877	0
6	AUMCPEP	AUMC_.Extrap_pred	38.2803355	38.2803355	0
7	AUMCPEP	AUMC_.Extrap_pred	37.3769062	37.3769062	0
8	AUMCPEP	AUMC_.Extrap_pred	42.6058943	42.6058943	0
9	AUMCPEP	AUMC_.Extrap_pred	41.2412629	41.2412629	0
10	AUMCPEP	AUMC_.Extrap_pred	48.2701778	48.2701778	0
11	AUMCPEP	AUMC_.Extrap_pred	33.5219295	33.5219295	0
12	AUMCPEP	AUMC_.Extrap_pred	26.5884432	26.5884432	0
1	MRTEVLST	MRTlast	9.7974834	9.7974834	0
2	MRTEVLST	MRTlast	7.7199964	7.7199964	0
3	MRTEVLST	MRTlast	8.0895778	8.0895778	0
4	MRTEVLST	MRTlast	8.4374104	8.4374104	0
5	MRTEVLST	MRTlast	8.3855010	8.3855010	0
6	MRTEVLST	MRTlast	8.2568329	8.2568329	0
7	MRTEVLST	MRTlast	8.6213834	8.6213834	0
8	MRTEVLST	MRTlast	8.3506664	8.3506664	0
9	MRTEVLST	MRTlast	8.1693626	8.1693627	0
10	MRTEVLST	MRTlast	9.2375341	9.2375341	0
11	MRTEVLST	MRTlast	7.7065110	7.7065110	0
12	MRTEVLST	MRTlast	8.1505343	8.1505343	0
1	MRTEVIFO	MRTINF_obs	20.8000305	20.8000305	0
2	MRTEVIFO	MRTINF_obs	9.9804109	9.9804109	0
3	MRTEVIFO	MRTINF_obs	10.5076420	10.5076420	0
4	MRTEVIFO	MRTINF_obs	11.0091630	11.0091630	0
5	MRTEVIFO	MRTINF_obs	11.9618725	11.9618725	0
6	MRTEVIFO	MRTINF_obs	11.6127855	11.6127855	0
7	MRTEVIFO	MRTINF_obs	11.9984272	11.9984272	0
8	MRTEVIFO	MRTINF_obs	12.4930916	12.4930916	0
9	MRTEVIFO	MRTINF_obs	12.0286954	12.0286954	0
10	MRTEVIFO	MRTINF_obs	14.4972959	14.4972959	0
11	MRTEVIFO	MRTINF_obs	10.4212275	10.4212274	0
12	MRTEVIFO	MRTINF_obs	10.1875787	10.1875787	0
1	MRTEVIFP	MRTINF_pred	20.8003683	20.8003683	0
2	MRTEVIFP	MRTINF_pred	9.9543135	9.9543135	0
3	MRTEVIFP	MRTINF_pred	10.5182762	10.5182762	0
4	MRTEVIFP	MRTINF_pred	11.0221115	11.0221115	0
5	MRTEVIFP	MRTINF_pred	11.9334895	11.9334895	0
6	MRTEVIFP	MRTINF_pred	11.6805328	11.6805328	0
7	MRTEVIFP	MRTINF_pred	12.0259237	12.0259237	0
8	MRTEVIFP	MRTINF_pred	12.4322866	12.4322866	0
9	MRTEVIFP	MRTINF_pred	12.0182199	12.0182199	0
10	MRTEVIFP	MRTINF_pred	14.4861745	14.4861745	0
11	MRTEVIFP	MRTINF_pred	10.4206787	10.4206787	0
12	MRTEVIFP	MRTINF_pred	10.1964355	10.1964355	0

Test 2: Theoph (n=12), Log, Extravascular

table_wres_rres(Wres2, Rres2,
                Caption = 'Theoph (n=12), Log, Extravascular')

Theoph (n=12), Log, Extravascular

	Pharmacokinetic Parameters		Values
Subject	PPTESTCD	WNL	NonCompart	WinNonlin	Difference
1	R2	Rsq	0.9999997	0.9999997	0
2	R2	Rsq	0.9971954	0.9971954	0
3	R2	Rsq	0.9993250	0.9993250	0
4	R2	Rsq	0.9989241	0.9989241	0
5	R2	Rsq	0.9986472	0.9986472	0
6	R2	Rsq	0.9982413	0.9982413	0
7	R2	Rsq	0.9986702	0.9986702	0
8	R2	Rsq	0.9910124	0.9910124	0
9	R2	Rsq	0.9994437	0.9994437	0
10	R2	Rsq	0.9995087	0.9995087	0
11	R2	Rsq	0.9999983	0.9999983	0
12	R2	Rsq	0.9993968	0.9993968	0
1	R2ADJ	Rsq_adjusted	0.9999995	0.9999995	0
2	R2ADJ	Rsq_adjusted	0.9957931	0.9957931	0
3	R2ADJ	Rsq_adjusted	0.9986499	0.9986499	0
4	R2ADJ	Rsq_adjusted	0.9978483	0.9978483	0
5	R2ADJ	Rsq_adjusted	0.9979708	0.9979708	0
6	R2ADJ	Rsq_adjusted	0.9978896	0.9978896	0
7	R2ADJ	Rsq_adjusted	0.9980053	0.9980053	0
8	R2ADJ	Rsq_adjusted	0.9887655	0.9887655	0
9	R2ADJ	Rsq_adjusted	0.9988873	0.9988873	0
10	R2ADJ	Rsq_adjusted	0.9990174	0.9990174	0
11	R2ADJ	Rsq_adjusted	0.9999965	0.9999965	0
12	R2ADJ	Rsq_adjusted	0.9987936	0.9987936	0
1	CORRXY	Corr_XY	-0.9999999	-0.9999999	0
2	CORRXY	Corr_XY	-0.9985967	-0.9985967	0
3	CORRXY	Corr_XY	-0.9996624	-0.9996624	0
4	CORRXY	Corr_XY	-0.9994619	-0.9994619	0
5	CORRXY	Corr_XY	-0.9993234	-0.9993234	0
6	CORRXY	Corr_XY	-0.9991203	-0.9991203	0
7	CORRXY	Corr_XY	-0.9993349	-0.9993349	0
8	CORRXY	Corr_XY	-0.9954961	-0.9954961	0
9	CORRXY	Corr_XY	-0.9997218	-0.9997218	0
10	CORRXY	Corr_XY	-0.9997543	-0.9997543	0
11	CORRXY	Corr_XY	-0.9999991	-0.9999991	0
12	CORRXY	Corr_XY	-0.9996984	-0.9996984	0
1	LAMZNPT	No_points_lambda_z	3.0000000	3.0000000	0
2	LAMZNPT	No_points_lambda_z	4.0000000	4.0000000	0
3	LAMZNPT	No_points_lambda_z	3.0000000	3.0000000	0
4	LAMZNPT	No_points_lambda_z	3.0000000	3.0000000	0
5	LAMZNPT	No_points_lambda_z	4.0000000	4.0000000	0
6	LAMZNPT	No_points_lambda_z	7.0000000	7.0000000	0
7	LAMZNPT	No_points_lambda_z	4.0000000	4.0000000	0
8	LAMZNPT	No_points_lambda_z	6.0000000	6.0000000	0
9	LAMZNPT	No_points_lambda_z	3.0000000	3.0000000	0
10	LAMZNPT	No_points_lambda_z	3.0000000	3.0000000	0
11	LAMZNPT	No_points_lambda_z	3.0000000	3.0000000	0
12	LAMZNPT	No_points_lambda_z	3.0000000	3.0000000	0
1	LAMZ	Lambda_z	0.0484570	0.0484570	0
2	LAMZ	Lambda_z	0.1040864	0.1040864	0
3	LAMZ	Lambda_z	0.1024443	0.1024443	0
4	LAMZ	Lambda_z	0.0992870	0.0992870	0
5	LAMZ	Lambda_z	0.0866189	0.0866189	0
6	LAMZ	Lambda_z	0.0877957	0.0877957	0
7	LAMZ	Lambda_z	0.0883365	0.0883365	0
8	LAMZ	Lambda_z	0.0814505	0.0814505	0
9	LAMZ	Lambda_z	0.0824586	0.0824586	0
10	LAMZ	Lambda_z	0.0749598	0.0749598	0
11	LAMZ	Lambda_z	0.0954586	0.0954586	0
12	LAMZ	Lambda_z	0.1102595	0.1102595	0
1	LAMZLL	Lambda_z_lower	9.0500000	9.0500000	0
2	LAMZLL	Lambda_z_lower	7.0300000	7.0300000	0
3	LAMZLL	Lambda_z_lower	9.0000000	9.0000000	0
4	LAMZLL	Lambda_z_lower	9.0200000	9.0200000	0
5	LAMZLL	Lambda_z_lower	7.0200000	7.0200000	0
6	LAMZLL	Lambda_z_lower	2.0300000	2.0300000	0
7	LAMZLL	Lambda_z_lower	6.9800000	6.9800000	0
8	LAMZLL	Lambda_z_lower	3.5300000	3.5300000	0
9	LAMZLL	Lambda_z_lower	8.8000000	8.8000000	0
10	LAMZLL	Lambda_z_lower	9.3800000	9.3800000	0
11	LAMZLL	Lambda_z_lower	9.0300000	9.0300000	0
12	LAMZLL	Lambda_z_lower	9.0300000	9.0300000	0
1	LAMZUL	Lambda_z_upper	24.3700000	24.3700000	0
2	LAMZUL	Lambda_z_upper	24.3000000	24.3000000	0
3	LAMZUL	Lambda_z_upper	24.1700000	24.1700000	0
4	LAMZUL	Lambda_z_upper	24.6500000	24.6500000	0
5	LAMZUL	Lambda_z_upper	24.3500000	24.3500000	0
6	LAMZUL	Lambda_z_upper	23.8500000	23.8500000	0
7	LAMZUL	Lambda_z_upper	24.2200000	24.2200000	0
8	LAMZUL	Lambda_z_upper	24.1200000	24.1200000	0
9	LAMZUL	Lambda_z_upper	24.4300000	24.4300000	0
10	LAMZUL	Lambda_z_upper	23.7000000	23.7000000	0
11	LAMZUL	Lambda_z_upper	24.0800000	24.0800000	0
12	LAMZUL	Lambda_z_upper	24.1500000	24.1500000	0
1	LAMZHL	HL_Lambda_z	14.3043776	14.3043776	0
2	LAMZHL	HL_Lambda_z	6.6593416	6.6593416	0
3	LAMZHL	HL_Lambda_z	6.7660874	6.7660874	0
4	LAMZHL	HL_Lambda_z	6.9812467	6.9812467	0
5	LAMZHL	HL_Lambda_z	8.0022640	8.0022640	0
6	LAMZHL	HL_Lambda_z	7.8949979	7.8949979	0
7	LAMZHL	HL_Lambda_z	7.8466683	7.8466683	0
8	LAMZHL	HL_Lambda_z	8.5100379	8.5100379	0
9	LAMZHL	HL_Lambda_z	8.4059988	8.4059988	0
10	LAMZHL	HL_Lambda_z	9.2469158	9.2469158	0
11	LAMZHL	HL_Lambda_z	7.2612365	7.2612365	0
12	LAMZHL	HL_Lambda_z	6.2865082	6.2865082	0
1	TLAG	Tlag	0.0000000	0.0000000	0
2	TLAG	Tlag	0.0000000	0.0000000	0
3	TLAG	Tlag	0.0000000	0.0000000	0
4	TLAG	Tlag	0.0000000	0.0000000	0
5	TLAG	Tlag	0.0000000	0.0000000	0
6	TLAG	Tlag	0.0000000	0.0000000	0
7	TLAG	Tlag	0.0000000	0.0000000	0
8	TLAG	Tlag	0.0000000	0.0000000	0
9	TLAG	Tlag	0.0000000	0.0000000	0
10	TLAG	Tlag	0.0000000	0.0000000	0
11	TLAG	Tlag	0.0000000	0.0000000	0
12	TLAG	Tlag	0.0000000	0.0000000	0
1	TMAX	Tmax	1.1200000	1.1200000	0
2	TMAX	Tmax	1.9200000	1.9200000	0
3	TMAX	Tmax	1.0200000	1.0200000	0
4	TMAX	Tmax	1.0700000	1.0700000	0
5	TMAX	Tmax	1.0000000	1.0000000	0
6	TMAX	Tmax	1.1500000	1.1500000	0
7	TMAX	Tmax	3.4800000	3.4800000	0
8	TMAX	Tmax	2.0200000	2.0200000	0
9	TMAX	Tmax	0.6300000	0.6300000	0
10	TMAX	Tmax	3.5500000	3.5500000	0
11	TMAX	Tmax	0.9800000	0.9800000	0
12	TMAX	Tmax	3.5200000	3.5200000	0
1	CMAX	Cmax	10.5000000	10.5000000	0
2	CMAX	Cmax	8.3300000	8.3300000	0
3	CMAX	Cmax	8.2000000	8.2000000	0
4	CMAX	Cmax	8.6000000	8.6000000	0
5	CMAX	Cmax	11.4000000	11.4000000	0
6	CMAX	Cmax	6.4400000	6.4400000	0
7	CMAX	Cmax	7.0900000	7.0900000	0
8	CMAX	Cmax	7.5600000	7.5600000	0
9	CMAX	Cmax	9.0300000	9.0300000	0
10	CMAX	Cmax	10.2100000	10.2100000	0
11	CMAX	Cmax	8.0000000	8.0000000	0
12	CMAX	Cmax	9.7500000	9.7500000	0
1	CMAXD	Cmax_D	0.0328125	0.0328125	0
2	CMAXD	Cmax_D	0.0260312	0.0260312	0
3	CMAXD	Cmax_D	0.0256250	0.0256250	0
4	CMAXD	Cmax_D	0.0268750	0.0268750	0
5	CMAXD	Cmax_D	0.0356250	0.0356250	0
6	CMAXD	Cmax_D	0.0201250	0.0201250	0
7	CMAXD	Cmax_D	0.0221562	0.0221562	0
8	CMAXD	Cmax_D	0.0236250	0.0236250	0
9	CMAXD	Cmax_D	0.0282188	0.0282188	0
10	CMAXD	Cmax_D	0.0319063	0.0319062	0
11	CMAXD	Cmax_D	0.0250000	0.0250000	0
12	CMAXD	Cmax_D	0.0304688	0.0304688	0
1	TLST	Tlast	24.3700000	24.3700000	0
2	TLST	Tlast	24.3000000	24.3000000	0
3	TLST	Tlast	24.1700000	24.1700000	0
4	TLST	Tlast	24.6500000	24.6500000	0
5	TLST	Tlast	24.3500000	24.3500000	0
6	TLST	Tlast	23.8500000	23.8500000	0
7	TLST	Tlast	24.2200000	24.2200000	0
8	TLST	Tlast	24.1200000	24.1200000	0
9	TLST	Tlast	24.4300000	24.4300000	0
10	TLST	Tlast	23.7000000	23.7000000	0
11	TLST	Tlast	24.0800000	24.0800000	0
12	TLST	Tlast	24.1500000	24.1500000	0
1	CLST	Clast	3.2800000	3.2800000	0
2	CLST	Clast	0.9000000	0.9000000	0
3	CLST	Clast	1.0500000	1.0500000	0
4	CLST	Clast	1.1500000	1.1500000	0
5	CLST	Clast	1.5700000	1.5700000	0
6	CLST	Clast	0.9200000	0.9200000	0
7	CLST	Clast	1.1500000	1.1500000	0
8	CLST	Clast	1.2500000	1.2500000	0
9	CLST	Clast	1.1200000	1.1200000	0
10	CLST	Clast	2.4200000	2.4200000	0
11	CLST	Clast	0.8600000	0.8600000	0
12	CLST	Clast	1.1700000	1.1700000	0
1	AUCLST	AUClast	147.2347485	147.2347485	0
2	AUCLST	AUClast	88.7312755	88.7312755	0
3	AUCLST	AUClast	95.8781978	95.8781978	0
4	AUCLST	AUClast	102.6336232	102.6336232	0
5	AUCLST	AUClast	118.1793538	118.1793538	0
6	AUCLST	AUClast	71.6970150	71.6970150	0
7	AUCLST	AUClast	87.9692274	87.9692274	0
8	AUCLST	AUClast	86.8065635	86.8065635	0
9	AUCLST	AUClast	83.9374360	83.9374360	0
10	AUCLST	AUClast	135.5760701	135.5760701	0
11	AUCLST	AUClast	77.8934723	77.8934723	0
12	AUCLST	AUClast	115.2202082	115.2202082	0
1	AUCALL	AUCall	147.2347485	147.2347485	0
2	AUCALL	AUCall	88.7312755	88.7312755	0
3	AUCALL	AUCall	95.8781978	95.8781978	0
4	AUCALL	AUCall	102.6336232	102.6336232	0
5	AUCALL	AUCall	118.1793538	118.1793538	0
6	AUCALL	AUCall	71.6970150	71.6970150	0
7	AUCALL	AUCall	87.9692274	87.9692274	0
8	AUCALL	AUCall	86.8065635	86.8065635	0
9	AUCALL	AUCall	83.9374360	83.9374360	0
10	AUCALL	AUCall	135.5760701	135.5760701	0
11	AUCALL	AUCall	77.8934723	77.8934723	0
12	AUCALL	AUCall	115.2202082	115.2202082	0
1	AUCIFO	AUCINF_obs	214.9236316	214.9236316	0
2	AUCIFO	AUCINF_obs	97.3779346	97.3779346	0
3	AUCIFO	AUCINF_obs	106.1276685	106.1276685	0
4	AUCIFO	AUCINF_obs	114.2162046	114.2162046	0
5	AUCIFO	AUCINF_obs	136.3047316	136.3047316	0
6	AUCIFO	AUCINF_obs	82.1758833	82.1758833	0
7	AUCIFO	AUCINF_obs	100.9876292	100.9876292	0
8	AUCIFO	AUCINF_obs	102.1533003	102.1533003	0
9	AUCIFO	AUCINF_obs	97.5200039	97.5200039	0
10	AUCIFO	AUCINF_obs	167.8600307	167.8600307	0
11	AUCIFO	AUCINF_obs	86.9026173	86.9026173	0
12	AUCIFO	AUCINF_obs	125.8315397	125.8315397	0
1	AUCIFOD	AUCINF_D_obs	0.6716363	0.6716363	0
2	AUCIFOD	AUCINF_D_obs	0.3043060	0.3043060	0
3	AUCIFOD	AUCINF_D_obs	0.3316490	0.3316490	0
4	AUCIFOD	AUCINF_D_obs	0.3569256	0.3569256	0
5	AUCIFOD	AUCINF_D_obs	0.4259523	0.4259523	0
6	AUCIFOD	AUCINF_D_obs	0.2567996	0.2567996	0
7	AUCIFOD	AUCINF_D_obs	0.3155863	0.3155863	0
8	AUCIFOD	AUCINF_D_obs	0.3192291	0.3192291	0
9	AUCIFOD	AUCINF_D_obs	0.3047500	0.3047500	0
10	AUCIFOD	AUCINF_D_obs	0.5245626	0.5245626	0
11	AUCIFOD	AUCINF_D_obs	0.2715707	0.2715707	0
12	AUCIFOD	AUCINF_D_obs	0.3932236	0.3932236	0
1	AUCPEO	AUC_.Extrap_obs	31.4943883	31.4943883	0
2	AUCPEO	AUC_.Extrap_obs	8.8794850	8.8794850	0
3	AUCPEO	AUC_.Extrap_obs	9.6576801	9.6576801	0
4	AUCPEO	AUC_.Extrap_obs	10.1409266	10.1409266	0
5	AUCPEO	AUC_.Extrap_obs	13.2976879	13.2976879	0
6	AUCPEO	AUC_.Extrap_obs	12.7517562	12.7517562	0
7	AUCPEO	AUC_.Extrap_obs	12.8910857	12.8910857	0
8	AUCPEO	AUC_.Extrap_obs	15.0232413	15.0232413	0
9	AUCPEO	AUC_.Extrap_obs	13.9279813	13.9279813	0
10	AUCPEO	AUC_.Extrap_obs	19.2326669	19.2326669	0
11	AUCPEO	AUC_.Extrap_obs	10.3669431	10.3669432	0
12	AUCPEO	AUC_.Extrap_obs	8.4329665	8.4329665	0
1	VZFO	Vz_F_obs	30.7262325	30.7262325	0
2	VZFO	Vz_F_obs	31.5715024	31.5715024	0
3	VZFO	Vz_F_obs	29.4329299	29.4329299	0
4	VZFO	Vz_F_obs	28.2182304	28.2182304	0
5	VZFO	Vz_F_obs	27.1035678	27.1035677	0
6	VZFO	Vz_F_obs	44.3539348	44.3539348	0
7	VZFO	Vz_F_obs	35.8708471	35.8708471	0
8	VZFO	Vz_F_obs	38.4594978	38.4594978	0
9	VZFO	Vz_F_obs	39.7942323	39.7942323	0
10	VZFO	Vz_F_obs	25.4316257	25.4316257	0
11	VZFO	Vz_F_obs	38.5746722	38.5746722	0
12	VZFO	Vz_F_obs	23.0645237	23.0645237	0
1	CLFO	Cl_F_obs	1.4889010	1.4889010	0
2	CLFO	Cl_F_obs	3.2861654	3.2861654	0
3	CLFO	Cl_F_obs	3.0152363	3.0152363	0
4	CLFO	Cl_F_obs	2.8017040	2.8017040	0
5	CLFO	Cl_F_obs	2.3476808	2.3476808	0
6	CLFO	Cl_F_obs	3.8940865	3.8940865	0
7	CLFO	Cl_F_obs	3.1687049	3.1687049	0
8	CLFO	Cl_F_obs	3.1325469	3.1325469	0
9	CLFO	Cl_F_obs	3.2813780	3.2813780	0
10	CLFO	Cl_F_obs	1.9063502	1.9063502	0
11	CLFO	Cl_F_obs	3.6822827	3.6822827	0
12	CLFO	Cl_F_obs	2.5430826	2.5430826	0
1	AUCIFP	AUCINF_pred	214.9266543	214.9266543	0
2	AUCIFP	AUCINF_pred	97.2687931	97.2687931	0
3	AUCIFP	AUCINF_pred	106.1774195	106.1774195	0
4	AUCIFP	AUCINF_pred	114.2808818	114.2808818	0
5	AUCIFP	AUCINF_pred	136.1395842	136.1395842	0
6	AUCIFP	AUCINF_pred	82.4181636	82.4181636	0
7	AUCIFP	AUCINF_pred	101.1089745	101.1089745	0
8	AUCIFP	AUCINF_pred	101.8896649	101.8896649	0
9	AUCIFP	AUCINF_pred	97.4773537	97.4773537	0
10	AUCIFP	AUCINF_pred	167.7758826	167.7758826	0
11	AUCIFP	AUCINF_pred	86.9005913	86.9005913	0
12	AUCIFP	AUCINF_pred	125.8817762	125.8817762	0
1	AUCIFPD	AUCINF_D_pred	0.6716458	0.6716458	0
2	AUCIFPD	AUCINF_D_pred	0.3039650	0.3039650	0
3	AUCIFPD	AUCINF_D_pred	0.3318044	0.3318044	0
4	AUCIFPD	AUCINF_D_pred	0.3571278	0.3571278	0
5	AUCIFPD	AUCINF_D_pred	0.4254362	0.4254362	0
6	AUCIFPD	AUCINF_D_pred	0.2575568	0.2575568	0
7	AUCIFPD	AUCINF_D_pred	0.3159655	0.3159655	0
8	AUCIFPD	AUCINF_D_pred	0.3184052	0.3184052	0
9	AUCIFPD	AUCINF_D_pred	0.3046167	0.3046167	0
10	AUCIFPD	AUCINF_D_pred	0.5242996	0.5242996	0
11	AUCIFPD	AUCINF_D_pred	0.2715643	0.2715643	0
12	AUCIFPD	AUCINF_D_pred	0.3933806	0.3933806	0
1	AUCPEP	AUC_.Extrap_pred	31.4953518	31.4953518	0
2	AUCPEP	AUC_.Extrap_pred	8.7772423	8.7772423	0
3	AUCPEP	AUC_.Extrap_pred	9.7000114	9.7000114	0
4	AUCPEP	AUC_.Extrap_pred	10.1917822	10.1917822	0
5	AUCPEP	AUC_.Extrap_pred	13.1925116	13.1925116	0
6	AUCPEP	AUC_.Extrap_pred	13.0082352	13.0082352	0
7	AUCPEP	AUC_.Extrap_pred	12.9956288	12.9956288	0
8	AUCPEP	AUC_.Extrap_pred	14.8033674	14.8033674	0
9	AUCPEP	AUC_.Extrap_pred	13.8903213	13.8903213	0
10	AUCPEP	AUC_.Extrap_pred	19.1921580	19.1921580	0
11	AUCPEP	AUC_.Extrap_pred	10.3648535	10.3648535	0
12	AUCPEP	AUC_.Extrap_pred	8.4695087	8.4695087	0
1	VZFP	Vz_F_pred	30.7258003	30.7258003	0
2	VZFP	Vz_F_pred	31.6069275	31.6069275	0
3	VZFP	Vz_F_pred	29.4191386	29.4191386	0
4	VZFP	Vz_F_pred	28.2022603	28.2022603	0
5	VZFP	Vz_F_pred	27.1364464	27.1364464	0
6	VZFP	Vz_F_pred	44.2235499	44.2235499	0
7	VZFP	Vz_F_pred	35.8277969	35.8277969	0
8	VZFP	Vz_F_pred	38.5590101	38.5590101	0
9	VZFP	Vz_F_pred	39.8116439	39.8116439	0
10	VZFP	Vz_F_pred	25.4443810	25.4443809	0
11	VZFP	Vz_F_pred	38.5755715	38.5755715	0
12	VZFP	Vz_F_pred	23.0553192	23.0553192	0
1	CLFP	Cl_F_pred	1.4888800	1.4888800	0
2	CLFP	Cl_F_pred	3.2898527	3.2898527	0
3	CLFP	Cl_F_pred	3.0138235	3.0138235	0
4	CLFP	Cl_F_pred	2.8001184	2.8001184	0
5	CLFP	Cl_F_pred	2.3505287	2.3505287	0
6	CLFP	Cl_F_pred	3.8826393	3.8826393	0
7	CLFP	Cl_F_pred	3.1649020	3.1649020	0
8	CLFP	Cl_F_pred	3.1406522	3.1406522	0
9	CLFP	Cl_F_pred	3.2828138	3.2828138	0
10	CLFP	Cl_F_pred	1.9073063	1.9073063	0
11	CLFP	Cl_F_pred	3.6823685	3.6823685	0
12	CLFP	Cl_F_pred	2.5420677	2.5420677	0
1	AUMCLST	AUMClast	1499.1290852	1499.1290850	0
2	AUMCLST	AUMClast	716.2787279	716.2787279	0
3	AUMCLST	AUMClast	810.8726830	810.8726830	0
4	AUMCLST	AUMClast	911.7828093	911.7828093	0
5	AUMCLST	AUMClast	1038.8799844	1038.8799840	0
6	AUMCLST	AUMClast	618.6659191	618.6659191	0
7	AUMCLST	AUMClast	795.6267785	795.6267785	0
8	AUMCLST	AUMClast	756.3619816	756.3619816	0
9	AUMCLST	AUMClast	723.3794155	723.3794155	0
10	AUMCLST	AUMClast	1306.7406149	1306.7406150	0
11	AUMCLST	AUMClast	626.6357849	626.6357849	0
12	AUMCLST	AUMClast	982.6343023	982.6343023	0
1	AUMCIFO	AUMCINF_obs	4545.5928011	4545.5928010	0
2	AUMCIFO	AUMCINF_obs	1009.4644499	1009.4644500	0
3	AUMCIFO	AUMCINF_obs	1158.6515817	1158.6515820	0
4	AUMCIFO	AUMCINF_obs	1313.9510002	1313.9510000	0
5	AUMCIFO	AUMCINF_obs	1689.4872798	1689.4872800	0
6	AUMCIFO	AUMCINF_obs	987.9420173	987.9420173	0
7	AUMCIFO	AUMCINF_obs	1258.3053268	1258.3053270	0
8	AUMCIFO	AUMCINF_obs	1314.9431383	1314.9431380	0
9	AUMCIFO	AUMCINF_obs	1219.9213281	1219.9213280	0
10	AUMCIFO	AUMCINF_obs	2502.5540002	2502.5540000	0
11	AUMCIFO	AUMCINF_obs	937.9535438	937.9535438	0
12	AUMCIFO	AUMCINF_obs	1335.1375811	1335.1375810	0
1	AUMCPEO	AUMC_.Extrap_obs	67.0201632	67.0201632	0
2	AUMCPEO	AUMC_.Extrap_obs	29.0436897	29.0436897	0
3	AUMCPEO	AUMC_.Extrap_obs	30.0158308	30.0158308	0
4	AUMCPEO	AUMC_.Extrap_obs	30.6075486	30.6075486	0
5	AUMCPEO	AUMC_.Extrap_obs	38.5091562	38.5091562	0
6	AUMCPEO	AUMC_.Extrap_obs	37.3783169	37.3783169	0
7	AUMCPEO	AUMC_.Extrap_obs	36.7699745	36.7699745	0
8	AUMCPEO	AUMC_.Extrap_obs	42.4794913	42.4794914	0
9	AUMCPEO	AUMC_.Extrap_obs	40.7027815	40.7027815	0
10	AUMCPEO	AUMC_.Extrap_obs	47.7837196	47.7837196	0
11	AUMCPEO	AUMC_.Extrap_obs	33.1911704	33.1911704	0
12	AUMCPEO	AUMC_.Extrap_obs	26.4020191	26.4020191	0
1	AUMCIFP	AUMCINF_pred	4545.7288462	4545.7288460	0
2	AUMCIFP	AUMCINF_pred	1005.7637454	1005.7637450	0
3	AUMCIFP	AUMCINF_pred	1160.3397033	1160.3397030	0
4	AUMCIFP	AUMCINF_pred	1316.1967080	1316.1967080	0
5	AUMCIFP	AUMCINF_pred	1683.5593423	1683.5593420	0
6	AUMCIFP	AUMCINF_pred	996.4799913	996.4799913	0
7	AUMCIFP	AUMCINF_pred	1262.6179786	1262.6179790	0
8	AUMCIFP	AUMCINF_pred	1305.3474998	1305.3475000	0
9	AUMCIFP	AUMCINF_pred	1218.3621498	1218.3621500	0
10	AUMCIFP	AUMCINF_pred	2499.4371146	2499.4371150	0
11	AUMCIFP	AUMCINF_pred	937.8835360	937.8835360	0
12	AUMCIFP	AUMCINF_pred	1336.8064129	1336.8064130	0
1	AUMCPEP	AUMC_.Extrap_pred	67.0211503	67.0211503	0
2	AUMCPEP	AUMC_.Extrap_pred	28.7826061	28.7826061	0
3	AUMCPEP	AUMC_.Extrap_pred	30.1176474	30.1176474	0
4	AUMCPEP	AUMC_.Extrap_pred	30.7259467	30.7259467	0
5	AUMCPEP	AUMC_.Extrap_pred	38.2926424	38.2926424	0
6	AUMCPEP	AUMC_.Extrap_pred	37.9148679	37.9148679	0
7	AUMCPEP	AUMC_.Extrap_pred	36.9859457	36.9859457	0
8	AUMCPEP	AUMC_.Extrap_pred	42.0566568	42.0566568	0
9	AUMCPEP	AUMC_.Extrap_pred	40.6268969	40.6268969	0
10	AUMCPEP	AUMC_.Extrap_pred	47.7186040	47.7186040	0
11	AUMCPEP	AUMC_.Extrap_pred	33.1861835	33.1861835	0
12	AUMCPEP	AUMC_.Extrap_pred	26.4938967	26.4938967	0
1	MRTEVLST	MRTlast	10.1818973	10.1818973	0
2	MRTEVLST	MRTlast	8.0724494	8.0724494	0
3	MRTEVLST	MRTlast	8.4573209	8.4573209	0
4	MRTEVLST	MRTlast	8.8838607	8.8838607	0
5	MRTEVLST	MRTlast	8.7907063	8.7907063	0
6	MRTEVLST	MRTlast	8.6288937	8.6288937	0
7	MRTEVLST	MRTlast	9.0443761	9.0443761	0
8	MRTEVLST	MRTlast	8.7131889	8.7131889	0
9	MRTEVLST	MRTlast	8.6180785	8.6180785	0
10	MRTEVLST	MRTlast	9.6384311	9.6384311	0
11	MRTEVLST	MRTlast	8.0447792	8.0447792	0
12	MRTEVLST	MRTlast	8.5283156	8.5283156	0
1	MRTEVIFO	MRTINF_obs	21.1498046	21.1498045	0
2	MRTEVIFO	MRTINF_obs	10.3664599	10.3664599	0
3	MRTEVIFO	MRTINF_obs	10.9175260	10.9175260	0
4	MRTEVIFO	MRTINF_obs	11.5040681	11.5040681	0
5	MRTEVIFO	MRTINF_obs	12.3949276	12.3949276	0
6	MRTEVIFO	MRTINF_obs	12.0222866	12.0222866	0
7	MRTEVIFO	MRTINF_obs	12.4599947	12.4599947	0
8	MRTEVIFO	MRTINF_obs	12.8722531	12.8722531	0
9	MRTEVIFO	MRTINF_obs	12.5094471	12.5094471	0
10	MRTEVIFO	MRTINF_obs	14.9085758	14.9085758	0
11	MRTEVIFO	MRTINF_obs	10.7931564	10.7931564	0
12	MRTEVIFO	MRTINF_obs	10.6105161	10.6105161	0
1	MRTEVIFP	MRTINF_pred	21.1501401	21.1501401	0
2	MRTEVIFP	MRTINF_pred	10.3400455	10.3400455	0
3	MRTEVIFP	MRTINF_pred	10.9283095	10.9283095	0
4	MRTEVIFP	MRTINF_pred	11.5172082	11.5172082	0
5	MRTEVIFP	MRTINF_pred	12.3664205	12.3664205	0
6	MRTEVIFP	MRTINF_pred	12.0905386	12.0905386	0
7	MRTEVIFP	MRTINF_pred	12.4876944	12.4876944	0
8	MRTEVIFP	MRTINF_pred	12.8113828	12.8113828	0
9	MRTEVIFP	MRTINF_pred	12.4989252	12.4989252	0
10	MRTEVIFP	MRTINF_pred	14.8974756	14.8974756	0
11	MRTEVIFP	MRTINF_pred	10.7926025	10.7926025	0
12	MRTEVIFP	MRTINF_pred	10.6195388	10.6195388	0

Test 3: Indometh (n=6), Linear, IV Bolus

table_wres_rres(Wres3, Rres3,
                Caption = 'Indometh (n=6), Linear, IV Bolus')

Indometh (n=6), Linear, IV Bolus

	Pharmacokinetic Parameters		Values
Subject	PPTESTCD	WNL	NonCompart	WinNonlin	Difference
1	R2	Rsq	0.9970667	0.9970667	0
2	R2	Rsq	0.9476691	0.9476691	0
3	R2	Rsq	0.8758261	0.8758261	0
4	R2	Rsq	0.8728249	0.8728249	0
5	R2	Rsq	0.8752442	0.8752442	0
6	R2	Rsq	0.9039538	0.9039538	0
1	R2ADJ	Rsq_adjusted	0.9941335	0.9941335	0
2	R2ADJ	Rsq_adjusted	0.9401933	0.9401933	0
3	R2ADJ	Rsq_adjusted	0.8603043	0.8603043	0
4	R2ADJ	Rsq_adjusted	0.8586943	0.8586943	0
5	R2ADJ	Rsq_adjusted	0.8544516	0.8544516	0
6	R2ADJ	Rsq_adjusted	0.8902329	0.8902329	0
1	CORRXY	Corr_XY	-0.9985323	-0.9985323	0
2	CORRXY	Corr_XY	-0.9734830	-0.9734830	0
3	CORRXY	Corr_XY	-0.9358558	-0.9358558	0
4	CORRXY	Corr_XY	-0.9342510	-0.9342510	0
5	CORRXY	Corr_XY	-0.9355449	-0.9355449	0
6	CORRXY	Corr_XY	-0.9507649	-0.9507649	0
1	LAMZNPT	No_points_lambda_z	3.0000000	3.0000000	0
2	LAMZNPT	No_points_lambda_z	9.0000000	9.0000000	0
3	LAMZNPT	No_points_lambda_z	10.0000000	10.0000000	0
4	LAMZNPT	No_points_lambda_z	11.0000000	11.0000000	0
5	LAMZNPT	No_points_lambda_z	8.0000000	8.0000000	0
6	LAMZNPT	No_points_lambda_z	9.0000000	9.0000000	0
1	LAMZ	Lambda_z	0.1583205	0.1583205	0
2	LAMZ	Lambda_z	0.3022800	0.3022800	0
3	LAMZ	Lambda_z	0.4218926	0.4218926	0
4	LAMZ	Lambda_z	0.4554455	0.4554455	0
5	LAMZ	Lambda_z	0.2527478	0.2527478	0
6	LAMZ	Lambda_z	0.3535205	0.3535205	0
1	LAMZLL	Lambda_z_lower	5.0000000	5.0000000	0
2	LAMZLL	Lambda_z_lower	0.7500000	0.7500000	0
3	LAMZLL	Lambda_z_lower	0.5000000	0.5000000	0
4	LAMZLL	Lambda_z_lower	0.2500000	0.2500000	0
5	LAMZLL	Lambda_z_lower	1.0000000	1.0000000	0
6	LAMZLL	Lambda_z_lower	0.7500000	0.7500000	0
1	LAMZUL	Lambda_z_upper	8.0000000	8.0000000	0
2	LAMZUL	Lambda_z_upper	8.0000000	8.0000000	0
3	LAMZUL	Lambda_z_upper	8.0000000	8.0000000	0
4	LAMZUL	Lambda_z_upper	8.0000000	8.0000000	0
5	LAMZUL	Lambda_z_upper	8.0000000	8.0000000	0
6	LAMZUL	Lambda_z_upper	8.0000000	8.0000000	0
1	LAMZHL	HL_Lambda_z	4.3781270	4.3781270	0
2	LAMZHL	HL_Lambda_z	2.2930632	2.2930632	0
3	LAMZHL	HL_Lambda_z	1.6429468	1.6429468	0
4	LAMZHL	HL_Lambda_z	1.5219104	1.5219104	0
5	LAMZHL	HL_Lambda_z	2.7424461	2.7424461	0
6	LAMZHL	HL_Lambda_z	1.9606986	1.9606986	0
1	TMAX	Tmax	0.2500000	0.2500000	0
2	TMAX	Tmax	0.2500000	0.2500000	0
3	TMAX	Tmax	0.2500000	0.2500000	0
4	TMAX	Tmax	0.2500000	0.2500000	0
5	TMAX	Tmax	0.2500000	0.2500000	0
6	TMAX	Tmax	0.2500000	0.2500000	0
1	CMAX	Cmax	1.5000000	1.5000000	0
2	CMAX	Cmax	2.0300000	2.0300000	0
3	CMAX	Cmax	2.7200000	2.7200000	0
4	CMAX	Cmax	1.8500000	1.8500000	0
5	CMAX	Cmax	2.0500000	2.0500000	0
6	CMAX	Cmax	2.3100000	2.3100000	0
1	CMAXD	Cmax_D	0.0600000	0.0600000	0
2	CMAXD	Cmax_D	0.0812000	0.0812000	0
3	CMAXD	Cmax_D	0.1088000	0.1088000	0
4	CMAXD	Cmax_D	0.0740000	0.0740000	0
5	CMAXD	Cmax_D	0.0820000	0.0820000	0
6	CMAXD	Cmax_D	0.0924000	0.0924000	0
1	C0	C0	2.3936170	2.3936170	0
2	C0	C0	2.5281595	2.5281595	0
3	C0	C0	4.9653691	4.9653691	0
4	C0	C0	2.4622302	2.4622302	0
5	C0	C0	4.0408654	4.0408654	0
6	C0	C0	3.7056250	3.7056250	0
1	TLST	Tlast	8.0000000	8.0000000	0
2	TLST	Tlast	8.0000000	8.0000000	0
3	TLST	Tlast	8.0000000	8.0000000	0
4	TLST	Tlast	8.0000000	8.0000000	0
5	TLST	Tlast	8.0000000	8.0000000	0
6	TLST	Tlast	8.0000000	8.0000000	0
1	CLST	Clast	0.0500000	0.0500000	0
2	CLST	Clast	0.0800000	0.0800000	0
3	CLST	Clast	0.0800000	0.0800000	0
4	CLST	Clast	0.0700000	0.0700000	0
5	CLST	Clast	0.0600000	0.0600000	0
6	CLST	Clast	0.0900000	0.0900000	0
1	AUCLST	AUClast	2.0404521	2.0404521	0
2	AUCLST	AUClast	3.2485199	3.2485199	0
3	AUCLST	AUClast	3.5544211	3.5544211	0
4	AUCLST	AUClast	2.7852788	2.7852788	0
5	AUCLST	AUClast	2.4588582	2.4588582	0
6	AUCLST	AUClast	3.3357031	3.3357031	0
1	AUCALL	AUCall	2.0404521	2.0404521	0
2	AUCALL	AUCall	3.2485199	3.2485199	0
3	AUCALL	AUCall	3.5544211	3.5544211	0
4	AUCALL	AUCall	2.7852788	2.7852788	0
5	AUCALL	AUCall	2.4588582	2.4588582	0
6	AUCALL	AUCall	3.3357031	3.3357031	0
1	AUCIFO	AUCINF_obs	2.3562672	2.3562672	0
2	AUCIFO	AUCINF_obs	3.5131752	3.5131752	0
3	AUCIFO	AUCINF_obs	3.7440428	3.7440428	0
4	AUCIFO	AUCINF_obs	2.9389745	2.9389745	0
5	AUCIFO	AUCINF_obs	2.6962490	2.6962490	0
6	AUCIFO	AUCINF_obs	3.5902852	3.5902852	0
1	AUCIFOD	AUCINF_D_obs	0.0942507	0.0942507	0
2	AUCIFOD	AUCINF_D_obs	0.1405270	0.1405270	0
3	AUCIFOD	AUCINF_D_obs	0.1497617	0.1497617	0
4	AUCIFOD	AUCINF_D_obs	0.1175590	0.1175590	0
5	AUCIFOD	AUCINF_D_obs	0.1078500	0.1078500	0
6	AUCIFOD	AUCINF_D_obs	0.1436114	0.1436114	0
1	AUCPEO	AUC_.Extrap_obs	13.4031956	13.4031956	0
2	AUCPEO	AUC_.Extrap_obs	7.5332215	7.5332215	0
3	AUCPEO	AUC_.Extrap_obs	5.0646241	5.0646241	0
4	AUCPEO	AUC_.Extrap_obs	5.2295685	5.2295685	0
5	AUCPEO	AUC_.Extrap_obs	8.8044838	8.8044838	0
6	AUCPEO	AUC_.Extrap_obs	7.0908603	7.0908603	0
1	AUCPBEO	AUC_.Back_Ext_obs	20.6556421	20.6556421	0
2	AUCPBEO	AUC_.Back_Ext_obs	16.2180906	16.2180906	0
3	AUCPBEO	AUC_.Back_Ext_obs	25.6586578	25.6586578	0
4	AUCPBEO	AUC_.Back_Ext_obs	18.3407098	18.3407098	0
5	AUCPBEO	AUC_.Back_Ext_obs	28.2376805	28.2376805	0
6	AUCPBEO	AUC_.Back_Ext_obs	20.9441054	20.9441054	0
1	VZO	Vz_obs	67.0159780	67.0159780	0
2	VZO	Vz_obs	23.5413171	23.5413171	0
3	VZO	Vz_obs	15.8269504	15.8269504	0
4	VZO	Vz_obs	18.6770303	18.6770303	0
5	VZO	Vz_obs	36.6853493	36.6853493	0
6	VZO	Vz_obs	19.6968341	19.6968341	0
1	CLO	Cl_obs	10.6100020	10.6100020	0
2	CLO	Cl_obs	7.1160698	7.1160698	0
3	CLO	Cl_obs	6.6772740	6.6772740	0
4	CLO	Cl_obs	8.5063686	8.5063686	0
5	CLO	Cl_obs	9.2721407	9.2721407	0
6	CLO	Cl_obs	6.9632351	6.9632351	0
1	AUCIFP	AUCINF_pred	2.3578369	2.3578369	0
2	AUCIFP	AUCINF_pred	3.4958268	3.4958268	0
3	AUCIFP	AUCINF_pred	3.6491670	3.6491670	0
4	AUCIFP	AUCINF_pred	2.8554521	2.8554521	0
5	AUCIFP	AUCINF_pred	2.6549884	2.6549884	0
6	AUCIFP	AUCINF_pred	3.4947956	3.4947956	0
1	AUCIFPD	AUCINF_D_pred	0.0943135	0.0943135	0
2	AUCIFPD	AUCINF_D_pred	0.1398331	0.1398331	0
3	AUCIFPD	AUCINF_D_pred	0.1459667	0.1459667	0
4	AUCIFPD	AUCINF_D_pred	0.1142181	0.1142181	0
5	AUCIFPD	AUCINF_D_pred	0.1061995	0.1061995	0
6	AUCIFPD	AUCINF_D_pred	0.1397918	0.1397918	0
1	AUCPEP	AUC_.Extrap_pred	13.4608442	13.4608442	0
2	AUCPEP	AUC_.Extrap_pred	7.0743442	7.0743442	0
3	AUCPEP	AUC_.Extrap_pred	2.5963692	2.5963692	0
4	AUCPEP	AUC_.Extrap_pred	2.4575198	2.4575198	0
5	AUCPEP	AUC_.Extrap_pred	7.3872362	7.3872362	0
6	AUCPEP	AUC_.Extrap_pred	4.5522694	4.5522694	0
1	AUCPBEP	AUC_.Back_Ext_pred	20.6418914	20.6418914	0
2	AUCPBEP	AUC_.Back_Ext_pred	16.2985748	16.2985748	0
3	AUCPBEP	AUC_.Back_Ext_pred	26.3257654	26.3257654	0
4	AUCPBEP	AUC_.Back_Ext_pred	18.8771782	18.8771782	0
5	AUCPBEP	AUC_.Back_Ext_pred	28.6765156	28.6765156	0
6	AUCPBEP	AUC_.Back_Ext_pred	21.5163690	21.5163690	0
1	VZP	Vz_pred	66.9713647	66.9713647	0
2	VZP	Vz_pred	23.6581437	23.6581437	0
3	VZP	Vz_pred	16.2384403	16.2384403	0
4	VZP	Vz_pred	19.2233361	19.2233361	0
5	VZP	Vz_pred	37.2554675	37.2554675	0
6	VZP	Vz_pred	20.2350180	20.2350180	0
1	CLP	Cl_pred	10.6029388	10.6029388	0
2	CLP	Cl_pred	7.1513841	7.1513841	0
3	CLP	Cl_pred	6.8508786	6.8508786	0
4	CLP	Cl_pred	8.7551811	8.7551811	0
5	CLP	Cl_pred	9.4162369	9.4162369	0
6	CLP	Cl_pred	7.1534941	7.1534941	0
1	AUMCLST	AUMClast	3.2712500	3.2712500	0
2	AUMCLST	AUMClast	6.3987500	6.3987500	0
3	AUMCLST	AUMClast	5.0062500	5.0062500	0
4	AUMCLST	AUMClast	4.3818750	4.3818750	0
5	AUMCLST	AUMClast	3.7075000	3.7075000	0
6	AUMCLST	AUMClast	5.5325000	5.5325000	0
1	AUMCIFO	AUMCINF_obs	7.7925545	7.7925545	0
2	AUMCIFO	AUMCINF_obs	9.3915223	9.3915223	0
3	AUMCIFO	AUMCINF_obs	6.9726784	6.9726784	0
4	AUMCIFO	AUMCINF_obs	5.9489028	5.9489028	0
5	AUMCIFO	AUMCINF_obs	6.5458663	6.5458663	0
6	AUMCIFO	AUMCINF_obs	8.2892908	8.2892908	0
1	AUMCPEO	AUMC_.Extrap_obs	58.0208261	58.0208261	0
2	AUMCPEO	AUMC_.Extrap_obs	31.8667432	31.8667432	0
3	AUMCPEO	AUMC_.Extrap_obs	28.2019090	28.2019090	0
4	AUMCPEO	AUMC_.Extrap_obs	26.3414589	26.3414589	0
5	AUMCPEO	AUMC_.Extrap_obs	43.3612023	43.3612023	0
6	AUMCPEO	AUMC_.Extrap_obs	33.2572574	33.2572574	0
1	AUMCIFP	AUMCINF_pred	7.8150259	7.8150259	0
2	AUMCIFP	AUMCINF_pred	9.1953427	9.1953427	0
3	AUMCIFP	AUMCINF_pred	5.9887901	5.9887901	0
4	AUMCIFP	AUMCINF_pred	5.0973376	5.0973376	0
5	AUMCIFP	AUMCINF_pred	6.0525342	6.0525342	0
6	AUMCIFP	AUMCINF_pred	7.2552635	7.2552635	0
1	AUMCPEP	AUMC_.Extrap_pred	58.1415337	58.1415337	0
2	AUMCPEP	AUMC_.Extrap_pred	30.4131425	30.4131425	0
3	AUMCPEP	AUMC_.Extrap_pred	16.4063210	16.4063210	0
4	AUMCPEP	AUMC_.Extrap_pred	14.0360055	14.0360055	0
5	AUMCPEP	AUMC_.Extrap_pred	38.7446663	38.7446663	0
6	AUMCPEP	AUMC_.Extrap_pred	23.7450164	23.7450164	0
1	MRTIVLST	MRTlast	1.6031986	1.6031986	0
2	MRTIVLST	MRTlast	1.9697432	1.9697432	0
3	MRTIVLST	MRTlast	1.4084572	1.4084572	0
4	MRTIVLST	MRTlast	1.5732267	1.5732267	0
5	MRTIVLST	MRTlast	1.5078137	1.5078137	0
6	MRTIVLST	MRTlast	1.6585709	1.6585709	0
1	MRTIVIFO	MRTINF_obs	3.3071607	3.3071607	0
2	MRTIVIFO	MRTINF_obs	2.6732291	2.6732291	0
3	MRTIVIFO	MRTINF_obs	1.8623394	1.8623394	0
4	MRTIVIFO	MRTINF_obs	2.0241424	2.0241424	0
5	MRTIVIFO	MRTINF_obs	2.4277678	2.4277678	0
6	MRTIVIFO	MRTINF_obs	2.3088112	2.3088112	0
1	MRTIVIFP	MRTINF_pred	3.3144897	3.3144897	0
2	MRTIVIFP	MRTINF_pred	2.6303771	2.6303771	0
3	MRTIVIFP	MRTINF_pred	1.6411390	1.6411390	0
4	MRTIVIFP	MRTINF_pred	1.7851245	1.7851245	0
5	MRTIVIFP	MRTINF_pred	2.2796838	2.2796838	0
6	MRTIVIFP	MRTINF_pred	2.0760194	2.0760194	0
1	VSSO	Vss_obs	35.0889819	35.0889819	0
2	VSSO	Vss_obs	19.0228851	19.0228851	0
3	VSSO	Vss_obs	12.4353504	12.4353504	0
4	VSSO	Vss_obs	17.2181012	17.2181012	0
5	VSSO	Vss_obs	22.5106044	22.5106044	0
6	VSSO	Vss_obs	16.0767951	16.0767951	0
1	VSSP	Vss_pred	35.1433309	35.1433309	0
2	VSSP	Vss_pred	18.8108371	18.8108371	0
3	VSSP	Vss_pred	11.2432438	11.2432438	0
4	VSSP	Vss_pred	15.6290886	15.6290886	0
5	VSSP	Vss_pred	21.4660427	21.4660427	0
6	VSSP	Vss_pred	14.8507925	14.8507925	0

Test 4: Indometh (n=6), Log, IV Bolus

table_wres_rres(Wres4, Rres4,
                Caption = 'Indometh (n=6), Log, IV Bolus')

Indometh (n=6), Log, IV Bolus

	Pharmacokinetic Parameters		Values
Subject	PPTESTCD	WNL	NonCompart	WinNonlin	Difference
1	R2	Rsq	0.9970667	0.9970667	0
2	R2	Rsq	0.9476691	0.9476691	0
3	R2	Rsq	0.8758261	0.8758261	0
4	R2	Rsq	0.8728249	0.8728249	0
5	R2	Rsq	0.8752442	0.8752442	0
6	R2	Rsq	0.9039538	0.9039538	0
1	R2ADJ	Rsq_adjusted	0.9941335	0.9941335	0
2	R2ADJ	Rsq_adjusted	0.9401933	0.9401933	0
3	R2ADJ	Rsq_adjusted	0.8603043	0.8603043	0
4	R2ADJ	Rsq_adjusted	0.8586943	0.8586943	0
5	R2ADJ	Rsq_adjusted	0.8544516	0.8544516	0
6	R2ADJ	Rsq_adjusted	0.8902329	0.8902329	0
1	CORRXY	Corr_XY	-0.9985323	-0.9985323	0
2	CORRXY	Corr_XY	-0.9734830	-0.9734830	0
3	CORRXY	Corr_XY	-0.9358558	-0.9358558	0
4	CORRXY	Corr_XY	-0.9342510	-0.9342510	0
5	CORRXY	Corr_XY	-0.9355449	-0.9355449	0
6	CORRXY	Corr_XY	-0.9507649	-0.9507649	0
1	LAMZNPT	No_points_lambda_z	3.0000000	3.0000000	0
2	LAMZNPT	No_points_lambda_z	9.0000000	9.0000000	0
3	LAMZNPT	No_points_lambda_z	10.0000000	10.0000000	0
4	LAMZNPT	No_points_lambda_z	11.0000000	11.0000000	0
5	LAMZNPT	No_points_lambda_z	8.0000000	8.0000000	0
6	LAMZNPT	No_points_lambda_z	9.0000000	9.0000000	0
1	LAMZ	Lambda_z	0.1583205	0.1583205	0
2	LAMZ	Lambda_z	0.3022800	0.3022800	0
3	LAMZ	Lambda_z	0.4218926	0.4218926	0
4	LAMZ	Lambda_z	0.4554455	0.4554455	0
5	LAMZ	Lambda_z	0.2527478	0.2527478	0
6	LAMZ	Lambda_z	0.3535205	0.3535205	0
1	LAMZLL	Lambda_z_lower	5.0000000	5.0000000	0
2	LAMZLL	Lambda_z_lower	0.7500000	0.7500000	0
3	LAMZLL	Lambda_z_lower	0.5000000	0.5000000	0
4	LAMZLL	Lambda_z_lower	0.2500000	0.2500000	0
5	LAMZLL	Lambda_z_lower	1.0000000	1.0000000	0
6	LAMZLL	Lambda_z_lower	0.7500000	0.7500000	0
1	LAMZUL	Lambda_z_upper	8.0000000	8.0000000	0
2	LAMZUL	Lambda_z_upper	8.0000000	8.0000000	0
3	LAMZUL	Lambda_z_upper	8.0000000	8.0000000	0
4	LAMZUL	Lambda_z_upper	8.0000000	8.0000000	0
5	LAMZUL	Lambda_z_upper	8.0000000	8.0000000	0
6	LAMZUL	Lambda_z_upper	8.0000000	8.0000000	0
1	LAMZHL	HL_Lambda_z	4.3781270	4.3781270	0
2	LAMZHL	HL_Lambda_z	2.2930632	2.2930632	0
3	LAMZHL	HL_Lambda_z	1.6429468	1.6429468	0
4	LAMZHL	HL_Lambda_z	1.5219104	1.5219104	0
5	LAMZHL	HL_Lambda_z	2.7424461	2.7424461	0
6	LAMZHL	HL_Lambda_z	1.9606986	1.9606986	0
1	TMAX	Tmax	0.2500000	0.2500000	0
2	TMAX	Tmax	0.2500000	0.2500000	0
3	TMAX	Tmax	0.2500000	0.2500000	0
4	TMAX	Tmax	0.2500000	0.2500000	0
5	TMAX	Tmax	0.2500000	0.2500000	0
6	TMAX	Tmax	0.2500000	0.2500000	0
1	CMAX	Cmax	1.5000000	1.5000000	0
2	CMAX	Cmax	2.0300000	2.0300000	0
3	CMAX	Cmax	2.7200000	2.7200000	0
4	CMAX	Cmax	1.8500000	1.8500000	0
5	CMAX	Cmax	2.0500000	2.0500000	0
6	CMAX	Cmax	2.3100000	2.3100000	0
1	CMAXD	Cmax_D	0.0600000	0.0600000	0
2	CMAXD	Cmax_D	0.0812000	0.0812000	0
3	CMAXD	Cmax_D	0.1088000	0.1088000	0
4	CMAXD	Cmax_D	0.0740000	0.0740000	0
5	CMAXD	Cmax_D	0.0820000	0.0820000	0
6	CMAXD	Cmax_D	0.0924000	0.0924000	0
1	C0	C0	2.3936170	2.3936170	0
2	C0	C0	2.5281595	2.5281595	0
3	C0	C0	4.9653691	4.9653691	0
4	C0	C0	2.4622302	2.4622302	0
5	C0	C0	4.0408654	4.0408654	0
6	C0	C0	3.7056250	3.7056250	0
1	TLST	Tlast	8.0000000	8.0000000	0
2	TLST	Tlast	8.0000000	8.0000000	0
3	TLST	Tlast	8.0000000	8.0000000	0
4	TLST	Tlast	8.0000000	8.0000000	0
5	TLST	Tlast	8.0000000	8.0000000	0
6	TLST	Tlast	8.0000000	8.0000000	0
1	CLST	Clast	0.0500000	0.0500000	0
2	CLST	Clast	0.0800000	0.0800000	0
3	CLST	Clast	0.0800000	0.0800000	0
4	CLST	Clast	0.0700000	0.0700000	0
5	CLST	Clast	0.0600000	0.0600000	0
6	CLST	Clast	0.0900000	0.0900000	0
1	AUCLST	AUClast	2.0098984	2.0098984	0
2	AUCLST	AUClast	3.2028878	3.2028878	0
3	AUCLST	AUClast	3.4743971	3.4743971	0
4	AUCLST	AUClast	2.7483832	2.7483832	0
5	AUCLST	AUClast	2.3983736	2.3983736	0
6	AUCLST	AUClast	3.2908266	3.2908266	0
1	AUCALL	AUCall	2.0098984	2.0098984	0
2	AUCALL	AUCall	3.2028878	3.2028878	0
3	AUCALL	AUCall	3.4743971	3.4743971	0
4	AUCALL	AUCall	2.7483832	2.7483832	0
5	AUCALL	AUCall	2.3983736	2.3983736	0
6	AUCALL	AUCall	3.2908266	3.2908266	0
1	AUCIFO	AUCINF_obs	2.3257135	2.3257135	0
2	AUCIFO	AUCINF_obs	3.4675431	3.4675431	0
3	AUCIFO	AUCINF_obs	3.6640188	3.6640188	0
4	AUCIFO	AUCINF_obs	2.9020789	2.9020789	0
5	AUCIFO	AUCINF_obs	2.6357645	2.6357645	0
6	AUCIFO	AUCINF_obs	3.5454087	3.5454087	0
1	AUCIFOD	AUCINF_D_obs	0.0930285	0.0930285	0
2	AUCIFOD	AUCINF_D_obs	0.1387017	0.1387017	0
3	AUCIFOD	AUCINF_D_obs	0.1465608	0.1465608	0
4	AUCIFOD	AUCINF_D_obs	0.1160832	0.1160832	0
5	AUCIFOD	AUCINF_D_obs	0.1054306	0.1054306	0
6	AUCIFOD	AUCINF_D_obs	0.1418163	0.1418163	0
1	AUCPEO	AUC_.Extrap_obs	13.5792780	13.5792780	0
2	AUCPEO	AUC_.Extrap_obs	7.6323571	7.6323571	0
3	AUCPEO	AUC_.Extrap_obs	5.1752381	5.1752381	0
4	AUCPEO	AUC_.Extrap_obs	5.2960545	5.2960545	0
5	AUCPEO	AUC_.Extrap_obs	9.0065258	9.0065258	0
6	AUCPEO	AUC_.Extrap_obs	7.1806138	7.1806138	0
1	AUCPBEO	AUC_.Back_Ext_obs	20.5542573	20.5542573	0
2	AUCPBEO	AUC_.Back_Ext_obs	16.3658871	16.3658871	0
3	AUCPBEO	AUC_.Back_Ext_obs	25.4552663	25.4552663	0
4	AUCPBEO	AUC_.Back_Ext_obs	18.4484084	18.4484084	0
5	AUCPBEO	AUC_.Back_Ext_obs	27.8259014	27.8259014	0
6	AUCPBEO	AUC_.Back_Ext_obs	20.8230657	20.8230657	0
1	VZO	Vz_obs	67.8963898	67.8963898	0
2	VZO	Vz_obs	23.8511160	23.8511160	0
3	VZO	Vz_obs	16.1726192	16.1726192	0
4	VZO	Vz_obs	18.9144805	18.9144805	0
5	VZO	Vz_obs	37.5271908	37.5271908	0
6	VZO	Vz_obs	19.9461495	19.9461495	0
1	CLO	Cl_obs	10.7493892	10.7493892	0
2	CLO	Cl_obs	7.2097158	7.2097158	0
3	CLO	Cl_obs	6.8231092	6.8231092	0
4	CLO	Cl_obs	8.6145142	8.6145142	0
5	CLO	Cl_obs	9.4849143	9.4849143	0
6	CLO	Cl_obs	7.0513732	7.0513732	0
1	AUCIFP	AUCINF_pred	2.3272832	2.3272832	0
2	AUCIFP	AUCINF_pred	3.4501946	3.4501946	0
3	AUCIFP	AUCINF_pred	3.5691429	3.5691429	0
4	AUCIFP	AUCINF_pred	2.8185565	2.8185565	0
5	AUCIFP	AUCINF_pred	2.5945039	2.5945039	0
6	AUCIFP	AUCINF_pred	3.4499191	3.4499191	0
1	AUCIFPD	AUCINF_D_pred	0.0930913	0.0930913	0
2	AUCIFPD	AUCINF_D_pred	0.1380078	0.1380078	0
3	AUCIFPD	AUCINF_D_pred	0.1427657	0.1427657	0
4	AUCIFPD	AUCINF_D_pred	0.1127423	0.1127423	0
5	AUCIFPD	AUCINF_D_pred	0.1037802	0.1037802	0
6	AUCIFPD	AUCINF_D_pred	0.1379968	0.1379968	0
1	AUCPEP	AUC_.Extrap_pred	13.6375646	13.6375646	0
2	AUCPEP	AUC_.Extrap_pred	7.1679092	7.1679092	0
3	AUCPEP	AUC_.Extrap_pred	2.6545826	2.6545826	0
4	AUCPEP	AUC_.Extrap_pred	2.4896893	2.4896893	0
5	AUCPEP	AUC_.Extrap_pred	7.5594516	7.5594516	0
6	AUCPEP	AUC_.Extrap_pred	4.6114853	4.6114853	0
1	AUCPBEP	AUC_.Back_Ext_pred	20.5403945	20.5403945	0
2	AUCPBEP	AUC_.Back_Ext_pred	16.4481790	16.4481790	0
3	AUCPBEP	AUC_.Back_Ext_pred	26.1319245	26.1319245	0
4	AUCPBEP	AUC_.Back_Ext_pred	18.9950907	18.9950907	0
5	AUCPBEP	AUC_.Back_Ext_pred	28.2684182	28.2684182	0
6	AUCPBEP	AUC_.Back_Ext_pred	21.3994230	21.3994230	0
1	VZP	Vz_pred	67.8505969	67.8505969	0
2	VZP	Vz_pred	23.9710455	23.9710455	0
3	VZP	Vz_pred	16.6025238	16.6025238	0
4	VZP	Vz_pred	19.4749739	19.4749739	0
5	VZP	Vz_pred	38.1239878	38.1239878	0
6	VZP	Vz_pred	20.4982349	20.4982349	0
1	CLP	Cl_pred	10.7421392	10.7421392	0
2	CLP	Cl_pred	7.2459681	7.2459681	0
3	CLP	Cl_pred	7.0044827	7.0044827	0
4	CLP	Cl_pred	8.8697884	8.8697884	0
5	CLP	Cl_pred	9.6357534	9.6357534	0
6	CLP	Cl_pred	7.2465467	7.2465467	0
1	AUMCLST	AUMClast	3.3047961	3.3047961	0
2	AUMCLST	AUMClast	6.4131687	6.4131687	0
3	AUMCLST	AUMClast	5.0552993	5.0552993	0
4	AUMCLST	AUMClast	4.4049718	4.4049718	0
5	AUMCLST	AUMClast	3.7472994	3.7472994	0
6	AUMCLST	AUMClast	5.5904206	5.5904206	0
1	AUMCIFO	AUMCINF_obs	7.8261005	7.8261005	0
2	AUMCIFO	AUMCINF_obs	9.4059410	9.4059410	0
3	AUMCIFO	AUMCINF_obs	7.0217278	7.0217278	0
4	AUMCIFO	AUMCINF_obs	5.9719996	5.9719996	0
5	AUMCIFO	AUMCINF_obs	6.5856658	6.5856658	0
6	AUMCIFO	AUMCINF_obs	8.3472113	8.3472113	0
1	AUMCPEO	AUMC_.Extrap_obs	57.7721236	57.7721236	0
2	AUMCPEO	AUMC_.Extrap_obs	31.8178935	31.8178935	0
3	AUMCPEO	AUMC_.Extrap_obs	28.0049084	28.0049084	0
4	AUMCPEO	AUMC_.Extrap_obs	26.2395827	26.2395827	0
5	AUMCPEO	AUMC_.Extrap_obs	43.0991557	43.0991557	0
6	AUMCPEO	AUMC_.Extrap_obs	33.0264883	33.0264883	0
1	AUMCIFP	AUMCINF_pred	7.8485720	7.8485720	0
2	AUMCIFP	AUMCINF_pred	9.2097614	9.2097614	0
3	AUMCIFP	AUMCINF_pred	6.0378395	6.0378395	0
4	AUMCIFP	AUMCINF_pred	5.1204344	5.1204344	0
5	AUMCIFP	AUMCINF_pred	6.0923336	6.0923336	0
6	AUMCIFP	AUMCINF_pred	7.3131841	7.3131841	0
1	AUMCPEP	AUMC_.Extrap_pred	57.8930274	57.8930274	0
2	AUMCPEP	AUMC_.Extrap_pred	30.3655279	30.3655279	0
3	AUMCPEP	AUMC_.Extrap_pred	16.2730417	16.2730417	0
4	AUMCPEP	AUMC_.Extrap_pred	13.9726930	13.9726930	0
5	AUMCPEP	AUMC_.Extrap_pred	38.4915588	38.4915588	0
6	AUMCPEP	AUMC_.Extrap_pred	23.5569554	23.5569554	0
1	MRTIVLST	MRTlast	1.6442602	1.6442602	0
2	MRTIVLST	MRTlast	2.0023083	2.0023083	0
3	MRTIVLST	MRTlast	1.4550148	1.4550148	0
4	MRTIVLST	MRTlast	1.6027502	1.6027502	0
5	MRTIVLST	MRTlast	1.5624335	1.5624335	0
6	MRTIVLST	MRTlast	1.6987892	1.6987892	0
1	MRTIVIFO	MRTINF_obs	3.3650320	3.3650320	0
2	MRTIVIFO	MRTINF_obs	2.7125665	2.7125665	0
3	MRTIVIFO	MRTINF_obs	1.9164006	1.9164006	0
4	MRTIVIFO	MRTINF_obs	2.0578350	2.0578350	0
5	MRTIVIFO	MRTINF_obs	2.4985790	2.4985790	0
6	MRTIVIFO	MRTINF_obs	2.3543721	2.3543721	0
1	MRTIVIFP	MRTINF_pred	3.3724181	3.3724181	0
2	MRTIVIFP	MRTINF_pred	2.6693455	2.6693455	0
3	MRTIVIFP	MRTINF_pred	1.6916777	1.6916777	0
4	MRTIVIFP	MRTINF_pred	1.8166868	1.8166868	0
5	MRTIVIFP	MRTINF_pred	2.3481690	2.3481690	0
6	MRTIVIFP	MRTINF_pred	2.1198132	2.1198132	0
1	VSSO	Vss_obs	36.1720388	36.1720388	0
2	VSSO	Vss_obs	19.5568334	19.5568334	0
3	VSSO	Vss_obs	13.0758105	13.0758105	0
4	VSSO	Vss_obs	17.7272490	17.7272490	0
5	VSSO	Vss_obs	23.6988080	23.6988080	0
6	VSSO	Vss_obs	16.6015562	16.6015562	0
1	VSSP	Vss_pred	36.2269851	36.2269851	0
2	VSSP	Vss_pred	19.3419923	19.3419923	0
3	VSSP	Vss_pred	11.8493272	11.8493272	0
4	VSSP	Vss_pred	16.1136274	16.1136274	0
5	VSSP	Vss_pred	22.6263772	22.6263772	0
6	VSSP	Vss_pred	15.3613252	15.3613252	0

Test 5: Indometh (n=6), Linear, IV Infusion (0.25hr)

table_wres_rres(Wres5, Rres5,
                Caption = 'Indometh (n=6), Linear, IV Infusion (0.25hr)')

Indometh (n=6), Linear, IV Infusion (0.25hr)

	Pharmacokinetic Parameters		Values
Subject	PPTESTCD	WNL	NonCompart	WinNonlin	Difference
1	R2	Rsq	0.9970667	0.9970667	0
2	R2	Rsq	0.9476691	0.9476691	0
3	R2	Rsq	0.8758261	0.8758261	0
4	R2	Rsq	0.8671179	0.8671179	0
5	R2	Rsq	0.8752442	0.8752442	0
6	R2	Rsq	0.9039538	0.9039538	0
1	R2ADJ	Rsq_adjusted	0.9941335	0.9941335	0
2	R2ADJ	Rsq_adjusted	0.9401933	0.9401933	0
3	R2ADJ	Rsq_adjusted	0.8603043	0.8603043	0
4	R2ADJ	Rsq_adjusted	0.8505077	0.8505077	0
5	R2ADJ	Rsq_adjusted	0.8544516	0.8544516	0
6	R2ADJ	Rsq_adjusted	0.8902329	0.8902329	0
1	CORRXY	Corr_XY	-0.9985323	-0.9985323	0
2	CORRXY	Corr_XY	-0.9734830	-0.9734830	0
3	CORRXY	Corr_XY	-0.9358558	-0.9358558	0
4	CORRXY	Corr_XY	-0.9311917	-0.9311917	0
5	CORRXY	Corr_XY	-0.9355449	-0.9355449	0
6	CORRXY	Corr_XY	-0.9507649	-0.9507649	0
1	LAMZNPT	No_points_lambda_z	3.0000000	3.0000000	0
2	LAMZNPT	No_points_lambda_z	9.0000000	9.0000000	0
3	LAMZNPT	No_points_lambda_z	10.0000000	10.0000000	0
4	LAMZNPT	No_points_lambda_z	10.0000000	10.0000000	0
5	LAMZNPT	No_points_lambda_z	8.0000000	8.0000000	0
6	LAMZNPT	No_points_lambda_z	9.0000000	9.0000000	0
1	LAMZ	Lambda_z	0.1583205	0.1583205	0
2	LAMZ	Lambda_z	0.3022800	0.3022800	0
3	LAMZ	Lambda_z	0.4218926	0.4218926	0
4	LAMZ	Lambda_z	0.4290762	0.4290762	0
5	LAMZ	Lambda_z	0.2527478	0.2527478	0
6	LAMZ	Lambda_z	0.3535205	0.3535205	0
1	LAMZLL	Lambda_z_lower	5.0000000	5.0000000	0
2	LAMZLL	Lambda_z_lower	0.7500000	0.7500000	0
3	LAMZLL	Lambda_z_lower	0.5000000	0.5000000	0
4	LAMZLL	Lambda_z_lower	0.5000000	0.5000000	0
5	LAMZLL	Lambda_z_lower	1.0000000	1.0000000	0
6	LAMZLL	Lambda_z_lower	0.7500000	0.7500000	0
1	LAMZUL	Lambda_z_upper	8.0000000	8.0000000	0
2	LAMZUL	Lambda_z_upper	8.0000000	8.0000000	0
3	LAMZUL	Lambda_z_upper	8.0000000	8.0000000	0
4	LAMZUL	Lambda_z_upper	8.0000000	8.0000000	0
5	LAMZUL	Lambda_z_upper	8.0000000	8.0000000	0
6	LAMZUL	Lambda_z_upper	8.0000000	8.0000000	0
1	LAMZHL	HL_Lambda_z	4.3781270	4.3781270	0
2	LAMZHL	HL_Lambda_z	2.2930632	2.2930632	0
3	LAMZHL	HL_Lambda_z	1.6429468	1.6429468	0
4	LAMZHL	HL_Lambda_z	1.6154409	1.6154409	0
5	LAMZHL	HL_Lambda_z	2.7424461	2.7424461	0
6	LAMZHL	HL_Lambda_z	1.9606986	1.9606986	0
1	TMAX	Tmax	0.2500000	0.2500000	0
2	TMAX	Tmax	0.2500000	0.2500000	0
3	TMAX	Tmax	0.2500000	0.2500000	0
4	TMAX	Tmax	0.2500000	0.2500000	0
5	TMAX	Tmax	0.2500000	0.2500000	0
6	TMAX	Tmax	0.2500000	0.2500000	0
1	CMAX	Cmax	1.5000000	1.5000000	0
2	CMAX	Cmax	2.0300000	2.0300000	0
3	CMAX	Cmax	2.7200000	2.7200000	0
4	CMAX	Cmax	1.8500000	1.8500000	0
5	CMAX	Cmax	2.0500000	2.0500000	0
6	CMAX	Cmax	2.3100000	2.3100000	0
1	CMAXD	Cmax_D	0.0600000	0.0600000	0
2	CMAXD	Cmax_D	0.0812000	0.0812000	0
3	CMAXD	Cmax_D	0.1088000	0.1088000	0
4	CMAXD	Cmax_D	0.0740000	0.0740000	0
5	CMAXD	Cmax_D	0.0820000	0.0820000	0
6	CMAXD	Cmax_D	0.0924000	0.0924000	0
1	TLST	Tlast	8.0000000	8.0000000	0
2	TLST	Tlast	8.0000000	8.0000000	0
3	TLST	Tlast	8.0000000	8.0000000	0
4	TLST	Tlast	8.0000000	8.0000000	0
5	TLST	Tlast	8.0000000	8.0000000	0
6	TLST	Tlast	8.0000000	8.0000000	0
1	CLST	Clast	0.0500000	0.0500000	0
2	CLST	Clast	0.0800000	0.0800000	0
3	CLST	Clast	0.0800000	0.0800000	0
4	CLST	Clast	0.0700000	0.0700000	0
5	CLST	Clast	0.0600000	0.0600000	0
6	CLST	Clast	0.0900000	0.0900000	0
1	AUCLST	AUClast	1.7412500	1.7412500	0
2	AUCLST	AUClast	2.9325000	2.9325000	0
3	AUCLST	AUClast	2.9337500	2.9337500	0
4	AUCLST	AUClast	2.4775000	2.4775000	0
5	AUCLST	AUClast	1.9537500	1.9537500	0
6	AUCLST	AUClast	2.8725000	2.8725000	0
1	AUCALL	AUCall	1.7412500	1.7412500	0
2	AUCALL	AUCall	2.9325000	2.9325000	0
3	AUCALL	AUCall	2.9337500	2.9337500	0
4	AUCALL	AUCall	2.4775000	2.4775000	0
5	AUCALL	AUCall	1.9537500	1.9537500	0
6	AUCALL	AUCall	2.8725000	2.8725000	0
1	AUCIFO	AUCINF_obs	2.0570651	2.0570651	0
2	AUCIFO	AUCINF_obs	3.1971553	3.1971553	0
3	AUCIFO	AUCINF_obs	3.1233717	3.1233717	0
4	AUCIFO	AUCINF_obs	2.6406412	2.6406412	0
5	AUCIFO	AUCINF_obs	2.1911408	2.1911408	0
6	AUCIFO	AUCINF_obs	3.1270821	3.1270821	0
1	AUCIFOD	AUCINF_D_obs	0.0822826	0.0822826	0
2	AUCIFOD	AUCINF_D_obs	0.1278862	0.1278862	0
3	AUCIFOD	AUCINF_D_obs	0.1249349	0.1249349	0
4	AUCIFOD	AUCINF_D_obs	0.1056256	0.1056256	0
5	AUCIFOD	AUCINF_D_obs	0.0876456	0.0876456	0
6	AUCIFOD	AUCINF_D_obs	0.1250833	0.1250833	0
1	AUCPEO	AUC_.Extrap_obs	15.3527035	15.3527035	0
2	AUCPEO	AUC_.Extrap_obs	8.2778360	8.2778360	0
3	AUCPEO	AUC_.Extrap_obs	6.0710577	6.0710577	0
4	AUCPEO	AUC_.Extrap_obs	6.1780905	6.1780905	0
5	AUCPEO	AUC_.Extrap_obs	10.8341191	10.8341191	0
6	AUCPEO	AUC_.Extrap_obs	8.1412032	8.1412032	0
1	VZO	Vz_obs	76.7635175	76.7635175	0
2	VZO	Vz_obs	25.8682374	25.8682374	0
3	VZO	Vz_obs	18.9720552	18.9720552	0
4	VZO	Vz_obs	22.0646091	22.0646091	0
5	VZO	Vz_obs	45.1421631	45.1421631	0
6	VZO	Vz_obs	22.6144534	22.6144534	0
1	CLO	Cl_obs	12.1532371	12.1532371	0
2	CLO	Cl_obs	7.8194513	7.8194513	0
3	CLO	Cl_obs	8.0041706	8.0041706	0
4	CLO	Cl_obs	9.4673975	9.4673975	0
5	CLO	Cl_obs	11.4095817	11.4095817	0
6	CLO	Cl_obs	7.9946733	7.9946733	0
1	AUCIFP	AUCINF_pred	2.0586347	2.0586347	0
2	AUCIFP	AUCINF_pred	3.1798068	3.1798068	0
3	AUCIFP	AUCINF_pred	3.0284958	3.0284958	0
4	AUCIFP	AUCINF_pred	2.5577884	2.5577884	0
5	AUCIFP	AUCINF_pred	2.1498803	2.1498803	0
6	AUCIFP	AUCINF_pred	3.0315925	3.0315925	0
1	AUCIFPD	AUCINF_D_pred	0.0823454	0.0823454	0
2	AUCIFPD	AUCINF_D_pred	0.1271923	0.1271923	0
3	AUCIFPD	AUCINF_D_pred	0.1211398	0.1211398	0
4	AUCIFPD	AUCINF_D_pred	0.1023115	0.1023115	0
5	AUCIFPD	AUCINF_D_pred	0.0859952	0.0859952	0
6	AUCIFPD	AUCINF_D_pred	0.1212637	0.1212637	0
1	AUCPEP	AUC_.Extrap_pred	15.4172443	15.4172443	0
2	AUCPEP	AUC_.Extrap_pred	7.7774164	7.7774164	0
3	AUCPEP	AUC_.Extrap_pred	3.1284787	3.1284787	0
4	AUCPEP	AUC_.Extrap_pred	3.1389787	3.1389787	0
5	AUCPEP	AUC_.Extrap_pred	9.1228460	9.1228460	0
6	AUCPEP	AUC_.Extrap_pred	5.2478198	5.2478198	0
1	VZP	Vz_pred	76.7049878	76.7049878	0
2	VZP	Vz_pred	26.0093699	26.0093699	0
3	VZP	Vz_pred	19.5664063	19.5664063	0
4	VZP	Vz_pred	22.7793336	22.7793336	0
5	VZP	Vz_pred	46.0085322	46.0085322	0
6	VZP	Vz_pred	23.3267671	23.3267671	0
1	CLP	Cl_pred	12.1439707	12.1439707	0
2	CLP	Cl_pred	7.8621128	7.8621128	0
3	CLP	Cl_pred	8.2549230	8.2549230	0
4	CLP	Cl_pred	9.7740688	9.7740688	0
5	CLP	Cl_pred	11.6285546	11.6285546	0
6	CLP	Cl_pred	8.2464909	8.2464909	0
1	AUMCLST	AUMClast	3.2712500	3.2712500	0
2	AUMCLST	AUMClast	6.3987500	6.3987500	0
3	AUMCLST	AUMClast	5.0062500	5.0062500	0
4	AUMCLST	AUMClast	4.3818750	4.3818750	0
5	AUMCLST	AUMClast	3.7075000	3.7075000	0
6	AUMCLST	AUMClast	5.5325000	5.5325000	0
1	AUMCIFO	AUMCINF_obs	7.7925545	7.7925545	0
2	AUMCIFO	AUMCINF_obs	9.3915223	9.3915223	0
3	AUMCIFO	AUMCINF_obs	6.9726784	6.9726784	0
4	AUMCIFO	AUMCINF_obs	6.0672197	6.0672197	0
5	AUMCIFO	AUMCINF_obs	6.5458663	6.5458663	0
6	AUMCIFO	AUMCINF_obs	8.2892908	8.2892908	0
1	AUMCPEO	AUMC_.Extrap_obs	58.0208261	58.0208261	0
2	AUMCPEO	AUMC_.Extrap_obs	31.8667432	31.8667432	0
3	AUMCPEO	AUMC_.Extrap_obs	28.2019090	28.2019090	0
4	AUMCPEO	AUMC_.Extrap_obs	27.7778746	27.7778746	0
5	AUMCPEO	AUMC_.Extrap_obs	43.3612023	43.3612023	0
6	AUMCPEO	AUMC_.Extrap_obs	33.2572574	33.2572574	0
1	AUMCIFP	AUMCINF_pred	7.8150259	7.8150259	0
2	AUMCIFP	AUMCINF_pred	9.1953427	9.1953427	0
3	AUMCIFP	AUMCINF_pred	5.9887901	5.9887901	0
4	AUMCIFP	AUMCINF_pred	5.2113018	5.2113018	0
5	AUMCIFP	AUMCINF_pred	6.0525342	6.0525342	0
6	AUMCIFP	AUMCINF_pred	7.2552635	7.2552635	0
1	AUMCPEP	AUMC_.Extrap_pred	58.1415337	58.1415337	0
2	AUMCPEP	AUMC_.Extrap_pred	30.4131425	30.4131425	0
3	AUMCPEP	AUMC_.Extrap_pred	16.4063210	16.4063210	0
4	AUMCPEP	AUMC_.Extrap_pred	15.9159231	15.9159231	0
5	AUMCPEP	AUMC_.Extrap_pred	38.7446663	38.7446663	0
6	AUMCPEP	AUMC_.Extrap_pred	23.7450164	23.7450164	0
1	MRTIVLST	MRTlast	1.7536791	1.7536791	0
2	MRTIVLST	MRTlast	2.0570119	2.0570119	0
3	MRTIVLST	MRTlast	1.5814337	1.5814337	0
4	MRTIVLST	MRTlast	1.6436680	1.6436680	0
5	MRTIVLST	MRTlast	1.7726328	1.7726328	0
6	MRTIVLST	MRTlast	1.8010226	1.8010226	0
1	MRTIVIFO	MRTINF_obs	3.6631905	3.6631905	0
2	MRTIVIFO	MRTINF_obs	2.8124621	2.8124621	0
3	MRTIVIFO	MRTINF_obs	2.1074203	2.1074203	0
4	MRTIVIFO	MRTINF_obs	2.1726312	2.1726312	0
5	MRTIVIFO	MRTINF_obs	2.8624239	2.8624239	0
6	MRTIVIFO	MRTINF_obs	2.5258069	2.5258069	0
1	MRTIVIFP	MRTINF_pred	3.6712178	3.6712178	0
2	MRTIVIFP	MRTINF_pred	2.7667929	2.7667929	0
3	MRTIVIFP	MRTINF_pred	1.8524801	1.8524801	0
4	MRTIVIFP	MRTINF_pred	1.9124249	1.9124249	0
5	MRTIVIFP	MRTINF_pred	2.6902890	2.6902890	0
6	MRTIVIFP	MRTINF_pred	2.2682186	2.2682186	0
1	VSSO	Vss_obs	44.5196227	44.5196227	0
2	VSSO	Vss_obs	21.9919102	21.9919102	0
3	VSSO	Vss_obs	16.8681518	16.8681518	0
4	VSSO	Vss_obs	20.5691634	20.5691634	0
5	VSSO	Vss_obs	32.6590590	32.6590590	0
6	VSSO	Vss_obs	20.1930009	20.1930009	0
1	VSSP	Vss_pred	44.5831617	44.5831617	0
2	VSSP	Vss_pred	21.7528377	21.7528377	0
3	VSSP	Vss_pred	15.2920802	15.2920802	0
4	VSSP	Vss_pred	18.6921722	18.6921722	0
5	VSSP	Vss_pred	31.2841719	31.2841719	0
6	VSSP	Vss_pred	18.7048438	18.7048438	0

Test 6: Indometh (n=6), Log, IV Infusion (0.25hr)

table_wres_rres(Wres6, Rres6,
                Caption = 'Indometh (n=6), Log, IV Infusion (0.25hr)')

Indometh (n=6), Log, IV Infusion (0.25hr)

	Pharmacokinetic Parameters		Values
Subject	PPTESTCD	WNL	NonCompart	WinNonlin	Difference
1	R2	Rsq	0.9970667	0.9970667	0
2	R2	Rsq	0.9476691	0.9476691	0
3	R2	Rsq	0.8758261	0.8758261	0
4	R2	Rsq	0.8671179	0.8671179	0
5	R2	Rsq	0.8752442	0.8752442	0
6	R2	Rsq	0.9039538	0.9039538	0
1	R2ADJ	Rsq_adjusted	0.9941335	0.9941335	0
2	R2ADJ	Rsq_adjusted	0.9401933	0.9401933	0
3	R2ADJ	Rsq_adjusted	0.8603043	0.8603043	0
4	R2ADJ	Rsq_adjusted	0.8505077	0.8505077	0
5	R2ADJ	Rsq_adjusted	0.8544516	0.8544516	0
6	R2ADJ	Rsq_adjusted	0.8902329	0.8902329	0
1	CORRXY	Corr_XY	-0.9985323	-0.9985323	0
2	CORRXY	Corr_XY	-0.9734830	-0.9734830	0
3	CORRXY	Corr_XY	-0.9358558	-0.9358558	0
4	CORRXY	Corr_XY	-0.9311917	-0.9311917	0
5	CORRXY	Corr_XY	-0.9355449	-0.9355449	0
6	CORRXY	Corr_XY	-0.9507649	-0.9507649	0
1	LAMZNPT	No_points_lambda_z	3.0000000	3.0000000	0
2	LAMZNPT	No_points_lambda_z	9.0000000	9.0000000	0
3	LAMZNPT	No_points_lambda_z	10.0000000	10.0000000	0
4	LAMZNPT	No_points_lambda_z	10.0000000	10.0000000	0
5	LAMZNPT	No_points_lambda_z	8.0000000	8.0000000	0
6	LAMZNPT	No_points_lambda_z	9.0000000	9.0000000	0
1	LAMZ	Lambda_z	0.1583205	0.1583205	0
2	LAMZ	Lambda_z	0.3022800	0.3022800	0
3	LAMZ	Lambda_z	0.4218926	0.4218926	0
4	LAMZ	Lambda_z	0.4290762	0.4290762	0
5	LAMZ	Lambda_z	0.2527478	0.2527478	0
6	LAMZ	Lambda_z	0.3535205	0.3535205	0
1	LAMZLL	Lambda_z_lower	5.0000000	5.0000000	0
2	LAMZLL	Lambda_z_lower	0.7500000	0.7500000	0
3	LAMZLL	Lambda_z_lower	0.5000000	0.5000000	0
4	LAMZLL	Lambda_z_lower	0.5000000	0.5000000	0
5	LAMZLL	Lambda_z_lower	1.0000000	1.0000000	0
6	LAMZLL	Lambda_z_lower	0.7500000	0.7500000	0
1	LAMZUL	Lambda_z_upper	8.0000000	8.0000000	0
2	LAMZUL	Lambda_z_upper	8.0000000	8.0000000	0
3	LAMZUL	Lambda_z_upper	8.0000000	8.0000000	0
4	LAMZUL	Lambda_z_upper	8.0000000	8.0000000	0
5	LAMZUL	Lambda_z_upper	8.0000000	8.0000000	0
6	LAMZUL	Lambda_z_upper	8.0000000	8.0000000	0
1	LAMZHL	HL_Lambda_z	4.3781270	4.3781270	0
2	LAMZHL	HL_Lambda_z	2.2930632	2.2930632	0
3	LAMZHL	HL_Lambda_z	1.6429468	1.6429468	0
4	LAMZHL	HL_Lambda_z	1.6154409	1.6154409	0
5	LAMZHL	HL_Lambda_z	2.7424461	2.7424461	0
6	LAMZHL	HL_Lambda_z	1.9606986	1.9606986	0
1	TMAX	Tmax	0.2500000	0.2500000	0
2	TMAX	Tmax	0.2500000	0.2500000	0
3	TMAX	Tmax	0.2500000	0.2500000	0
4	TMAX	Tmax	0.2500000	0.2500000	0
5	TMAX	Tmax	0.2500000	0.2500000	0
6	TMAX	Tmax	0.2500000	0.2500000	0
1	CMAX	Cmax	1.5000000	1.5000000	0
2	CMAX	Cmax	2.0300000	2.0300000	0
3	CMAX	Cmax	2.7200000	2.7200000	0
4	CMAX	Cmax	1.8500000	1.8500000	0
5	CMAX	Cmax	2.0500000	2.0500000	0
6	CMAX	Cmax	2.3100000	2.3100000	0
1	CMAXD	Cmax_D	0.0600000	0.0600000	0
2	CMAXD	Cmax_D	0.0812000	0.0812000	0
3	CMAXD	Cmax_D	0.1088000	0.1088000	0
4	CMAXD	Cmax_D	0.0740000	0.0740000	0
5	CMAXD	Cmax_D	0.0820000	0.0820000	0
6	CMAXD	Cmax_D	0.0924000	0.0924000	0
1	TLST	Tlast	8.0000000	8.0000000	0
2	TLST	Tlast	8.0000000	8.0000000	0
3	TLST	Tlast	8.0000000	8.0000000	0
4	TLST	Tlast	8.0000000	8.0000000	0
5	TLST	Tlast	8.0000000	8.0000000	0
6	TLST	Tlast	8.0000000	8.0000000	0
1	CLST	Clast	0.0500000	0.0500000	0
2	CLST	Clast	0.0800000	0.0800000	0
3	CLST	Clast	0.0800000	0.0800000	0
4	CLST	Clast	0.0700000	0.0700000	0
5	CLST	Clast	0.0600000	0.0600000	0
6	CLST	Clast	0.0900000	0.0900000	0
1	AUCLST	AUClast	1.7193653	1.7193653	0
2	AUCLST	AUClast	2.8891436	2.8891436	0
3	AUCLST	AUClast	2.8817113	2.8817113	0
4	AUCLST	AUClast	2.4442459	2.4442459	0
5	AUCLST	AUClast	1.9211984	1.9211984	0
6	AUCLST	AUClast	2.8413138	2.8413138	0
1	AUCALL	AUCall	1.7193653	1.7193653	0
2	AUCALL	AUCall	2.8891436	2.8891436	0
3	AUCALL	AUCall	2.8817113	2.8817113	0
4	AUCALL	AUCall	2.4442459	2.4442459	0
5	AUCALL	AUCall	1.9211984	1.9211984	0
6	AUCALL	AUCall	2.8413138	2.8413138	0
1	AUCIFO	AUCINF_obs	2.0351804	2.0351804	0
2	AUCIFO	AUCINF_obs	3.1537989	3.1537989	0
3	AUCIFO	AUCINF_obs	3.0713330	3.0713330	0
4	AUCIFO	AUCINF_obs	2.6073871	2.6073871	0
5	AUCIFO	AUCINF_obs	2.1585892	2.1585892	0
6	AUCIFO	AUCINF_obs	3.0958959	3.0958959	0
1	AUCIFOD	AUCINF_D_obs	0.0814072	0.0814072	0
2	AUCIFOD	AUCINF_D_obs	0.1261520	0.1261520	0
3	AUCIFOD	AUCINF_D_obs	0.1228533	0.1228533	0
4	AUCIFOD	AUCINF_D_obs	0.1042955	0.1042955	0
5	AUCIFOD	AUCINF_D_obs	0.0863436	0.0863436	0
6	AUCIFOD	AUCINF_D_obs	0.1238358	0.1238358	0
1	AUCPEO	AUC_.Extrap_obs	15.5177942	15.5177942	0
2	AUCPEO	AUC_.Extrap_obs	8.3916343	8.3916343	0
3	AUCPEO	AUC_.Extrap_obs	6.1739217	6.1739217	0
4	AUCPEO	AUC_.Extrap_obs	6.2568848	6.2568848	0
5	AUCPEO	AUC_.Extrap_obs	10.9974979	10.9974979	0
6	AUCPEO	AUC_.Extrap_obs	8.2232127	8.2232127	0
1	VZO	Vz_obs	77.5889712	77.5889712	0
2	VZO	Vz_obs	26.2238573	26.2238573	0
3	VZO	Vz_obs	19.2935053	19.2935053	0
4	VZO	Vz_obs	22.3460171	22.3460171	0
5	VZO	Vz_obs	45.8229078	45.8229078	0
6	VZO	Vz_obs	22.8422576	22.8422576	0
1	CLO	Cl_obs	12.2839234	12.2839234	0
2	CLO	Cl_obs	7.9269481	7.9269481	0
3	CLO	Cl_obs	8.1397881	8.1397881	0
4	CLO	Cl_obs	9.5881430	9.5881430	0
5	CLO	Cl_obs	11.5816384	11.5816384	0
6	CLO	Cl_obs	8.0752068	8.0752068	0
1	AUCIFP	AUCINF_pred	2.0367500	2.0367500	0
2	AUCIFP	AUCINF_pred	3.1364504	3.1364504	0
3	AUCIFP	AUCINF_pred	2.9764572	2.9764572	0
4	AUCIFP	AUCINF_pred	2.5245343	2.5245343	0
5	AUCIFP	AUCINF_pred	2.1173287	2.1173287	0
6	AUCIFP	AUCINF_pred	3.0004063	3.0004063	0
1	AUCIFPD	AUCINF_D_pred	0.0814700	0.0814700	0
2	AUCIFPD	AUCINF_D_pred	0.1254580	0.1254580	0
3	AUCIFPD	AUCINF_D_pred	0.1190583	0.1190583	0
4	AUCIFPD	AUCINF_D_pred	0.1009814	0.1009814	0
5	AUCIFPD	AUCINF_D_pred	0.0846931	0.0846931	0
6	AUCIFPD	AUCINF_D_pred	0.1200163	0.1200163	0
1	AUCPEP	AUC_.Extrap_pred	15.5829013	15.5829013	0
2	AUCPEP	AUC_.Extrap_pred	7.8849267	7.8849267	0
3	AUCPEP	AUC_.Extrap_pred	3.1831752	3.1831752	0
4	AUCPEP	AUC_.Extrap_pred	3.1803265	3.1803265	0
5	AUCPEP	AUC_.Extrap_pred	9.2630996	9.2630996	0
6	AUCPEP	AUC_.Extrap_pred	5.3023656	5.3023656	0
1	VZP	Vz_pred	77.5291765	77.5291765	0
2	VZP	Vz_pred	26.3689077	26.3689077	0
3	VZP	Vz_pred	19.9084941	19.9084941	0
4	VZP	Vz_pred	23.0793917	23.0793917	0
5	VZP	Vz_pred	46.7158621	46.7158621	0
6	VZP	Vz_pred	23.5692251	23.5692251	0
1	CLP	Cl_pred	12.2744566	12.2744566	0
2	CLP	Cl_pred	7.9707940	7.9707940	0
3	CLP	Cl_pred	8.3992473	8.3992473	0
4	CLP	Cl_pred	9.9028165	9.9028165	0
5	CLP	Cl_pred	11.8073306	11.8073306	0
6	CLP	Cl_pred	8.3322048	8.3322048	0
1	AUMCLST	AUMClast	3.2965543	3.2965543	0
2	AUMCLST	AUMClast	6.4082620	6.4082620	0
3	AUMCLST	AUMClast	5.0353383	5.0353383	0
4	AUMCLST	AUMClast	4.3990453	4.3990453	0
5	AUMCLST	AUMClast	3.7299741	3.7299741	0
6	AUMCLST	AUMClast	5.5775672	5.5775672	0
1	AUMCIFO	AUMCINF_obs	7.8178588	7.8178588	0
2	AUMCIFO	AUMCINF_obs	9.4010343	9.4010343	0
3	AUMCIFO	AUMCINF_obs	7.0017667	7.0017667	0
4	AUMCIFO	AUMCINF_obs	6.0843899	6.0843899	0
5	AUMCIFO	AUMCINF_obs	6.5683405	6.5683405	0
6	AUMCIFO	AUMCINF_obs	8.3343579	8.3343579	0
1	AUMCPEO	AUMC_.Extrap_obs	57.8330281	57.8330281	0
2	AUMCPEO	AUMC_.Extrap_obs	31.8345005	31.8345005	0
3	AUMCPEO	AUMC_.Extrap_obs	28.0847466	28.0847466	0
4	AUMCPEO	AUMC_.Extrap_obs	27.6994849	27.6994849	0
5	AUMCPEO	AUMC_.Extrap_obs	43.2128382	43.2128382	0
6	AUMCPEO	AUMC_.Extrap_obs	33.0774222	33.0774222	0
1	AUMCIFP	AUMCINF_pred	7.8403303	7.8403303	0
2	AUMCIFP	AUMCINF_pred	9.2048546	9.2048546	0
3	AUMCIFP	AUMCINF_pred	6.0178784	6.0178784	0
4	AUMCIFP	AUMCINF_pred	5.2284721	5.2284721	0
5	AUMCIFP	AUMCINF_pred	6.0750083	6.0750083	0
6	AUMCIFP	AUMCINF_pred	7.3003307	7.3003307	0
1	AUMCPEP	AUMC_.Extrap_pred	57.9538845	57.9538845	0
2	AUMCPEP	AUMC_.Extrap_pred	30.3817147	30.3817147	0
3	AUMCPEP	AUMC_.Extrap_pred	16.3270188	16.3270188	0
4	AUMCPEP	AUMC_.Extrap_pred	15.8636553	15.8636553	0
5	AUMCPEP	AUMC_.Extrap_pred	38.6013327	38.6013327	0
6	AUMCPEP	AUMC_.Extrap_pred	23.5984312	23.5984312	0
1	MRTIVLST	MRTlast	1.7923089	1.7923089	0
2	MRTIVLST	MRTlast	2.0930490	2.0930490	0
3	MRTIVLST	MRTlast	1.6223430	1.6223430	0
4	MRTIVLST	MRTlast	1.6747556	1.6747556	0
5	MRTIVLST	MRTlast	1.8164830	1.8164830	0
6	MRTIVLST	MRTlast	1.8380240	1.8380240	0
1	MRTIVIFO	MRTINF_obs	3.7163591	3.7163591	0
2	MRTIVIFO	MRTINF_obs	2.8558604	2.8558604	0
3	MRTIVIFO	MRTINF_obs	2.1547159	2.1547159	0
4	MRTIVIFO	MRTINF_obs	2.2085200	2.2085200	0
5	MRTIVIFO	MRTINF_obs	2.9178858	2.9178858	0
6	MRTIVIFO	MRTINF_obs	2.5670666	2.5670666	0
1	MRTIVIFP	MRTINF_pred	3.7244318	3.7244318	0
2	MRTIVIFP	MRTINF_pred	2.8098000	2.8098000	0
3	MRTIVIFP	MRTINF_pred	1.8968260	1.8968260	0
4	MRTIVIFP	MRTINF_pred	1.9460640	1.9460640	0
5	MRTIVIFP	MRTINF_pred	2.7441853	2.7441853	0
6	MRTIVIFP	MRTINF_pred	2.3081140	2.3081140	0
1	VSSO	Vss_obs	45.6514707	45.6514707	0
2	VSSO	Vss_obs	22.6382575	22.6382575	0
3	VSSO	Vss_obs	17.5389306	17.5389306	0
4	VSSO	Vss_obs	21.1756058	21.1756058	0
5	VSSO	Vss_obs	33.7938980	33.7938980	0
6	VSSO	Vss_obs	20.7295934	20.7295934	0
1	VSSP	Vss_pred	45.7153760	45.7153760	0
2	VSSP	Vss_pred	22.3963368	22.3963368	0
3	VSSP	Vss_pred	15.9319103	15.9319103	0
4	VSSP	Vss_pred	19.2715146	19.2715146	0
5	VSSP	Vss_pred	32.4015028	32.4015028	0
6	VSSP	Vss_pred	19.2316785	19.2316785	0

Test 7: Indometh (n=6), Linear, Extravascular

table_wres_rres(Wres7, Rres7,
                Caption = 'Indometh (n=6), Linear, Extravascular')

Indometh (n=6), Linear, Extravascular

	Pharmacokinetic Parameters		Values
Subject	PPTESTCD	WNL	NonCompart	WinNonlin	Difference
1	R2	Rsq	0.9970667	0.9970667	0
2	R2	Rsq	0.9476691	0.9476691	0
3	R2	Rsq	0.8758261	0.8758261	0
4	R2	Rsq	0.8671179	0.8671179	0
5	R2	Rsq	0.8752442	0.8752442	0
6	R2	Rsq	0.9039538	0.9039538	0
1	R2ADJ	Rsq_adjusted	0.9941335	0.9941335	0
2	R2ADJ	Rsq_adjusted	0.9401933	0.9401933	0
3	R2ADJ	Rsq_adjusted	0.8603043	0.8603043	0
4	R2ADJ	Rsq_adjusted	0.8505077	0.8505077	0
5	R2ADJ	Rsq_adjusted	0.8544516	0.8544516	0
6	R2ADJ	Rsq_adjusted	0.8902329	0.8902329	0
1	CORRXY	Corr_XY	-0.9985323	-0.9985323	0
2	CORRXY	Corr_XY	-0.9734830	-0.9734830	0
3	CORRXY	Corr_XY	-0.9358558	-0.9358558	0
4	CORRXY	Corr_XY	-0.9311917	-0.9311917	0
5	CORRXY	Corr_XY	-0.9355449	-0.9355449	0
6	CORRXY	Corr_XY	-0.9507649	-0.9507649	0
1	LAMZNPT	No_points_lambda_z	3.0000000	3.0000000	0
2	LAMZNPT	No_points_lambda_z	9.0000000	9.0000000	0
3	LAMZNPT	No_points_lambda_z	10.0000000	10.0000000	0
4	LAMZNPT	No_points_lambda_z	10.0000000	10.0000000	0
5	LAMZNPT	No_points_lambda_z	8.0000000	8.0000000	0
6	LAMZNPT	No_points_lambda_z	9.0000000	9.0000000	0
1	LAMZ	Lambda_z	0.1583205	0.1583205	0
2	LAMZ	Lambda_z	0.3022800	0.3022800	0
3	LAMZ	Lambda_z	0.4218926	0.4218926	0
4	LAMZ	Lambda_z	0.4290762	0.4290762	0
5	LAMZ	Lambda_z	0.2527478	0.2527478	0
6	LAMZ	Lambda_z	0.3535205	0.3535205	0
1	LAMZLL	Lambda_z_lower	5.0000000	5.0000000	0
2	LAMZLL	Lambda_z_lower	0.7500000	0.7500000	0
3	LAMZLL	Lambda_z_lower	0.5000000	0.5000000	0
4	LAMZLL	Lambda_z_lower	0.5000000	0.5000000	0
5	LAMZLL	Lambda_z_lower	1.0000000	1.0000000	0
6	LAMZLL	Lambda_z_lower	0.7500000	0.7500000	0
1	LAMZUL	Lambda_z_upper	8.0000000	8.0000000	0
2	LAMZUL	Lambda_z_upper	8.0000000	8.0000000	0
3	LAMZUL	Lambda_z_upper	8.0000000	8.0000000	0
4	LAMZUL	Lambda_z_upper	8.0000000	8.0000000	0
5	LAMZUL	Lambda_z_upper	8.0000000	8.0000000	0
6	LAMZUL	Lambda_z_upper	8.0000000	8.0000000	0
1	LAMZHL	HL_Lambda_z	4.3781270	4.3781270	0
2	LAMZHL	HL_Lambda_z	2.2930632	2.2930632	0
3	LAMZHL	HL_Lambda_z	1.6429468	1.6429468	0
4	LAMZHL	HL_Lambda_z	1.6154409	1.6154409	0
5	LAMZHL	HL_Lambda_z	2.7424461	2.7424461	0
6	LAMZHL	HL_Lambda_z	1.9606986	1.9606986	0
1	TLAG	Tlag	0.0000000	0.0000000	0
2	TLAG	Tlag	0.0000000	0.0000000	0
3	TLAG	Tlag	0.0000000	0.0000000	0
4	TLAG	Tlag	0.0000000	0.0000000	0
5	TLAG	Tlag	0.0000000	0.0000000	0
6	TLAG	Tlag	0.0000000	0.0000000	0
1	TMAX	Tmax	0.2500000	0.2500000	0
2	TMAX	Tmax	0.2500000	0.2500000	0
3	TMAX	Tmax	0.2500000	0.2500000	0
4	TMAX	Tmax	0.2500000	0.2500000	0
5	TMAX	Tmax	0.2500000	0.2500000	0
6	TMAX	Tmax	0.2500000	0.2500000	0
1	CMAX	Cmax	1.5000000	1.5000000	0
2	CMAX	Cmax	2.0300000	2.0300000	0
3	CMAX	Cmax	2.7200000	2.7200000	0
4	CMAX	Cmax	1.8500000	1.8500000	0
5	CMAX	Cmax	2.0500000	2.0500000	0
6	CMAX	Cmax	2.3100000	2.3100000	0
1	CMAXD	Cmax_D	0.0600000	0.0600000	0
2	CMAXD	Cmax_D	0.0812000	0.0812000	0
3	CMAXD	Cmax_D	0.1088000	0.1088000	0
4	CMAXD	Cmax_D	0.0740000	0.0740000	0
5	CMAXD	Cmax_D	0.0820000	0.0820000	0
6	CMAXD	Cmax_D	0.0924000	0.0924000	0
1	TLST	Tlast	8.0000000	8.0000000	0
2	TLST	Tlast	8.0000000	8.0000000	0
3	TLST	Tlast	8.0000000	8.0000000	0
4	TLST	Tlast	8.0000000	8.0000000	0
5	TLST	Tlast	8.0000000	8.0000000	0
6	TLST	Tlast	8.0000000	8.0000000	0
1	CLST	Clast	0.0500000	0.0500000	0
2	CLST	Clast	0.0800000	0.0800000	0
3	CLST	Clast	0.0800000	0.0800000	0
4	CLST	Clast	0.0700000	0.0700000	0
5	CLST	Clast	0.0600000	0.0600000	0
6	CLST	Clast	0.0900000	0.0900000	0
1	AUCLST	AUClast	1.7412500	1.7412500	0
2	AUCLST	AUClast	2.9325000	2.9325000	0
3	AUCLST	AUClast	2.9337500	2.9337500	0
4	AUCLST	AUClast	2.4775000	2.4775000	0
5	AUCLST	AUClast	1.9537500	1.9537500	0
6	AUCLST	AUClast	2.8725000	2.8725000	0
1	AUCALL	AUCall	1.7412500	1.7412500	0
2	AUCALL	AUCall	2.9325000	2.9325000	0
3	AUCALL	AUCall	2.9337500	2.9337500	0
4	AUCALL	AUCall	2.4775000	2.4775000	0
5	AUCALL	AUCall	1.9537500	1.9537500	0
6	AUCALL	AUCall	2.8725000	2.8725000	0
1	AUCIFO	AUCINF_obs	2.0570651	2.0570651	0
2	AUCIFO	AUCINF_obs	3.1971553	3.1971553	0
3	AUCIFO	AUCINF_obs	3.1233717	3.1233717	0
4	AUCIFO	AUCINF_obs	2.6406412	2.6406412	0
5	AUCIFO	AUCINF_obs	2.1911408	2.1911408	0
6	AUCIFO	AUCINF_obs	3.1270821	3.1270821	0
1	AUCIFOD	AUCINF_D_obs	0.0822826	0.0822826	0
2	AUCIFOD	AUCINF_D_obs	0.1278862	0.1278862	0
3	AUCIFOD	AUCINF_D_obs	0.1249349	0.1249349	0
4	AUCIFOD	AUCINF_D_obs	0.1056256	0.1056256	0
5	AUCIFOD	AUCINF_D_obs	0.0876456	0.0876456	0
6	AUCIFOD	AUCINF_D_obs	0.1250833	0.1250833	0
1	AUCPEO	AUC_.Extrap_obs	15.3527035	15.3527035	0
2	AUCPEO	AUC_.Extrap_obs	8.2778360	8.2778360	0
3	AUCPEO	AUC_.Extrap_obs	6.0710577	6.0710577	0
4	AUCPEO	AUC_.Extrap_obs	6.1780905	6.1780905	0
5	AUCPEO	AUC_.Extrap_obs	10.8341191	10.8341191	0
6	AUCPEO	AUC_.Extrap_obs	8.1412032	8.1412032	0
1	VZFO	Vz_F_obs	76.7635175	76.7635175	0
2	VZFO	Vz_F_obs	25.8682374	25.8682374	0
3	VZFO	Vz_F_obs	18.9720552	18.9720552	0
4	VZFO	Vz_F_obs	22.0646091	22.0646091	0
5	VZFO	Vz_F_obs	45.1421631	45.1421631	0
6	VZFO	Vz_F_obs	22.6144534	22.6144534	0
1	CLFO	Cl_F_obs	12.1532371	12.1532371	0
2	CLFO	Cl_F_obs	7.8194513	7.8194513	0
3	CLFO	Cl_F_obs	8.0041706	8.0041706	0
4	CLFO	Cl_F_obs	9.4673975	9.4673975	0
5	CLFO	Cl_F_obs	11.4095817	11.4095817	0
6	CLFO	Cl_F_obs	7.9946733	7.9946733	0
1	AUCIFP	AUCINF_pred	2.0586347	2.0586347	0
2	AUCIFP	AUCINF_pred	3.1798068	3.1798068	0
3	AUCIFP	AUCINF_pred	3.0284958	3.0284958	0
4	AUCIFP	AUCINF_pred	2.5577884	2.5577884	0
5	AUCIFP	AUCINF_pred	2.1498803	2.1498803	0
6	AUCIFP	AUCINF_pred	3.0315925	3.0315925	0
1	AUCIFPD	AUCINF_D_pred	0.0823454	0.0823454	0
2	AUCIFPD	AUCINF_D_pred	0.1271923	0.1271923	0
3	AUCIFPD	AUCINF_D_pred	0.1211398	0.1211398	0
4	AUCIFPD	AUCINF_D_pred	0.1023115	0.1023115	0
5	AUCIFPD	AUCINF_D_pred	0.0859952	0.0859952	0
6	AUCIFPD	AUCINF_D_pred	0.1212637	0.1212637	0
1	AUCPEP	AUC_.Extrap_pred	15.4172443	15.4172443	0
2	AUCPEP	AUC_.Extrap_pred	7.7774164	7.7774164	0
3	AUCPEP	AUC_.Extrap_pred	3.1284787	3.1284787	0
4	AUCPEP	AUC_.Extrap_pred	3.1389787	3.1389787	0
5	AUCPEP	AUC_.Extrap_pred	9.1228460	9.1228460	0
6	AUCPEP	AUC_.Extrap_pred	5.2478198	5.2478198	0
1	VZFP	Vz_F_pred	76.7049878	76.7049878	0
2	VZFP	Vz_F_pred	26.0093699	26.0093699	0
3	VZFP	Vz_F_pred	19.5664063	19.5664063	0
4	VZFP	Vz_F_pred	22.7793336	22.7793336	0
5	VZFP	Vz_F_pred	46.0085322	46.0085322	0
6	VZFP	Vz_F_pred	23.3267671	23.3267671	0
1	CLFP	Cl_F_pred	12.1439707	12.1439707	0
2	CLFP	Cl_F_pred	7.8621128	7.8621128	0
3	CLFP	Cl_F_pred	8.2549230	8.2549230	0
4	CLFP	Cl_F_pred	9.7740688	9.7740687	0
5	CLFP	Cl_F_pred	11.6285546	11.6285546	0
6	CLFP	Cl_F_pred	8.2464909	8.2464909	0
1	AUMCLST	AUMClast	3.2712500	3.2712500	0
2	AUMCLST	AUMClast	6.3987500	6.3987500	0
3	AUMCLST	AUMClast	5.0062500	5.0062500	0
4	AUMCLST	AUMClast	4.3818750	4.3818750	0
5	AUMCLST	AUMClast	3.7075000	3.7075000	0
6	AUMCLST	AUMClast	5.5325000	5.5325000	0
1	AUMCIFO	AUMCINF_obs	7.7925545	7.7925545	0
2	AUMCIFO	AUMCINF_obs	9.3915223	9.3915223	0
3	AUMCIFO	AUMCINF_obs	6.9726784	6.9726784	0
4	AUMCIFO	AUMCINF_obs	6.0672197	6.0672197	0
5	AUMCIFO	AUMCINF_obs	6.5458663	6.5458663	0
6	AUMCIFO	AUMCINF_obs	8.2892908	8.2892908	0
1	AUMCPEO	AUMC_.Extrap_obs	58.0208261	58.0208261	0
2	AUMCPEO	AUMC_.Extrap_obs	31.8667432	31.8667432	0
3	AUMCPEO	AUMC_.Extrap_obs	28.2019090	28.2019090	0
4	AUMCPEO	AUMC_.Extrap_obs	27.7778746	27.7778746	0
5	AUMCPEO	AUMC_.Extrap_obs	43.3612023	43.3612023	0
6	AUMCPEO	AUMC_.Extrap_obs	33.2572574	33.2572574	0
1	AUMCIFP	AUMCINF_pred	7.8150259	7.8150259	0
2	AUMCIFP	AUMCINF_pred	9.1953427	9.1953427	0
3	AUMCIFP	AUMCINF_pred	5.9887901	5.9887901	0
4	AUMCIFP	AUMCINF_pred	5.2113018	5.2113018	0
5	AUMCIFP	AUMCINF_pred	6.0525342	6.0525342	0
6	AUMCIFP	AUMCINF_pred	7.2552635	7.2552635	0
1	AUMCPEP	AUMC_.Extrap_pred	58.1415337	58.1415337	0
2	AUMCPEP	AUMC_.Extrap_pred	30.4131425	30.4131425	0
3	AUMCPEP	AUMC_.Extrap_pred	16.4063210	16.4063210	0
4	AUMCPEP	AUMC_.Extrap_pred	15.9159231	15.9159230	0
5	AUMCPEP	AUMC_.Extrap_pred	38.7446663	38.7446663	0
6	AUMCPEP	AUMC_.Extrap_pred	23.7450164	23.7450164	0
1	MRTEVLST	MRTlast	1.8786791	1.8786791	0
2	MRTEVLST	MRTlast	2.1820119	2.1820119	0
3	MRTEVLST	MRTlast	1.7064337	1.7064337	0
4	MRTEVLST	MRTlast	1.7686680	1.7686680	0
5	MRTEVLST	MRTlast	1.8976328	1.8976328	0
6	MRTEVLST	MRTlast	1.9260226	1.9260226	0
1	MRTEVIFO	MRTINF_obs	3.7881905	3.7881905	0
2	MRTEVIFO	MRTINF_obs	2.9374621	2.9374621	0
3	MRTEVIFO	MRTINF_obs	2.2324203	2.2324203	0
4	MRTEVIFO	MRTINF_obs	2.2976312	2.2976312	0
5	MRTEVIFO	MRTINF_obs	2.9874239	2.9874239	0
6	MRTEVIFO	MRTINF_obs	2.6508069	2.6508069	0
1	MRTEVIFP	MRTINF_pred	3.7962178	3.7962178	0
2	MRTEVIFP	MRTINF_pred	2.8917929	2.8917929	0
3	MRTEVIFP	MRTINF_pred	1.9774801	1.9774801	0
4	MRTEVIFP	MRTINF_pred	2.0374249	2.0374249	0
5	MRTEVIFP	MRTINF_pred	2.8152890	2.8152890	0
6	MRTEVIFP	MRTINF_pred	2.3932186	2.3932186	0

Test 8: Indometh (n=6), Log, Extravascular

table_wres_rres(Wres8, Rres8,
                Caption = 'Indometh (n=6), Log, Extravascular')

Indometh (n=6), Log, Extravascular

	Pharmacokinetic Parameters		Values
Subject	PPTESTCD	WNL	NonCompart	WinNonlin	Difference
1	R2	Rsq	0.9970667	0.9970667	0
2	R2	Rsq	0.9476691	0.9476691	0
3	R2	Rsq	0.8758261	0.8758261	0
4	R2	Rsq	0.8671179	0.8671179	0
5	R2	Rsq	0.8752442	0.8752442	0
6	R2	Rsq	0.9039538	0.9039538	0
1	R2ADJ	Rsq_adjusted	0.9941335	0.9941335	0
2	R2ADJ	Rsq_adjusted	0.9401933	0.9401933	0
3	R2ADJ	Rsq_adjusted	0.8603043	0.8603043	0
4	R2ADJ	Rsq_adjusted	0.8505077	0.8505077	0
5	R2ADJ	Rsq_adjusted	0.8544516	0.8544516	0
6	R2ADJ	Rsq_adjusted	0.8902329	0.8902329	0
1	CORRXY	Corr_XY	-0.9985323	-0.9985323	0
2	CORRXY	Corr_XY	-0.9734830	-0.9734830	0
3	CORRXY	Corr_XY	-0.9358558	-0.9358558	0
4	CORRXY	Corr_XY	-0.9311917	-0.9311917	0
5	CORRXY	Corr_XY	-0.9355449	-0.9355449	0
6	CORRXY	Corr_XY	-0.9507649	-0.9507649	0
1	LAMZNPT	No_points_lambda_z	3.0000000	3.0000000	0
2	LAMZNPT	No_points_lambda_z	9.0000000	9.0000000	0
3	LAMZNPT	No_points_lambda_z	10.0000000	10.0000000	0
4	LAMZNPT	No_points_lambda_z	10.0000000	10.0000000	0
5	LAMZNPT	No_points_lambda_z	8.0000000	8.0000000	0
6	LAMZNPT	No_points_lambda_z	9.0000000	9.0000000	0
1	LAMZ	Lambda_z	0.1583205	0.1583205	0
2	LAMZ	Lambda_z	0.3022800	0.3022800	0
3	LAMZ	Lambda_z	0.4218926	0.4218926	0
4	LAMZ	Lambda_z	0.4290762	0.4290762	0
5	LAMZ	Lambda_z	0.2527478	0.2527478	0
6	LAMZ	Lambda_z	0.3535205	0.3535205	0
1	LAMZLL	Lambda_z_lower	5.0000000	5.0000000	0
2	LAMZLL	Lambda_z_lower	0.7500000	0.7500000	0
3	LAMZLL	Lambda_z_lower	0.5000000	0.5000000	0
4	LAMZLL	Lambda_z_lower	0.5000000	0.5000000	0
5	LAMZLL	Lambda_z_lower	1.0000000	1.0000000	0
6	LAMZLL	Lambda_z_lower	0.7500000	0.7500000	0
1	LAMZUL	Lambda_z_upper	8.0000000	8.0000000	0
2	LAMZUL	Lambda_z_upper	8.0000000	8.0000000	0
3	LAMZUL	Lambda_z_upper	8.0000000	8.0000000	0
4	LAMZUL	Lambda_z_upper	8.0000000	8.0000000	0
5	LAMZUL	Lambda_z_upper	8.0000000	8.0000000	0
6	LAMZUL	Lambda_z_upper	8.0000000	8.0000000	0
1	LAMZHL	HL_Lambda_z	4.3781270	4.3781270	0
2	LAMZHL	HL_Lambda_z	2.2930632	2.2930632	0
3	LAMZHL	HL_Lambda_z	1.6429468	1.6429468	0
4	LAMZHL	HL_Lambda_z	1.6154409	1.6154409	0
5	LAMZHL	HL_Lambda_z	2.7424461	2.7424461	0
6	LAMZHL	HL_Lambda_z	1.9606986	1.9606986	0
1	TLAG	Tlag	0.0000000	0.0000000	0
2	TLAG	Tlag	0.0000000	0.0000000	0
3	TLAG	Tlag	0.0000000	0.0000000	0
4	TLAG	Tlag	0.0000000	0.0000000	0
5	TLAG	Tlag	0.0000000	0.0000000	0
6	TLAG	Tlag	0.0000000	0.0000000	0
1	TMAX	Tmax	0.2500000	0.2500000	0
2	TMAX	Tmax	0.2500000	0.2500000	0
3	TMAX	Tmax	0.2500000	0.2500000	0
4	TMAX	Tmax	0.2500000	0.2500000	0
5	TMAX	Tmax	0.2500000	0.2500000	0
6	TMAX	Tmax	0.2500000	0.2500000	0
1	CMAX	Cmax	1.5000000	1.5000000	0
2	CMAX	Cmax	2.0300000	2.0300000	0
3	CMAX	Cmax	2.7200000	2.7200000	0
4	CMAX	Cmax	1.8500000	1.8500000	0
5	CMAX	Cmax	2.0500000	2.0500000	0
6	CMAX	Cmax	2.3100000	2.3100000	0
1	CMAXD	Cmax_D	0.0600000	0.0600000	0
2	CMAXD	Cmax_D	0.0812000	0.0812000	0
3	CMAXD	Cmax_D	0.1088000	0.1088000	0
4	CMAXD	Cmax_D	0.0740000	0.0740000	0
5	CMAXD	Cmax_D	0.0820000	0.0820000	0
6	CMAXD	Cmax_D	0.0924000	0.0924000	0
1	TLST	Tlast	8.0000000	8.0000000	0
2	TLST	Tlast	8.0000000	8.0000000	0
3	TLST	Tlast	8.0000000	8.0000000	0
4	TLST	Tlast	8.0000000	8.0000000	0
5	TLST	Tlast	8.0000000	8.0000000	0
6	TLST	Tlast	8.0000000	8.0000000	0
1	CLST	Clast	0.0500000	0.0500000	0
2	CLST	Clast	0.0800000	0.0800000	0
3	CLST	Clast	0.0800000	0.0800000	0
4	CLST	Clast	0.0700000	0.0700000	0
5	CLST	Clast	0.0600000	0.0600000	0
6	CLST	Clast	0.0900000	0.0900000	0
1	AUCLST	AUClast	1.7193653	1.7193653	0
2	AUCLST	AUClast	2.8891436	2.8891436	0
3	AUCLST	AUClast	2.8817113	2.8817113	0
4	AUCLST	AUClast	2.4442459	2.4442459	0
5	AUCLST	AUClast	1.9211984	1.9211984	0
6	AUCLST	AUClast	2.8413138	2.8413138	0
1	AUCALL	AUCall	1.7193653	1.7193653	0
2	AUCALL	AUCall	2.8891436	2.8891436	0
3	AUCALL	AUCall	2.8817113	2.8817113	0
4	AUCALL	AUCall	2.4442459	2.4442459	0
5	AUCALL	AUCall	1.9211984	1.9211984	0
6	AUCALL	AUCall	2.8413138	2.8413138	0
1	AUCIFO	AUCINF_obs	2.0351804	2.0351804	0
2	AUCIFO	AUCINF_obs	3.1537989	3.1537989	0
3	AUCIFO	AUCINF_obs	3.0713330	3.0713330	0
4	AUCIFO	AUCINF_obs	2.6073871	2.6073871	0
5	AUCIFO	AUCINF_obs	2.1585892	2.1585892	0
6	AUCIFO	AUCINF_obs	3.0958959	3.0958959	0
1	AUCIFOD	AUCINF_D_obs	0.0814072	0.0814072	0
2	AUCIFOD	AUCINF_D_obs	0.1261520	0.1261520	0
3	AUCIFOD	AUCINF_D_obs	0.1228533	0.1228533	0
4	AUCIFOD	AUCINF_D_obs	0.1042955	0.1042955	0
5	AUCIFOD	AUCINF_D_obs	0.0863436	0.0863436	0
6	AUCIFOD	AUCINF_D_obs	0.1238358	0.1238358	0
1	AUCPEO	AUC_.Extrap_obs	15.5177942	15.5177942	0
2	AUCPEO	AUC_.Extrap_obs	8.3916343	8.3916343	0
3	AUCPEO	AUC_.Extrap_obs	6.1739217	6.1739217	0
4	AUCPEO	AUC_.Extrap_obs	6.2568848	6.2568848	0
5	AUCPEO	AUC_.Extrap_obs	10.9974979	10.9974979	0
6	AUCPEO	AUC_.Extrap_obs	8.2232127	8.2232127	0
1	VZFO	Vz_F_obs	77.5889712	77.5889712	0
2	VZFO	Vz_F_obs	26.2238573	26.2238573	0
3	VZFO	Vz_F_obs	19.2935053	19.2935053	0
4	VZFO	Vz_F_obs	22.3460171	22.3460171	0
5	VZFO	Vz_F_obs	45.8229078	45.8229078	0
6	VZFO	Vz_F_obs	22.8422576	22.8422576	0
1	CLFO	Cl_F_obs	12.2839234	12.2839234	0
2	CLFO	Cl_F_obs	7.9269481	7.9269481	0
3	CLFO	Cl_F_obs	8.1397881	8.1397881	0
4	CLFO	Cl_F_obs	9.5881430	9.5881430	0
5	CLFO	Cl_F_obs	11.5816384	11.5816384	0
6	CLFO	Cl_F_obs	8.0752068	8.0752068	0
1	AUCIFP	AUCINF_pred	2.0367500	2.0367500	0
2	AUCIFP	AUCINF_pred	3.1364504	3.1364504	0
3	AUCIFP	AUCINF_pred	2.9764572	2.9764572	0
4	AUCIFP	AUCINF_pred	2.5245343	2.5245343	0
5	AUCIFP	AUCINF_pred	2.1173287	2.1173287	0
6	AUCIFP	AUCINF_pred	3.0004063	3.0004063	0
1	AUCIFPD	AUCINF_D_pred	0.0814700	0.0814700	0
2	AUCIFPD	AUCINF_D_pred	0.1254580	0.1254580	0
3	AUCIFPD	AUCINF_D_pred	0.1190583	0.1190583	0
4	AUCIFPD	AUCINF_D_pred	0.1009814	0.1009814	0
5	AUCIFPD	AUCINF_D_pred	0.0846931	0.0846931	0
6	AUCIFPD	AUCINF_D_pred	0.1200163	0.1200163	0
1	AUCPEP	AUC_.Extrap_pred	15.5829013	15.5829013	0
2	AUCPEP	AUC_.Extrap_pred	7.8849267	7.8849267	0
3	AUCPEP	AUC_.Extrap_pred	3.1831752	3.1831752	0
4	AUCPEP	AUC_.Extrap_pred	3.1803265	3.1803265	0
5	AUCPEP	AUC_.Extrap_pred	9.2630996	9.2630996	0
6	AUCPEP	AUC_.Extrap_pred	5.3023656	5.3023656	0
1	VZFP	Vz_F_pred	77.5291765	77.5291765	0
2	VZFP	Vz_F_pred	26.3689077	26.3689077	0
3	VZFP	Vz_F_pred	19.9084941	19.9084941	0
4	VZFP	Vz_F_pred	23.0793917	23.0793917	0
5	VZFP	Vz_F_pred	46.7158621	46.7158621	0
6	VZFP	Vz_F_pred	23.5692251	23.5692252	0
1	CLFP	Cl_F_pred	12.2744566	12.2744566	0
2	CLFP	Cl_F_pred	7.9707940	7.9707940	0
3	CLFP	Cl_F_pred	8.3992473	8.3992473	0
4	CLFP	Cl_F_pred	9.9028165	9.9028165	0
5	CLFP	Cl_F_pred	11.8073306	11.8073306	0
6	CLFP	Cl_F_pred	8.3322048	8.3322048	0
1	AUMCLST	AUMClast	3.2965543	3.2965543	0
2	AUMCLST	AUMClast	6.4082620	6.4082620	0
3	AUMCLST	AUMClast	5.0353383	5.0353382	0
4	AUMCLST	AUMClast	4.3990453	4.3990453	0
5	AUMCLST	AUMClast	3.7299741	3.7299741	0
6	AUMCLST	AUMClast	5.5775672	5.5775672	0
1	AUMCIFO	AUMCINF_obs	7.8178588	7.8178588	0
2	AUMCIFO	AUMCINF_obs	9.4010343	9.4010343	0
3	AUMCIFO	AUMCINF_obs	7.0017667	7.0017667	0
4	AUMCIFO	AUMCINF_obs	6.0843899	6.0843899	0
5	AUMCIFO	AUMCINF_obs	6.5683405	6.5683405	0
6	AUMCIFO	AUMCINF_obs	8.3343579	8.3343579	0
1	AUMCPEO	AUMC_.Extrap_obs	57.8330281	57.8330281	0
2	AUMCPEO	AUMC_.Extrap_obs	31.8345005	31.8345005	0
3	AUMCPEO	AUMC_.Extrap_obs	28.0847466	28.0847466	0
4	AUMCPEO	AUMC_.Extrap_obs	27.6994849	27.6994849	0
5	AUMCPEO	AUMC_.Extrap_obs	43.2128382	43.2128382	0
6	AUMCPEO	AUMC_.Extrap_obs	33.0774222	33.0774222	0
1	AUMCIFP	AUMCINF_pred	7.8403303	7.8403303	0
2	AUMCIFP	AUMCINF_pred	9.2048546	9.2048546	0
3	AUMCIFP	AUMCINF_pred	6.0178784	6.0178784	0
4	AUMCIFP	AUMCINF_pred	5.2284721	5.2284721	0
5	AUMCIFP	AUMCINF_pred	6.0750083	6.0750083	0
6	AUMCIFP	AUMCINF_pred	7.3003307	7.3003307	0
1	AUMCPEP	AUMC_.Extrap_pred	57.9538845	57.9538845	0
2	AUMCPEP	AUMC_.Extrap_pred	30.3817147	30.3817147	0
3	AUMCPEP	AUMC_.Extrap_pred	16.3270188	16.3270188	0
4	AUMCPEP	AUMC_.Extrap_pred	15.8636553	15.8636553	0
5	AUMCPEP	AUMC_.Extrap_pred	38.6013327	38.6013327	0
6	AUMCPEP	AUMC_.Extrap_pred	23.5984312	23.5984312	0
1	MRTEVLST	MRTlast	1.9173089	1.9173089	0
2	MRTEVLST	MRTlast	2.2180490	2.2180490	0
3	MRTEVLST	MRTlast	1.7473430	1.7473430	0
4	MRTEVLST	MRTlast	1.7997556	1.7997556	0
5	MRTEVLST	MRTlast	1.9414830	1.9414830	0
6	MRTEVLST	MRTlast	1.9630240	1.9630240	0
1	MRTEVIFO	MRTINF_obs	3.8413591	3.8413591	0
2	MRTEVIFO	MRTINF_obs	2.9808604	2.9808604	0
3	MRTEVIFO	MRTINF_obs	2.2797159	2.2797159	0
4	MRTEVIFO	MRTINF_obs	2.3335200	2.3335200	0
5	MRTEVIFO	MRTINF_obs	3.0428858	3.0428858	0
6	MRTEVIFO	MRTINF_obs	2.6920666	2.6920666	0
1	MRTEVIFP	MRTINF_pred	3.8494318	3.8494318	0
2	MRTEVIFP	MRTINF_pred	2.9348000	2.9348000	0
3	MRTEVIFP	MRTINF_pred	2.0218260	2.0218260	0
4	MRTEVIFP	MRTINF_pred	2.0710640	2.0710640	0
5	MRTEVIFP	MRTINF_pred	2.8691853	2.8691853	0
6	MRTEVIFP	MRTINF_pred	2.4331140	2.4331140	0

Session Information

devtools::session_info()

##  setting  value                       
##  version  R version 3.5.1 (2018-07-02)
##  system   x86_64, mingw32             
##  ui       RTerm                       
##  language (EN)                        
##  collate  Korean_Korea.949            
##  tz       Asia/Seoul                  
##  date     2018-08-07                  
## 
##  package     * version date       source                             
##  assertthat    0.2.0   2017-04-11 CRAN (R 3.5.0)                     
##  backports     1.1.2   2017-12-13 CRAN (R 3.5.0)                     
##  base        * 3.5.1   2018-07-02 local                              
##  bindr         0.1.1   2018-03-13 CRAN (R 3.5.0)                     
##  bindrcpp    * 0.2.2   2018-03-29 CRAN (R 3.5.0)                     
##  colorspace    1.3-2   2016-12-14 CRAN (R 3.5.0)                     
##  compiler      3.5.1   2018-07-02 local                              
##  crayon        1.3.4   2018-06-08 Github (gaborcsardi/crayon@3e751fb)
##  datasets    * 3.5.1   2018-07-02 local                              
##  devtools      1.13.6  2018-06-27 CRAN (R 3.5.0)                     
##  digest        0.6.15  2018-01-28 CRAN (R 3.5.0)                     
##  dplyr       * 0.7.6   2018-06-29 CRAN (R 3.5.0)                     
##  evaluate      0.11    2018-07-17 CRAN (R 3.5.1)                     
##  glue          1.3.0   2018-07-17 CRAN (R 3.5.1)                     
##  graphics    * 3.5.1   2018-07-02 local                              
##  grDevices   * 3.5.1   2018-07-02 local                              
##  highr         0.7     2018-06-09 CRAN (R 3.5.0)                     
##  hms           0.4.2   2018-03-10 CRAN (R 3.5.0)                     
##  htmltools     0.3.6   2017-04-28 CRAN (R 3.5.0)                     
##  httr          1.3.1   2017-08-20 CRAN (R 3.5.0)                     
##  kableExtra  * 0.9.0   2018-05-21 CRAN (R 3.5.0)                     
##  knitr       * 1.20    2018-02-20 CRAN (R 3.5.0)                     
##  magrittr      1.5     2014-11-22 CRAN (R 3.5.0)                     
##  memoise       1.1.0   2017-04-21 CRAN (R 3.5.0)                     
##  methods     * 3.5.1   2018-07-02 local                              
##  munsell       0.5.0   2018-06-12 CRAN (R 3.5.0)                     
##  NonCompart  * 0.4.4   2018-08-06 CRAN (R 3.5.1)                     
##  pillar        1.3.0   2018-07-14 CRAN (R 3.5.1)                     
##  pkgconfig     2.0.1   2017-03-21 CRAN (R 3.5.0)                     
##  plyr          1.8.4   2016-06-08 CRAN (R 3.5.0)                     
##  purrr         0.2.5   2018-05-29 CRAN (R 3.5.0)                     
##  R6            2.2.2   2017-06-17 CRAN (R 3.5.0)                     
##  Rcpp          0.12.18 2018-07-23 CRAN (R 3.5.1)                     
##  readr         1.1.1   2017-05-16 CRAN (R 3.5.0)                     
##  rlang         0.2.1   2018-05-30 CRAN (R 3.5.0)                     
##  rmarkdown     1.10    2018-06-11 CRAN (R 3.5.0)                     
##  rprojroot     1.3-2   2018-01-03 CRAN (R 3.5.0)                     
##  rstudioapi    0.7     2017-09-07 CRAN (R 3.5.0)                     
##  rvest         0.3.2   2016-06-17 CRAN (R 3.5.0)                     
##  scales        0.5.0   2017-08-24 CRAN (R 3.5.0)                     
##  stats       * 3.5.1   2018-07-02 local                              
##  stringi       1.2.4   2018-07-20 CRAN (R 3.5.1)                     
##  stringr       1.3.1   2018-05-10 CRAN (R 3.5.0)                     
##  tibble        1.4.2   2018-01-22 CRAN (R 3.5.0)                     
##  tidyr       * 0.8.1   2018-05-18 CRAN (R 3.5.0)                     
##  tidyselect    0.2.4   2018-02-26 CRAN (R 3.5.0)                     
##  tools         3.5.1   2018-07-02 local                              
##  utils       * 3.5.1   2018-07-02 local                              
##  viridisLite   0.3.0   2018-02-01 CRAN (R 3.5.0)                     
##  withr         2.1.2   2018-03-15 CRAN (R 3.5.0)                     
##  xml2          1.2.0   2018-01-24 CRAN (R 3.5.0)                     
##  yaml          2.2.0   2018-07-25 CRAN (R 3.5.1)

References

Bae, Kyun-Seop. 2018. NonCompart: Noncompartmental Analysis for Pharmacokinetic Data. https://CRAN.R-project.org/package=NonCompart.

Certara USA, Inc. 2018. Phoenix Winnonlin: The Industry Standard for Nca and Pk/Pd Modeling and Simulation. https://www.certara.com/software/pkpd-modeling-and-simulation/phoenix-winnonlin/.

Kim, Hyungsub, Sungpil Han, Yong-Soon Cho, Seok-Kyu Yoon, and Kyun-Seop Bae. 2018. “Development of R Packages: ‘NonCompart’ and ‘Ncar’ for Noncompartmental Analysis (Nca).” Translational and Clinical Pharmacology 26 (1). Korean Society for Clinical Pharmacology; Therapeutics (KAMJE):10–15. http://www.tcpharm.org/Data/Journal/2/358.pdf.

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validation.md

validation.md

Validation of Noncompartmental Analysis Performed by NonCompart R package

Introduction

Results

Conclusion

(APPENDIX) Appendix

Side-by-side comparison of results

Test 1: Theoph (n=12), Linear, Extravascular

Test 2: Theoph (n=12), Log, Extravascular

Test 3: Indometh (n=6), Linear, IV Bolus

Test 4: Indometh (n=6), Log, IV Bolus

Test 5: Indometh (n=6), Linear, IV Infusion (0.25hr)

Test 6: Indometh (n=6), Log, IV Infusion (0.25hr)

Test 7: Indometh (n=6), Linear, Extravascular

Test 8: Indometh (n=6), Log, Extravascular

Session Information

References

Files

validation.md

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validation.md

File metadata and controls

Validation of Noncompartmental Analysis Performed by NonCompart R package

Introduction

Results

Conclusion

(APPENDIX) Appendix

Side-by-side comparison of results

Test 1: Theoph (n=12), Linear, Extravascular

Test 2: Theoph (n=12), Log, Extravascular

Test 3: Indometh (n=6), Linear, IV Bolus

Test 4: Indometh (n=6), Log, IV Bolus

Test 5: Indometh (n=6), Linear, IV Infusion (0.25hr)

Test 6: Indometh (n=6), Log, IV Infusion (0.25hr)

Test 7: Indometh (n=6), Linear, Extravascular

Test 8: Indometh (n=6), Log, Extravascular

Session Information

References