NTM resistance mutation database and drug resistance prediction.

[harrismia]

It would be great to add resistance prediction capabilities similar to what is available for TB Profiler. Is there a known database of resistance mutations for NTM?

[jodyphelan]

From what I have seen it is mostly scattered in the literature (e.g. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3028756/). I haven't come across a central database, though I could have missed it. I'm happy to make a start for some of the most clinically relevant NTMs.

[harrismia]

That would be great! It might be good to have a similar separate database (similar to tbdb for TB Profiler) that can be updated as new variants are reported in the literature. ntmdb ? I guess this would also need to include the name of the NTM ?

[harrismia]

One more publication: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325232/

[jodyphelan]

Resistance prediction is now available for Mycobacteroides abscessus in v0.1.1

[harrismia]

Fantastic! Can't wait to give it a try!

[harrismia]

Other suggested organisms are:

Mycobacterium avium complex (MAC)
Mycobacterium kansasii

[yugen-miyahara]

I would like to suggest adding resistance prediction for: Mycolicibacterium fortuitum