Replies: 2 comments 16 replies
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The first issue is the main one. Without fixing it, I'm not sure how you got results of any type. The way that you specified the call to PKNCAconc, you didn't indicate a subject column. Given your description of the study, that is the most likely issue. The way to specify the subject column is to add the subject as the last grouping level similar to the.below call:
To get the group mean, you would run For the difference with Phoenix, I would need to know more about what parameters you are calculating and your data. Prior tests comparing PKNCA to Phoenix have found almost no differences, and where the differences exist, they are intentional (AUC for all 0 concentrations and an edge case of half lives around order of automatically selecting the best half life). |
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https://cran.r-project.org/web/packages/PKNCA/vignettes/v04-sparse.html |
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Rversion = 4.3.2
I want to perform an NCA analysis for a single dose studies. I have concentration measurements at 5 timepoints for each subject, and have 3 subjects for each single dose - 1) 1mg/kg IV, 2) 9mg/kg IV and 3) 15mg/kg PO. In the end I want to have a table with pk parameters for the mean between the 3 subjects at each single dose study.
I am encountering 3 problems:
Rows that are not unique per group and time (column names: Time, Dose) found within concentration data. Row numbers: 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48
Note: I am using asnumeric and is.na to make sure my dose, concentration and time are manipulated correctly; I am using read_excel() to read my data and in the beginning I split my data by route creating 2 data frames
Thank you so much for your help!
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