herpesdrg-db.tsv

mutation_id	virus	genotype	gene	aa_change	Ganciclovir	Aciclovir	Cidofovir	Foscarnet	Brincidofovir	Letermovir	Brivudine	Penciclovir	Tomeglovir	Maribavir	Cyclopropavir	Amenamevir	Pritelivir	ref_title	ref_link	ref_doi	strain_generation	test_method	co_gene	co_aa	created_date	created_by	note	control_strain	status
1	HCMV	TOWNE	UL54	D301N	2.6		3	0.5										Viral DNA Polymerase Mutations Associated with Drug Resistance in Human Cytomegalovirus	https://academic.oup.com/jid/article/188/1/32/821141	doi.org/10.1086/375743	Marker Transfer 	 PRA			17/11/2019	OJCharles			A
2	HCMV	AD169	UL54	C304S	1.3		1.4	1.1										Phenotypic Diversity of Cytomegalovirus DNA Polymerase Gene Variants Observed after Antiviral Therapy	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059355/	doi.org/10.1016/j.jcv.2011.01.004	Recombinant BAC 	SEAP			16/03/2020	OJCharles			A
3	HCMV	TOWNE	UL54	N408D	4.9		5.6	1.3										Characterization of Drug Resistance-Associated Mutations in the Human Cytomegalovirus DNA Polymerase Gene by Using Recombinant Mutant Viruses Generated from Overlapping DNA Fragments	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC110397/		Marker Transfer 	 PRA			17/11/2019	OJCharles			A
4	HCMV	AD169	UL54	N408K	4.2		21	0.7										Multidrug resistance conferred by novel DNA polymerase mutations in human cytomegalovirus isolates.	https://europepmc.org/article/pmc/pmc1797699	doi.org/10.1128/AAC.00633-06	Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
5	HCMV	AD169	UL54	N408S	3.1		7.5	1										Novel DNA polymerase mutations conferring cytomegalovirus resistance: Input of BAC-recombinant phenotyping and 3D model	https://www.sciencedirect.com/science/article/abs/pii/S0166354213000259?via%3Dihub	doi.org/10.1016/j.antiviral.2013.02.002	Recombinant BAC 	 PRA			17/11/2019	OJCharles			A
6	HCMV	TOWNE	UL54	N410K	2.9		3	0.8										Viral DNA Polymerase Mutations Associated with Drug Resistance in Human Cytomegalovirus	https://academic.oup.com/jid/article/188/1/32/821141	doi.org/10.1086/375743	Marker Transfer 	 PRA			17/11/2019	OJCharles			A
7	HCMV	TOWNE	UL54	F412C	4.2		18	1.2										Characterization of Drug Resistance-Associated Mutations in the Human Cytomegalovirus DNA Polymerase Gene by Using Recombinant Mutant Viruses Generated from Overlapping DNA Fragments	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC110397/		Marker Transfer 	 PRA			17/11/2019	OJCharles			A
8	HCMV	AD169	UL54	F412L	4.6		9.4	1.1										Phenotypic Diversity of Cytomegalovirus DNA Polymerase Gene Variants Observed after Antiviral Therapy	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059355/	doi.org/10.1016/j.jcv.2011.01.004	Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
9	HCMV	AD169	UL54	F412S	5.3		13	0.8										Phenotypic Diversity of Cytomegalovirus DNA Polymerase Gene Variants Observed after Antiviral Therapy	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059355/	doi.org/10.1016/j.jcv.2011.01.004	Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
10	HCMV	TOWNE	UL54	F412V	4.3		15.5	1.1										Characterization of Drug Resistance-Associated Mutations in the Human Cytomegalovirus DNA Polymerase Gene by Using Recombinant Mutant Viruses Generated from Overlapping DNA Fragments	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC110397/		Marker Transfer 	 PRA			17/11/2019	OJCharles			A
11	HCMV	AD169	UL54	D413A	6.5		11	0.8										Development of new cytomegalovirus UL97 and DNA polymerase mutations conferring drug resistance after valganciclovir therapy in allogeneic stem cell recipients	https://www.sciencedirect.com/science/article/pii/S1386653206004161	doi.org/10.1016/j.jcv.2006.11.005	Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
12	HCMV	TOWNE	UL54	D413E	4.8		4.3	0.8										Viral DNA Polymerase Mutations Associated with Drug Resistance in Human Cytomegalovirus	https://academic.oup.com/jid/article/188/1/32/821141	doi.org/10.1086/375743	Marker Transfer 	 PRA			17/11/2019	OJCharles			A
13	HCMV	AD169	UL54	D413N	3.8		10	1										Improved Detection of Emerging Drug-Resistant Mutant Cytomegalovirus Subpopulations by Deep Sequencing	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135977/	doi.org/10.1128/AAC.03214-14	Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
14	HCMV	Susceptible Clinical Isolate	UL54	P488R	3.5		7.9	0.6										Recombinant Phenotyping of Cytomegalovirus UL54 Mutations That Emerged during Cell Passages in the Presence of either Ganciclovir or Foscarnet	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165324/	doi.org/10.1128/AAC.00334-11	Isolated strain	PRA			17/11/2019	OJCharles			A
15	HCMV		UL54	N495K	1.1		1.1	3.4										A novel mutation in the UL54 gene of human cytomegalovirus isolates that confers resistance to foscarnet	https://journals.sagepub.com/doi/abs/10.1177/135965350601100416	doi.org/10.1177/1359653506011004	Lab derived mutant 	PRA or SEAP			17/11/2019	OJCharles			A
16	HCMV	AD169	UL54	K500N	3.2		3	1.2										Recombinant Phenotyping of Cytomegalovirus UL54 Mutations That Emerged during Cell Passages in the Presence of either Ganciclovir or Foscarnet	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165324/	doi.org/10.1128%2FAAC.00334-11	Recombinant BAC 	PRA			17/11/2019	OJCharles			A
17	HCMV	TOWNE	UL54	L501I	6		9.1	1.4										Characterization of Drug Resistance-Associated Mutations in the Human Cytomegalovirus DNA Polymerase Gene by Using Recombinant Mutant Viruses Generated from Overlapping DNA Fragments	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC110397/		Marker Transfer 	PRA			17/11/2019	OJCharles			A
18	HCMV	TOWNE	UL54	T503I	2.9		6.1	0.5										Viral DNA Polymerase Mutations Associated with Drug Resistance in Human Cytomegalovirus	https://academic.oup.com/jid/article/188/1/32/821141	doi.org/10.1086/375743	Marker Transfer 	PRA			17/11/2019	OJCharles			A
19	HCMV	AD169	UL54	A505V	1.8		2	1.1										Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial	https://academic.oup.com/jid/article/209/8/1219/831553	doi.org/10.1093/infdis/jit654	Lab derived mutant 	PRA or SEAP			17/11/2019	OJCharles	minor disparity in fold change ref - rev. ignoring Rev using original reference only		A
20	HCMV	TOWNE	UL54	K513E	5		9.1	1.4										Characterization of Drug Resistance-Associated Mutations in the Human Cytomegalovirus DNA Polymerase Gene by Using Recombinant Mutant Viruses Generated from Overlapping DNA Fragments	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC110397/		Marker Transfer 	PRA			17/11/2019	OJCharles			A
21	HCMV	AD169	UL54	K513N	6		12.5	1.5										A Point Mutation in the Human Cytomegalovirus DNA Polymerase Gene Selected in Vitro by Cidofovir Confers a Slow Replication Phenotype in Cell Culture	https://www.sciencedirect.com/science/article/pii/S0042682298992996	doi.org/10.1006/viro.1998.9299	Marker Transfer 	PRA			17/11/2019	OJCharles			A
22	HCMV	AD169	UL54	K513N	9.8		34	3										A Point Mutation in the Human Cytomegalovirus DNA Polymerase Gene Selected in Vitro by Cidofovir Confers a Slow Replication Phenotype in Cell Culture	https://www.sciencedirect.com/science/article/pii/S0042682298992996	doi.org/10.1006/viro.1998.9299	Marker Transfer 	PRA	UL54	V812L	17/11/2019	OJCharles			A
23	HCMV	AD169	UL54	K513R	3.7		10	1.1										Improved Detection of Emerging Drug-Resistant Mutant Cytomegalovirus Subpopulations by Deep Sequencing	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135977/	doi.org/10.1128/AAC.03214-14	Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
24	HCMV	Clinical Isolate	UL54	D515E	2.7			4.6										Drug-resistant human cytomegalovirus infection in children after allogeneic stem cell transplantation may have different clinical outcomes	https://ashpublications.org/blood/article/96/9/3286/181219/Drug-resistant-human-cytomegalovirus-infection-in?searchresult=1	doi.org/10.1182/blood.V96.9.3286.h8003286_3286_3289	Lab derived mutant 	PRA or SEAP	UL54	L516M;I521T	17/11/2019	OJCharles			A
25	HCMV	TOWNE	UL54	D515G	1		1	1.2										Viral DNA Polymerase Mutations Associated with Drug Resistance in Human Cytomegalovirus	https://academic.oup.com/jid/article/188/1/32/821141	doi.org/10.1086/375743	Marker Transfer 	PRA			16/03/2020	OJCharles			A
26	HCMV	Clinical Isolate	UL54	D515Y	6.2		0.9	4.7										Contrasting effect of new HCMV pUL54 mutations on antiviral drug susceptibility: Benefits and limits of 3D analysis	https://www.sciencedirect.com/science/article/pii/S0166354216300365?via%3Dihub	doi.org/10.1016/j.antiviral.2016.02.004	Recombinant BAC 	GFP fluorescence reduction assay			23/11/2020	OJCharles			A
27	HCMV	TOWNE	UL54	L516R	2.1		5.1	0.8										Viral DNA Polymerase Mutations Associated with Drug Resistance in Human Cytomegalovirus	https://academic.oup.com/jid/article/188/1/32/821141	doi.org/10.1086/375743	Marker Transfer 	PRA			17/11/2019	OJCharles			A
28	HCMV		UL54	I521T	2.1		5.1	0.8										Rev. Med. Virol. 2016; 26: 161-182			Lab derived mutant 	PRA or SEAP			17/11/2019	OJCharles	Unable to substantiate review values from their references		O
29	HCMV	AD169	UL54	I521T	3		3.9	1										Contrasting drug resistance phenotypes resulting from cytomegalovirus DNA polymerase mutations at the same exonuclease locus	http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC2576411&blobtype=pdf	doi.org/10.1016/j.jcv.2008.04.005.	Marker Transfer 	SEAP			16/03/2020	OJCharles		AD169	A
30	HCMV	AD169	UL54	P522A	3		4.1	1										Contrasting drug resistance phenotypes resulting from cytomegalovirus DNA polymerase mutations at the same exonuclease locus	http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC2576411&blobtype=pdf	doi.org/10.1016/j.jcv.2008.04.005.	Marker Transfer 	SEAP			17/11/2019	OJCharles		AD169	A
31	HCMV	AD169	UL54	P522L	1.3		1.2	1.4										Contrasting drug resistance phenotypes resulting from cytomegalovirus DNA polymerase mutations at the same exonuclease locus	http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC2576411&blobtype=pdf	doi.org/10.1016/j.jcv.2008.04.005.	Marker Transfer 	SEAP			16/03/2020	OJCharles		AD169	A
32	HCMV	TOWNE	UL54	P522S	3.1		3.6	1.1										Characterization of Drug Resistance-Associated Mutations in the Human Cytomegalovirus DNA Polymerase Gene by Using Recombinant Mutant Viruses Generated from Overlapping DNA Fragments	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC110397/		Marker Transfer 	PRA			17/11/2019	OJCharles			A
33	HCMV	AD169	UL54	del524	3.5		9.7	1.1										Novel DNA polymerase mutations conferring cytomegalovirus resistance: Input of BAC-recombinant phenotyping and 3D model	https://www.sciencedirect.com/science/article/abs/pii/S0166354213000259?via%3Dihub	doi.org/10.1016/j.antiviral.2013.02.002	Recombinant BAC 	PRA			17/11/2019	OJCharles			A
34	HCMV	AD169	UL54	V526L	5.5		2.5	1.8										Characterization of Multiple Cytomegalovirus Drug Resistance Mutations Detected in a Hematopoietic Stem Cell Transplant Recipient by Recombinant Phenotyping	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313248/	doi.org/10.1128%2FJCM.02205-14	Recombinant BAC 	GLuc reporter assay			23/11/2020	OJCharles			A
35	HCMV	AD169	UL54	C539G	3.1		4.4	1										Improved Detection of Emerging Drug-Resistant Mutant Cytomegalovirus Subpopulations by Deep Sequencing	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135977/	doi.org/10.1128/AAC.03214-14					17/11/2019	OJCharles			A
36	HCMV	Susceptible Clinical Isolate	UL54	C539R	3.2		13.3	0.7										Recombinant Phenotyping of Cytomegalovirus UL54 Mutations That Emerged during Cell Passages in the Presence of either Ganciclovir or Foscarnet	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165324/	doi.org/10.1128%2FAAC.00334-11	Isolated strain	PRA			17/11/2019	OJCharles			A
37	HCMV		UL54	D542E	1.5		12	1.7										Selection and Recombinant Phenotyping of a Novel CMX001 and Cidofovir Resistance Mutation in Human Cytomegalovirus	https://aac.asm.org/content/57/7/3321	doi.org/10.1128/AAC.00062-13	Recombinant BAC 	PRA			23/11/2020	OJCharles			A
38	HCMV	AD169	UL54	V544A	1		1.1	0.9										Phenotypic Diversity of Cytomegalovirus DNA Polymerase Gene Variants Observed after Antiviral Therapy	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059355/	doi.org/10.1016/j.jcv.2011.01.004	Recombinant BAC 	SEAP			16/03/2020	OJCharles			A
39	HCMV	TOWNE	UL54	L545S	3.5		9.1	1.2										Characterization of Drug Resistance-Associated Mutations in the Human Cytomegalovirus DNA Polymerase Gene by Using Recombinant Mutant Viruses Generated from Overlapping DNA Fragments	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC110397/		Marker Transfer 	PRA			17/11/2019	OJCharles			A
40	HCMV	AD169	UL54	L545W	4.9		6.3	1.3										Phenotypic Diversity of Cytomegalovirus DNA Polymerase Gene Variants Observed after Antiviral Therapy	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059355/	doi.org/10.1016/j.jcv.2011.01.004	Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
41	HCMV	AD169	UL54	T552N	1.9		1.2	2.6										Recombinant Phenotyping of Cytomegalovirus UL54 Mutations That Emerged during Cell Passages in the Presence of either Ganciclovir or Foscarnet	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165324/	doi.org/10.1128%2FAAC.00334-11	Recombinant BAC 	PRA			17/11/2019	OJCharles			A
42	HCMV	AD169	UL54	Q578H	3.3		2.3	4.5										Phenotypic Diversity of Cytomegalovirus DNA Polymerase Gene Variants Observed after Antiviral Therapy	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059355/	doi.org/10.1016/j.jcv.2011.01.004	Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
43	HCMV	AD169	UL54	S585A	1.5		1.4	2.7										Recombinant Phenotyping of Cytomegalovirus UL54 Mutations That Emerged during Cell Passages in the Presence of either Ganciclovir or Foscarnet	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165324/	doi.org/10.1128%2FAAC.00334-11	Recombinant BAC 	PRA			17/11/2019	OJCharles			A
44	HCMV	TOWNE	UL54	D588E	1.3		1.1	2.3										Characterization of Drug Resistance-Associated Mutations in the Human Cytomegalovirus DNA Polymerase Gene by Using Recombinant Mutant Viruses Generated from Overlapping DNA Fragments	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC110397/		Marker Transfer 	PRA			17/11/2019	OJCharles			A
45	HCMV	AD169	UL54	D588N	2		1.3	2.8										Phenotypic Diversity of Cytomegalovirus DNA Polymerase Gene Variants Observed after Antiviral Therapy	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059355/	doi.org/10.1016/j.jcv.2011.01.004	Recombinant BAC 	SEAP			16/03/2020	OJCharles			A
46	HCMV		UL54	D588N	3.8		2.7	9										Variations in the cytomegalovirus DNA polymerase and phosphotransferase genes in relation to foscarnet and ganciclovir sensitivity	https://www.sciencedirect.com/science/article/pii/S1386653201001603?via%3Dihub	doi.org/10.1016/S1386-6532(01)00160-3	Lab derived mutant 	PRA or SEAP			17/11/2019	OJCharles			A
47	HCMV	Susceptible Clinical Isolate	UL54	F595I	1.3		1.2	2										Recombinant Phenotyping of Cytomegalovirus UL54 Mutations That Emerged during Cell Passages in the Presence of either Ganciclovir or Foscarnet	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165324/	doi.org/10.1128%2FAAC.00334-11	Isolated strain	PRA			17/11/2019	OJCharles			A
48	HCMV	TOWNE	UL54	A692S	1.6		1.7	3.3										Viral DNA Polymerase Mutations Associated with Drug Resistance in Human Cytomegalovirus	https://academic.oup.com/jid/article/188/1/32/821141	doi.org/10.1086/375743	Marker Transfer 	PRA			16/03/2020	OJCharles			A
49	HCMV	Clinical Isolate	UL54	T700A	1.2		1.3	5.8										Characterization of Drug Resistance-Associated Mutations in the Human Cytomegalovirus DNA Polymerase Gene by Using Recombinant Mutant Viruses Generated from Overlapping DNA Fragments	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC110397/		Marker Transfer 	PRA			17/11/2019	OJCharles			A
50	HCMV	AD169	UL54	A714V	0.8		0.7	0.8										Phenotypic Diversity of Cytomegalovirus DNA Polymerase Gene Variants Observed after Antiviral Therapy	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059355/	doi.org/10.1016/j.jcv.2011.01.004	Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
51	HCMV		UL54	V715M	1.3		1.1	9.5										Characterization of Drug Resistance-Associated Mutations in the Human Cytomegalovirus DNA Polymerase Gene by Using Recombinant Mutant Viruses Generated from Overlapping DNA Fragments	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC110397/		Marker Transfer 	PRA			17/11/2019	OJCharles			A
52	HCMV		UL54	V715M	1		1.1	5.5										Rev. Med. Virol. 2016; 26: 161-182			Lab derived mutant 	PRA or SEAP			17/11/2019	OJCharles	Unable to substantiate review values from their references		O
53	HCMV	AD169	UL54	I726V	1.9		1.9	1.2										Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969548/	doi.org/10.1093/infdis/jit654	Recombinant BAC 	PRA			17/11/2019	OJCharles			A
54	HCMV	TOWNE	UL54	E756D	1.2		0.7	3.4										Viral DNA Polymerase Mutations Associated with Drug Resistance in Human Cytomegalovirus	https://academic.oup.com/jid/article/188/1/32/821141	doi.org/10.1086/375743	Marker Transfer 	PRA			17/11/2019	OJCharles			A
55	HCMV	AD169	UL54	E756K	8.1		2.7	8										Characterization of Multiple Cytomegalovirus Drug Resistance Mutations Detected in a Hematopoietic Stem Cell Transplant Recipient by Recombinant Phenotyping	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313248/	doi.org/10.1128%2FJCM.02205-14	Recombinant BAC 	GLuc reporter assay			23/11/2020	OJCharles			A
56	HCMV	TOWNE	UL54	E756Q	1.7		1	4.3										Mutations Conferring Foscarnet Resistance in A Cohort of Patients with Acquired Immunodeficiency Syndrome and Cytomegalovirus Retinitis	https://academic.oup.com/jid/article/187/5/777/2191368	doi.org/10.1086/368385	Marker Transfer 	PRA			23/11/2020	OJCharles			A
57	HCMV	AD169	UL54	L773V	3		2.5	4.4										Improved Detection of Emerging Drug-Resistant Mutant Cytomegalovirus Subpopulations by Deep Sequencing	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135977/	doi.org/10.1128/AAC.03214-14	Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
58	HCMV	AD169	UL54	L776M	2.5		1	3.5										Artesunate as a Potent Antiviral Agent in a Patient with Late Drug-Resistant Cytomegalovirus Infection after Hematopoietic Stem Cell Transplantation	https://academic.oup.com/cid/article/46/9/1455/330370	doi.org/10.1086/587106	Marker Transfer 	PRA			23/11/2020	OJCharles			A
59	HCMV	TOWNE	UL54	V781I	1		1.2	5.2										Characterization of Drug Resistance-Associated Mutations in the Human Cytomegalovirus DNA Polymerase Gene by Using Recombinant Mutant Viruses Generated from Overlapping DNA Fragments	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC110397/		Marker Transfer 	PRA			17/11/2019	OJCharles			A
60	HCMV		UL54	V787A	4.7		0.7	3.2										Contrasting effect of new HCMV pUL54 mutations on antiviral drug susceptibility: Benefits and limits of 3D analysis	https://www.sciencedirect.com/science/article/pii/S0166354216300365?via%3Dihub	doi.org/10.1016/j.antiviral.2016.02.004	Recombinant BAC 	GFP fluorescence reduction assay			23/11/2020	OJCharles			A
61	HCMV	TOWNE	UL54	V787L	2.4		1	4.1										Mutations Conferring Foscarnet Resistance in A Cohort of Patients with Acquired Immunodeficiency Syndrome and Cytomegalovirus Retinitis	https://academic.oup.com/jid/article/187/5/777/2191368	doi.org/10.1086/368385	Marker Transfer 	PRA			23/11/2020	OJCharles			A
62	HCMV	TOWNE	UL54	L802M	1.1		0.9	3.2										Characterization of Drug Resistance-Associated Mutations in the Human Cytomegalovirus DNA Polymerase Gene by Using Recombinant Mutant Viruses Generated from Overlapping DNA Fragments	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC110397/		Marker Transfer 	PRA			17/11/2019	OJCharles			A
63	HCMV	AD169	UL54	L802V	1.8		1.1	0.9										Recombinant Phenotyping of Cytomegalovirus UL54 Mutations That Emerged during Cell Passages in the Presence of either Ganciclovir or Foscarnet	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165324/	doi.org/10.1128%2FAAC.00334-11	Recombinant BAC 	PRA			17/11/2019	OJCharles			A
64	HCMV	TOWNE	UL54	K805Q	1		2.2	0.18										Characterization of Drug Resistance-Associated Mutations in the Human Cytomegalovirus DNA Polymerase Gene by Using Recombinant Mutant Viruses Generated from Overlapping DNA Fragments	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC110397/		Marker Transfer 	PRA			17/11/2019	OJCharles			A
65	HCMV	AD169	UL54	A809V	2.4		1.9	3.3										Growth and Drug Resistance Phenotypes Resulting from Cytomegalovirus DNA Polymerase Region III Mutations Observed in Clinical Specimens	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151462/	doi.org/10.1128%2FAAC.00736-07	Recombinant BAC 	SEAP			23/11/2020	OJCharles			A
66	HCMV	AD169	UL54	A809V				3.6										Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969548/	doi.org/10.1093/infdis/jit654	Recombinant BAC 	PRA			16/03/2020	OJCharles			A
67	HCMV	AD169	UL54	V812L	2.5		3.2	2.9										A  Point  Mutation  in  the  Human  Cytomegalovirus  DNA  Polymerase  Gene  Selectedin  Vitroby  Cidofovir  Confers  a  Slow  Replication  Phenotype  in  Cell  Culture	https://www.sciencedirect.com/science/article/pii/S0042682298992996?via%3Dihub	doi.org/10.1006/viro.1998.9299	Marker Transfer 	PRA			23/11/2020	OJCharles			A
68	HCMV	AD169	UL54	T813S	2.5		2.7	4.9										Growth and Drug Resistance Phenotypes Resulting from Cytomegalovirus DNA Polymerase Region III Mutations Observed in Clinical Specimens	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151462/	doi.org/10.1128%2FAAC.00736-07	Recombinant BAC 	SEAP			23/11/2020	OJCharles			A
69	HCMV	TOWNE	UL54	T821I	4.5		1.9	21										Characterization of Drug Resistance-Associated Mutations in the Human Cytomegalovirus DNA Polymerase Gene by Using Recombinant Mutant Viruses Generated from Overlapping DNA Fragments	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC110397/		Marker Transfer 	PRA			17/11/2019	OJCharles			A
70	HCMV	AD169	UL54	P829S	2		1.6	1.1										Recombinant Phenotyping of Cytomegalovirus UL54 Mutations That Emerged during Cell Passages in the Presence of either Ganciclovir or Foscarnet	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165324/	doi.org/10.1128%2FAAC.00334-11	Recombinant BAC 	PRA			17/11/2019	OJCharles			A
71	HCMV	AD169	UL54	A834P	5.4		3	6.4										Multidrug resistance conferred by novel DNA polymerase mutations in human cytomegalovirus isolates.	https://europepmc.org/article/pmc/pmc1797699	doi.org/10.1128/AAC.00633-06	Recombinant BAC 	SEAP			16/03/2020	OJCharles			A
72	HCMV	AD169	UL54	A834P	22.7		18.8	7.2										Multidrug resistance conferred by novel DNA polymerase mutations in human cytomegalovirus isolates.	https://europepmc.org/article/pmc/pmc1797699	doi.org/10.1128/AAC.00633-06	Recombinant BAC 	SEAP	UL54	N408K	17/11/2019	OJCharles			A
73	HCMV	TOWNE	UL54	T838A	1.8		0.8	2.4										How Evolution of Mutations Conferring Drug Resistance Affects Viral Dynamics and Clinical Outcomes of Cytomegalovirus-Infected Hematopoietic Cell Transplant Recipients	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC540138/	doi.org/10.1128%2FJCM.43.1.208-213.2005	Marker Transfer 	PRA			23/11/2020	OJCharles			A
74	HCMV	AD169	UL54	G841A	3.2		2.6	4.3										Growth and Drug Resistance Phenotypes Resulting from Cytomegalovirus DNA Polymerase Region III Mutations Observed in Clinical Specimens	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151462/	doi.org/10.1128%2FAAC.00736-07	Recombinant BAC 	SEAP			23/11/2020	OJCharles			A
75	HCMV	AD169	UL54	M844T	1.4		1.3	2.5										Cyclopropavir Susceptibility of Cytomegalovirus DNA Polymerase Mutants Selected after Antiviral Drug Exposure	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256009/	doi.org/10.1128%2FAAC.05559-11	Lab derived mutant 	PRA or SEAP			23/11/2020	OJCharles			A
76	HCMV	AD169	UL54	M844V	2.3		1.6	2.2										Cyclopropavir Susceptibility of Cytomegalovirus DNA Polymerase Mutants Selected after Antiviral Drug Exposure	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256009/	doi.org/10.1128%2FAAC.05559-11	Lab derived mutant 	PRA or SEAP			23/11/2020	OJCharles			A
77	HCMV	Susceptible Clinical Isolate	UL54	L862F	1.7		0.9	1.1										Recombinant Phenotyping of Cytomegalovirus UL54 Mutations That Emerged during Cell Passages in the Presence of either Ganciclovir or Foscarnet	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165324/	doi.org/10.1128%2FAAC.00334-11	Isolated strain	PRA			17/11/2019	OJCharles			A
78	HCMV	Susceptible Clinical Isolate	UL54	V946L	1.1		0.9	2.4										Recombinant Phenotyping of Cytomegalovirus UL54 Mutations That Emerged during Cell Passages in the Presence of either Ganciclovir or Foscarnet	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165324/	doi.org/10.1128%2FAAC.00334-11	Isolated strain	PRA			17/11/2019	OJCharles			A
79	HCMV	AD169	UL54	L957F	2.7		1.4	1.3										Recombinant Phenotyping of Cytomegalovirus UL54 Mutations That Emerged during Cell Passages in the Presence of either Ganciclovir or Foscarnet	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165324/	doi.org/10.1128%2FAAC.00334-11	Recombinant BAC 	PRA			17/11/2019	OJCharles			A
80	HCMV	TOWNE	UL54	G971D	1.4		1	1.2										Viral DNA Polymerase Mutations Associated with Drug Resistance in Human Cytomegalovirus	https://academic.oup.com/jid/article/188/1/32/821141	doi.org/10.1086/375743	Marker Transfer 	PRA			16/03/2020	OJCharles			A
81	HCMV	TOWNE	UL54	del981-982	8.3		2.8	3.6										Viral DNA Polymerase Mutations Associated with Drug Resistance in Human Cytomegalovirus	https://academic.oup.com/jid/article/188/1/32/821141	doi.org/10.1086/375743	Marker Transfer 	PRA			23/11/2020	OJCharles			A
82	HCMV	AD169	UL54	A987G	5.1		4.5											Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969548/	doi.org/10.1093/infdis/jit654	Recombinant BAC 	PRA			16/03/2020	OJCharles			A
83	HCMV	TOWNE	UL54	A987G	5.3		11.3	1.2										Characterization of Drug Resistance-Associated Mutations in the Human Cytomegalovirus DNA Polymerase Gene by Using Recombinant Mutant Viruses Generated from Overlapping DNA Fragments	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC110397/		Marker Transfer 	PRA			17/11/2019	OJCharles			A
84	HCMV	Susceptible Clinical Isolate	UL54	L802M	1.7		1	2.7										Recombinant Phenotyping of Cytomegalovirus UL54 Mutations That Emerged during Cell Passages in the Presence of either Ganciclovir or Foscarnet	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165324/	doi.org/10.1128%2FAAC.00334-11	Isolated strain	PRA			17/11/2019	OJCharles			A
85	HCMV	Susceptible Clinical Isolate	UL54	P488R	7.5		7.4	1										Recombinant Phenotyping of Cytomegalovirus UL54 Mutations That Emerged during Cell Passages in the Presence of either Ganciclovir or Foscarnet	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165324/	doi.org/10.1128%2FAAC.00334-11	Isolated strain	PRA			17/11/2019	OJCharles			A
86	HCMV	Susceptible Clinical Isolate	UL54	C539R	6.3													Recombinant Phenotyping of Cytomegalovirus UL54 Mutations That Emerged during Cell Passages in the Presence of either Ganciclovir or Foscarnet	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165324/	doi.org/10.1128%2FAAC.00334-11	Isolated strain	PRA			17/11/2019	OJCharles			A
87	HCMV	Susceptible Clinical Isolate	UL54	C539R	59		7.4											Recombinant Phenotyping of Cytomegalovirus UL54 Mutations That Emerged during Cell Passages in the Presence of either Ganciclovir or Foscarnet	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165324/	doi.org/10.1128%2FAAC.00334-11	Isolated strain	PRA	UL97	H520Q	17/11/2019	OJCharles			A
88	HCMV	Susceptible Clinical Isolate	UL54	C539R;F595I	28													Recombinant Phenotyping of Cytomegalovirus UL54 Mutations That Emerged during Cell Passages in the Presence of either Ganciclovir or Foscarnet	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165324/	doi.org/10.1128%2FAAC.00334-11	Isolated strain	PRA	UL97	G598D	17/11/2019	OJCharles			A
89	HCMV	Susceptible Clinical Isolate	UL54	C539R; F595I	79		13	6.3										Recombinant Phenotyping of Cytomegalovirus UL54 Mutations That Emerged during Cell Passages in the Presence of either Ganciclovir or Foscarnet	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165324/	doi.org/10.1128%2FAAC.00334-11	Isolated strain	PRA	UL97	H520Q	17/11/2019	OJCharles			A
90	HCMV	TOWNE	UL54	S676G	1.1		1.2	0.9										Characterization of Drug Resistance-Associated Mutations in the Human Cytomegalovirus DNA Polymerase Gene by Using Recombinant Mutant Viruses Generated from Overlapping DNA Fragments	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC110397/		Marker Transfer 	PRA			16/03/2020	OJCharles			A
91	HCMV	TOWNE	UL54	V759M	1.5		1.1	1.1										Characterization of Drug Resistance-Associated Mutations in the Human Cytomegalovirus DNA Polymerase Gene by Using Recombinant Mutant Viruses Generated from Overlapping DNA Fragments	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC110397/		Marker Transfer 	PRA			16/03/2020	OJCharles			A
92	HCMV	TOWNE	UL54	F412C	6.2		16	3.1										Characterization of Drug Resistance-Associated Mutations in the Human Cytomegalovirus DNA Polymerase Gene by Using Recombinant Mutant Viruses Generated from Overlapping DNA Fragments	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC110397/		Marker Transfer 	PRA	UL54	L802M	16/03/2020	OJCharles			A
93	HCMV	TOWNE	UL54	K513E	6.6		11.1	2.7										Characterization of Drug Resistance-Associated Mutations in the Human Cytomegalovirus DNA Polymerase Gene by Using Recombinant Mutant Viruses Generated from Overlapping DNA Fragments	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC110397/		Marker Transfer 	PRA	UL54	D558E	16/03/2020	OJCharles			A
94	HCMV	TOWNE	UL54	K805Q	4.3		2.1	10.1										Characterization of Drug Resistance-Associated Mutations in the Human Cytomegalovirus DNA Polymerase Gene by Using Recombinant Mutant Viruses Generated from Overlapping DNA Fragments	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC110397/		Marker Transfer 	PRA	UL54	T821I	16/03/2020	OJCharles			A
95	HCMV	AD169	UL54	L545S	5		11.9	1										Recombinant Phenotyping of Cytomegalovirus UL54 Mutations That Emerged during Cell Passages in the Presence of either Ganciclovir or Foscarnet	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165324/	doi.org/10.1128%2FAAC.00334-11	Recombinant BAC 	PRA			16/03/2020	OJCharles			A
96	HCMV	AD169	UL54	D879G	1.2		0.9	0.9										Recombinant Phenotyping of Cytomegalovirus UL54 Mutations That Emerged during Cell Passages in the Presence of either Ganciclovir or Foscarnet	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165324/	doi.org/10.1128%2FAAC.00334-11	Recombinant BAC 	PRA			16/03/2020	OJCharles			A
97	HCMV	AD169	UL54	L545S	7.3		4.5	1.8										Recombinant Phenotyping of Cytomegalovirus UL54 Mutations That Emerged during Cell Passages in the Presence of either Ganciclovir or Foscarnet	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165324/	doi.org/10.1128%2FAAC.00334-11	Recombinant BAC 	PRA	UL54	P829S	16/03/2020	OJCharles			A
98	HCMV	AD169	UL54	N408D	4		4.2	1.3										Recombinant Phenotyping of Cytomegalovirus UL54 Mutations That Emerged during Cell Passages in the Presence of either Ganciclovir or Foscarnet	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165324/	doi.org/10.1128%2FAAC.00334-11	Recombinant BAC 	PRA			16/03/2020	OJCharles			A
99	HCMV	AD169	UL54	N408D	4.2		1.9	4										Recombinant Phenotyping of Cytomegalovirus UL54 Mutations That Emerged during Cell Passages in the Presence of either Ganciclovir or Foscarnet	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165324/	doi.org/10.1128%2FAAC.00334-11	Recombinant BAC 	PRA	UL54	T552N	16/03/2020	OJCharles			A
100	HCMV	AD169	UL54	N408D	4.9		4.5	3.3										Recombinant Phenotyping of Cytomegalovirus UL54 Mutations That Emerged during Cell Passages in the Presence of either Ganciclovir or Foscarnet	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165324/	doi.org/10.1128%2FAAC.00334-11	Recombinant BAC 	PRA	UL54	L957F	16/03/2020	OJCharles			A
101	HCMV	AD169	UL54	T552N	1.6		0.9	5.5										Recombinant Phenotyping of Cytomegalovirus UL54 Mutations That Emerged during Cell Passages in the Presence of either Ganciclovir or Foscarnet	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165324/	doi.org/10.1128%2FAAC.00334-11	Recombinant BAC 	PRA	UL54	L957F	16/03/2020	OJCharles			A
102	HCMV	AD169	UL54	N757K	1.3		0.8	1.3										Recombinant Phenotyping of Cytomegalovirus UL54 Mutations That Emerged during Cell Passages in the Presence of either Ganciclovir or Foscarnet	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165324/	doi.org/10.1128%2FAAC.00334-11	Recombinant BAC 	PRA			16/03/2020	OJCharles			A
103	HCMV	AD169	UL54	L802M	1.7		1	2.7										Recombinant Phenotyping of Cytomegalovirus UL54 Mutations That Emerged during Cell Passages in the Presence of either Ganciclovir or Foscarnet	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165324/	doi.org/10.1128%2FAAC.00334-11	Recombinant BAC 	PRA			16/03/2020	OJCharles			A
104	HCMV	AD169	UL54	L926V	1.3		1.1	0.9										Recombinant Phenotyping of Cytomegalovirus UL54 Mutations That Emerged during Cell Passages in the Presence of either Ganciclovir or Foscarnet	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165324/	doi.org/10.1128%2FAAC.00334-11	Recombinant BAC 	PRA			16/03/2020	OJCharles			A
105	HCMV	AD169	UL54	K500N	2.4		2.4	2.7										Recombinant Phenotyping of Cytomegalovirus UL54 Mutations That Emerged during Cell Passages in the Presence of either Ganciclovir or Foscarnet	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165324/	doi.org/10.1128%2FAAC.00334-11	Recombinant BAC 	PRA	UL54	S585A	16/03/2020	OJCharles			A
106	HCMV	Susceptible Clinical Isolate	UL54	V787L	1.8		0.9	2.4										Recombinant Phenotyping of Cytomegalovirus UL54 Mutations That Emerged during Cell Passages in the Presence of either Ganciclovir or Foscarnet	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165324/	doi.org/10.1128%2FAAC.00334-11	Isolated strain	PRA			16/03/2020	OJCharles			A
107	HCMV	AD169	UL97	del590-593	4.8		1											New Reporter Cell Line To Evaluate the Sequential Emergence of Multiple Human Cytomegalovirus Mutations during In Vitro Drug Exposure	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1315956/		Lab derived mutant 	PRA			16/03/2020	OJCharles			A
108	HCMV	AD169	UL54	L545S	7.4		16	1.5										New Reporter Cell Line To Evaluate the Sequential Emergence of Multiple Human Cytomegalovirus Mutations during In Vitro Drug Exposure	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1315956/		Lab derived mutant 	PRA			16/03/2020	OJCharles			A
109	HCMV	AD169	UL54	L545S	16		6.5	1.3										New Reporter Cell Line To Evaluate the Sequential Emergence of Multiple Human Cytomegalovirus Mutations during In Vitro Drug Exposure	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1315956/		Lab derived mutant 	PRA	UL97	M460I	16/03/2020	OJCharles			A
110	HCMV	AD169	UL54	T552N	3.2		2.1	5.8										New Reporter Cell Line To Evaluate the Sequential Emergence of Multiple Human Cytomegalovirus Mutations during In Vitro Drug Exposure	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1315956/		Lab derived mutant 	PRA			16/03/2020	OJCharles			A
111	HCMV	TOWNE	UL54	L737M	1.1		2	1										Multidrug resistance conferred by novel DNA polymerase mutations in human cytomegalovirus isolates.	https://europepmc.org/article/pmc/pmc1797699	doi.org/10.1128/AAC.00633-06	Marker Transfer 	PRA			16/03/2020	OJCharles			A
112	HCMV	TOWNE	UL54	A834P	6.1		6	7.7										Multidrug resistance conferred by novel DNA polymerase mutations in human cytomegalovirus isolates.	https://europepmc.org/article/pmc/pmc1797699	doi.org/10.1128/AAC.00633-06	Marker Transfer 	PRA			16/03/2020	OJCharles			A
113	HCMV	AD169	UL54	Q229K	1.2		1	1.2										Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969548/	doi.org/10.1093/infdis/jit654	Recombinant BAC 	PRA			16/03/2020	OJCharles			A
114	HCMV	AD169	UL54	D247N	0.9		0.9	1.3										Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969548/	doi.org/10.1093/infdis/jit654	Recombinant BAC 	PRA			16/03/2020	OJCharles			A
115	HCMV	AD169	UL54	D262N	1.1		1	1.2										Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969548/	doi.org/10.1093/infdis/jit654	Recombinant BAC 	PRA			16/03/2020	OJCharles			A
116	HCMV	AD169	UL54	T271A	1		0.7	0.9										Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969548/	doi.org/10.1093/infdis/jit654	Recombinant BAC 	PRA			16/03/2020	OJCharles			A
117	HCMV	AD169	UL54	V284E	1.2		1.1	1.2										Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969548/	doi.org/10.1093/infdis/jit654	Recombinant BAC 	PRA			16/03/2020	OJCharles			A
118	HCMV	AD169	UL54	D288N	1.2		1.2	1.2										Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969548/	doi.org/10.1093/infdis/jit654	Recombinant BAC 	PRA			16/03/2020	OJCharles			A
119	HCMV	AD169	UL54	F396L	1.4		0.9	0.9										Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969548/	doi.org/10.1093/infdis/jit654	Recombinant BAC 	PRA			16/03/2020	OJCharles			A
120	HCMV	AD169	UL54	L424V	1.3		1.3	1.2										Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969548/	doi.org/10.1093/infdis/jit654	Recombinant BAC 	PRA			16/03/2020	OJCharles			A
121	HCMV	AD169	UL54	T437M	1		1	0.8										Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969548/	doi.org/10.1093/infdis/jit654	Recombinant BAC 	PRA			16/03/2020	OJCharles			A
122	HCMV	AD169	UL54	F460L	1.2		1.2	1.2										Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969548/	doi.org/10.1093/infdis/jit654	Recombinant BAC 	PRA			16/03/2020	OJCharles			A
123	HCMV	AD169	UL54	A505V	1.9		1.9	1										Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969548/	doi.org/10.1093/infdis/jit654	Recombinant BAC 	PRA			16/03/2020	OJCharles			A
124	HCMV	AD169	UL54	A543S	1		1	1										Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969548/	doi.org/10.1093/infdis/jit654	Recombinant BAC 	PRA			16/03/2020	OJCharles			A
125	HCMV	AD169	UL54	S612N	0.9		1	0.7										Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969548/	doi.org/10.1093/infdis/jit654	Recombinant BAC 	PRA			16/03/2020	OJCharles			A
126	HCMV	AD169	UL54	V654G	1.1		1.1	1.1										Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969548/	doi.org/10.1093/infdis/jit654	Recombinant BAC 	PRA			16/03/2020	OJCharles			A
127	HCMV	AD169	UL54	S660G	1		0.9	1.1										Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969548/	doi.org/10.1093/infdis/jit654	Recombinant BAC 	PRA			16/03/2020	OJCharles			A
128	HCMV	AD169	UL54	S660N	1.2		1	0.8										Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969548/	doi.org/10.1093/infdis/jit654	Recombinant BAC 	PRA			16/03/2020	OJCharles			A
129	HCMV	AD169	UL54	G667N	0.9		0.8	1										Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969548/	doi.org/10.1093/infdis/jit654	Recombinant BAC 	PRA			16/03/2020	OJCharles			A
130	HCMV	AD169	UL54	A692G	0.8		0.9	1										Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969548/	doi.org/10.1093/infdis/jit654	Recombinant BAC 	PRA			16/03/2020	OJCharles			A
131	HCMV	AD169	UL54	I726T	2		1.7	1.1										Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969548/	doi.org/10.1093/infdis/jit654	Recombinant BAC 	PRA			16/03/2020	OJCharles			A
132	HCMV	AD169	UL54	E793V	0.9		0.7	1.1										Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969548/	doi.org/10.1093/infdis/jit654	Recombinant BAC 	PRA			16/03/2020	OJCharles			A
133	HCMV	AD169	UL54	Q795P	0.9		0.9	1.1										Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969548/	doi.org/10.1093/infdis/jit654	Recombinant BAC 	PRA			16/03/2020	OJCharles			A
134	HCMV	AD169	UL54	Q795R	1		0.9	1										Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969548/	doi.org/10.1093/infdis/jit654	Recombinant BAC 	PRA			16/03/2020	OJCharles			A
135	HCMV	AD169	UL54	G841S	2.2		1.1	2.1										Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969548/	doi.org/10.1093/infdis/jit654	Recombinant BAC 	PRA			16/03/2020	OJCharles			A
136	HCMV	AD169	UL54	P859A	0.8		1	0.8										Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969548/	doi.org/10.1093/infdis/jit654	Recombinant BAC 	PRA			16/03/2020	OJCharles			A
137	HCMV	AD169	UL54	V902G	1.2		1	1										Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969548/	doi.org/10.1093/infdis/jit654	Recombinant BAC 	PRA			16/03/2020	OJCharles			A
138	HCMV	AD169	UL54	E903G	1.1		1	0.9										Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969548/	doi.org/10.1093/infdis/jit654	Recombinant BAC 	PRA			16/03/2020	OJCharles			A
139	HCMV	AD169	UL54	K947E	1		1	1.1										Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969548/	doi.org/10.1093/infdis/jit654	Recombinant BAC 	PRA			16/03/2020	OJCharles			A
140	HCMV	AD169	UL54	M959T	1.2		0.9	1.2										Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969548/	doi.org/10.1093/infdis/jit654	Recombinant BAC 	PRA			16/03/2020	OJCharles			A
141	HCMV	AD169	UL54	N345S	1.2		0.7	0.9										Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969548/	doi.org/10.1093/infdis/jit654	Recombinant BAC 	PRA			16/03/2020	OJCharles			A
142	HCMV	AD169	UL54	V476G	0.9		0.8	0.4										Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969548/	doi.org/10.1093/infdis/jit654	Recombinant BAC 	PRA			16/03/2020	OJCharles			A
143	HCMV	AD169	UL54	Q578L	1.9		0.8	3										Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969548/	doi.org/10.1093/infdis/jit654	Recombinant BAC 	PRA			16/03/2020	OJCharles			A
144	HCMV		UL97	D605E	Polymorphism													Rev. Med. Virol. 2016; 26: 161-182			Lab derived mutant 	PRA or SEAP			17/11/2019	OJCharles	Typo?		O
148	HCMV		UL97	L405P	2.5													Recombinant Phenotyping of Cytomegalovirus UL97 Kinase Sequence Variants for Ganciclovir Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876423/	doi.org/10.1128/AAC.00186-10	Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
149	HCMV		UL97	D456N	12													Rev. Med. Virol. 2016; 26: 161-182			Lab derived mutant 	PRA or SEAP			17/11/2019	OJCharles	Review value does not match reference		O
150	HCMV	Clinical Isolate	UL97	M460I	2.2		1	1										Analysis and Characterization of Antiviral Drug–Resistant Cytomegalovirus Isolates from Solid Organ Transplant Recipients	https://academic.oup.com/jid/article/186/6/760/2191110	doi.org/10.1086/342844	Isolated strain 	PRA			07/08/2023	OJCharles			A
151	HCMV	AD169	UL97	M460T	9.3													Recombinant Phenotyping of Cytomegalovirus UL97 Kinase Sequence Variants for Ganciclovir Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876423/	doi.org/10.1128/AAC.00186-10	Recombinant BAC 	SEAP			17/11/2019	OJCharles		AD169	A
152	HCMV	AD169	UL97	M460V	8.3													Recombinant Phenotyping of Cytomegalovirus UL97 Kinase Sequence Variants for Ganciclovir Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876423/	doi.org/10.1128/AAC.00186-10	Recombinant BAC 	SEAP			17/11/2019	OJCharles		AD169	A
153	HCMV		UL97	V466G	3.5													Incidence and characterization of cytomegalovirus resistance mutations among pediatric solid organ transplant patients who received valganciclovir prophylaxis	https://www.sciencedirect.com/science/article/abs/pii/S1386653210000181	doi.org/10.1016/j.jcv.2010.01.009	Recombinant BAC 	PRA			17/11/2019	OJCharles			A
155	HCMV	AD169	UL97	C518Y	12													A new mutation in the human cytomegalovirus UL97 gene may confer ganciclovir resistance in Chinese kidney transplant recipients	https://link.springer.com/article/10.1007/s00705-012-1479-4	doi.org/10.1007/s00705-012-1479-4	Marker Transfer	PRA			17/11/2019	OJCharles		AD169	A
161	HCMV	Towne	UL97	A591V	1.3													Cytomegalovirus UL97 Phosphotransferase Mutations That Affect Susceptibility to Ganciclovir	https://academic.oup.com/jid/article/185/2/162/2191141	doi.org/10.1086/338362	Marker Transfer 	PRA			17/11/2019	OJCharles		Towne	A
164	HCMV	AD169	UL97	C592G	4.05													Recombinant Phenotyping of Cytomegalovirus UL97 Kinase Sequence Variants for Ganciclovir Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876423/	doi.org/10.1128/AAC.00186-10	Recombinant BAC 	SEAP			17/11/2019	OJCharles		AD169	A
165	HCMV	AD169	UL97	A594E	3													Recombinant Phenotyping of Cytomegalovirus UL97 Kinase Sequence Variants for Ganciclovir Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876423/	doi.org/10.1128/AAC.00186-10	Recombinant BAC 	SEAP			17/11/2019	OJCharles		AD169	A
166	HCMV	AD169	UL97	A594G	13.5													"Value of a ligase chain reaction assay for detection of
ganciclovir resistance-related mutation 594 in UL97 gene of
human cytomegalovirus"	https://linkinghub.elsevier.com/retrieve/pii/S0166-0934(97)00093-1	doi.org/10.1016/S0166-0934(97)00093-1	Marker Transfer	PRA			17/11/2019	OJCharles		AD169	A
168	HCMV	Towne	UL97	A594T	2.7													Cytomegalovirus UL97 Phosphotransferase Mutations That Affect Susceptibility to Ganciclovir	https://academic.oup.com/jid/article/185/2/162/2191141	doi.org/10.1086/338362	Marker Transfer 	PRA			17/11/2019	OJCharles		Towne	A
169	HCMV	AD169	UL97	A594V	6.4													Characterization of Multiple Cytomegalovirus Drug Resistance Mutations Detected in a Hematopoietic Stem Cell Transplant Recipient by Recombinant Phenotyping	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313248/	doi.org/10.1128%2FJCM.02205-14	Recombinant BAC 	GLuc reporter assay			23/11/2020	OJCharles			A
170	HCMV	AD169	UL97	L595F	11.4													Characterization of Multiple Cytomegalovirus Drug Resistance Mutations Detected in a Hematopoietic Stem Cell Transplant Recipient by Recombinant Phenotyping	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313248/	doi.org/10.1128%2FJCM.02205-14	Recombinant BAC 	GLuc reporter assay			23/11/2020	OJCharles			A
171	HCMV		UL97	L595S	5.5													Mutations in human cytomegalovirus UL97 gene confer clinical resistance to ganciclovir and can be detected directly in patient plasma	https://www.jci.org/articles/view/117648	doi.org/10.1172/jci117648	Isolated strain 	PRA			17/11/2019	OJCharles			A
172	HCMV	Towne	UL97	L595W	5.1													Cytomegalovirus UL97 Phosphotransferase Mutations That Affect Susceptibility to Ganciclovir	https://academic.oup.com/jid/article/185/2/162/2191141	doi.org/10.1086/338362	Marker Transfer 	PRA			17/11/2019	OJCharles		Towne	A
174	HCMV	Towne	UL97	del595-603	8.4													A Nine-Codon Deletion Mutation in the Cytomegalovirus UL97 Phosphotransferase Gene Confers Resistance to Ganciclovir	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC89650	doi.org/10.1128/aac.44.1.183-185.2000	Marker Transfer 	PRA			17/11/2019	OJCharles		Towne	A
176	HCMV	Towne	UL97	E596G	2.3													Cytomegalovirus UL97 Phosphotransferase Mutations That Affect Susceptibility to Ganciclovir	https://academic.oup.com/jid/article/185/2/162/2191141	doi.org/10.1086/338362	Marker Transfer 	PRA			17/11/2019	OJCharles		Towne	A
177	HCMV	TB40	UL97	E596Y	6.4													Identification of newly detected, drug-related HCMV UL97- and UL54-mutations using a modified plaque reduction assay	https://www.sciencedirect.com/science/article/abs/pii/S1386653215002759	doi.org/10.1016/j.jcv.2015.06.090	Recombinant BAC	PRA			17/11/2019	OJCharles		TB40	A
180	HCMV	Clinical Isolate	UL97	K599T	5.3													Genetic analysis of a ganciclovir-resistant human cytomegalovirus mutant	https://www.sciencedirect.com/science/article/abs/pii/S0166354298000515	https://doi.org/10.1016/S0166-3542(98)00051-5	Isolated strain 	PRA			17/11/2019	OJCharles		AD169	A
181	HCMV	Towne	UL97	del600	1.9													Cytomegalovirus UL97 Phosphotransferase Mutations That Affect Susceptibility to Ganciclovir	https://academic.oup.com/jid/article/185/2/162/2191141	doi.org/10.1086/338362	Marker Transfer 	PRA			17/11/2019	OJCharles		Towne	A
183	HCMV		UL97	C603R	3.6													Rev. Med. Virol. 2016; 26: 161-182			Lab derived mutant 	PRA or SEAP			17/11/2019	OJCharles	Review value does not match reference ref51 has no useable data ref61 is in here with a different ratio and ref65 has a different ratio too with an unusable datapoint		O
184	HCMV	AD169	UL97	C603S	1.9													Recombinant Phenotyping of Cytomegalovirus UL97 Kinase Sequence Variants for Ganciclovir Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876423/	doi.org/10.1128/AAC.00186-10	Recombinant BAC 	SEAP			17/11/2019	OJCharles		AD169	A
185	HCMV	AD169	UL97	C603W	7.9													Recombinant Phenotyping of Cytomegalovirus UL97 Kinase Sequence Variants for Ganciclovir Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876423/	doi.org/10.1128/AAC.00186-10	Recombinant BAC 	SEAP			17/11/2019	OJCharles		AD169	A
186	HCMV		UL97	C607F	1.9													Rev. Med. Virol. 2016; 26: 161-182			Lab derived mutant 	PRA or SEAP			17/11/2019	OJCharles	Cannot find value 1.9 in references ref72 does no tests ref77 no tests. Following ref trail leads to nowhere concrete		O
187	HCMV		UL97	C607Y	12.5													The Cys607→Tyr Change in the UL97 Phosphotransferase Confers Ganciclovir Resistance to Two Human Cytomegalovirus Strains Recovered from Two Immunocompromised Patients	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC105432/	doi.org/10.1128%2Faac.42.2.444	Marker Transfer	PRA			17/11/2019	OJCharles		AD169	A
188	HCMV		UL97	I610T	2.8													Rev. Med. Virol. 2016; 26: 161-182			Lab derived mutant 	PRA or SEAP			17/11/2019	OJCharles	typ0 2.8 should be 2.6?		O
189	HCMV	TB40	UL97	A613V	2.3													"Generation and characterization of a GCV resistant HCMV
UL97-mutation and a drug sensitive UL54-mutation"	https://www.sciencedirect.com/science/article/abs/pii/S0166354213002866	https://doi.org/10.1016/j.antiviral.2013.09.026	Recombinant BAC	PRA			17/11/2019	OJCharles		TB40	A
191	HCMV	AD169	UL97	E655K	1.7													Characterization of Multiple Cytomegalovirus Drug Resistance Mutations Detected in a Hematopoietic Stem Cell Transplant Recipient by Recombinant Phenotyping	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313248/	doi.org/10.1128%2FJCM.02205-14	Recombinant BAC 	GLuc reporter assay			23/11/2020	OJCharles			A
192	HCMV	AD169	UL89	D344E						1.8			1.7					Comparison of Cytomegalovirus Terminase Gene Mutations Selected after Exposure to Three Distinct Inhibitor Compounds	https://aac.asm.org/content/61/11/e01325-17	doi.org/10.1128/AAC.01325-17	Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
193	HCMV	AD169	UL89	C347S						0.6			0.3					Comparison of Cytomegalovirus Terminase Gene Mutations Selected after Exposure to Three Distinct Inhibitor Compounds	https://aac.asm.org/content/61/11/e01325-18	doi.org/10.1128/AAC.01325-17	Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
194	HCMV	AD169	UL89	R351H						0.7			0.4					Comparison of Cytomegalovirus Terminase Gene Mutations Selected after Exposure to Three Distinct Inhibitor Compounds	https://aac.asm.org/content/61/11/e01325-19	doi.org/10.1128/AAC.01325-17	Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
195	HCMV	AD169	UL56	E769D						1			0.8					Comparison of Cytomegalovirus Terminase Gene Mutations Selected after Exposure to Three Distinct Inhibitor Compounds	https://aac.asm.org/content/61/11/e01325-20	doi.org/10.1128/AAC.01325-17	Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
196	HCMV	AD169	UL56	Q204R						1.5			2.7					Comparison of Cytomegalovirus Terminase Gene Mutations Selected after Exposure to Three Distinct Inhibitor Compounds	https://aac.asm.org/content/61/11/e01325-21	doi.org/10.1128/AAC.01325-17	Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
197	HCMV	AD169	UL56	Q204R						2.5			5.8					Comparison of Cytomegalovirus Terminase Gene Mutations Selected after Exposure to Three Distinct Inhibitor Compounds	https://aac.asm.org/content/61/11/e01325-22	doi.org/10.1128/AAC.01325-17	Recombinant BAC 	SEAP	UL89	D344E	17/11/2019	OJCharles			A
198	HCMV	AD169	UL56	N232Y						17			2.7					Comparison of Cytomegalovirus Terminase Gene Mutations Selected after Exposure to Three Distinct Inhibitor Compounds	https://aac.asm.org/content/61/11/e01325-23	doi.org/10.1128/AAC.01325-17	Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
199	HCMV	AD169	UL56	K258E						14			0.3					Comparison of Cytomegalovirus Terminase Gene Mutations Selected after Exposure to Three Distinct Inhibitor Compounds	https://aac.asm.org/content/61/11/e01325-24	doi.org/10.1128/AAC.01325-17	Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
200	HCMV	AD169	UL56	F261L						2.5			1					Comparison of Cytomegalovirus Terminase Gene Mutations Selected after Exposure to Three Distinct Inhibitor Compounds	https://aac.asm.org/content/61/11/e01325-25	doi.org/10.1128/AAC.01325-17	Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
201	HCMV	AD169	UL56	F261L						4.8			2.1					Comparison of Cytomegalovirus Terminase Gene Mutations Selected after Exposure to Three Distinct Inhibitor Compounds	https://aac.asm.org/content/61/11/e01325-26	doi.org/10.1128/AAC.01325-17	Recombinant BAC 	SEAP	UL89	D344E	17/11/2019	OJCharles			A
202	HCMV	AD169	UL56	M329T						4.5			1.1					Comparison of Cytomegalovirus Terminase Gene Mutations Selected after Exposure to Three Distinct Inhibitor Compounds	https://aac.asm.org/content/61/11/e01325-27	doi.org/10.1128/AAC.01325-17	Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
203	HCMV	AD169	UL56	M329T						8			2.2					Comparison of Cytomegalovirus Terminase Gene Mutations Selected after Exposure to Three Distinct Inhibitor Compounds	https://aac.asm.org/content/61/11/e01325-28	doi.org/10.1128/AAC.01325-17	Recombinant BAC 	SEAP	UL89	D344E	17/11/2019	OJCharles			A
204	HCMV	AD169	UL56	E237D						16			0.3					Comparison of Cytomegalovirus Terminase Gene Mutations Selected after Exposure to Three Distinct Inhibitor Compounds	https://aac.asm.org/content/61/11/e01325-29	doi.org/10.1128/AAC.01325-17	Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
205	HCMV	AD169	UL56	E237D						34			0.6					Comparison of Cytomegalovirus Terminase Gene Mutations Selected after Exposure to Three Distinct Inhibitor Compounds	https://aac.asm.org/content/61/11/e01325-30	doi.org/10.1128/AAC.01325-17	Recombinant BAC 	SEAP	UL89	D344E	17/11/2019	OJCharles			A
206	HCMV	AD169	UL89	N320H						1.8			6.5					Comparison of Cytomegalovirus Terminase Gene Mutations Selected after Exposure to Three Distinct Inhibitor Compounds	https://aac.asm.org/content/61/11/e01325-31	doi.org/10.1128/AAC.01325-17	Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
207	HCMV	AD169	UL89	M359I						1.5			7.4					Comparison of Cytomegalovirus Terminase Gene Mutations Selected after Exposure to Three Distinct Inhibitor Compounds	https://aac.asm.org/content/61/11/e01325-32	doi.org/10.1128/AAC.01325-17	Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
208	HCMV	AD169	UL89	I334V						1.1			0.9					Comparison of Cytomegalovirus Terminase Gene Mutations Selected after Exposure to Three Distinct Inhibitor Compounds	https://aac.asm.org/content/61/11/e01325-33	doi.org/10.1128/AAC.01325-17	Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
209	HCMV	AD169	UL89	N329S						2			15					Comparison of Cytomegalovirus Terminase Gene Mutations Selected after Exposure to Three Distinct Inhibitor Compounds	https://aac.asm.org/content/61/11/e01325-34	doi.org/10.1128/AAC.01325-17	Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
210	HCMV	AD169	UL89	T350M						2.8			8.7					Comparison of Cytomegalovirus Terminase Gene Mutations Selected after Exposure to Three Distinct Inhibitor Compounds	https://aac.asm.org/content/61/11/e01325-35	doi.org/10.1128/AAC.01325-17	Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
211	HCMV	AD169	UL89	V362M						1.2			98					Comparison of Cytomegalovirus Terminase Gene Mutations Selected after Exposure to Three Distinct Inhibitor Compounds	https://aac.asm.org/content/61/11/e01325-36	doi.org/10.1128/AAC.01325-17	Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
212	HCMV	AD169	UL89	H389N						1.1			29					Comparison of Cytomegalovirus Terminase Gene Mutations Selected after Exposure to Three Distinct Inhibitor Compounds	https://aac.asm.org/content/61/11/e01325-37	doi.org/10.1128/AAC.01325-17	Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
213	HCMV	AD169	UL89	N405D						1			15					Comparison of Cytomegalovirus Terminase Gene Mutations Selected after Exposure to Three Distinct Inhibitor Compounds	https://aac.asm.org/content/61/11/e01325-38	doi.org/10.1128/AAC.01325-17	Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
214	HCMV	AD169	UL89	I334V						1.2			12					Comparison of Cytomegalovirus Terminase Gene Mutations Selected after Exposure to Three Distinct Inhibitor Compounds	https://aac.asm.org/content/61/11/e01325-39	doi.org/10.1128/AAC.01325-17	Recombinant BAC 	SEAP	UL89	N405D	17/11/2019	OJCharles			A
215	HCMV	AD169	UL56	L208M						0.8			3.4					Comparison of Cytomegalovirus Terminase Gene Mutations Selected after Exposure to Three Distinct Inhibitor Compounds	https://aac.asm.org/content/61/11/e01325-40	doi.org/10.1128/AAC.01325-17	Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
216	HCMV	AD169	UL56	E407D						1.3			6					Comparison of Cytomegalovirus Terminase Gene Mutations Selected after Exposure to Three Distinct Inhibitor Compounds	https://aac.asm.org/content/61/11/e01325-41	doi.org/10.1128/AAC.01325-17	Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
217	HCMV	AD169	UL56	H637Q						0.9			2					Comparison of Cytomegalovirus Terminase Gene Mutations Selected after Exposure to Three Distinct Inhibitor Compounds	https://aac.asm.org/content/61/11/e01325-42	doi.org/10.1128/AAC.01325-17	Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
218	HCMV	AD169	UL56	V639M						1			10					Comparison of Cytomegalovirus Terminase Gene Mutations Selected after Exposure to Three Distinct Inhibitor Compounds	https://aac.asm.org/content/61/11/e01325-43	doi.org/10.1128/AAC.01325-17	Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
219	HCMV	AD169	UL56	H637Q						1.2			17					Comparison of Cytomegalovirus Terminase Gene Mutations Selected after Exposure to Three Distinct Inhibitor Compounds	https://aac.asm.org/content/61/11/e01325-44	doi.org/10.1128/AAC.01325-17	Recombinant BAC 	SEAP	UL56	V639M	17/11/2019	OJCharles			A
220	HCMV	AD169	UL56	L764M						1.1			0.4					Comparison of Cytomegalovirus Terminase Gene Mutations Selected after Exposure to Three Distinct Inhibitor Compounds	https://aac.asm.org/content/61/11/e01325-45	doi.org/10.1128/AAC.01325-17	Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
221	HCMV	AD169	UL54	del981-982	7.3		3.8	3.1										New Locus of Drug Resistance in the Human Cytomegalovirus UL56 Gene Revealed by In Vitro Exposure to Letermovir and Ganciclovir	https://aac.asm.org/content/aac/62/9/e00922-18.full.pdf	doi.org/10.1128/AAC.00922-18	Recombinant BAC 	SEAP			16/03/2020	OJCharles		AD169	A
222	HCMV	AD169	UL56	C25F						5.4								New Locus of Drug Resistance in the Human Cytomegalovirus UL56 Gene Revealed by In Vitro Exposure to Letermovir and Ganciclovir	https://aac.asm.org/content/aac/62/9/e00922-18.full.pdf	doi.org/10.1128/AAC.00922-18	Recombinant BAC 	SEAP			17/11/2019	OJCharles		AD169	A
223	HCMV	AD169	UL56	L51M						0.8								Rapid In Vitro Evolution of Human Cytomegalovirus UL56 Mutations That Confer Letermovir Resistance	https://aac.asm.org/content/aac/59/10/6588.full.pdf		Recombinant BAC 	SEAP			16/03/2020	OJCharles			A
224	HCMV	AD169	UL56	S229F						1.8								A third component of the human cytomegalovirus terminase complex is involved in letermovir resistance	https://www.sciencedirect.com/science/article/pii/S0166354217306393	doi.org/10.1016/j.antiviral.2017.10.019	Recombinant BAC 	SEAP			17/11/2019	OJCharles		AD169	A
225	HCMV	AD169	UL56	V231A						2.1								Rapid In Vitro Evolution of Human Cytomegalovirus UL56 Mutations That Confer Letermovir Resistance	https://aac.asm.org/content/aac/59/10/6588.full.pdf		Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
226	HCMV	AD169	UL56	V231L						5.1								Rapid In Vitro Evolution of Human Cytomegalovirus UL56 Mutations That Confer Letermovir Resistance	https://aac.asm.org/content/aac/59/10/6588.full.pdf		Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
227	HCMV		UL56	N232Y						17								Comparison of Cytomegalovirus Terminase Gene Mutations Selected after Exposure to Three Distinct Inhibitor Compounds	https://aac.asm.org/content/61/11/e01325-17.short	doi.org/10.1128/AAC.01325-17	Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
228	HCMV	AD169	UL56	V236A						2.9								New Locus of Drug Resistance in the Human Cytomegalovirus UL56 Gene Revealed by In Vitro Exposure to Letermovir and Ganciclovir	https://aac.asm.org/content/aac/62/9/e00922-18.full.pdf	doi.org/10.1128/AAC.00922-18	Recombinant BAC 	SEAP			17/11/2019	OJCharles		AD169	A
229	HCMV	AD169	UL56	V236L						14								Rapid In Vitro Evolution of Human Cytomegalovirus UL56 Mutations That Confer Letermovir Resistance	https://aac.asm.org/content/aac/59/10/6588.full.pdf		Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
230	HCMV	AD169	UL56	V236M						32								A third component of the human cytomegalovirus terminase complex is involved in letermovir resistance	https://www.sciencedirect.com/science/article/pii/S0166354217306393	doi.org/10.1016/j.antiviral.2017.10.019	Recombinant BAC 	SEAP			17/11/2019	OJCharles		AD169	A
231	HCMV	AD169	UL56	E237D						10								Rapid In Vitro Evolution of Human Cytomegalovirus UL56 Mutations That Confer Letermovir Resistance	https://aac.asm.org/content/aac/59/10/6588.full.pdf		Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
232	HCMV	AD169	UL56	L241P						96								Rapid In Vitro Evolution of Human Cytomegalovirus UL56 Mutations That Confer Letermovir Resistance	https://aac.asm.org/content/aac/59/10/6588.full.pdf		Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
233	HCMV	AD169	UL56	T244K						3.3								Rapid In Vitro Evolution of Human Cytomegalovirus UL56 Mutations That Confer Letermovir Resistance	https://aac.asm.org/content/aac/59/10/6588.full.pdf		Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
234	HCMV		UL56	L254F						3.2								A third component of the human cytomegalovirus terminase complex is involved in letermovir resistance	https://www.sciencedirect.com/science/article/pii/S0166354217306393	doi.org/10.1016/j.antiviral.2017.10.019	Recombinant BAC 	SEAP			17/11/2019	OJCharles		AD169	A
235	HCMV	AD169	UL56	L257F						8.6								A third component of the human cytomegalovirus terminase complex is involved in letermovir resistance	https://www.sciencedirect.com/science/article/pii/S0166354217306393	doi.org/10.1016/j.antiviral.2017.10.019	Recombinant BAC 	SEAP			17/11/2019	OJCharles		AD169	A
236	HCMV	AD169	UL56	L257I						4.9								Rapid In Vitro Evolution of Human Cytomegalovirus UL56 Mutations That Confer Letermovir Resistance	https://aac.asm.org/content/aac/59/10/6588.full.pdf		Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
238	HCMV	AD169	UL56	F261C						4.4								Rapid In Vitro Evolution of Human Cytomegalovirus UL56 Mutations That Confer Letermovir Resistance	https://aac.asm.org/content/aac/59/10/6588.full.pdf		Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
239	HCMV	AD169	UL56	F261L						2.8								Rapid In Vitro Evolution of Human Cytomegalovirus UL56 Mutations That Confer Letermovir Resistance	https://aac.asm.org/content/aac/59/10/6588.full.pdf		Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
240	HCMV	AD169	UL56	Y321C						4.6								Rapid In Vitro Evolution of Human Cytomegalovirus UL56 Mutations That Confer Letermovir Resistance	https://aac.asm.org/content/aac/59/10/6588.full.pdf		Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
241	HCMV	AD169	UL56	C325F						3000								Rapid In Vitro Evolution of Human Cytomegalovirus UL56 Mutations That Confer Letermovir Resistance	https://aac.asm.org/content/aac/59/10/6588.full.pdf		Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
242	HCMV	AD169	UL56	C325R						3000								Rapid In Vitro Evolution of Human Cytomegalovirus UL56 Mutations That Confer Letermovir Resistance	https://aac.asm.org/content/aac/59/10/6588.full.pdf		Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
243	HCMV	AD169	UL56	C325Y						3000								Rapid In Vitro Evolution of Human Cytomegalovirus UL56 Mutations That Confer Letermovir Resistance	https://aac.asm.org/content/aac/59/10/6588.full.pdf		Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
244	HCMV	AD169	UL56	C325W						9300								New Locus of Drug Resistance in the Human Cytomegalovirus UL56 Gene Revealed by In Vitro Exposure to Letermovir and Ganciclovir	https://aac.asm.org/content/aac/62/9/e00922-18.full.pdf	doi.org/10.1128/AAC.00922-18	Recombinant BAC 	SEAP			17/11/2019	OJCharles		AD169	A
245	HCMV	AD169	UL56	L328V						1.9								New Locus of Drug Resistance in the Human Cytomegalovirus UL56 Gene Revealed by In Vitro Exposure to Letermovir and Ganciclovir	https://aac.asm.org/content/aac/62/9/e00922-18.full.pdf	doi.org/10.1128/AAC.00922-18	Recombinant BAC 	SEAP			17/11/2019	OJCharles		AD169	A
246	HCMV	AD169	UL56	M329T						4.4								Rapid In Vitro Evolution of Human Cytomegalovirus UL56 Mutations That Confer Letermovir Resistance	https://aac.asm.org/content/aac/59/10/6588.full.pdf		Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
247	HCMV	AD169	UL56	A365S						2								New Locus of Drug Resistance in the Human Cytomegalovirus UL56 Gene Revealed by In Vitro Exposure to Letermovir and Ganciclovir	https://aac.asm.org/content/aac/62/9/e00922-18.full.pdf	doi.org/10.1128/AAC.00922-18	Recombinant BAC 	SEAP			17/11/2019	OJCharles		AD169	A
248	HCMV	AD169	UL56	N368D						2								A third component of the human cytomegalovirus terminase complex is involved in letermovir resistance	https://www.sciencedirect.com/science/article/pii/S0166354217306393	doi.org/10.1016/j.antiviral.2017.10.019	Recombinant BAC 	SEAP			17/11/2019	OJCharles		AD169	A
249	HCMV	AD169	UL56	V231L						5								Geno- and Phenotypic Characterization of Human Cytomegalovirus Mutants Selected In Vitro after Letermovir (AIC246) Exposure	https://aac.asm.org/content/aac/58/1/610.full.pdf		Recombinant BAC 	GFP fluorescence reduction assay			17/11/2019	OJCharles			A
250	HCMV	AD169	UL56	L241P						218								Geno- and Phenotypic Characterization of Human Cytomegalovirus Mutants Selected In Vitro after Letermovir (AIC246) Exposure	https://aac.asm.org/content/aac/58/1/610.full.pdf		Recombinant BAC 	GFP fluorescence reduction assay			17/11/2019	OJCharles			A
251	HCMV	AD169	UL56	V236M						45								Geno- and Phenotypic Characterization of Human Cytomegalovirus Mutants Selected In Vitro after Letermovir (AIC246) Exposure	https://aac.asm.org/content/aac/58/1/610.full.pdf		Recombinant BAC 	GFP fluorescence reduction assay			17/11/2019	OJCharles			A
252	HCMV	AD169	UL56	R369G						44								Geno- and Phenotypic Characterization of Human Cytomegalovirus Mutants Selected In Vitro after Letermovir (AIC246) Exposure	https://aac.asm.org/content/aac/58/1/610.full.pdf		Recombinant BAC 	GFP fluorescence reduction assay			17/11/2019	OJCharles			A
253	HCMV	AD169	UL56	R369M						13								Geno- and Phenotypic Characterization of Human Cytomegalovirus Mutants Selected In Vitro after Letermovir (AIC246) Exposure	https://aac.asm.org/content/aac/58/1/610.full.pdf		Recombinant BAC 	GFP fluorescence reduction assay			17/11/2019	OJCharles			A
254	HCMV	AD169	UL56	R369S						48								Geno- and Phenotypic Characterization of Human Cytomegalovirus Mutants Selected In Vitro after Letermovir (AIC246) Exposure	https://aac.asm.org/content/aac/58/1/610.full.pdf		Recombinant BAC 	GFP fluorescence reduction assay			17/11/2019	OJCharles			A
255	HCMV	AD169	UL56	C25F						46								New Locus of Drug Resistance in the Human Cytomegalovirus UL56 Gene Revealed by In Vitro Exposure to Letermovir and Ganciclovir	https://aac.asm.org/content/aac/62/9/e00922-18.full.pdf	doi.org/10.1128/AAC.00922-18	Recombinant BAC 	SEAP	UL56	V231L	17/11/2019	OJCharles		AD169	A
256	HCMV	AD169	UL56	T244K						8.2								Rapid In Vitro Evolution of Human Cytomegalovirus UL56 Mutations That Confer Letermovir Resistance	https://aac.asm.org/content/aac/59/10/6588.full.pdf		Recombinant BAC 	SEAP	UL56	F261L	17/11/2019	OJCharles			A
257	HCMV	AD169	UL56	E237D						104								Rapid In Vitro Evolution of Human Cytomegalovirus UL56 Mutations That Confer Letermovir Resistance	https://aac.asm.org/content/aac/59/10/6588.full.pdf		Recombinant BAC 	SEAP	UL56	T244K; F261L	17/11/2019	OJCharles			A
258	HCMV	AD169	UL56	V236L						260								Rapid In Vitro Evolution of Human Cytomegalovirus UL56 Mutations That Confer Letermovir Resistance	https://aac.asm.org/content/aac/59/10/6588.full.pdf		Recombinant BAC 	SEAP	UL56	L257I	17/11/2019	OJCharles			A
259	HCMV	AD169	UL56	V236M						3000								Rapid In Vitro Evolution of Human Cytomegalovirus UL56 Mutations That Confer Letermovir Resistance	https://aac.asm.org/content/aac/59/10/6588.full.pdf		Recombinant BAC 	SEAP	UL56	L257I; M329T	17/11/2019	OJCharles			A
260	HCMV	AD169	UL56	S229F						54								A third component of the human cytomegalovirus terminase complex is involved in letermovir resistance	https://www.sciencedirect.com/science/article/pii/S0166354217306393	doi.org/10.1016/j.antiviral.2017.10.019	Recombinant BAC 	SEAP	UL56	L254F; L257I	17/11/2019	OJCharles		AD169	A
265	HCMV	AD169	UL56	E237D						34								A third component of the human cytomegalovirus terminase complex is involved in letermovir resistance	https://www.sciencedirect.com/science/article/pii/S0166354217306393	doi.org/10.1016/j.antiviral.2017.10.019	Recombinant BAC 	SEAP	UL89	D344E	17/11/2019	OJCharles		AD169	A
266	HCMV	AD169	UL56	F261L						4.8								A third component of the human cytomegalovirus terminase complex is involved in letermovir resistance	https://www.sciencedirect.com/science/article/pii/S0166354217306393	doi.org/10.1016/j.antiviral.2017.10.019	Recombinant BAC 	SEAP	UL89	D344E	17/11/2019	OJCharles		AD169	A
267	HCMV	AD169	UL56	M329T						8								A third component of the human cytomegalovirus terminase complex is involved in letermovir resistance	https://www.sciencedirect.com/science/article/pii/S0166354217306393	doi.org/10.1016/j.antiviral.2017.10.019	Recombinant BAC 	SEAP	UL89	D344E	17/11/2019	OJCharles		AD169	A
268	HCMV	AD169	UL56	Q204R						2.5								A third component of the human cytomegalovirus terminase complex is involved in letermovir resistance	https://www.sciencedirect.com/science/article/pii/S0166354217306393	doi.org/10.1016/j.antiviral.2017.10.019	Recombinant BAC 	SEAP	UL89	D344E	17/11/2019	OJCharles		AD169	A
269	HCMV	AD169	UL51	P91S						2.1								A third component of the human cytomegalovirus terminase complex is involved in letermovir resistance	https://www.sciencedirect.com/science/article/pii/S0166354217306393	doi.org/10.1016/j.antiviral.2017.10.019	Recombinant BAC 	SEAP			17/11/2019	OJCharles		AD169	A
270	HCMV	AD169	UL51	P91S						6.3								A third component of the human cytomegalovirus terminase complex is involved in letermovir resistance	https://www.sciencedirect.com/science/article/pii/S0166354217306393	doi.org/10.1016/j.antiviral.2017.10.019	Recombinant BAC 	SEAP	UL56	S229F	17/11/2019	OJCharles		AD169	A
271	HCMV	AD169	UL51	P91S						28								A third component of the human cytomegalovirus terminase complex is involved in letermovir resistance	https://www.sciencedirect.com/science/article/pii/S0166354217306393	doi.org/10.1016/j.antiviral.2017.10.019	Recombinant BAC 	SEAP	UL56	V236M	17/11/2019	OJCharles		AD169	A
272	HCMV	AD169	UL51	P91S						126								A third component of the human cytomegalovirus terminase complex is involved in letermovir resistance	https://www.sciencedirect.com/science/article/pii/S0166354217306393	doi.org/10.1016/j.antiviral.2017.10.019	Recombinant BAC 	SEAP	UL56	R369M	17/11/2019	OJCharles		AD169	A
273	HCMV	AD169	UL51	P91S						4								A third component of the human cytomegalovirus terminase complex is involved in letermovir resistance	https://www.sciencedirect.com/science/article/pii/S0166354217306393	doi.org/10.1016/j.antiviral.2017.10.019	Recombinant BAC 	SEAP	UL89	D344E	17/11/2019	OJCharles		AD169	A
274	HCMV	AD169	UL97	L337M	1									3.5				Effects on maribavir susceptibility of cytomegalovirus UL97 kinase ATP binding region mutations detected after drug exposure in vitro and in vivo	https://www.sciencedirect.com/science/article/pii/S0166354212001283	doi.org/10.1016/j.antiviral.2012.05.013	Recombinant BAC 	SEAP			17/11/2019	OJCharles		AD169	A
275	HCMV	AD169	UL97	F342S	7.8		17							18				Cytomegalovirus UL97 Kinase Catalytic Domain Mutations That Confer Multidrug Resistance	https://aac.asm.org/content/aac/57/7/3375.full.pdf		Recombinant BAC 	SEAP			17/11/2019	OJCharles		AD169	A
276	HCMV		UL97	V353A	1									14				Cytomegalovirus UL97 Kinase Mutations That Confer Maribavir Resistance	https://academic.oup.com/jid/article/196/1/91/844651	doi.org/10.1086/518514	Marker Transfer 	SEAP			17/11/2019	OJCharles		AD169	A
277	HCMV	AD169	UL97	del355	16		23							304				Cytomegalovirus UL97 Kinase Catalytic Domain Mutations That Confer Multidrug Resistance	https://aac.asm.org/content/aac/57/7/3375.full.pdf		Recombinant BAC 	SEAP			17/11/2019	OJCharles		AD169	A
278	HCMV	AD169	UL97	V356G	5.5		7							108				Cytomegalovirus UL97 Kinase Catalytic Domain Mutations That Confer Multidrug Resistance	https://aac.asm.org/content/aac/57/7/3375.full.pdf		Recombinant BAC 	SEAP			17/11/2019	OJCharles		AD169	A
279	HCMV	AD169	UL97	L397R	1.5									200				Cytomegalovirus UL97 Kinase Mutations That Confer Maribavir Resistance	https://academic.oup.com/jid/article-lookup/doi/10.1086/518514	doi.org/10.1086/518514	Marker Transfer 	SEAP			17/11/2019	OJCharles			A
280	HCMV	AD169	UL97	T409M	0.9									81				Cytomegalovirus UL97 Kinase Mutations That Confer Maribavir Resistance	https://academic.oup.com/jid/article/196/1/91/844651	doi.org/10.1086/518514	Marker Transfer 	SEAP			17/11/2019	OJCharles		AD169	A
281	HCMV	AD169	UL97	H411L	0.7									69				Accelerated Evolution of Maribavir Resistance in a Cytomegalovirus Exonuclease Domain II Mutant	https://jvi.asm.org/content/82/1/246.short	doi.org/10.1128/JVI.01787-07	Marker transfer	SEAP			17/11/2019	OJCharles		AD169	A
282	HCMV	AD169	UL97	H411N	1									9				Accelerated Evolution of Maribavir Resistance in a Cytomegalovirus Exonuclease Domain II Mutant	https://jvi.asm.org/content/82/1/246.short	doi.org/10.1128/JVI.01787-07	Marker transfer	SEAP			17/11/2019	OJCharles		AD169	A
283	HCMV	AD169	UL97	H411Y	0.5									12				Accelerated Evolution of Maribavir Resistance in a Cytomegalovirus Exonuclease Domain II Mutant	https://jvi.asm.org/content/82/1/246.short	doi.org/10.1128/JVI.01787-07	Marker transfer	SEAP			17/11/2019	OJCharles		AD169	A
284	HCMV	AD169	UL97	D456N	12									278	4.6			Human Cytomegalovirus UL97 Kinase Is Involved in the Mechanism of Action of Methylenecyclopropane Analogs with 6-Ether and -Thioether Substitutions	https://journals.asm.org/doi/full/10.1128/aac.01726-13	doi.org/10.1128/aac.01726-13	Recombinant BAC 	SEAP			17/11/2019	OJCharles		AD169	A
285	HCMV	AD169	UL97	V466G	11		17							321				Cytomegalovirus UL97 Kinase Catalytic Domain Mutations That Confer Multidrug Resistance	https://aac.asm.org/content/aac/57/7/3375.full.pdf		Recombinant BAC 	SEAP			17/11/2019	OJCharles		AD169	A
286	HCMV	AD169	UL97	C480R	9									243	9			Human Cytomegalovirus UL97 Kinase Is Involved in the Mechanism of Action of Methylenecyclopropane Analogs with 6-Ether and -Thioether Substitutions	https://journals.asm.org/doi/full/10.1128/aac.01726-13	doi.org/10.1128/aac.01726-13	Lab derived mutant 	PRA or SEAP			17/11/2019	OJCharles		AD169	A
287	HCMV	AD169	UL97	P521L	17		20							445				Cytomegalovirus UL97 Kinase Catalytic Domain Mutations That Confer Multidrug Resistance	https://aac.asm.org/content/aac/57/7/3375.full.pdf		Recombinant BAC 	SEAP			17/11/2019	OJCharles		AD169	A
288	HCMV	AD169	UL97	del617	10									372	22			Human Cytomegalovirus UL97 Kinase Is Involved in the Mechanism of Action of Methylenecyclopropane Analogs with 6-Ether and -Thioether Substitutions	https://journals.asm.org/doi/full/10.1128/aac.01726-13	doi.org/10.1128/aac.01726-13	Lab derived mutant 	PRA or SEAP			17/11/2019	OJCharles		AD169	A
289	HCMV	AD169	UL97	V353A	1									227				Accelerated Evolution of Maribavir Resistance in a Cytomegalovirus Exonuclease Domain II Mutant	https://jvi.asm.org/content/82/1/246.short	doi.org/10.1128/JVI.01787-07	Marker transfer	SEAP	UL97	H411L	17/11/2019	OJCharles		AD169	A
290	HCMV	AD169	UL97	V353A	0.7									164				Accelerated Evolution of Maribavir Resistance in a Cytomegalovirus Exonuclease Domain II Mutant	https://jvi.asm.org/content/82/1/246.short	doi.org/10.1128/JVI.01787-07	Marker transfer	SEAP	UL97	H411Y	17/11/2019	OJCharles		AD169	A
291	HCMV	AD169	UL27	E22*										2				Diverse Cytomegalovirus UL27 Mutations Adapt to Loss of Viral UL97 Kinase Activity under Maribavir	https://aac.asm.org/content/53/1/81	doi.org/10.1128/AAC.01177-08	Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
292	HCMV	AD169	UL27	W153R										1.7				Diverse Cytomegalovirus UL27 Mutations Adapt to Loss of Viral UL97 Kinase Activity under Maribavir	https://aac.asm.org/content/53/1/81	doi.org/10.1128/AAC.01177-08	Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
293	HCMV	AD169	UL27	L193F										2.6				Diverse Cytomegalovirus UL27 Mutations Adapt to Loss of Viral UL97 Kinase Activity under Maribavir	https://aac.asm.org/content/53/1/81	doi.org/10.1128/AAC.01177-08	Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
294	HCMV	AD169	UL27	del218										2.5				Diverse Cytomegalovirus UL27 Mutations Adapt to Loss of Viral UL97 Kinase Activity under Maribavir	https://aac.asm.org/content/53/1/81	doi.org/10.1128/AAC.01177-08	Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
295	HCMV	AD169	UL27	R233S										1.8				Effects on maribavir susceptibility of cytomegalovirus UL97 kinase ATP binding region mutations detected after drug exposure in vitro and in vivo	https://www.sciencedirect.com/science/article/pii/S0166354212001283	doi.org/10.1016/j.antiviral.2012.05.013	Recombinant BAC 	SEAP			17/11/2019	OJCharles		AD169	A
296	HCMV	AD169	UL27	A269T										2				Diverse Cytomegalovirus UL27 Mutations Adapt to Loss of Viral UL97 Kinase Activity under Maribavir	https://aac.asm.org/content/53/1/81	doi.org/10.1128/AAC.01177-08	Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
297	HCMV	AD169	UL27	del301-311										3.1				Diverse Cytomegalovirus UL27 Mutations Adapt to Loss of Viral UL97 Kinase Activity under Maribavir	https://aac.asm.org/content/53/1/81	doi.org/10.1128/AAC.01177-08	Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
298	HCMV	Clinical Isolate	UL27	L335P	1.2									23				Resistance of Human Cytomegalovirus to the Benzimidazole l-Ribonucleoside Maribavir Maps to UL27	https://journals.asm.org/doi/full/10.1128/jvi.77.21.11499-11506.2003#T1	doi.org/10.1128/jvi.77.21.11499-11506.2003	Lab derived mutant 	PRA			17/11/2019	OJCharles		Towne	A
299	HCMV	AD169	UL27	V353E										2.1				Diverse Cytomegalovirus UL27 Mutations Adapt to Loss of Viral UL97 Kinase Activity under Maribavir	https://aac.asm.org/content/53/1/81	doi.org/10.1128/AAC.01177-08	Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
300	HCMV	AD169	UL27	W362R										1.9				Diverse Cytomegalovirus UL27 Mutations Adapt to Loss of Viral UL97 Kinase Activity under Maribavir	https://aac.asm.org/content/53/1/81	doi.org/10.1128/AAC.01177-08	Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
301	HCMV	AD169	UL27	W362*										2.2				Diverse Cytomegalovirus UL27 Mutations Adapt to Loss of Viral UL97 Kinase Activity under Maribavir	https://aac.asm.org/content/53/1/81	doi.org/10.1128/AAC.01177-08	Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
302	HCMV	AD169	UL27	L426F										2.2				Diverse Cytomegalovirus UL27 Mutations Adapt to Loss of Viral UL97 Kinase Activity under Maribavir	https://aac.asm.org/content/53/1/81	doi.org/10.1128/AAC.01177-08	Recombinant BAC 	SEAP			17/11/2019	OJCharles			A
303	HCMV	AD169	UL27	C415*										3.5				Mutations in the Human Cytomegalovirus UL27 Gene That Confer Resistance to Maribavir	https://journals.asm.org/doi/full/10.1128/jvi.78.13.7124-7130.2004	doi.org/10.1128/jvi.78.13.7124-7130.2004	Marker Transfer	PRA	UL27	A406V	17/11/2019	OJCharles		AD169	A
304	HCMV		UL27	R233S										7.2				Effects on maribavir susceptibility of cytomegalovirus UL97 kinase ATP binding region mutations detected after drug exposure in vitro and in vivo	https://www.sciencedirect.com/science/article/pii/S0166354212001283	doi.org/10.1016/j.antiviral.2012.05.013	Lab derived mutant 	PRA or SEAP	UL97	L337M	17/11/2019	OJCharles			A
305	HCMV		UL27	R233S										27				Effects on maribavir susceptibility of cytomegalovirus UL97 kinase ATP binding region mutations detected after drug exposure in vitro and in vivo	https://www.sciencedirect.com/science/article/pii/S0166354212001283	doi.org/10.1016/j.antiviral.2012.05.013	Lab derived mutant 	PRA or SEAP	UL97	V353A	17/11/2019	OJCharles		AD169	A
306	HCMV		UL97	C670Y	Resistant													Management of Ganciclovir Resistant Cytomegalovirus Retinitis in a Solid Organ Transplant Recipient: A Review of Current Evidence and Treatment Approaches	https://www.tandfonline.com/doi/full/10.1080/09273948.2019.1645188	doi.org/10.1080/09273948.2019.1645188	Isolated strain 				19/11/2019	OJCharles	Anecdotal		O
307	HCMV	AD169	UL97	F342Y	6									4.5				Novel UL97 drug resistance mutations identified at baseline in a clinical trial of maribavir for resistant or refractory cytomegalovirus infection	https://www.sciencedirect.com/science/article/pii/S0166354219304115?via%3Dihub	doi.org/10.1016/j.antiviral.2019.104616	Recombinant BAC 	SEAP			21/11/2019	OJCharles			A
308	HCMV	AD169	UL97	C592G	3													Novel UL97 drug resistance mutations identified at baseline in a clinical trial of maribavir for resistant or refractory cytomegalovirus infection	https://www.sciencedirect.com/science/article/pii/S0166354219304115?via%3Dihub	doi.org/10.1016/j.antiviral.2019.104616	Recombinant BAC 	SEAP			16/03/2020	OJCharles			A
309	HCMV	AD169	UL97	H411Y										18				Novel UL97 drug resistance mutations identified at baseline in a clinical trial of maribavir for resistant or refractory cytomegalovirus infection	https://www.sciencedirect.com/science/article/pii/S0166354219304115?via%3Dihub	doi.org/10.1016/j.antiviral.2019.104616	Recombinant BAC 	SEAP			16/03/2020	OJCharles			A
310	HCMV	AD169	UL97	T409M										90				Novel UL97 drug resistance mutations identified at baseline in a clinical trial of maribavir for resistant or refractory cytomegalovirus infection	https://www.sciencedirect.com/science/article/pii/S0166354219304115?via%3Dihub	doi.org/10.1016/j.antiviral.2019.104616	Recombinant BAC 	SEAP			21/11/2019	OJCharles			A
311	HCMV	AD169	UL97	K359E	3.8									1.2				Novel UL97 drug resistance mutations identified at baseline in a clinical trial of maribavir for resistant or refractory cytomegalovirus infection	https://www.sciencedirect.com/science/article/pii/S0166354219304115?via%3Dihub	doi.org/10.1016/j.antiviral.2019.104616	Recombinant BAC 	SEAP			21/11/2019	OJCharles			A
312	HCMV	AD169	UL97	K359Q	3.7									1.3				Novel UL97 drug resistance mutations identified at baseline in a clinical trial of maribavir for resistant or refractory cytomegalovirus infection	https://www.sciencedirect.com/science/article/pii/S0166354219304115?via%3Dihub	doi.org/10.1016/j.antiviral.2019.104616	Recombinant BAC 	SEAP			21/11/2019	OJCharles			A
313	HCMV	AD169	UL97	F342Y	5.9									56				Novel UL97 drug resistance mutations identified at baseline in a clinical trial of maribavir for resistant or refractory cytomegalovirus infection	https://www.sciencedirect.com/science/article/pii/S0166354219304115?via%3Dihub	doi.org/10.1016/j.antiviral.2019.104616	Recombinant BAC 	SEAP	UL97	H411Y	21/11/2019	OJCharles			A
320	HCMV	TB40	UL54	L516W	Resistant		Resistant											Identification of resistance-associated HCMV UL97- and UL54-mutations and a UL97-polymporphism with impact on phenotypic drug-resistance	https://www.sciencedirect.com/science/article/abs/pii/S0166354216300870?via%3Dihub	doi.org/10.1016/j.antiviral.2016.04.002	Recombinant BAC 	PRA or SEAP			21/11/2019	OJCharles		TB40	A
321	HCMV	TB40	UL54	V715A			Polymorphism	Resistant										Identification of resistance-associated HCMV UL97- and UL54-mutations and a UL97-polymporphism with impact on phenotypic drug-resistance	https://www.sciencedirect.com/science/article/abs/pii/S0166354216300870?via%3Dihub	doi.org/10.1016/j.antiviral.2016.04.002	Recombinant BAC 	PRA or SEAP			21/11/2019	OJCharles		TB40	A
341	HCMV	Susceptible Clinical Isolate	UL97	A594V	Resistant													Human cytomegalovirus double resistance in a donor-positive/recipient-negative lung transplant patient with an impaired CD4-mediated specific immune response.	https://www.ncbi.nlm.nih.gov/pubmed/14739146	doi.org/10.1093/jac/dkh065	Isolated strain 				16/03/2020	OJCharles	Anecdotal		O
342	HCMV	Susceptible Clinical Isolate	UL54	P522S	Resistant		Resistant											Human cytomegalovirus double resistance in a donor-positive/recipient-negative lung transplant patient with an impaired CD4-mediated specific immune response.	https://www.ncbi.nlm.nih.gov/pubmed/14739146	doi.org/10.1093/jac/dkh065	Isolated strain 				16/03/2020	OJCharles	Anecdotal		O
343	HCMV	AD169	UL56	V236M	1		1.9	1.1		46								Characterization of Cytomegalovirus Breakthrough Events in a Phase 2 Prophylaxis Trial of Letermovir	https://www.ncbi.nlm.nih.gov/pubmed/26113373?dopt=Abstract	doi.org/10.1093/infdis/jiv352	Recombinant BAC 	GFP fluorescence reduction assay			16/03/2020	OJCharles			A
344	HCMV	AD169	UL56	D414N	0.4		0.3	0.4		0.9								Characterization of Cytomegalovirus Breakthrough Events in a Phase 2 Prophylaxis Trial of Letermovir	https://www.ncbi.nlm.nih.gov/pubmed/26113373?dopt=Abstract	doi.org/10.1093/infdis/jiv352	Recombinant BAC 	GFP fluorescence reduction assay			16/03/2020	OJCharles			A
345	HCMV	AD169	UL56	S227I	0.4		0.3	0.4		0.2								Characterization of Cytomegalovirus Breakthrough Events in a Phase 2 Prophylaxis Trial of Letermovir	https://www.ncbi.nlm.nih.gov/pubmed/26113373?dopt=Abstract	doi.org/10.1093/infdis/jiv352	Recombinant BAC 	GFP fluorescence reduction assay			16/03/2020	OJCharles			A
346	HCMV	AD169	UL56	R410G	0.8		0.2	0.4		0.4								Characterization of Cytomegalovirus Breakthrough Events in a Phase 2 Prophylaxis Trial of Letermovir	https://www.ncbi.nlm.nih.gov/pubmed/26113373?dopt=Abstract	doi.org/10.1093/infdis/jiv352	Recombinant BAC 	GFP fluorescence reduction assay			16/03/2020	OJCharles			A
347	HCMV		UL56	E237G						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	cannot find key supporting data		O
348	HCMV		UL56	M31I						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
349	HCMV		UL56	M31V						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
350	HCMV		UL56	F41L						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
351	HCMV		UL56	L26P						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
352	HCMV		UL56	I48M						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
353	HCMV		UL56	A103V						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
354	HCMV		UL56	E141*						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
355	HCMV		UL56	N148D						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
356	HCMV		UL56	E157G						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
357	HCMV		UL56	Q182K						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
358	HCMV		UL56	Q213R						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
359	HCMV		UL56	S255L						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
360	HCMV		UL56	S269G						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
361	HCMV		UL56	E276G						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
362	HCMV		UL56	I313V						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
363	HCMV		UL56	C325W						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
364	HCMV		UL56	S378N						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
365	HCMV		UL56	S445N						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
366	HCMV		UL56	E485G						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
367	HCMV		UL56	I535V						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
368	HCMV		UL56	del542						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
369	HCMV		UL56	Y575C						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
370	HCMV		UL56	M641T						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
371	HCMV		UL56	L658S						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
372	HCMV		UL56	Y667H						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
373	HCMV		UL56	S705F						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
374	HCMV		UL56	V706A						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
375	HCMV		UL56	L750P						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
376	HCMV		UL56	Y757H						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
377	HCMV		UL56	T775I						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
378	HCMV		UL56	R816W						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
379	HCMV		UL56	P846L						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
380	HCMV		UL89	K41E						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
381	HCMV		UL89	N74S						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
382	HCMV		UL89	S102F						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
383	HCMV		UL89	F124L						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
384	HCMV		UL89	T132A						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
385	HCMV		UL89	V146I						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
386	HCMV		UL89	P176S						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
387	HCMV		UL89	H243R						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
388	HCMV		UL89	H246R						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
389	HCMV		UL89	D309G						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
390	HCMV		UL89	L323P						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
391	HCMV		UL89	T331A						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
392	HCMV		UL89	S373G						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
393	HCMV		UL89	M406V						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
394	HCMV		UL89	N426D						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
395	HCMV		UL89	L458P						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
396	HCMV		UL89	S521G						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
397	HCMV		UL89	L522P						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
398	HCMV		UL89	A532T						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
399	HCMV		UL89	I572V						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
400	HCMV		UL89	Q625*						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
401	HCMV		UL89	T637A						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
402	HCMV		UL89	V656A						Resistant								In-depth genomic analyses identified novel letermovir resistance-associated substitutions in the cytomegalovirus UL56 and UL89 gene products	https://www.sciencedirect.com/science/article/pii/S0166354219302128?via%3Dihub	doi.org/10.1080/14656566.2019.1637418	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
403	HCMV	AD169	UL54	V787A	2.9		1.3	5.25										Compartmentalization of a Multidrug-Resistant Cytomegalovirus UL54 Mutant in a Stem Cell Transplant Recipient with Encephalitis	https://academic.oup.com/jid/article/220/8/1302/5519111	doi.org/10.1093/infdis/jiz298	Recombinant BAC 	GLuc reporter assay			16/03/2020	OJCharles			A
404	HCMV	AD169	UL54	V787E	8.5		2.9	3.4										Compartmentalization of a Multidrug-Resistant Cytomegalovirus UL54 Mutant in a Stem Cell Transplant Recipient with Encephalitis	https://academic.oup.com/jid/article/220/8/1302/5519111	doi.org/10.1093/infdis/jiz298	Recombinant BAC 	GLuc reporter assay			21/11/2019	OJCharles			A
405	HCMV	AD169	UL54	V787K	3.2		1.8	9.4										Compartmentalization of a Multidrug-Resistant Cytomegalovirus UL54 Mutant in a Stem Cell Transplant Recipient with Encephalitis	https://academic.oup.com/jid/article/220/8/1302/5519111	doi.org/10.1093/infdis/jiz298	Recombinant BAC 	GLuc reporter assay			21/11/2019	OJCharles			A
406	HCMV		UL54	L501F			Resistant											Antiviral-resistant cytomegalovirus infections in solid organ transplantation in the Netherlands	https://academic.oup.com/jac/article/74/8/2370/5489804	doi.org/10.1093/jac/dkz196	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
407	HCMV		UL54	A505T			Resistant											Antiviral-resistant cytomegalovirus infections in solid organ transplantation in the Netherlands	https://academic.oup.com/jac/article/74/8/2370/5489804	doi.org/10.1093/jac/dkz196	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
408	HCMV		UL97	H469Y	Resistant													Antiviral-resistant cytomegalovirus infections in solid organ transplantation in the Netherlands	https://academic.oup.com/jac/article/74/8/2370/5489804	doi.org/10.1093/jac/dkz196	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
409	HCMV		UL97	A590V	Resistant													Antiviral-resistant cytomegalovirus infections in solid organ transplantation in the Netherlands	https://academic.oup.com/jac/article/74/8/2370/5489804	doi.org/10.1093/jac/dkz196	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
410	HCMV		UL54	D1129N	Resistant													Antiviral-resistant cytomegalovirus infections in solid organ transplantation in the Netherlands	https://academic.oup.com/jac/article/74/8/2370/5489804	doi.org/10.1093/jac/dkz196	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
411	HCMV		UL54	V321I	Resistant													Antiviral-resistant cytomegalovirus infections in solid organ transplantation in the Netherlands	https://academic.oup.com/jac/article/74/8/2370/5489804	doi.org/10.1093/jac/dkz196	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
412	HCMV		UL97	L609F	Resistant		Resistant											Antiviral-resistant cytomegalovirus infections in solid organ transplantation in the Netherlands	https://academic.oup.com/jac/article/74/8/2370/5489804	doi.org/10.1093/jac/dkz196	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
413	HCMV		UL54	R1030C	Resistant													Antiviral-resistant cytomegalovirus infections in solid organ transplantation in the Netherlands	https://academic.oup.com/jac/article/74/8/2370/5489804	doi.org/10.1093/jac/dkz196	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
414	HCMV		UL54	G1031A	Resistant													Antiviral-resistant cytomegalovirus infections in solid organ transplantation in the Netherlands	https://academic.oup.com/jac/article/74/8/2370/5489804	doi.org/10.1093/jac/dkz196	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
415	HCMV		UL54	L394F	Resistant													Antiviral-resistant cytomegalovirus infections in solid organ transplantation in the Netherlands	https://academic.oup.com/jac/article/74/8/2370/5489804	doi.org/10.1093/jac/dkz196	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
416	HCMV		UL54	E877K	Resistant													Antiviral-resistant cytomegalovirus infections in solid organ transplantation in the Netherlands	https://academic.oup.com/jac/article/74/8/2370/5489804	doi.org/10.1093/jac/dkz196	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
417	HCMV		UL97	L609F	Resistant		Resistant											Antiviral-resistant cytomegalovirus infections in solid organ transplantation in the Netherlands	https://academic.oup.com/jac/article/74/8/2370/5489804	doi.org/10.1093/jac/dkz196	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
418	HCMV		UL54	T892A	Resistant													Antiviral-resistant cytomegalovirus infections in solid organ transplantation in the Netherlands	https://academic.oup.com/jac/article/74/8/2370/5489804	doi.org/10.1093/jac/dkz196	Isolated strain 				21/11/2019	OJCharles	Anecdotal		O
419	HCMV		UL97	M460I	7.8										12			Cytomegalovirus UL97 Mutations Affecting Cyclopropavir and Ganciclovir Susceptibility	https://aac.asm.org/content/55/1/382	doi.org/10.1128%2FAAC.01259-10	Recombinant BAC 	SEAP			22/11/2019	OJCharles			A
420	HCMV		UL97	M460T	9.3										10			Cytomegalovirus UL97 Mutations Affecting Cyclopropavir and Ganciclovir Susceptibility	https://aac.asm.org/content/55/1/382	doi.org/10.1128%2FAAC.01259-10	Recombinant BAC 	SEAP			22/11/2019	OJCharles			A
421	HCMV		UL97	M460V	8.3										4			Cytomegalovirus UL97 Mutations Affecting Cyclopropavir and Ganciclovir Susceptibility	https://aac.asm.org/content/55/1/382	doi.org/10.1128%2FAAC.01259-10	Recombinant BAC 	SEAP			22/11/2019	OJCharles			A
422	HCMV		UL97	H520Q	7.8										20			Cytomegalovirus UL97 Mutations Affecting Cyclopropavir and Ganciclovir Susceptibility	https://aac.asm.org/content/55/1/382	doi.org/10.1128%2FAAC.01259-10	Recombinant BAC 	SEAP			22/11/2019	OJCharles			A
423	HCMV		UL97	C592G	3										3.3			Cytomegalovirus UL97 Mutations Affecting Cyclopropavir and Ganciclovir Susceptibility	https://aac.asm.org/content/55/1/382	doi.org/10.1128%2FAAC.01259-10	Recombinant BAC 	SEAP			22/11/2019	OJCharles			A
424	HCMV		UL97	A594V	8.6										4.5			Cytomegalovirus UL97 Mutations Affecting Cyclopropavir and Ganciclovir Susceptibility	https://aac.asm.org/content/55/1/382	doi.org/10.1128%2FAAC.01259-10	Recombinant BAC 	SEAP			22/11/2019	OJCharles			A
425	HCMV		UL97	L595S	8.5										1.3			Cytomegalovirus UL97 Mutations Affecting Cyclopropavir and Ganciclovir Susceptibility	https://aac.asm.org/content/55/1/382	doi.org/10.1128%2FAAC.01259-10	Recombinant BAC 	SEAP			22/11/2019	OJCharles			A
426	HCMV		UL97	C603R	8.3										8.4			Cytomegalovirus UL97 Mutations Affecting Cyclopropavir and Ganciclovir Susceptibility	https://aac.asm.org/content/55/1/382	doi.org/10.1128%2FAAC.01259-10	Recombinant BAC 	SEAP			22/11/2019	OJCharles			A
427	HCMV		UL97	C603S	1.9										2.8			Cytomegalovirus UL97 Mutations Affecting Cyclopropavir and Ganciclovir Susceptibility	https://aac.asm.org/content/55/1/382	doi.org/10.1128%2FAAC.01259-10	Recombinant BAC 	SEAP			22/11/2019	OJCharles			A
428	HCMV		UL97	C603W	7.9										4.6			Cytomegalovirus UL97 Mutations Affecting Cyclopropavir and Ganciclovir Susceptibility	https://aac.asm.org/content/55/1/382	doi.org/10.1128%2FAAC.01259-10	Recombinant BAC 	SEAP			22/11/2019	OJCharles			A
429	HCMV	AD169	UL54	D515Y	3.2		2.6											Emergence of letermovir resistance in a lung transplant recipient with ganciclovir?resistant cytomegalovirus infection	https://onlinelibrary.wiley.com/doi/full/10.1111/ajt.15135	doi.org/10.1111/ajt.15135	Recombinant BAC 	SEAP			22/11/2019	OJCharles			A
430	HCMV	AD169	UL54	L516P	4.4		5.9											Emergence of letermovir resistance in a lung transplant recipient with ganciclovir?resistant cytomegalovirus infection	https://onlinelibrary.wiley.com/doi/full/10.1111/ajt.15135	doi.org/10.1111/ajt.15135	Recombinant BAC 	SEAP			22/11/2019	OJCharles			A
431	HCMV	AD169	UL54	del981-982	7		3.2	2.7										Emergence of letermovir resistance in a lung transplant recipient with ganciclovir?resistant cytomegalovirus infection	https://onlinelibrary.wiley.com/doi/full/10.1111/ajt.15135	doi.org/10.1111/ajt.15135	Recombinant BAC 	SEAP			16/03/2020	OJCharles			A
432	HCMV		UL54	L415N				Resistant										Autologous Adoptive T-cell Therapy for Recurrent or Drug-resistant Cytomegalovirus Complications in Solid Organ Transplant Recipients: A Single-arm Open-label Phase I Clinical Trial	https://academic.oup.com/cid/article/68/4/632/5049442	doi.org/10.1093/cid/ciy549	Isolated strain 				22/11/2019	OJCharles	Anecdotal		O
433	HCMV		UL54	S734P				Resistant										Autologous Adoptive T-cell Therapy for Recurrent or Drug-resistant Cytomegalovirus Complications in Solid Organ Transplant Recipients: A Single-arm Open-label Phase I Clinical Trial	https://academic.oup.com/cid/article/68/4/632/5049442	doi.org/10.1093/cid/ciy549	Isolated strain 				22/11/2019	OJCharles	Anecdotal		O
434	HCMV	AD169	UL54	A543P	4.7		16	0.6										New Locus of Drug Resistance in the Human Cytomegalovirus UL56 Gene Revealed by In Vitro Exposure to Letermovir and Ganciclovir	https://aac.asm.org/content/aac/62/9/e00922-18.full.pdf	doi.org/10.1128/AAC.00922-18	Recombinant BAC 	SEAP			22/11/2019	OJCharles			A
435	HCMV	AD169	UL54	S290R	1.7		1.4	2.3										Foscarnet resistance mutations mapping to atypical domains of the cytomegalovirus DNA polymerase gene	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209250/	doi.org/10.1016/j.antiviral.2016.12.003	Recombinant BAC 	SEAP			16/03/2020	OJCharles			A
436	HCMV	AD169	UL54	K426E	1.1		1	1.1										Foscarnet resistance mutations mapping to atypical domains of the cytomegalovirus DNA polymerase gene	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209250/	doi.org/10.1016/j.antiviral.2016.12.003	Recombinant BAC 	SEAP			16/03/2020	OJCharles			A
437	HCMV	AD169	UL54	N495K	1.3		1	2.6										Foscarnet resistance mutations mapping to atypical domains of the cytomegalovirus DNA polymerase gene	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209250/	doi.org/10.1016/j.antiviral.2016.12.003	Recombinant BAC 	SEAP			16/03/2020	OJCharles			A
438	HCMV	AD169	UL54	N495K	1.7		1.2	3.5										Foscarnet resistance mutations mapping to atypical domains of the cytomegalovirus DNA polymerase gene	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209250/	doi.org/10.1016/j.antiviral.2016.12.003	Recombinant BAC 	SEAP	UL54	Q738R	16/03/2020	OJCharles			A
439	HCMV	AD169	UL54	T552N	1.8		1	2.5										Foscarnet resistance mutations mapping to atypical domains of the cytomegalovirus DNA polymerase gene	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209250/	doi.org/10.1016/j.antiviral.2016.12.003	Recombinant BAC 	SEAP			16/03/2020	OJCharles			A
440	HCMV	AD169	UL54	Q783R	1.8		0.9	1.7										Foscarnet resistance mutations mapping to atypical domains of the cytomegalovirus DNA polymerase gene	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209250/	doi.org/10.1016/j.antiviral.2016.12.003	Recombinant BAC 	SEAP			16/03/2020	OJCharles			A
441	HCMV	AD169	UL54	V798A	1.5		1.1	1.7										Foscarnet resistance mutations mapping to atypical domains of the cytomegalovirus DNA polymerase gene	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209250/	doi.org/10.1016/j.antiviral.2016.12.003	Recombinant BAC 	SEAP			16/03/2020	OJCharles			A
442	HCMV	AD169	UL54	E951D	1.8		1.2	3.9										Foscarnet resistance mutations mapping to atypical domains of the cytomegalovirus DNA polymerase gene	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209250/	doi.org/10.1016/j.antiviral.2016.12.003	Recombinant BAC 	SEAP			16/03/2020	OJCharles			A
443	HCMV	TOWNE	UL54	T419M	1			8										Point mutations induced by foscarnet (PFA) in the human cytomegalovirus DNA polymerase	https://www.sciencedirect.com/science/article/pii/S138665320200046X?via%3Dihub	doi.org/10.1016/S1386-6532(02)00046-X	Drug induced lab mutant 	CMV antigen ELISA 			16/03/2020	OJCharles			A
444	HCMV	TOWNE	UL54	Q578H	2			10										Point mutations induced by foscarnet (PFA) in the human cytomegalovirus DNA polymerase	https://www.sciencedirect.com/science/article/pii/S138665320200046X?via%3Dihub	doi.org/10.1016/S1386-6532(02)00046-X	Drug induced lab mutant 	CMV antigen ELISA 			16/03/2020	OJCharles			A
445	HCMV	TOWNE	UL54	L773V	2			5										Point mutations induced by foscarnet (PFA) in the human cytomegalovirus DNA polymerase	https://www.sciencedirect.com/science/article/pii/S138665320200046X?via%3Dihub	doi.org/10.1016/S1386-6532(02)00046-X	Drug induced lab mutant 	CMV antigen ELISA 			16/03/2020	OJCharles			A
446	HCMV	TOWNE	UL97	M460V	10			1										Point mutations induced by foscarnet (PFA) in the human cytomegalovirus DNA polymerase	https://www.sciencedirect.com/science/article/pii/S138665320200046X?via%3Dihub	doi.org/10.1016/S1386-6532(02)00046-X	Drug induced lab mutant 	CMV antigen ELISA 			16/03/2020	OJCharles			A
448	HCMV		UL97	D68N	Polymorphism													Recombinant Phenotyping of Cytomegalovirus UL97 Kinase Sequence Variants for Ganciclovir Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876423/	doi.org/10.1128/AAC.00186-10	Recombinant BAC 	SEAP			16/03/2020	OJCharles	occurs with many other mutations unable to establish its solo phenotype		O
449	HCMV		UL97	Q126L	Polymorphism													Recombinant Phenotyping of Cytomegalovirus UL97 Kinase Sequence Variants for Ganciclovir Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876423/	doi.org/10.1128/AAC.00186-10	Recombinant BAC 	SEAP			16/03/2020	OJCharles	occurs with many other mutations unable to establish its solo phenotype		O
450	HCMV		UL97	V244I	Polymorphism													Recombinant Phenotyping of Cytomegalovirus UL97 Kinase Sequence Variants for Ganciclovir Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876423/	doi.org/10.1128/AAC.00186-10	Recombinant BAC 	SEAP			16/03/2020	OJCharles	occurs with many other mutations unable to establish its solo phenotype		O
451	HCMV	AD169	UL97	D329H	Polymorphism													Cytomegalovirus UL97 Phosphotransferase Mutations That Affect Susceptibility to Ganciclovir	https://academic.oup.com/jid/article/185/2/162/2191141	doi.org/10.1086/338362	Marker Transfer 	PRA			16/03/2020	OJCharles		Towne	A
452	HCMV	AD169	UL97	A427V	1													Characterization of Human Cytomegalovirus (HCMV) UL97 Mutations Found in a Valganciclovir/Oral Ganciclovir Prophylactic Trial by Use of a Bacterial Artificial Chromosome Containing the HCMV Genome	https://academic.oup.com/jid/article/194/5/579/2191670	doi.org/10.1086/505882	Lab derived mutant 	PRA			16/03/2020	OJCharles			A
453	HCMV	AD169	UL97	Q449K	Polymorphism													Cytomegalovirus UL97 Kinase Mutations That Confer Maribavir Resistance	https://academic.oup.com/jid/article-lookup/doi/10.1086/518514	doi.org/10.1086/518514	Lab derived mutant 	SEAP			16/03/2020	OJCharles		AD169	A
454	HCMV	AD169	UL97	V466M	1.3													Recombinant Phenotyping of Cytomegalovirus UL97 Kinase Sequence Variants for Ganciclovir Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876423/	doi.org/10.1128/AAC.00186-10	Recombinant BAC 	SEAP			16/03/2020	OJCharles		AD169	A
455	HCMV	AD169	UL97	H469Y	1.2													Recombinant Phenotyping of Cytomegalovirus UL97 Kinase Sequence Variants for Ganciclovir Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876423/	doi.org/10.1128/AAC.00186-10	Recombinant BAC 	SEAP			16/03/2020	OJCharles		AD169	A
456	HCMV	AD169	UL97	A478V	0.8													Recombinant Phenotyping of Cytomegalovirus UL97 Kinase Sequence Variants for Ganciclovir Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876423/	doi.org/10.1128/AAC.00186-10	Recombinant BAC 	SEAP			16/03/2020	OJCharles		AD169	A
457	HCMV	AD169	UL97	N510S	1.2													Recombinant Phenotyping of Cytomegalovirus UL97 Kinase Sequence Variants for Ganciclovir Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876423/	doi.org/10.1128/AAC.00186-10	Recombinant BAC 	SEAP			16/03/2020	OJCharles		AD169	A
458	HCMV	AD169	UL97	M550I	0.85													Characterization of Human Cytomegalovirus (HCMV) UL97 Mutations Found in a Valganciclovir/Oral Ganciclovir Prophylactic Trial by Use of a Bacterial Artificial Chromosome Containing the HCMV Genome	https://academic.oup.com/jid/article/194/5/579/2191670	doi.org/10.1086/505882	Lab derived mutant 	PRA			16/03/2020	OJCharles			A
459	HCMV	AD169	UL97	A582V	0.82													Characterization of Human Cytomegalovirus (HCMV) UL97 Mutations Found in a Valganciclovir/Oral Ganciclovir Prophylactic Trial by Use of a Bacterial Artificial Chromosome Containing the HCMV Genome	https://academic.oup.com/jid/article/194/5/579/2191670	doi.org/10.1086/505882	Lab derived mutant 	PRA			16/03/2020	OJCharles			A
460	HCMV	AD169	UL97	H587Y	1		1	0.8										Phenotyping of Cytomegalovirus Drug Resistance Mutations by Using Recombinant Viruses Incorporating a Reporter Gene	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1168698/	doi.org/10.1128/AAC.49.7.2710-2715.2005	Lab derived mutant 	SEAP			16/03/2020	OJCharles			A
461	HCMV	AD169	UL97	A588V	1.1													Recombinant Phenotyping of Cytomegalovirus UL97 Kinase Sequence Variants for Ganciclovir Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876423/	doi.org/10.1128/AAC.00186-10	Recombinant BAC 	SEAP			16/03/2020	OJCharles		AD169	A
462	HCMV		UL97	A591V	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Lab derived mutant 	PRA or SEAP			16/03/2020	OJCharles	unable to find referred mutation		O
463	HCMV	AD169	UL97	N597D	1.4													Successful valganciclovir treatment of post-transplant cytomegalovirus infection in the presence of UL97 mutation N597D	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2786239/	doi.org/10.1002/jmv.21397	Lab derived mutant 	SEAP			16/03/2020	OJCharles			A
464	HCMV	AD169	UL97	K599R	0.9													Recombinant Phenotyping of Cytomegalovirus UL97 Kinase Sequence Variants for Ganciclovir Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876423/	doi.org/10.1128/AAC.00186-10	Recombinant BAC 	SEAP			16/03/2020	OJCharles		AD169	A
465	HCMV	AD169	UL97	L600I	1.4													Recombinant Phenotyping of Cytomegalovirus UL97 Kinase Sequence Variants for Ganciclovir Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876423/	doi.org/10.1128/AAC.00186-10	Recombinant BAC 	SEAP			16/03/2020	OJCharles		AD169	A
468	HCMV	AD169	UL97	Y617H	0.84													Characterization of Human Cytomegalovirus (HCMV) UL97 Mutations Found in a Valganciclovir/Oral Ganciclovir Prophylactic Trial by Use of a Bacterial Artificial Chromosome Containing the HCMV Genome	https://academic.oup.com/jid/article/194/5/579/2191670	doi.org/10.1086/505882	Lab derived mutant 	PRA			16/03/2020	OJCharles			A
469	HCMV	AD169	UL97	G623S	1.1													Recombinant Phenotyping of Cytomegalovirus UL97 Kinase Sequence Variants for Ganciclovir Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876423/	doi.org/10.1128/AAC.00186-10	Recombinant BAC 	SEAP			16/03/2020	OJCharles		AD169	A
471	HCMV	AD169	UL97	T659I	1.3													Recombinant Phenotyping of Cytomegalovirus UL97 Kinase Sequence Variants for Ganciclovir Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876423/	doi.org/10.1128/AAC.00186-10	Recombinant BAC 	SEAP			16/03/2020	OJCharles		AD169	A
473	HCMV	AD169	UL97	A674T	0.92													Characterization of Human Cytomegalovirus (HCMV) UL97 Mutations Found in a Valganciclovir/Oral Ganciclovir Prophylactic Trial by Use of a Bacterial Artificial Chromosome Containing the HCMV Genome	https://academic.oup.com/jid/article/194/5/579/2191670	doi.org/10.1086/505882	Lab derived mutant 	PRA			16/03/2020	OJCharles			A
474	HCMV	Clinical Isolate	UL97	Q19E	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
475	HCMV	Clinical Isolate	UL97	T95S	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
476	HCMV	Clinical Isolate	UL97	S108N	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
477	HCMV	Clinical Isolate	UL97	R112C	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
478	HCMV	Clinical Isolate	UL97	R137C	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
479	HCMV	Clinical Isolate	UL97	E227D	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
480	HCMV	Clinical Isolate	UL97	A582T	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
481	HCMV		UL54	D515G	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Lab derived mutant 	PRA or SEAP			16/03/2020	OJCharles	Ref never shows this		O
485	HCMV	Clinical Isolate	UL54	A15T	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
486	HCMV	Clinical Isolate	UL54	S24L	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
487	HCMV	Clinical Isolate	UL54	S32P	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
488	HCMV	Clinical Isolate	UL54	V95E	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
489	HCMV	Clinical Isolate	UL54	H142Y	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
490	HCMV	Clinical Isolate	UL54	G143S	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
491	HCMV	Clinical Isolate	UL54	I341T	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
492	HCMV	Clinical Isolate	UL54	N345S	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
493	HCMV	Clinical Isolate	UL54	G347D	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
494	HCMV	Clinical Isolate	UL54	V355A	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
495	HCMV	Clinical Isolate	UL54	S464F	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
496	HCMV	Clinical Isolate	UL54	A626V	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
497	HCMV	Clinical Isolate	UL54	P628L	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
498	HCMV	Clinical Isolate	UL54	G629S	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
499	HCMV	Clinical Isolate	UL54	A631G	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
500	HCMV	Clinical Isolate	UL54	S633F	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
501	HCMV	Clinical Isolate	UL54	M640R	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
502	HCMV	Clinical Isolate	UL54	S655L	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
503	HCMV	Clinical Isolate	UL54	S663N	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
504	HCMV	Clinical Isolate	UL54	F669L	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
505	HCMV	Clinical Isolate	UL54	S676G	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
506	HCMV	Clinical Isolate	UL54	G678S	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
507	HCMV	Clinical Isolate	UL54	del 681-688	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
508	HCMV	Clinical Isolate	UL54	N685S	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
509	HCMV	Clinical Isolate	UL54	A688V	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
510	HCMV	Clinical Isolate	UL54	T691A	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
511	HCMV	Clinical Isolate	UL54	A693T	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
512	HCMV	Clinical Isolate	UL54	S695T	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
513	HCMV	Clinical Isolate	UL54	Q697H	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
514	HCMV	Clinical Isolate	UL54	L737M	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
515	HCMV	Clinical Isolate	UL54	V759M	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
516	HCMV	Clinical Isolate	UL54	Q868R	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
517	HCMV	Clinical Isolate	UL54	D870H	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
518	HCMV	Clinical Isolate	UL54	V873L	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
519	HCMV	Clinical Isolate	UL54	G874R	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
520	HCMV	Clinical Isolate	UL54	S884Insert T	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
521	HCMV	Clinical Isolate	UL54	A885S	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
522	HCMV	Clinical Isolate	UL54	A885T	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
523	HCMV	Clinical Isolate	UL54	P887S	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
524	HCMV	Clinical Isolate	UL54	L890F	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
525	HCMV	Clinical Isolate	UL54	T892I	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
527	HCMV	Clinical Isolate	UL54	N898D	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
528	HCMV	Clinical Isolate	UL54	E899K	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
529	HCMV	Clinical Isolate	UL54	V927M	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
530	HCMV	Clinical Isolate	UL54	V953A	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
531	HCMV	Clinical Isolate	UL54	A1012V	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
532	HCMV	Clinical Isolate	UL54	L1020I	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
533	HCMV	Clinical Isolate	UL54	T1108A	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
534	HCMV	Clinical Isolate	UL54	N1116H	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
535	HCMV	Clinical Isolate	UL54	A1122T	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
536	HCMV	Clinical Isolate	UL54	G1133S	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
537	HCMV	Clinical Isolate	UL54	S1146N	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
538	HCMV	Clinical Isolate	UL54	N1147S	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
539	HCMV	Clinical Isolate	UL54	R1149T	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
540	HCMV	Clinical Isolate	UL54	del1151	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
541	HCMV	Clinical Isolate	UL54	P1153S	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
542	HCMV	Clinical Isolate	UL54	A1154P	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
543	HCMV	Clinical Isolate	UL54	del1156	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
544	HCMV	Clinical Isolate	UL54	P1162L	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
545	HCMV	Clinical Isolate	UL54	S1235T	Polymorphism													Antiviral Drug Resistance of Human Cytomegalovirus	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952978/	doi.org/10.1128/CMR.00009-10	Isolated strain 	Genotyping sensitive clinical isolates			16/03/2020	OJCharles	Anecdotal		O
546	HCMV	Clinical Isolate	UL97	C603W	1.1		0.9	1.5										High-Level Resistance of Cytomegalovirus to Ganciclovir Is Associated with Alterations in Both the UL97 and DNA Polymerase Genes	https://academic.oup.com/jid/article/176/1/69/901024	doi.org/10.1086/514041	Isolated strain 	PRA			16/03/2020	OJCharles			A
547	HCMV	Clinical Isolate	UL97	H469Y	1.3		1.5	1.9										High-Level Resistance of Cytomegalovirus to Ganciclovir Is Associated with Alterations in Both the UL97 and DNA Polymerase Genes	https://academic.oup.com/jid/article/176/1/69/901024	doi.org/10.1086/514041	Isolated strain 	PRA			16/03/2020	OJCharles			A
548	HCMV	Clinical Isolate	UL97	C603W	2		0.8	2										High-Level Resistance of Cytomegalovirus to Ganciclovir Is Associated with Alterations in Both the UL97 and DNA Polymerase Genes	https://academic.oup.com/jid/article/176/1/69/901024	doi.org/10.1086/514041	Isolated strain 	PRA			16/03/2020	OJCharles			A
549	HCMV	AD169	UL54	del413	3.8		5.8	1.3	5.2									Novel Cytomegalovirus UL54 DNA Polymerase Gene Mutations Selected In Vitro That Confer Brincidofovir Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879386/	doi.org/10.1128/AAC.00214-16	Recombinant BAC 	SEAP			16/03/2020	OJCharles			A
550	HCMV	AD169	UL54	A809V				4.3										Novel Cytomegalovirus UL54 DNA Polymerase Gene Mutations Selected In Vitro That Confer Brincidofovir Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879386/	doi.org/10.1128/AAC.00214-16	Recombinant BAC 	SEAP			16/03/2020	OJCharles			A
551	HCMV	AD169	UL54	E303G	7.3		20	0.8	11									Novel Cytomegalovirus UL54 DNA Polymerase Gene Mutations Selected In Vitro That Confer Brincidofovir Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879386/	doi.org/10.1128/AAC.00214-16	Recombinant BAC 	SEAP			16/03/2020	OJCharles			A
552	HCMV	AD169	UL54	E303D	6.3		16	0.8	9.7									Novel Cytomegalovirus UL54 DNA Polymerase Gene Mutations Selected In Vitro That Confer Brincidofovir Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879386/	doi.org/10.1128/AAC.00214-16	Recombinant BAC 	SEAP			16/03/2020	OJCharles			A
553	HCMV	AD169	UL54	N408K	3.9		21	0.8	11									Novel Cytomegalovirus UL54 DNA Polymerase Gene Mutations Selected In Vitro That Confer Brincidofovir Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879386/	doi.org/10.1128/AAC.00214-16	Recombinant BAC 	SEAP			16/03/2020	OJCharles			A
554	HCMV	AD169	UL54	D413Y	4.4		9.3	1	6									Novel Cytomegalovirus UL54 DNA Polymerase Gene Mutations Selected In Vitro That Confer Brincidofovir Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879386/	doi.org/10.1128/AAC.00214-16	Recombinant BAC 	SEAP			16/03/2020	OJCharles			A
555	HCMV	AD169	UL54	V812L	2.1		3.1	2	2.4									Novel Cytomegalovirus UL54 DNA Polymerase Gene Mutations Selected In Vitro That Confer Brincidofovir Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879386/	doi.org/10.1128/AAC.00214-16	Recombinant BAC 	SEAP			16/03/2020	OJCharles			A
556	HCMV	AD169	UL54	E303G	10		34	1.4	17									Novel Cytomegalovirus UL54 DNA Polymerase Gene Mutations Selected In Vitro That Confer Brincidofovir Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879386/	doi.org/10.1128/AAC.00214-16	Recombinant BAC 	SEAP	UL54	V812L	16/03/2020	OJCharles			A
557	HCMV	AD169	UL56	M3V						1								Letermovir Resistance Analysis in a Clinical Trial of Cytomegalovirus Prophylaxis for Hematopoietic Stem Cell Transplant Recipients	https://academic.oup.com/jid/article/221/7/1117/5645458	doi.org/10.1093/infdis/jiz577	Recombinant BAC 	SEAP			14/05/2020	OJCharles			A
558	HCMV	AD169	UL56	V236M						50.2								Letermovir Resistance Analysis in a Clinical Trial of Cytomegalovirus Prophylaxis for Hematopoietic Stem Cell Transplant Recipients	https://academic.oup.com/jid/article/221/7/1117/5645458	doi.org/10.1093/infdis/jiz577	Recombinant BAC 	SEAP			14/05/2020	OJCharles			A
559	HCMV	AD169	UL56	E237G	2.1		1.4	1.3		13								Letermovir Resistance Analysis in a Clinical Trial of Cytomegalovirus Prophylaxis for Hematopoietic Stem Cell Transplant Recipients	https://academic.oup.com/jid/article/221/7/1117/5645458	doi.org/10.1093/infdis/jiz577	Recombinant BAC 	SEAP			14/05/2020	OJCharles			A
560	HCMV	AD169	UL56	S255L						1.1								Letermovir Resistance Analysis in a Clinical Trial of Cytomegalovirus Prophylaxis for Hematopoietic Stem Cell Transplant Recipients	https://academic.oup.com/jid/article/221/7/1117/5645458	doi.org/10.1093/infdis/jiz577	Recombinant BAC 	SEAP			14/05/2020	OJCharles			A
561	HCMV	AD169	UL56	C325W	1.2		1	1.1		8262								Letermovir Resistance Analysis in a Clinical Trial of Cytomegalovirus Prophylaxis for Hematopoietic Stem Cell Transplant Recipients	https://academic.oup.com/jid/article/221/7/1117/5645458	doi.org/10.1093/infdis/jiz577	Recombinant BAC 	SEAP			14/05/2020	OJCharles			A
562	HCMV	AD169	UL56	R369T	1.5		1.2	1.1		52								Letermovir Resistance Analysis in a Clinical Trial of Cytomegalovirus Prophylaxis for Hematopoietic Stem Cell Transplant Recipients	https://academic.oup.com/jid/article/221/7/1117/5645458	doi.org/10.1093/infdis/jiz577	Recombinant BAC 	SEAP			14/05/2020	OJCharles			A
563	HCMV	AD169	UL56	del445-447						1								Letermovir Resistance Analysis in a Clinical Trial of Cytomegalovirus Prophylaxis for Hematopoietic Stem Cell Transplant Recipients	https://academic.oup.com/jid/article/221/7/1117/5645458	doi.org/10.1093/infdis/jiz577	Recombinant BAC 	SEAP	UL56	E485G	14/05/2020	OJCharles			A
564	HCMV	AD169	UL56	E485G						0.9								Letermovir Resistance Analysis in a Clinical Trial of Cytomegalovirus Prophylaxis for Hematopoietic Stem Cell Transplant Recipients	https://academic.oup.com/jid/article/221/7/1117/5645458	doi.org/10.1093/infdis/jiz577	Recombinant BAC 	SEAP			14/05/2020	OJCharles			A
565	HCMV	AD169	UL56	Y575C						0.9								Letermovir Resistance Analysis in a Clinical Trial of Cytomegalovirus Prophylaxis for Hematopoietic Stem Cell Transplant Recipients	https://academic.oup.com/jid/article/221/7/1117/5645458	doi.org/10.1093/infdis/jiz577	Recombinant BAC 	SEAP			14/05/2020	OJCharles			A
566	HCMV	AD169	UL56	F626S						0.5								Letermovir Resistance Analysis in a Clinical Trial of Cytomegalovirus Prophylaxis for Hematopoietic Stem Cell Transplant Recipients	https://academic.oup.com/jid/article/221/7/1117/5645458	doi.org/10.1093/infdis/jiz577	Recombinant BAC 	SEAP			14/05/2020	OJCharles			A
567	HCMV	AD169	UL56	L726V						1								Letermovir Resistance Analysis in a Clinical Trial of Cytomegalovirus Prophylaxis for Hematopoietic Stem Cell Transplant Recipients	https://academic.oup.com/jid/article/221/7/1117/5645458	doi.org/10.1093/infdis/jiz577	Recombinant BAC 	SEAP			14/05/2020	OJCharles			A
568	HCMV	AD169	UL56	T775I						1								Letermovir Resistance Analysis in a Clinical Trial of Cytomegalovirus Prophylaxis for Hematopoietic Stem Cell Transplant Recipients	https://academic.oup.com/jid/article/221/7/1117/5645458	doi.org/10.1093/infdis/jiz577	Recombinant BAC 	SEAP			14/05/2020	OJCharles			A
569	HCMV	AD169	UL56	del789-791						1								Letermovir Resistance Analysis in a Clinical Trial of Cytomegalovirus Prophylaxis for Hematopoietic Stem Cell Transplant Recipients	https://academic.oup.com/jid/article/221/7/1117/5645458	doi.org/10.1093/infdis/jiz577	Recombinant BAC 	SEAP			14/05/2020	OJCharles			A
570	HCMV	AD169	UL56	V814A						1								Letermovir Resistance Analysis in a Clinical Trial of Cytomegalovirus Prophylaxis for Hematopoietic Stem Cell Transplant Recipients	https://academic.oup.com/jid/article/221/7/1117/5645458	doi.org/10.1093/infdis/jiz577	Recombinant BAC 	SEAP			14/05/2020	OJCharles			A
571	HCMV	AD169	UL56	R816W						0.9								Letermovir Resistance Analysis in a Clinical Trial of Cytomegalovirus Prophylaxis for Hematopoietic Stem Cell Transplant Recipients	https://academic.oup.com/jid/article/221/7/1117/5645458	doi.org/10.1093/infdis/jiz577	Recombinant BAC 	SEAP			14/05/2020	OJCharles			A
572	HCMV	AD169	UL89	I531T						1								Letermovir Resistance Analysis in a Clinical Trial of Cytomegalovirus Prophylaxis for Hematopoietic Stem Cell Transplant Recipients	https://academic.oup.com/jid/article/221/7/1117/5645458	doi.org/10.1093/infdis/jiz577	Recombinant BAC 	SEAP			14/05/2020	OJCharles			A
573	HCMV	AD169	UL54	Q579I	0.16			0.06										Hypersusceptibility of Human Cytomegalovirus to Foscarnet Induced by Mutations in Helices K and P of the Viral DNA Polymerase	https://aac.asm.org/content/aac/64/4/e01910-19.full.pdf	doi.org/10.1128/AAC.01910-19	Recombinant BAC 	GLuc reporter assay			22/07/2020	OJCharles			A
574	HCMV	AD169	UL54	K805Q	1			0.19										Hypersusceptibility of Human Cytomegalovirus to Foscarnet Induced by Mutations in Helices K and P of the Viral DNA Polymerase	https://aac.asm.org/content/aac/64/4/e01910-19.full.pdf	doi.org/10.1128/AAC.01910-19	Recombinant BAC 	GLuc reporter assay			22/07/2020	OJCharles			A
575	HCMV	AD169	UL54	E756K	12.7		2.9	5.3										Characterization of Multiple Cytomegalovirus Drug Resistance Mutations Detected in a Hematopoietic Stem Cell Transplant Recipient by Recombinant Phenotyping	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313248/	doi.org/10.1128%2FJCM.02205-14	Recombinant BAC 	GLuc reporter assay	UL54	A594V	23/11/2020	OJCharles			A
576	HCMV	AD169	UL54	V526L	13.2		2.7	1.7										Characterization of Multiple Cytomegalovirus Drug Resistance Mutations Detected in a Hematopoietic Stem Cell Transplant Recipient by Recombinant Phenotyping	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313248/	doi.org/10.1128%2FJCM.02205-14	Recombinant BAC 	GLuc reporter assay	UL54	A594V	23/11/2020	OJCharles			A
577	HCMV	AD169	UL54	V526L	18.9		3.5	1.9										Characterization of Multiple Cytomegalovirus Drug Resistance Mutations Detected in a Hematopoietic Stem Cell Transplant Recipient by Recombinant Phenotyping	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313248/	doi.org/10.1128%2FJCM.02205-14	Recombinant BAC 	GLuc reporter assay	UL54	L595F	23/11/2020	OJCharles			A
578	HCMV	AD169	UL54	P744T	0.9		1.1	1.1										Cyclopropavir Susceptibility of Cytomegalovirus DNA Polymerase Mutants Selected after Antiviral Drug Exposure	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256009/	doi.org/10.1128%2FAAC.05559-11	Lab derived mutant 	PRA or SEAP			23/11/2020	OJCharles			A
579	HCMV	AD169	UL54	W780V	1.5			1.9										Contrasting Effects of W781V and W780V Mutations in Helix N of Herpes Simplex Virus 1 and Human Cytomegalovirus DNA Polymerases on Antiviral Drug Susceptibility	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442382/	doi.org/10.1128/JVI.03360-14	Marker Transfer 	PRA			24/11/2020	OJCharles			A
580	HSV1	Clinical isolate	UL23	C6G		Polymorphism		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			23/11/2020	OJCharles			A
581	HSV1	Clinical isolate	UL23	H7P		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			24/11/2020	OJCharles	mutations not resolved by sequence	MacIntyre	A
582	HSV1	Clinical isolate	UL23	A12P		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			25/11/2020	OJCharles		KOS	A
583	HSV1	Clinical isolate	UL23	A12T		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			26/11/2020	OJCharles	mutations not resolved by sequence	MacIntyre	A
584	HSV1	Clinical isolate	UL23	D14V		Polymorphism	Polymorphism	Polymorphism			Polymorphism	Polymorphism						Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay			27/11/2020	OJCharles			A
585	HSV1	Clinical isolate	UL23	D14Y		Polymorphism		Polymorphism										Genotypic detection of acyclovir-resistant HSV-1: Characterization of 67 ACV-sensitive and 14 ACV-resistant viruses	https://www.sciencedirect.com/science/article/pii/S016635420800199X?via%3Dihub	doi.org/10.1016/j.antiviral.2008.01.153	Isolated strain 	dye uptake assay			28/11/2020	OJCharles			A
586	HSV1	Clinical isolate	UL23	Q15L		Polymorphism												Identification and characterization of acyclovir-resistant clinical HSV-1 isolates from children	https://www.sciencedirect.com/science/article/pii/S1386653211002575?via%3Dihub	doi.org/10.1016/j.jcv.2011.06.009	Isolated strain 	ICP10 Luciferase assay			29/11/2020	OJCharles			A
587	HSV1	Clinical isolate	UL23	C6G		Polymorphism												Genetic Characterization of Thymidine Kinase from Acyclovir-Resistant and -Susceptible Herpes Simplex Virus Type 1 Isolated from Bone Marrow Transplant Recipients	https://academic.oup.com/jid/article/182/1/290/883239	doi.org/10.1086/315696	Isolated strain 	dye uptake assay			30/11/2020	OJCharles			A
588	HSV1	Clinical isolate	UL23	R18C		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			01/12/2020	OJCharles	mutations not resolved by sequence	MacIntyre	A
589	HSV1	Clinical isolate	UL23	S19P		Polymorphism	Polymorphism	Polymorphism			Polymorphism	Polymorphism						Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay			02/12/2020	OJCharles	Only occurs with other unknown - cannot logically reconstruct its phenotype	KOS	A
590	HSV1	Clinical isolate	UL23	R20H		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			03/12/2020	OJCharles	mutations not resolved by sequence	MacIntyre	A
591	HSV1	Clinical isolate	UL23	R20S		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			04/12/2020	OJCharles		KOS	A
592	HSV1	Clinical isolate	UL23	M85I		Polymorphism												Genetic Characterization of Thymidine Kinase from Acyclovir-Resistant and -Susceptible Herpes Simplex Virus Type 1 Isolated from Bone Marrow Transplant Recipients	https://academic.oup.com/jid/article/182/1/290/883239	doi.org/10.1086/315696	Isolated strain 	dye uptake assay			05/12/2020	OJCharles			A
593	HSV1	Clinical isolate	UL23	R26H		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			06/12/2020	OJCharles	mutations not resolved by sequence	MacIntyre	A
594	HSV1	Clinical isolate	UL23	A28V		Polymorphism												Identification and characterization of acyclovir-resistant clinical HSV-1 isolates from children	https://www.sciencedirect.com/science/article/pii/S1386653211002575?via%3Dihub	doi.org/10.1016/j.jcv.2011.06.009	Isolated strain 	ICP10 Luciferase assay			07/12/2020	OJCharles			A
595	HSV1	Clinical isolate	UL23	L29V		Polymorphism		Polymorphism										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			08/12/2020	OJCharles			A
596	HSV1	Clinical isolate	UL23	R30C		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			09/12/2020	OJCharles		KOS	A
597	HSV1	Clinical isolate	UL23	R32C		Polymorphism		Polymorphism										Genotypic detection of acyclovir-resistant HSV-1: Characterization of 67 ACV-sensitive and 14 ACV-resistant viruses	https://www.sciencedirect.com/science/article/pii/S016635420800199X?via%3Dihub	doi.org/10.1016/j.antiviral.2008.01.153	Isolated strain 	dye uptake assay			10/12/2020	OJCharles			A
598	HSV1	Clinical isolate	UL23	delQ35		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			11/12/2020	OJCharles	mutations not resolved by sequence	MacIntyre	A
599	HSV1	Clinical isolate	UL23	K36D		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			12/12/2020	OJCharles		KOS	A
600	HSV1	Clinical isolate	UL23	delE36		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			13/12/2020	OJCharles	mutations not resolved by sequence	MacIntyre	A
601	HSV1	Clinical isolate	UL23	R89Q		Polymorphism												Genetic Characterization of Thymidine Kinase from Acyclovir-Resistant and -Susceptible Herpes Simplex Virus Type 1 Isolated from Bone Marrow Transplant Recipients	https://academic.oup.com/jid/article/182/1/290/883239	doi.org/10.1086/315696	Isolated strain 	dye uptake assay			14/12/2020	OJCharles			A
602	HSV1	Clinical isolate	UL23	R41H		Polymorphism		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			15/12/2020	OJCharles			A
603	HSV1	Clinical isolate	UL23	L42P		Polymorphism		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			16/12/2020	OJCharles			A
604	HSV1	Clinical isolate	UL23	Q44H		Polymorphism		Polymorphism										Gene polymorphism of thymidine kinase and DNA polymerase in clinical strains of herpes simplex virus	http://pdfs.semanticscholar.org/273d/230d2dc0f09225c569b99871ac2aa4e3da70.pdf	doi.org/10.3851/IMP1852	Isolated strain 	dye uptake assay			17/12/2020	OJCharles	unkown co-mutations		A
605	HSV1	Clinical isolate	UL23	G61A		Polymorphism	Polymorphism	Polymorphism			Polymorphism	Polymorphism						Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay			18/12/2020	OJCharles		KOS	A
606	HSV1	Clinical isolate	UL23	Q67R		Polymorphism												Identification and characterization of acyclovir-resistant clinical HSV-1 isolates from children	https://www.sciencedirect.com/science/article/pii/S1386653211002575?via%3Dihub	doi.org/10.1016/j.jcv.2011.06.009	Isolated strain 	ICP10 Luciferase assay			19/12/2020	OJCharles			A
607	HSV1	Clinical isolate	UL23	L72V		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			20/12/2020	OJCharles	mutations not resolved by sequence	MacIntyre	A
608	HSV1	Clinical isolate	UL23	R75C		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			21/12/2020	OJCharles	mutations not resolved by sequence	MacIntyre	A
609	HSV1	Clinical isolate	UL23	D76N		Polymorphism		Polymorphism										Resistance of herpes simplex viruses to acyclovir: An update from a ten-year survey in France	https://www.sciencedirect.com/science/article/pii/S0166354214002502	doi.org/10.1016/j.antiviral.2014.08.013	Isolated strain 	dye uptake assay			22/12/2020	OJCharles		sc16	A
610	HSV1	Clinical isolate	UL23	D77N		Polymorphism												Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			23/12/2020	OJCharles			A
611	HSV1	Clinical isolate	UL23	I78F		Polymorphism	Polymorphism	Polymorphism			Polymorphism	Polymorphism						Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay			24/12/2020	OJCharles		KOS	A
612	HSV1	Clinical isolate	UL23	R89Q		Polymorphism		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			25/12/2020	OJCharles			A
613	HSV1	Clinical isolate	UL23	A98T		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			26/12/2020	OJCharles	mutations not resolved by sequence	MacIntyre	A
614	HSV1	Clinical isolate	UL23	I100T		Polymorphism		Polymorphism										Resistance of herpes simplex viruses to acyclovir: An update from a ten-year survey in France	https://www.sciencedirect.com/science/article/pii/S0166354214002502	doi.org/10.1016/j.antiviral.2014.08.013	Isolated strain 	dye uptake assay			27/12/2020	OJCharles		sc16	A
615	HSV1	Clinical isolate	UL23	E111K		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			28/12/2020	OJCharles		KOS	A
616	HSV1	Clinical isolate	UL23	A118V		Polymorphism	Polymorphism	Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			29/12/2020	OJCharles	mutations not resolved by sequence	MacIntyre	A
617	HSV1	Clinical isolate	UL23	A137T		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			30/12/2020	OJCharles	mutations not resolved by sequence	MacIntyre	A
618	HSV1	Clinical isolate	UL23	V138F		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			31/12/2020	OJCharles	mutations not resolved by sequence	MacIntyre	A
619	HSV1	Clinical isolate	UL23	V138I		Polymorphism												Acyclovir Susceptibility and Genetic Characteristics of Sequential Herpes Simplex Virus Type 1 Corneal Isolates from Patients with Recurrent Herpetic Keratitis	https://academic.oup.com/jid/article/200/9/1402/851413	doi.org/10.1086/606028	Isolated strain 	PCR DNA hybridization assay			01/01/2021	OJCharles	Only sequences TK, so any Pol mutations are unnacounted for		A
620	HSV1	Clinical isolate	UL23	A140V		Polymorphism		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			02/01/2021	OJCharles			A
621	HSV1	Clinical isolate	UL23	H142Y		Polymorphism		Polymorphism										Resistance of herpes simplex viruses to acyclovir: An update from a ten-year survey in France	https://www.sciencedirect.com/science/article/pii/S0166354214002502	doi.org/10.1016/j.antiviral.2014.08.013	Isolated strain 	dye uptake assay			03/01/2021	OJCharles		sc16	A
622	HSV1	Clinical isolate	UL23	E146G		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			04/01/2021	OJCharles		KOS	A
623	HSV1	Clinical isolate	UL23	H151Y		Polymorphism		Polymorphism										Genotypic detection of acyclovir-resistant HSV-1: Characterization of 67 ACV-sensitive and 14 ACV-resistant viruses	https://www.sciencedirect.com/science/article/pii/S016635420800199X?via%3Dihub	doi.org/10.1016/j.antiviral.2008.01.153	Isolated strain 	dye uptake assay			05/01/2021	OJCharles			A
624	HSV1	Clinical isolate	UL23	A156P		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			06/01/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
625	HSV1	Clinical isolate	UL23	A156V		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			07/01/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
626	HSV1	Clinical isolate	UL23	F161L		Polymorphism		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			08/01/2021	OJCharles			A
627	HSV1	Clinical isolate	UL23	V191A		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			09/01/2021	OJCharles		KOS	A
628	HSV1	Clinical isolate	UL23	A192V		Polymorphism		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			10/01/2021	OJCharles			A
629	HSV1	Clinical isolate	UL23	I214T		0.25		0.5										Genotypic and phenotypic characterization of acyclovir-resistant herpes simplex viruses isolated from haematopoietic stem cell transplant recipients.	https://journals.sagepub.com/doi/10.1177/135965350400900413	doi.org/10.1177/135965350400900413	Isolated strain 	yield reduction assay (ELVIRA)			11/01/2021	OJCharles		KOS	A
630	HSV1	Clinical isolate	UL23	D215A		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			12/01/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
631	HSV1	Clinical isolate	UL23	D215H		Polymorphism		Polymorphism										Resistance of herpes simplex viruses to acyclovir: An update from a ten-year survey in France	https://www.sciencedirect.com/science/article/pii/S0166354214002502	doi.org/10.1016/j.antiviral.2014.08.013	Isolated strain 	dye uptake assay			13/01/2021	OJCharles		sc16	A
632	HSV1	Clinical isolate	UL23	D215N		Polymorphism												Identification and characterization of acyclovir-resistant clinical HSV-1 isolates from children	https://www.sciencedirect.com/science/article/pii/S1386653211002575?via%3Dihub	doi.org/10.1016/j.jcv.2011.06.009	Isolated strain 	ICP10 Luciferase assay			14/01/2021	OJCharles			A
633	HSV1	Clinical isolate	UL23	K219T		Polymorphism		Polymorphism										Gene polymorphism of thymidine kinase and DNA polymerase in clinical strains of herpes simplex virus	http://pdfs.semanticscholar.org/273d/230d2dc0f09225c569b99871ac2aa4e3da70.pdf	doi.org/10.3851/IMP1852	Isolated strain 	dye uptake assay			15/01/2021	OJCharles	unkown co-mutations		A
634	HSV1	Clinical isolate	UL23	A233S		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			16/01/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
635	HSV1	Clinical isolate	UL23	G240E		Polymorphism		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			17/01/2021	OJCharles			A
636	HSV1	Clinical isolate	UL23	A243S		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			18/01/2021	OJCharles		KOS	A
637	HSV1	Clinical isolate	UL23	A243S		Polymorphism		Polymorphism										Genotypic detection of acyclovir-resistant HSV-1: Characterization of 67 ACV-sensitive and 14 ACV-resistant viruses	https://www.sciencedirect.com/science/article/pii/S016635420800199X?via%3Dihub	doi.org/10.1016/j.antiviral.2008.01.153	Isolated strain 	dye uptake assay			18/01/2021	OJCharles			A
638	HSV1	Clinical isolate	UL23	G251C		Polymorphism		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			19/01/2021	OJCharles			A
639	HSV1	Clinical isolate	UL23	W259R		Polymorphism		Polymorphism										Gene polymorphism of thymidine kinase and DNA polymerase in clinical strains of herpes simplex virus	http://pdfs.semanticscholar.org/273d/230d2dc0f09225c569b99871ac2aa4e3da70.pdf	doi.org/10.3851/IMP1852	Isolated strain 	dye uptake assay			20/01/2021	OJCharles	unkown co-mutations		A
640	HSV1	Clinical isolate	UL23	A265T		Polymorphism		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			21/01/2021	OJCharles			A
641	HSV1	Clinical isolate	UL23	V267L		Polymorphism		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			22/01/2021	OJCharles			A
642	HSV1	Clinical isolate	UL23	P268L		Polymorphism		Polymorphism										Resistance of herpes simplex viruses to acyclovir: An update from a ten-year survey in France	https://www.sciencedirect.com/science/article/pii/S0166354214002502	doi.org/10.1016/j.antiviral.2014.08.013	Isolated strain 	dye uptake assay			23/01/2021	OJCharles		sc16	A
643	HSV1	Clinical isolate	UL23	P268M		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			24/01/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
644	HSV1	Clinical isolate	UL23	P268T		Polymorphism		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			25/01/2021	OJCharles			A
645	HSV1	Clinical isolate	UL23	G271D		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			26/01/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
646	HSV1	Clinical isolate	UL23	A272T		Polymorphism		Polymorphism										Genotypic detection of acyclovir-resistant HSV-1: Characterization of 67 ACV-sensitive and 14 ACV-resistant viruses	https://www.sciencedirect.com/science/article/pii/S016635420800199X?via%3Dihub	doi.org/10.1016/j.antiviral.2008.01.153	Isolated strain 	dye uptake assay			27/01/2021	OJCharles			A
647	HSV1	Clinical isolate	UL23	E273K		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			28/01/2021	OJCharles		KOS	A
648	HSV1	Clinical isolate	UL23	E273Q		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			29/01/2021	OJCharles		KOS	A
649	HSV1	Clinical isolate	UL23	P274T		Polymorphism		Polymorphism										Genotypic detection of acyclovir-resistant HSV-1: Characterization of 67 ACV-sensitive and 14 ACV-resistant viruses	https://www.sciencedirect.com/science/article/pii/S016635420800199X?via%3Dihub	doi.org/10.1016/j.antiviral.2008.01.153	Isolated strain 	dye uptake assay			30/01/2021	OJCharles			A
650	HSV1	Clinical isolate	UL23	Q275P		Polymorphism		Polymorphism										Identification and characterization of acyclovir-resistant clinical HSV-1 isolates from children	https://www.sciencedirect.com/science/article/pii/S1386653211002575?via%3Dihub	doi.org/10.1016/j.jcv.2011.06.009	Isolated strain 	ICP10 Luciferase assay			31/01/2021	OJCharles			A
651	HSV1	Clinical isolate	UL23	S276G		Polymorphism		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			01/02/2021	OJCharles			A
652	HSV1	Clinical isolate	UL23	S276R		Polymorphism		Polymorphism										Gene polymorphism of thymidine kinase and DNA polymerase in clinical strains of herpes simplex virus	http://pdfs.semanticscholar.org/273d/230d2dc0f09225c569b99871ac2aa4e3da70.pdf	doi.org/10.3851/IMP1852	Isolated strain 	dye uptake assay			02/02/2021	OJCharles	unkown co-mutations		A
653	HSV1	Clinical isolate	UL23	N277K		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			03/02/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
654	HSV1	Clinical isolate	UL23	N277S		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			04/02/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
655	HSV1	Clinical isolate	UL23	A192V		Polymorphism												Genetic Characterization of Thymidine Kinase from Acyclovir-Resistant and -Susceptible Herpes Simplex Virus Type 1 Isolated from Bone Marrow Transplant Recipients	https://academic.oup.com/jid/article/182/1/290/883239	doi.org/10.1086/315696	Isolated strain 	dye uptake assay			05/02/2021	OJCharles			A
656	HSV1	Clinical isolate	UL23	D286E		Polymorphism		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			06/02/2021	OJCharles			A
657	HSV1	Clinical isolate	UL23	R293W		Polymorphism	Polymorphism	Polymorphism			Polymorphism	Polymorphism						Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay			07/02/2021	OJCharles		KOS	A
658	HSV1	Clinical isolate	UL23	A294V		Polymorphism		Polymorphism										Genotypic detection of acyclovir-resistant HSV-1: Characterization of 67 ACV-sensitive and 14 ACV-resistant viruses	https://www.sciencedirect.com/science/article/pii/S016635420800199X?via%3Dihub	doi.org/10.1016/j.antiviral.2008.01.153	Isolated strain 	dye uptake assay			08/02/2021	OJCharles			A
659	HSV1	Clinical isolate	UL23	P295T		Polymorphism		Polymorphism										Gene polymorphism of thymidine kinase and DNA polymerase in clinical strains of herpes simplex virus	http://pdfs.semanticscholar.org/273d/230d2dc0f09225c569b99871ac2aa4e3da70.pdf	doi.org/10.3851/IMP1852	Isolated strain 	dye uptake assay			09/02/2021	OJCharles	unkown co-mutations		A
660	HSV1	Clinical isolate	UL23	A299S		Polymorphism		Polymorphism										Resistance of herpes simplex viruses to acyclovir: An update from a ten-year survey in France	https://www.sciencedirect.com/science/article/pii/S0166354214002502	doi.org/10.1016/j.antiviral.2014.08.013	Isolated strain 	dye uptake assay			10/02/2021	OJCharles		sc16	A
661	HSV1	Clinical isolate	UL23	G302S		Polymorphism		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			11/02/2021	OJCharles			A
662	HSV1	Clinical isolate	UL23	D303N		Polymorphism		Polymorphism										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			12/02/2021	OJCharles			A
663	HSV1	Clinical isolate	UL23	A309V		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			13/02/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
664	HSV1	Clinical isolate	UL23	A316V		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			14/02/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
665	HSV1	Clinical isolate	UL23	H323Y		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			15/02/2021	OJCharles		KOS	A
666	HSV1	Clinical isolate	UL23	L327M		Polymorphism		Polymorphism										Genotypic detection of acyclovir-resistant HSV-1: Characterization of 67 ACV-sensitive and 14 ACV-resistant viruses	https://www.sciencedirect.com/science/article/pii/S016635420800199X?via%3Dihub	doi.org/10.1016/j.antiviral.2008.01.153	Isolated strain 	dye uptake assay			16/02/2021	OJCharles			A
667	HSV1	Clinical isolate	UL23	D328E		Polymorphism		Polymorphism										Genotypic detection of acyclovir-resistant HSV-1: Characterization of 67 ACV-sensitive and 14 ACV-resistant viruses	https://www.sciencedirect.com/science/article/pii/S016635420800199X?via%3Dihub	doi.org/10.1016/j.antiviral.2008.01.153	Isolated strain 	dye uptake assay			17/02/2021	OJCharles			A
668	HSV1	Clinical isolate	UL23	S332L		Polymorphism												Acyclovir Susceptibility and Genetic Characteristics of Sequential Herpes Simplex Virus Type 1 Corneal Isolates from Patients with Recurrent Herpetic Keratitis	https://academic.oup.com/jid/article/200/9/1402/851413	doi.org/10.1086/606028	Isolated strain 	PCR DNA hybridization assay			18/02/2021	OJCharles	Only sequences TK, so any Pol mutations are unnacounted for	KOS	A
669	HSV1	Clinical isolate	UL23	S332P		Polymorphism		Polymorphism										Genotypic detection of acyclovir-resistant HSV-1: Characterization of 67 ACV-sensitive and 14 ACV-resistant viruses	https://www.sciencedirect.com/science/article/pii/S016635420800199X?via%3Dihub	doi.org/10.1016/j.antiviral.2008.01.153	Isolated strain 	dye uptake assay			19/02/2021	OJCharles			A
670	HSV1	Clinical isolate	UL23	A334T		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			20/02/2021	OJCharles		KOS	A
671	HSV1	Clinical isolate	UL23	G335D		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			21/02/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
672	HSV1	Clinical isolate	UL23	L341R		Polymorphism		Polymorphism										Resistance of herpes simplex viruses to acyclovir: An update from a ten-year survey in France	https://www.sciencedirect.com/science/article/pii/S0166354214002502	doi.org/10.1016/j.antiviral.2014.08.013	Isolated strain 	dye uptake assay			22/02/2021	OJCharles		sc16	A
673	HSV1	Clinical isolate	UL23	G346W		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			24/02/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
674	HSV1	Clinical isolate	UL23	V348I		0.3		0.8										Genotypic and phenotypic characterization of acyclovir-resistant herpes simplex viruses isolated from haematopoietic stem cell transplant recipients.	https://journals.sagepub.com/doi/10.1177/135965350400900413	doi.org/10.1177/135965350400900413	Isolated strain 	yield reduction assay (ELVIRA)			25/02/2021	OJCharles	As Susceptible and assume r+S -> S not sequencing Pol is fine to infer a susctpeitble mutant		A
675	HSV1	Clinical isolate	UL23	T350I		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			26/02/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
676	HSV1	Clinical isolate	UL23	T350S		Polymorphism	Polymorphism	Polymorphism			Polymorphism	Polymorphism						Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay			27/02/2021	OJCharles		KOS	A
677	HSV1	Clinical isolate	UL23	V352I		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			28/02/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
678	HSV1	Clinical isolate	UL23	S357C		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			01/03/2021	OJCharles		KOS	A
679	HSV1	Clinical isolate	UL23	I358V		Polymorphism		Polymorphism										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			02/03/2021	OJCharles			A
680	HSV1	Clinical isolate	UL23	D363N		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			03/03/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
681	HSV1	Clinical isolate	UL23	G240E		Polymorphism												Genetic Characterization of Thymidine Kinase from Acyclovir-Resistant and -Susceptible Herpes Simplex Virus Type 1 Isolated from Bone Marrow Transplant Recipients	https://academic.oup.com/jid/article/182/1/290/883239	doi.org/10.1086/315696	Isolated strain 	dye uptake assay			04/03/2021	OJCharles			A
682	HSV1	Clinical isolate	UL23	G251C		Polymorphism												Genetic Characterization of Thymidine Kinase from Acyclovir-Resistant and -Susceptible Herpes Simplex Virus Type 1 Isolated from Bone Marrow Transplant Recipients	https://academic.oup.com/jid/article/182/1/290/883239	doi.org/10.1086/315696	Isolated strain 	dye uptake assay			05/03/2021	OJCharles			A
683	HSV1	Clinical isolate	UL23	G373E		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			06/03/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
684	HSV1	Clinical isolate	UL23	V267L		Polymorphism												Genetic Characterization of Thymidine Kinase from Acyclovir-Resistant and -Susceptible Herpes Simplex Virus Type 1 Isolated from Bone Marrow Transplant Recipients	https://academic.oup.com/jid/article/182/1/290/883239	doi.org/10.1086/315696	Isolated strain 	dye uptake assay			07/03/2021	OJCharles			A
685	HSV1	Clinical isolate	UL23	A375P		Polymorphism												Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			08/03/2021	OJCharles			A
686	HSV1	Clinical isolate	UL23	N376H		Polymorphism		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			09/03/2021	OJCharles			A
687	HSV1	Clinical isolate	UL23	N376P		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			10/03/2021	OJCharles		KOS	A
688	HSV1	Clinical isolate	UL23	N376H		Polymorphism	Polymorphism	Polymorphism			Polymorphism	Polymorphism						Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay			11/03/2021	OJCharles		KOS	A
689	HSV1	Clinical isolate	UL23	N23S		Polymorphism												Phenotypic and genotypic characterization of induced acyclovir-resistant clinical isolates of herpes simplex virus type 1	https://www.sciencedirect.com/science/article/pii/S0166354213002544?via%3Dihub	doi.org/10.1016/j.antiviral.2013.09.008	Isolated strain 	PRA			12/03/2021	OJCharles			A
690	HSV1	Clinical isolate	UL23	R51W		Resistant	Polymorphism	Polymorphism			 	Resistant						Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			14/03/2021	OJCharles		KOS	A
691	HSV1	Clinical isolate	UL23	Y53C		Resistant	Polymorphism	Polymorphism			Resistant	Resistant						Screening of herpes simplex virus type 1 isolates for acyclovir resistance using DiviTum assay	https://www.sciencedirect.com/science/article/pii/S0166093412004351?via%3Dihub	doi.org/10.1016/j.jviromet.2012.12.001	Isolated strain 	dye uptake assay			15/03/2021	OJCharles			A
692	HSV1	Clinical isolate	UL23	Y53D		Resistant		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			16/03/2021	OJCharles		KOS	A
693	HSV1	Clinical isolate	UL23	Y53H		Resistant	Polymorphism	Polymorphism			Resistant	Resistant						Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay			17/03/2021	OJCharles	Only occurs with other resistant mutation R163H	KOS	O
694	HSV1	Clinical isolate	UL23	Y53stop		Resistant		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			18/03/2021	OJCharles			A
695	HSV1	TAS	UL23	D55N		110	0.1											Genotypic and phenotypic characterization of the thymidine kinase of ACV-resistant HSV-1 derived from an acyclovir-sensitive herpes simplex virus type 1 strain	https://www.sciencedirect.com/science/article/pii/S0166354202001316?via%3Dihub	doi.org/10.1016/S0166-3542(02)00131-6	Lab induced strain 	PRA			19/03/2021	OJCharles	there are only extreme values - concern?		A
696	HSV1	Clinical isolate	UL23	G56S		Resistant												Acyclovir Susceptibility and Genetic Characteristics of Sequential Herpes Simplex Virus Type 1 Corneal Isolates from Patients with Recurrent Herpetic Keratitis	https://academic.oup.com/jid/article/200/9/1402/851413	doi.org/10.1086/606028	Isolated strain 	PCR DNA hybridization assay			20/03/2021	OJCharles	Only sequences TK, so any Pol mutations are unnacounted for	KOS	A
697	HSV1	Clinical isolate	UL23	P57H		3.8												Phenotypic and Genotypic Characterization of Acyclovir-Resistant Herpes Simplex Viruses from Immunocompromised Patients	https://academic.oup.com/jid/article/178/2/297/904713	doi.org/10.1086/515626	Isolated strain 	PCR DNA hybridization assay			21/03/2021	OJCharles		A2	A
698	HSV1	Clinical isolate	UL23	H58N		Resistant	Polymorphism	Polymorphism			Resistant	Resistant						Single nucleotide polymorphisms of thymidine kinase and DNA polymerase genes in clinical herpes simplex virus type 1 isolates associated with different resistance phenotypes	https://www.sciencedirect.com/science/article/pii/S0166354214000898?via%3Dihub	doi.org/10.1016/j.antiviral.2014.03.015	Isolated strain 	dye uptake assay			22/03/2021	OJCharles			A
699	HSV1	Clinical isolate	UL23	H58R		45		0.6										Genotypic and phenotypic characterization of acyclovir-resistant herpes simplex viruses isolated from haematopoietic stem cell transplant recipients.	https://journals.sagepub.com/doi/10.1177/135965350400900413	doi.org/10.1177/135965350400900413	Isolated strain 	yield reduction assay (ELVIRA)			23/03/2021	OJCharles			A
700	HSV1	Clinical isolate	UL23	G59R		Resistant												Acyclovir Susceptibility and Genetic Characteristics of Sequential Herpes Simplex Virus Type 1 Corneal Isolates from Patients with Recurrent Herpetic Keratitis	https://academic.oup.com/jid/article/200/9/1402/851413	doi.org/10.1086/606028	Isolated strain 	PCR DNA hybridization assay			24/03/2021	OJCharles	co-occuring E83K is also resistance causing	KOS	O
701	HSV1	KOS	UL23	G59W*		Resistant	Polymorphism	Polymorphism			Resistant	Resistant						Characterization of Herpes Simplex Virus Type 1 Thymidine Kinase Mutants Selected under a Single Round of High-Dose Brivudin	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1082774/#r5	doi.org/10.1128/JVI.79.9.5863-5869.2005	Lab induced strain 	PRA			25/03/2021	OJCharles		KOS	A
702	HSV1		UL23	K62N		42												Thymidine Kinase Mutations Conferring Acyclovir Resistance in Herpes Simplex Type 1 Recombinant Viruses	https://aac.asm.org/content/aac/50/11/3889.full.pdf	 doi.org/10.1128/AAC.00889-06	Marker transfer 	PRA			26/03/2021	OJCharles			A
703	HSV1		UL23	T63A		Resistant												Differential Mutation Patterns in Thymidine Kinase and DNA Polymerase Genes of Herpes Simplex Virus Type 1 Clones Passaged in the Presence of Acyclovir or Penciclovir	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC153316/	doi.org/10.1128/AAC.47.5.1707-1713.2003	Lab induced strain 	PRA			27/03/2021	OJCharles	frameshift in tested strain		O
704	HSV1	Clinical isolate	UL23	T63I		10												Differential Mutation Patterns in Thymidine Kinase and DNA Polymerase Genes of Herpes Simplex Virus Type 1 Clones Passaged in the Presence of Acyclovir or Penciclovir	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC153316/	doi.org/10.1128/AAC.47.5.1707-1713.2003	Isolated strain 	PCR DNA hybridization assay			28/03/2021	OJCharles	ref wrong		E
705	HSV1	TAS	UL23	T65N		8	0.5											Differential Mutation Patterns in Thymidine Kinase and DNA Polymerase Genes of Herpes Simplex Virus Type 1 Clones Passaged in the Presence of Acyclovir or Penciclovir	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC153316/	doi.org/10.1128/AAC.47.5.1707-1713.2003	Lab induced strain 	PRA			29/03/2021	OJCharles	ref wrong		E
706	HSV1	Clinical isolate	UL23	Q67stop		Resistant												Differential Mutation Patterns in Thymidine Kinase and DNA Polymerase Genes of Herpes Simplex Virus Type 1 Clones Passaged in the Presence of Acyclovir or Penciclovir	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC153316/	doi.org/10.1128/AAC.47.5.1707-1713.2003	Isolated strain 	PRA			30/03/2021	OJCharles	ref wrong		O
707	HSV1	Clinical isolate	UL23	S74stop 		Resistant	Polymorphism	Polymorphism			Resistant	Resistant						Screening of herpes simplex virus type 1 isolates for acyclovir resistance using DiviTum assay	https://www.sciencedirect.com/science/article/pii/S0166093412004351?via%3Dihub	doi.org/10.1016/j.jviromet.2012.12.001	Isolated strain 	dye uptake assay			31/03/2021	OJCharles			A
708	HSV1	Clinical isolate	UL23	Y80N		Resistant												Acyclovir Susceptibility and Genetic Characteristics of Sequential Herpes Simplex Virus Type 1 Corneal Isolates from Patients with Recurrent Herpetic Keratitis	https://academic.oup.com/jid/article/200/9/1402/851413	doi.org/10.1086/606028	Isolated strain 	PCR DNA hybridization assay			01/04/2021	OJCharles	M128L is unknown	KOS	O
709	HSV1		UL23	E83K		Resistant		Polymorphism				Resistant						Differential Mutation Patterns in Thymidine Kinase and DNA Polymerase Genes of Herpes Simplex Virus Type 1 Clones Passaged in the Presence of Acyclovir or Penciclovir	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC153316/	doi.org/10.1128/AAC.47.5.1707-1713.2003	Lab induced strain 	PRA			02/04/2021	OJCharles	frameshift in tested strain		O
710	HSV1	Clinical isolate	UL23	P84L		Resistant	Polymorphism	Polymorphism			Resistant	Resistant						Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay			03/04/2021	OJCharles	Only occurs with other resistant mutation R163H and deletion	KOS	O
711	HSV1		UL23	P84L		Resistant	Polymorphism	Resistant			Resistant	Resistant						Differential Mutation Patterns in Thymidine Kinase and DNA Polymerase Genes of Herpes Simplex Virus Type 1 Clones Passaged in the Presence of Acyclovir or Penciclovir	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC153316/	doi.org/10.1128/AAC.47.5.1707-1713.2003	Isolated strain 	PRA			03/04/2021	OJCharles	ref wrong		E
712	HSV1	TAS	UL23	P84S		27	0.3											Differential Mutation Patterns in Thymidine Kinase and DNA Polymerase Genes of Herpes Simplex Virus Type 1 Clones Passaged in the Presence of Acyclovir or Penciclovir	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC153316/	doi.org/10.1128/AAC.47.5.1707-1713.2003	Lab induced strain 	PRA			04/04/2021	OJCharles	ref wrong		E
713	HSV1	Clinical isolate	UL23	M85stop		Resistant												Phenotypic and Genotypic Characterization of Acyclovir-Resistant Herpes Simplex Viruses from Immunocompromised Patients	https://academic.oup.com/jid/article/178/2/297/904713	doi.org/10.1086/515626	Isolated strain 	PCR DNA hybridization assay			05/04/2021	OJCharles		A2	A
714	HSV1	Clinical isolate	UL23	Y87H		Resistant												Acyclovir Susceptibility and Genetic Characteristics of Sequential Herpes Simplex Virus Type 1 Corneal Isolates from Patients with Recurrent Herpetic Keratitis	https://academic.oup.com/jid/article/200/9/1402/851413	doi.org/10.1086/606028	Isolated strain 	PCR DNA hybridization assay			07/04/2021	OJCharles	co-occuring R41H (H41R in pub) is subsequently shown to be resistant	KOS	O
715	HSV1	Clinical isolate	UL23	W88R		Resistant					Resistant							Mutations in the DNA Polymerase and Thymidine Kinase Genes of Herpes Simplex Virus Clinical Isolates Resistant to Antiherpetic Drugs	https://link.springer.com/article/10.1134/S0026893310030118		Isolated strain 	PRA			08/04/2021	OJCharles	co-occurs with resistant R220H	L2	O
716	HSV1	Clinical isolate	UL23	R89W		Resistant												Acyclovir Susceptibility and Genetic Characteristics of Sequential Herpes Simplex Virus Type 1 Corneal Isolates from Patients with Recurrent Herpetic Keratitis	https://academic.oup.com/jid/article/200/9/1402/851413	doi.org/10.1086/606028	Isolated strain 	PCR DNA hybridization assay			09/04/2021	OJCharles	co-occuring G200D is subsequently shown to be resistant	KOS	O
717	HSV1	Clinical isolate	UL23	T103P		Resistant	Polymorphism	Polymorphism			Resistant	Resistant						Screening of herpes simplex virus type 1 isolates for acyclovir resistance using DiviTum assay	https://www.sciencedirect.com/science/article/pii/S0166093412004351?via%3Dihub	doi.org/10.1016/j.jviromet.2012.12.001	Isolated strain 	dye uptake assay			11/04/2021	OJCharles			A
718	HSV1	TAS	UL23	T103stop		Resistant	Polymorphism	Polymorphism										Genotypic and phenotypic characterization of the thymidine kinase of ACV-resistant HSV-1 derived from an acyclovir-sensitive herpes simplex virus type 1 strain	https://www.sciencedirect.com/science/article/pii/S0166354202001316?via%3Dihub	doi.org/10.1016/S0166-3542(02)00131-6	Lab induced strain 	PRA			12/04/2021	OJCharles	there are only extreme values - concern?		A
719	HSV1	Clinical isolate	UL23	Q104H		Resistant												Phenotypic and Genotypic Characterization of Acyclovir-Resistant Herpes Simplex Viruses from Immunocompromised Patients	https://academic.oup.com/jid/article/178/2/297/904713	doi.org/10.1086/515626	Isolated strain 	PCR DNA hybridization assay	UL23	L297S	13/04/2021	OJCharles	co-occurs with resmut	A2	O
720	HSV1	Clinical isolate	UL23	Q104stop		Resistant	Polymorphism	Polymorphism			Resistant	Resistant						Screening of herpes simplex virus type 1 isolates for acyclovir resistance using DiviTum assay	https://www.sciencedirect.com/science/article/pii/S0166093412004351?via%3Dihub	doi.org/10.1016/j.jviromet.2012.12.001	Isolated strain 	dye uptake assay			14/04/2021	OJCharles			A
721	HSV1	Clinical isolate	UL23	Q104stop		Resistant	Polymorphism	Polymorphism			Resistant	Resistant						Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay			14/04/2021	OJCharles		KOS	A
722	HSV1		UL23	D116N		42						70						Intracellular uptake of thymidine and antiherpetic drugs for thymidine kinase-deficient mutants of herpes simplex virus type 1	https://www.sciencedirect.com/science/article/pii/S0166354206000313?via%3Dihub	doi.org/10.1016/j.antiviral.2006.01.010	Marker Transfer 	TK functional kinetic assay			18/04/2021	OJCharles	The mutation is a frameshift causing deletion, which is not possible to reconstruct		O
723	HSV1	Clinical isolate	UL23	V120stop		Resistant												Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			19/04/2021	OJCharles			A
724	HSV1	Clinical isolate	UL23	M121R		Resistant	Polymorphism	Polymorphism			Resistant	Resistant						Screening of herpes simplex virus type 1 isolates for acyclovir resistance using DiviTum assay	https://www.sciencedirect.com/science/article/pii/S0166093412004351?via%3Dihub	doi.org/10.1016/j.jviromet.2012.12.001	Isolated strain 	dye uptake assay			20/04/2021	OJCharles			A
725	HSV1	Clinical isolate	UL23	S123R		Resistant												Acyclovir Susceptibility and Genetic Characteristics of Sequential Herpes Simplex Virus Type 1 Corneal Isolates from Patients with Recurrent Herpetic Keratitis	https://academic.oup.com/jid/article/200/9/1402/851413	doi.org/10.1086/606028	Isolated strain 	PCR DNA hybridization assay			21/04/2021	OJCharles	S123R and R123S - return to WT is resistant? Really? Likely pol muts	KOS	O
726	HSV1	Clinical isolate	UL23	Q125H		Resistant					Polymorphism	Polymorphism						Neonatal Herpes Encephalitis Caused by a Virologically Confirmed Acyclovir-Resistant Herpes Simplex Virus 1 Strain	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536242/	doi.org/10.1128/JCM.02247-12	Isolated strain 	PRA			22/04/2021	OJCharles			A
727	HSV1	Clinical isolate	UL23	M128L		Resistant												Acyclovir Susceptibility and Genetic Characteristics of Sequential Herpes Simplex Virus Type 1 Corneal Isolates from Patients with Recurrent Herpetic Keratitis	https://academic.oup.com/jid/article/200/9/1402/851413	doi.org/10.1086/606028	Isolated strain 	PCR DNA hybridization assay			23/04/2021	OJCharles	co-occuring Y80N is unknwon	KOS	O
728	HSV1	Clinical isolate	UL23	G129D		102		0.7										Genotypic and phenotypic characterization of acyclovir-resistant herpes simplex viruses isolated from haematopoietic stem cell transplant recipients.	https://journals.sagepub.com/doi/10.1177/135965350400900413	doi.org/10.1177/135965350400900413	Isolated strain 	yield reduction assay (ELVIRA)			24/04/2021	OJCharles			A
729	HSV1		UL23	P131S		Resistant												Differential Mutation Patterns in Thymidine Kinase and DNA Polymerase Genes of Herpes Simplex Virus Type 1 Clones Passaged in the Presence of Acyclovir or Penciclovir	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC153316/	doi.org/10.1128/AAC.47.5.1707-1713.2003	Lab induced strain 	PRA			25/04/2021	OJCharles	co-occurs with resistant mutation		O
730	HSV1	Clinical isolate	UL23	D162A		Resistant		Polymorphism										Differential Mutation Patterns in Thymidine Kinase and DNA Polymerase Genes of Herpes Simplex Virus Type 1 Clones Passaged in the Presence of Acyclovir or Penciclovir	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC153316/	doi.org/10.1128/AAC.47.5.1707-1713.2003	Isolated strain 	PRA			27/04/2021	OJCharles	ref wrong		E
731	HSV1	Clinical isolate	UL23	D162N		Resistant		Polymorphism										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub#b0165	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			29/04/2021	OJCharles	co-occuring 365I later shown to be polymorphc		A
732	HSV1		UL23	A167V		Resistant												Differential Mutation Patterns in Thymidine Kinase and DNA Polymerase Genes of Herpes Simplex Virus Type 1 Clones Passaged in the Presence of Acyclovir or Penciclovir	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC153316/	doi.org/10.1128/AAC.47.5.1707-1713.2003	Lab induced strain 	PRA			01/05/2021	OJCharles	frameshift in tested strain		O
733	HSV1	KOS	UL23	A168T		Polymorphism	Polymorphism	Polymorphism			Resistant	Polymorphism						Differential Mutation Patterns in Thymidine Kinase and DNA Polymerase Genes of Herpes Simplex Virus Type 1 Clones Passaged in the Presence of Acyclovir or Penciclovir	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC153316/	doi.org/10.1128/AAC.47.5.1707-1713.2003	Lab induced strain 	PRA			02/05/2021	OJCharles	ref wrong	KOS	E
734	HSV1		UL23	L170P		Resistant	Polymorphism	Polymorphism			Resistant	Resistant						Differential Mutation Patterns in Thymidine Kinase and DNA Polymerase Genes of Herpes Simplex Virus Type 1 Clones Passaged in the Presence of Acyclovir or Penciclovir	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC153316/	doi.org/10.1128/AAC.47.5.1707-1713.2003	Lab induced strain 	PRA			03/05/2021	OJCharles	ref wrong		E
735	HSV1	Clinical isolate	UL23	Y172C		Resistant	Polymorphism	Polymorphism			Resistant	Resistant						Differential Mutation Patterns in Thymidine Kinase and DNA Polymerase Genes of Herpes Simplex Virus Type 1 Clones Passaged in the Presence of Acyclovir or Penciclovir	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC153316/	doi.org/10.1128/AAC.47.5.1707-1713.2003	Lab induced strain 	PRA			04/05/2021	OJCharles	ref wrong		E
736	HSV1		UL23	P173L		Resistant												Differential Mutation Patterns in Thymidine Kinase and DNA Polymerase Genes of Herpes Simplex Virus Type 1 Clones Passaged in the Presence of Acyclovir or Penciclovir	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC153316/	doi.org/10.1128/AAC.47.5.1707-1713.2003	Lab induced strain 	PRA			05/05/2021	OJCharles	frameshift in tested strain		O
737	HSV1	TAS	UL23	P173R		140	0.1											Differential Mutation Patterns in Thymidine Kinase and DNA Polymerase Genes of Herpes Simplex Virus Type 1 Clones Passaged in the Presence of Acyclovir or Penciclovir	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC153316/	doi.org/10.1128/AAC.47.5.1707-1713.2003	Lab induced strain 	PRA			06/05/2021	OJCharles	ref wrong		E
738	HSV1	Clinical isolate	UL23	A174P		Resistant	Polymorphism	Polymorphism			Resistant	Resistant						Differential Mutation Patterns in Thymidine Kinase and DNA Polymerase Genes of Herpes Simplex Virus Type 1 Clones Passaged in the Presence of Acyclovir or Penciclovir	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC153316/	doi.org/10.1128/AAC.47.5.1707-1713.2003	Lab induced strain 	PRA			07/05/2021	OJCharles	ref wrong		E
739	HSV1	Clinical isolate	UL23	A175V		Resistant		Polymorphism										Differential Mutation Patterns in Thymidine Kinase and DNA Polymerase Genes of Herpes Simplex Virus Type 1 Clones Passaged in the Presence of Acyclovir or Penciclovir	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC153316/	doi.org/10.1128/AAC.47.5.1707-1713.2003	Isolated strain 	PRA			08/05/2021	OJCharles	ref wrong		E
740	HSV1	Clinical isolate	UL23	R176Q		Resistant		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			09/05/2021	OJCharles			A
741	HSV1	Clinical isolate	UL23	R176stop		Resistant												Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			10/05/2021	OJCharles			A
742	HSV1		UL23	R176W		Resistant												Impact of novel mutations of herpes simplex virus 1 and 2 thymidine kinases on acyclovir phosphorylation activity	https://www.sciencedirect.com/science/article/pii/S0166354212002239?via%3Dihub#b0010	doi.org/10.1016/j.antiviral.2012.09.016	Marker Transfer 	TK functional kinetic assay			11/05/2021	OJCharles			A
743	HSV1	Clinical isolate	UL23	L178R		Resistant												Acyclovir-Resistant Corneal HSV-1 Isolates from Patients with Herpetic Keratitis	https://academic.oup.com/jid/article/198/5/659/865508	doi.org/10.1086/590668	Isolated strain 	PRA			12/05/2021	OJCharles			A
744	HSV1	Clinical isolate	UL23	S181N		Resistant		Resistant										Acyclovir-Resistant Corneal HSV-1 Isolates from Patients with Herpetic Keratitis	https://academic.oup.com/jid/article/198/5/659/865508	doi.org/10.1086/590668	Isolated strain 	PRA			13/05/2021	OJCharles			A
745	HSV1	Clinical isolate	UL23	M182stop		Resistant		Polymorphism										Genotypic and phenotypic characterization of acyclovir-resistant herpes simplex viruses isolated from haematopoietic stem cell transplant recipients.	https://journals.sagepub.com/doi/10.1177/135965350400900413	doi.org/10.1177/135965350400900413	Isolated strain 	yield reduction assay (ELVIRA)			14/05/2021	OJCharles			A
746	HSV1	Clinical isolate	UL23	T183stop		Resistant												Phenotypic and Genotypic Characterization of Acyclovir-Resistant Herpes Simplex Viruses from Immunocompromised Patients	https://academic.oup.com/jid/article/178/2/297/904713	doi.org/10.1086/515626	Isolated strain 	dye uptake assay			17/05/2021	OJCharles		A2	A
747	HSV1		UL23	Q185R		26						70						Intracellular uptake of thymidine and antiherpetic drugs for thymidine kinase-deficient mutants of herpes simplex virus type 1	https://www.sciencedirect.com/science/article/pii/S0166354206000313?via%3Dihub	doi.org/10.1016/j.antiviral.2006.01.010	Marker Transfer 	TK functional kinetic assay			18/05/2021	OJCharles	The mutation is a frameshift causing deletion, which is not possible to reconstruct		O
748	HSV1	Clinical isolate	UL23	V187M		Resistant												Recurrent Acyclovir-Resistant Herpes Simplex in an Immunocompromised Patient: Can Strain Differences Compensate for Loss of Thymidine Kinase in Pathogenesis?	https://academic.oup.com/jid/article/178/3/618/927942	doi.org/10.1086/515375	Isolated strain 	dye uptake assay			19/05/2021	OJCharles			A
749	HSV1	Clinical isolate	UL23	A189V		Resistant		Polymorphism				Resistant						Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PCR DNA hybridization assay			20/05/2021	OJCharles	co-occuring unknown L227F		O
750	HSV1	Clinical isolate	UL23	delI194		Resistant												Acyclovir Susceptibility and Genetic Characteristics of Sequential Herpes Simplex Virus Type 1 Corneal Isolates from Patients with Recurrent Herpetic Keratitis	https://academic.oup.com/jid/article/200/9/1402/851413	doi.org/10.1086/606028	Isolated strain 	PCR DNA hybridization assay			21/05/2021	OJCharles	Only sequences TK, so any Pol mutations are unnacounted for- but all early deletions shown to be resistant causing	KOS	A
751	HSV1	TAS	UL23	G200C		15	1											Genotypic and phenotypic characterization of the thymidine kinase of ACV-resistant HSV-1 derived from an acyclovir-sensitive herpes simplex virus type 1 strain	https://www.sciencedirect.com/science/article/pii/S0166354202001316?via%3Dihub	doi.org/10.1016/S0166-3542(02)00131-6	Lab induced strain 	PRA			22/05/2021	OJCharles	there are only extreme values - concern?		A
752	HSV1	Clinical isolate	UL23	G200S		Resistant												Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			24/05/2021	OJCharles		KOS	A
753	HSV1	Clinical isolate	UL23	T201P		2												Phenotypic and Genotypic Characterization of Acyclovir-Resistant Herpes Simplex Viruses from Immunocompromised Patients	https://academic.oup.com/jid/article/178/2/297/904713	doi.org/10.1086/515626	Isolated strain 	PCR DNA hybridization assay			25/05/2021	OJCharles		A2	A
754	HSV1	KOS	UL23	V204G		12		Polymorphism										Common and New Acyclovir Resistant Herpes Simplex Virus-1 Mutants Causing Bilateral Recurrent Herpetic Keratitis in an Immunocompetent Patient	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883165/	doi.org/10.1093/infdis/jit437	Isolated strain 	PRA			26/05/2021	OJCharles		KOS	A
755	HSV1	KOS	UL23	G206R		Resistant	Polymorphism	Polymorphism			Resistant	Resistant						Characterization of Herpes Simplex Virus Type 1 Thymidine Kinase Mutants Selected under a Single Round of High-Dose Brivudin	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1082774/#r5	doi.org/10.1128/JVI.79.9.5863-5869.2005	Lab induced strain 	PRA			27/05/2021	OJCharles		KOS	A
756	HSV1	Clinical isolate	UL23	A207P		Resistant		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			28/05/2021	OJCharles		KOS	A
757	HSV1	Clinical isolate	UL23	L208F		Resistant												Phenotypic and genotypic characterization of induced acyclovir-resistant clinical isolates of herpes simplex virus type 1	https://www.sciencedirect.com/science/article/pii/S0166354213002544?via%3Dihub	doi.org/10.1016/j.antiviral.2013.09.008	Isolated strain 	PRA			29/05/2021	OJCharles	co-occuring resistant mutant		O
758	HSV1	Clinical isolate	UL23	L208H		Resistant	Polymorphism	Polymorphism			Resistant	Resistant						Screening of herpes simplex virus type 1 isolates for acyclovir resistance using DiviTum assay	https://www.sciencedirect.com/science/article/pii/S0166093412004351?via%3Dihub	doi.org/10.1016/j.jviromet.2012.12.001	Isolated strain 	dye uptake assay			30/05/2021	OJCharles			A
759	HSV1	Clinical isolate	UL23	R216C		Resistant						Resistant						Phenotypic and Genotypic Characterization of Acyclovir-Resistant Herpes Simplex Viruses from Immunocompromised Patients	https://academic.oup.com/jid/article/178/2/297/904713	doi.org/10.1086/515626	Isolated strain 	dye uptake assay			31/05/2021	OJCharles		A2	O
760	HSV1	Clinical isolate	UL23	R216H		Resistant		Polymorphism										Genotypic and phenotypic characterization of acyclovir-resistant herpes simplex viruses isolated from haematopoietic stem cell transplant recipients.	https://journals.sagepub.com/doi/10.1177/135965350400900413	doi.org/10.1177/135965350400900413	Isolated strain 	yield reduction assay (ELVIRA)			01/06/2021	OJCharles			A
761	HSV1		UL23	R216S		Resistant	Polymorphism											Differential Mutation Patterns in Thymidine Kinase and DNA Polymerase Genes of Herpes Simplex Virus Type 1 Clones Passaged in the Presence of Acyclovir or Penciclovir	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC153316/	doi.org/10.1128/AAC.47.5.1707-1713.2003	Lab induced strain 	PRA			02/06/2021	OJCharles	co-occurs with resistant mutation	co-occurs with resistant mutation	O
762	HSV1	Clinical isolate	UL23	R220C		Resistant		Polymorphism										Differential Mutation Patterns in Thymidine Kinase and DNA Polymerase Genes of Herpes Simplex Virus Type 1 Clones Passaged in the Presence of Acyclovir or Penciclovir	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC153316/	doi.org/10.1128/AAC.47.5.1707-1713.2003	Isolated strain 	PRA			03/06/2021	OJCharles	ref wrong		E
763	HSV1	KOS	UL23	R220H		Resistant	Polymorphism	Polymorphism			Resistant	Resistant						Differential Mutation Patterns in Thymidine Kinase and DNA Polymerase Genes of Herpes Simplex Virus Type 1 Clones Passaged in the Presence of Acyclovir or Penciclovir	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC153316/	doi.org/10.1128/AAC.47.5.1707-1713.2003	Lab induced strain 	PRA			04/06/2021	OJCharles		KOS	O
764	HSV1		UL23	R222C		Resistant	Polymorphism	Polymorphism			Resistant	Resistant						Differential Mutation Patterns in Thymidine Kinase and DNA Polymerase Genes of Herpes Simplex Virus Type 1 Clones Passaged in the Presence of Acyclovir or Penciclovir	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC153316/	doi.org/10.1128/AAC.47.5.1707-1713.2003	Lab induced strain 	dye uptake assay			05/06/2021	OJCharles	ref wrong		E
765	HSV1	Clinical isolate	UL23	R222H		Resistant	Polymorphism	Polymorphism			Resistant	Resistant						Single nucleotide polymorphisms of thymidine kinase and DNA polymerase genes in clinical herpes simplex virus type 1 isolates associated with different resistance phenotypes	https://www.sciencedirect.com/science/article/pii/S0166354214000898?via%3Dihub	doi.org/10.1016/j.antiviral.2014.03.015	Isolated strain 	dye uptake assay			06/06/2021	OJCharles	Only sequences TK, so any Pol mutations are unnacounted for		A
766	HSV1	Clinical isolate	UL23	G224frameshift		Resistant	Polymorphism	Polymorphism			Resistant	Resistant						Screening of herpes simplex virus type 1 isolates for acyclovir resistance using DiviTum assay	https://www.sciencedirect.com/science/article/pii/S0166093412004351?via%3Dihub	doi.org/10.1016/j.jviromet.2012.12.001	Isolated strain 	dye uptake assay			07/06/2021	OJCharles			A
767	HSV1	Clinical isolate	UL23	L227F		Resistant		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PCR DNA hybridization assay			08/06/2021	OJCharles	co-occuring unknown A189V		O
768	HSV1		UL23	D228stop*		Resistant	Polymorphism	Polymorphism			Resistant	Resistant						Characterization of Herpes Simplex Viruses Selected in Culture for Resistance to Penciclovir or Acyclovir	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC114085/	doi.org/10.1128/JVI.75.4.1761-1769.2001	Lab induced strain 	PRA			09/06/2021	OJCharles			A
769	HSV1	Clinical isolate	UL23	D228stop		Resistant		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			11/06/2021	OJCharles		KOS	A
770	HSV1	Clinical isolate	UL23	D228stop		Resistant	Polymorphism	Polymorphism			Resistant	Resistant						Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			12/06/2021	OJCharles		KOS	A
771	HSV1	Clinical isolate	UL23	D228stop		Resistant	Polymorphism	Polymorphism			Resistant	Resistant						Screening of herpes simplex virus type 1 isolates for acyclovir resistance using DiviTum assay	https://www.sciencedirect.com/science/article/pii/S0166093412004351?via%3Dihub	doi.org/10.1016/j.jviromet.2012.12.001	Isolated strain 	dye uptake assay			13/06/2021	OJCharles			A
772	HSV1	KOS	UL23	Y239S*		Resistant	Polymorphism	Polymorphism			Resistant	Resistant						Characterization of Herpes Simplex Virus Type 1 Thymidine Kinase Mutants Selected under a Single Round of High-Dose Brivudin	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1082774/#r5	doi.org/10.1128/JVI.79.9.5863-5869.2005	Lab induced strain 	PRA			14/06/2021	OJCharles		KOS	A
773	HSV1	TAS	UL23	T245M		120	0.1	Polymorphism			Resistant	Resistant						Genotypic and phenotypic characterization of the thymidine kinase of ACV-resistant HSV-1 derived from an acyclovir-sensitive herpes simplex virus type 1 strain	https://www.sciencedirect.com/science/article/pii/S0166354202001316?via%3Dihub	doi.org/10.1016/S0166-3542(02)00131-6	Lab induced strain 	PRA			15/06/2021	OJCharles	there are only extreme values - concern?		A
774	HSV1	Clinical isolate	UL23	T245P		Resistant												Acyclovir Susceptibility and Genetic Characteristics of Sequential Herpes Simplex Virus Type 1 Corneal Isolates from Patients with Recurrent Herpetic Keratitis	https://academic.oup.com/jid/article/200/9/1402/851413	doi.org/10.1086/606028	Isolated strain 	PCR DNA hybridization assay			16/06/2021	OJCharles	co-occuring T354P is unknown	KOS	O
775	HSV1	Clinical isolate	UL23	L249P		Resistant												Resistance of herpes simplex viruses to acyclovir: An update from a ten-year survey in France	https://www.sciencedirect.com/science/article/pii/S0166354214002502	doi.org/10.1016/j.antiviral.2014.08.013	Isolated strain 	dye uptake assay			17/06/2021	OJCharles		sc16	A
776	HSV1	Clinical isolate	UL23	Q250stop		Resistant	Polymorphism	Polymorphism			Resistant	Resistant						Screening of herpes simplex virus type 1 isolates for acyclovir resistance using DiviTum assay	https://www.sciencedirect.com/science/article/pii/S0166093412004351?via%3Dihub	doi.org/10.1016/j.jviromet.2012.12.001	Isolated strain 	dye uptake assay			18/06/2021	OJCharles			A
777	HSV1	Clinical isolate	UL23	R256W		Resistant	Polymorphism	Polymorphism			Resistant	Resistant						Screening of herpes simplex virus type 1 isolates for acyclovir resistance using DiviTum assay	https://www.sciencedirect.com/science/article/pii/S0166093412004351?via%3Dihub	doi.org/10.1016/j.jviromet.2012.12.001	Isolated strain 	dye uptake assay			19/06/2021	OJCharles	Occurs with a resistant mutation		O
778	HSV1	Clinical isolate	UL23	E257K		59		1.2										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			20/06/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
779	HSV1	Clinical isolate	UL23	Q261R		Resistant		Polymorphism										Longitudinal Characterization of Herpes Simplex Virus (HSV) Isolates Acquired From Different Sites in an Immune-Compromised Child: A New HSV Thymidine Kinase Mutation Associated With Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656553/	doi.org/10.1093/jpids/pis009	Isolated strain 	PRA	UL23	A93V	21/06/2021	OJCharles	co-occurs with resistant mutation	strain 17	O
780	HSV1	KOS	UL23	Q261stop*		Resistant	Polymorphism	Polymorphism			Resistant	Resistant						Characterization of Herpes Simplex Virus Type 1 Thymidine Kinase Mutants Selected under a Single Round of High-Dose Brivudin	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1082774/#r5	doi.org/10.1128/JVI.79.9.5863-5869.2005	Lab induced strain 	PRA			22/06/2021	OJCharles		KOS	A
781	HSV1	Clinical isolate	UL23	S263*		Resistant		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			23/06/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
782	HSV1	TAS	UL23	V267frameshift		Resistant	Polymorphism											Genotypic and phenotypic characterization of the thymidine kinase of ACV-resistant HSV-1 derived from an acyclovir-sensitive herpes simplex virus type 1 strain	https://www.sciencedirect.com/science/article/pii/S0166354202001316?via%3Dihub	doi.org/10.1016/S0166-3542(02)00131-6	Lab induced strain 	PRA			24/06/2021	OJCharles	there are only extreme values - concern?		A
783	HSV1	KOS	UL23	R281stop*		Resistant	Polymorphism	Polymorphism			Resistant	Resistant						Characterization of Herpes Simplex Virus Type 1 Thymidine Kinase Mutants Selected under a Single Round of High-Dose Brivudin	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1082774/#r5	doi.org/10.1128/JVI.79.9.5863-5869.2005	Lab induced strain 	PRA			25/06/2021	OJCharles		KOS	A
784	HSV1	Clinical isolate	UL23	D286frameshift		Resistant		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			26/06/2021	OJCharles		KOS	A
785	HSV1	KOS	UL23	T287M		67	0.1	Polymorphism			Resistant	Resistant						Characterization of Herpes Simplex Virus Type 1 Thymidine Kinase Mutants Selected under a Single Round of High-Dose Brivudin	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1082774/#r5	doi.org/10.1128/JVI.79.9.5863-5869.2005	Lab induced strain 	PRA			27/06/2021	OJCharles	there are only extreme values - concern?	KOS	A
786	HSV1	Clinical isolate	UL23	L291R		Resistant												Acyclovir Susceptibility and Genetic Characteristics of Sequential Herpes Simplex Virus Type 1 Corneal Isolates from Patients with Recurrent Herpetic Keratitis	https://academic.oup.com/jid/article/200/9/1402/851413	doi.org/10.1086/606028	Isolated strain 	PCR DNA hybridization assay			29/06/2021	OJCharles	Only sequences TK, so any Pol mutations are unnacounted for - co-occuring E36del is polymorphism In later papers	KOS	A
787	HSV1	Clinical isolate	UL23	L297S		Resistant												Phenotypic and Genotypic Characterization of Acyclovir-Resistant Herpes Simplex Viruses from Immunocompromised Patients	https://academic.oup.com/jid/article/178/2/297/904713	doi.org/10.1086/515626	Isolated strain 	PCR DNA hybridization assay	UL23	Q104H	01/07/2021	OJCharles	co-occurs with resmut	A2	O
788	HSV1		UL23	N301+		Resistant	Polymorphism	Polymorphism			Resistant	Resistant						Characterization of Herpes Simplex Viruses Selected in Culture for Resistance to Penciclovir or Acyclovir	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC114085/	doi.org/10.1128/JVI.75.4.1761-1769.2001	Lab induced strain 	PRA			03/07/2021	OJCharles			A
789	HSV1		UL23	N306stop*		Resistant	Polymorphism	Polymorphism			Resistant	Resistant						Characterization of Herpes Simplex Viruses Selected in Culture for Resistance to Penciclovir or Acyclovir	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC114085/	doi.org/10.1128/JVI.75.4.1761-1769.2001	Lab induced strain 	PRA			04/07/2021	OJCharles			A
790	HSV1		UL23	N306stop**		Resistant	Polymorphism	Polymorphism			Resistant	Resistant						Characterization of Herpes Simplex Viruses Selected in Culture for Resistance to Penciclovir or Acyclovir	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC114085/	doi.org/10.1128/JVI.75.4.1761-1769.2001	Lab induced strain 	PRA			05/07/2021	OJCharles			A
791	HSV1		UL23	N306stop*		Resistant	Polymorphism	Polymorphism			Resistant	Resistant						Characterization of Herpes Simplex Viruses Selected in Culture for Resistance to Penciclovir or Acyclovir	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC114085/	doi.org/10.1128/JVI.75.4.1761-1769.2001	Lab induced strain 	PRA			06/07/2021	OJCharles			A
792	HSV1		UL23	N306stop*		Resistant	Polymorphism	Polymorphism			Resistant	Resistant						Characterization of Herpes Simplex Viruses Selected in Culture for Resistance to Penciclovir or Acyclovir	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC114085/	doi.org/10.1128/JVI.75.4.1761-1769.2001	Lab induced strain 	PRA			07/07/2021	OJCharles			A
793	HSV1		UL23	V307frameshift*		Resistant	Polymorphism	Polymorphism			Resistant	Resistant						Characterization of Herpes Simplex Viruses Selected in Culture for Resistance to Penciclovir or Acyclovir	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC114085/	doi.org/10.1128/JVI.75.4.1761-1769.2001	Lab induced strain 	PRA			08/07/2021	OJCharles			A
794	HSV1	Clinical isolate	UL23	L315S		Resistant	Polymorphism	Polymorphism			Resistant	Resistant						Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			09/07/2021	OJCharles		KOS	A
795	HSV1		UL23	M322K		37						71						Intracellular uptake of thymidine and antiherpetic drugs for thymidine kinase-deficient mutants of herpes simplex virus type 1	https://www.sciencedirect.com/science/article/pii/S0166354206000313?via%3Dihub	doi.org/10.1016/j.antiviral.2006.01.010	Marker Transfer 	TK functional kinetic assay			10/07/2021	OJCharles			A
796	HSV1	Clinical isolate	UL23	P334+		Resistant		Polymorphism										Genotypic detection of acyclovir-resistant HSV-1: Characterization of 67 ACV-sensitive and 14 ACV-resistant viruses	https://www.sciencedirect.com/science/article/pii/S016635420800199X?via%3Dihub	doi.org/10.1016/j.antiviral.2008.01.153	Isolated strain 	dye uptake assay			11/07/2021	OJCharles	cannot see in paper		O
797	HSV1	Clinical isolate	UL23	T354P		Resistant												Acyclovir Susceptibility and Genetic Characteristics of Sequential Herpes Simplex Virus Type 1 Corneal Isolates from Patients with Recurrent Herpetic Keratitis	https://academic.oup.com/jid/article/200/9/1402/851413	doi.org/10.1086/606028	Isolated strain 	PCR DNA hybridization assay			14/07/2021	OJCharles	co-occuring T245P is unknown	KOS	O
798	HSV1	TAS	UL23	P355frameshift		Resistant	Polymorphism											Genotypic and phenotypic characterization of the thymidine kinase of ACV-resistant HSV-1 derived from an acyclovir-sensitive herpes simplex virus type 1 strain	https://www.sciencedirect.com/science/article/pii/S0166354202001316?via%3Dihub	doi.org/10.1016/S0166-3542(02)00131-6	Lab induced strain 	PRA			15/07/2021	OJCharles	there are only extreme values - concern?		A
799	HSV1	Clinical isolate	UL23	G356frameshift		Resistant	Polymorphism	Polymorphism			Resistant	Resistant						Screening of herpes simplex virus type 1 isolates for acyclovir resistance using DiviTum assay	https://www.sciencedirect.com/science/article/pii/S0166093412004351?via%3Dihub	doi.org/10.1016/j.jviromet.2012.12.001	Isolated strain 	dye uptake assay			16/07/2021	OJCharles			A
800	HSV1	Clinical isolate	UL23	A365T		Resistant												Identification and characterization of acyclovir-resistant clinical HSV-1 isolates from children	https://www.sciencedirect.com/science/article/pii/S1386653211002575?via%3Dihub	doi.org/10.1016/j.jcv.2011.06.009	Isolated strain 	ICP10 Luciferase assay			17/07/2021	OJCharles			A
801	HSV1	Clinical isolate	UL23	E374frameshift		Resistant	Polymorphism	Polymorphism			Resistant	Resistant						Screening of herpes simplex virus type 1 isolates for acyclovir resistance using DiviTum assay	https://www.sciencedirect.com/science/article/pii/S0166093412004351?via%3Dihub	doi.org/10.1016/j.jviromet.2012.12.001	Isolated strain 	dye uptake assay			18/07/2021	OJCharles			A
802	HSV1	Clinical isolate	UL23	N376stop		Resistant												Phenotypic and genotypic characterization of induced acyclovir-resistant clinical isolates of herpes simplex virus type 1	https://www.sciencedirect.com/science/article/pii/S0166354213002544?via%3Dihub	doi.org/10.1016/j.antiviral.2013.09.008	Isolated strain 	PRA			20/07/2021	OJCharles			A
803	HSV1		UL23	N376stop*		Resistant	Polymorphism	Polymorphism			Resistant	Resistant						Characterization of Herpes Simplex Viruses Selected in Culture for Resistance to Penciclovir or Acyclovir	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC114085/	doi.org/10.1128/JVI.75.4.1761-1769.2001	Lab induced strain 	PRA			21/07/2021	OJCharles			A
804	HSV1		UL23	N376stop*		Resistant	Polymorphism	Polymorphism			Resistant	Resistant						Characterization of Herpes Simplex Viruses Selected in Culture for Resistance to Penciclovir or Acyclovir	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC114085/	doi.org/10.1128/JVI.75.4.1761-1769.2001	Lab induced strain 	PRA			22/07/2021	OJCharles			A
805	HSV1	Clinical isolate	UL30	S3A		Polymorphism		Polymorphism										Gene polymorphism of thymidine kinase and DNA polymerase in clinical strains of herpes simplex virus	http://pdfs.semanticscholar.org/273d/230d2dc0f09225c569b99871ac2aa4e3da70.pdf	doi.org/10.3851/IMP1852	Isolated strain 	dye uptake assay			24/07/2021	OJCharles	unkown co-mutations		A
806	HSV1	Clinical isolate	UL30	G12E		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			25/07/2021	OJCharles		KOS	A
807	HSV1	Clinical isolate	UL30	S15A		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			26/07/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
808	HSV1	Clinical isolate	UL30	A17T		Polymorphism		Polymorphism										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			27/07/2021	OJCharles			A
809	HSV1	Clinical isolate	UL30	A17V		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			28/07/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
810	HSV1	Clinical isolate	UL30	F23I		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			30/07/2021	OJCharles		KOS	A
811	HSV1	Clinical isolate	UL30	A25V		Polymorphism		Polymorphism										Gene polymorphism of thymidine kinase and DNA polymerase in clinical strains of herpes simplex virus	http://pdfs.semanticscholar.org/273d/230d2dc0f09225c569b99871ac2aa4e3da70.pdf	doi.org/10.3851/IMP1852	Isolated strain 	dye uptake assay			31/07/2021	OJCharles	unkown co-mutations		A
812	HSV1	Clinical isolate	UL30	A27T		Polymorphism	Polymorphism	Polymorphism			Polymorphism	Polymorphism						Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay			01/08/2021	OJCharles	Cannot be inferred	KOS	O
813	HSV1	Clinical isolate	UL30	P29H		Polymorphism		Polymorphism										Gene polymorphism of thymidine kinase and DNA polymerase in clinical strains of herpes simplex virus	http://pdfs.semanticscholar.org/273d/230d2dc0f09225c569b99871ac2aa4e3da70.pdf	doi.org/10.3851/IMP1852	Isolated strain 	dye uptake assay			02/08/2021	OJCharles	unkown co-mutations		A
814	HSV1	Clinical isolate	UL30	R30C		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			03/08/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
815	HSV1	Clinical isolate	UL30	A32I		Polymorphism		Polymorphism										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			04/08/2021	OJCharles			A
816	HSV1	Clinical isolate	UL30	S33G		Polymorphism		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PCR DNA hybridization assay			05/08/2021	OJCharles			A
817	HSV1	Clinical isolate	UL30	S33R		Polymorphism		Polymorphism										Gene polymorphism of thymidine kinase and DNA polymerase in clinical strains of herpes simplex virus	http://pdfs.semanticscholar.org/273d/230d2dc0f09225c569b99871ac2aa4e3da70.pdf	doi.org/10.3851/IMP1852	Isolated strain 	dye uptake assay			06/08/2021	OJCharles	unkown co-mutations		A
818	HSV1	Clinical isolate	UL30	Q42K		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			07/08/2021	OJCharles		KOS	A
819	HSV1	Clinical isolate	UL30	K57N		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			08/08/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
820	HSV1	Clinical isolate	UL30	P61S		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			09/08/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
821	HSV1	Clinical isolate	UL30	E70D		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			10/08/2021	OJCharles		KOS	A
822	HSV1	Clinical isolate	UL30	D72N		Polymorphism	Polymorphism	Polymorphism			Polymorphism	Polymorphism						Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay			11/08/2021	OJCharles	Cannot be inferred	KOS	O
823	HSV1	Clinical isolate	UL30	A78D		Polymorphism	Polymorphism	Polymorphism			Polymorphism	Polymorphism						Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay			11/08/2021	OJCharles	Cannot be inferred	KOS	O
824	HSV1	Clinical isolate	UL30	A78V		Polymorphism	Polymorphism	Polymorphism			Polymorphism	Polymorphism						Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay			13/08/2021	OJCharles		KOS	A
825	HSV1	Clinical isolate	UL30	R80L		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			14/08/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
826	HSV1	Clinical isolate	UL30	K90R		Polymorphism		Polymorphism										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			15/08/2021	OJCharles			A
827	HSV1	Clinical isolate	UL30	H98N		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			16/08/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
828	HSV1	Clinical isolate	UL30	A102T		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			17/08/2021	OJCharles		KOS	A
829	HSV1	Clinical isolate	UL30	K104Q		Polymorphism	Polymorphism	Polymorphism			Polymorphism	Polymorphism						Testing of herpes simplex virus for resistance to antiviral drugs	https://www.tandfonline.com/doi/abs/10.4161/viru.1.6.13806	doi.org/10.4161/viru.1.6.13806	Isolated strain 	dye uptake assay			18/08/2021	OJCharles	no data		O
830	HSV1	Clinical isolate	UL30	G108R		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			19/08/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
831	HSV1	Clinical isolate	UL30	E111K		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			20/08/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
832	HSV1	Clinical isolate	UL30	R116H		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			22/08/2021	OJCharles		KOS	A
833	HSV1	Clinical isolate	UL30	S127L		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			23/08/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
834	HSV1	Clinical isolate	UL30	G132C		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			24/08/2021	OJCharles		KOS	A
835	HSV1	Clinical isolate	UL30	P137G		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			25/08/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
836	HSV1	Clinical isolate	UL30	P137Q		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			26/08/2021	OJCharles		KOS	A
837	HSV1	Clinical isolate	UL30	A138V		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			27/08/2021	OJCharles		KOS	A
838	HSV1	Clinical isolate	UL30	V144I		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			28/08/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
839	HSV1	Clinical isolate	UL30	T145A		Polymorphism		Polymorphism										Gene polymorphism of thymidine kinase and DNA polymerase in clinical strains of herpes simplex virus	http://pdfs.semanticscholar.org/273d/230d2dc0f09225c569b99871ac2aa4e3da70.pdf	doi.org/10.3851/IMP1852	Isolated strain 	dye uptake assay			29/08/2021	OJCharles	unkown co-mutations		A
840	HSV1	Clinical isolate	UL30	V146I		Polymorphism		Polymorphism										Gene polymorphism of thymidine kinase and DNA polymerase in clinical strains of herpes simplex virus	http://pdfs.semanticscholar.org/273d/230d2dc0f09225c569b99871ac2aa4e3da70.pdf	doi.org/10.3851/IMP1852	Isolated strain 	dye uptake assay			30/08/2021	OJCharles	unkown co-mutations		A
841	HSV1	Clinical isolate	UL30	N155T		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			31/08/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
842	HSV1	Clinical isolate	UL30	A159V		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			01/09/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
843	HSV1	Clinical isolate	UL30	A164T		Polymorphism		Polymorphism										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			02/09/2021	OJCharles			A
844	HSV1	Clinical isolate	UL30	F167L		Polymorphism		Polymorphism										Gene polymorphism of thymidine kinase and DNA polymerase in clinical strains of herpes simplex virus	http://pdfs.semanticscholar.org/273d/230d2dc0f09225c569b99871ac2aa4e3da70.pdf	doi.org/10.3851/IMP1852	Isolated strain 	dye uptake assay			03/09/2021	OJCharles	unkown co-mutations		A
845	HSV1	Clinical isolate	UL30	F171S		Polymorphism		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PCR DNA hybridization assay			04/09/2021	OJCharles			A
846	HSV1	Clinical isolate	UL30	M207I		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			05/09/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
847	HSV1	Clinical isolate	UL30	K209T		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			06/09/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
848	HSV1	Clinical isolate	UL30	V212A		Polymorphism	Polymorphism	Polymorphism			Polymorphism	Polymorphism						Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			07/09/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
849	HSV1	Clinical isolate	UL30	R219S		Polymorphism		Polymorphism										Novel resistance-associated mutations of thymidine kinase and DNA polymerase genes of herpes simplex virus type 1 and type 2	https://pubmed.ncbi.nlm.nih.gov/22155911/	 doi.org/10.3851/IMP1870	Isolated strain 	dye uptake assay			08/09/2021	OJCharles			A
850	HSV1	Clinical isolate	UL30	A220T		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			09/09/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
851	HSV1	Clinical isolate	UL30	A229T		Polymorphism	Polymorphism	Polymorphism			Polymorphism	Polymorphism						Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay			10/09/2021	OJCharles	Cannot be inferred	KOS	O
852	HSV1	Clinical isolate	UL30	A230V		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			11/09/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
853	HSV1	Clinical isolate	UL30	I243T		Polymorphism		Polymorphism										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			12/09/2021	OJCharles			A
854	HSV1	Clinical isolate	UL30	F248L		Polymorphism	Polymorphism	Polymorphism			Polymorphism	Polymorphism						Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay			13/09/2021	OJCharles		KOS	A
855	HSV1	Clinical isolate	UL30	R264H		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			14/09/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
856	HSV1	Clinical isolate	UL30	L267M		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			15/09/2021	OJCharles		KOS	A
857	HSV1	Clinical isolate	UL30	S280A		Polymorphism		Polymorphism										Gene polymorphism of thymidine kinase and DNA polymerase in clinical strains of herpes simplex virus	http://pdfs.semanticscholar.org/273d/230d2dc0f09225c569b99871ac2aa4e3da70.pdf	doi.org/10.3851/IMP1852	Isolated strain 	dye uptake assay			16/09/2021	OJCharles	unkown co-mutations		A
858	HSV1	Clinical isolate	UL30	C287Y		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			17/09/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
859	HSV1	Clinical isolate	UL30	A289D		Polymorphism		Polymorphism										Gene polymorphism of thymidine kinase and DNA polymerase in clinical strains of herpes simplex virus	http://pdfs.semanticscholar.org/273d/230d2dc0f09225c569b99871ac2aa4e3da70.pdf	doi.org/10.3851/IMP1852	Isolated strain 	dye uptake assay			18/09/2021	OJCharles	unkown co-mutations		A
860	HSV1	Clinical isolate	UL30	V297A		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			19/09/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
861	HSV1	Clinical isolate	UL30	F303L		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			20/09/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
862	HSV1	Clinical isolate	UL30	P320S		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			21/09/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
863	HSV1	Clinical isolate	UL30	R322Q		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			22/09/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
864	HSV1	Clinical isolate	UL30	R330A		Polymorphism		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PCR DNA hybridization assay			23/09/2021	OJCharles			A
865	HSV1	Clinical isolate	UL30	I352V		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			24/09/2021	OJCharles		KOS	A
866	HSV1	Clinical isolate	UL30	G354V		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			25/09/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
867	HSV1	Clinical isolate	UL30	M356I		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			26/09/2021	OJCharles			A
868	HSV1	Clinical isolate	UL30	E376D		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			27/09/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
869	HSV1	Clinical isolate	UL30	E376G		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			28/09/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
870	HSV1	Clinical isolate	UL30	V383L		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			29/09/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
871	HSV1	Clinical isolate	UL30	H386Y		Polymorphism		Polymorphism										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			30/09/2021	OJCharles	co-occurs with unknwon mutation phenotype		O
872	HSV1	Clinical isolate	UL30	E421D		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			01/10/2021	OJCharles		KOS	A
873	HSV1	Clinical isolate	UL30	N425T		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			02/10/2021	OJCharles		KOS	A
874	HSV1	Clinical isolate	UL30	A428V		Polymorphism		Polymorphism										Gene polymorphism of thymidine kinase and DNA polymerase in clinical strains of herpes simplex virus	http://pdfs.semanticscholar.org/273d/230d2dc0f09225c569b99871ac2aa4e3da70.pdf	doi.org/10.3851/IMP1852	Isolated strain 	dye uptake assay			03/10/2021	OJCharles	unkown co-mutations		A
875	HSV1	Clinical isolate	UL30	A429T		Polymorphism	Polymorphism	Polymorphism			Polymorphism	Polymorphism						Novel resistance-associated mutations of thymidine kinase and DNA polymerase genes of herpes simplex virus type 1 and type 2	https://pubmed.ncbi.nlm.nih.gov/22155911/	 doi.org/10.3851/IMP1870	Isolated strain 	dye uptake assay			04/10/2021	OJCharles			A
876	HSV1	Clinical isolate	UL30	R430K		Polymorphism		Polymorphism										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			05/10/2021	OJCharles			A
877	HSV1	Clinical isolate	UL30	T434M		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			06/10/2021	OJCharles		KOS	A
878	HSV1	Clinical isolate	UL30	G458S		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			07/10/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
879	HSV1	Clinical isolate	UL30	L479M		Polymorphism		Polymorphism										Gene polymorphism of thymidine kinase and DNA polymerase in clinical strains of herpes simplex virus	http://pdfs.semanticscholar.org/273d/230d2dc0f09225c569b99871ac2aa4e3da70.pdf	doi.org/10.3851/IMP1852	Isolated strain 	dye uptake assay			08/10/2021	OJCharles	unkown co-mutations		A
880	HSV1	Clinical isolate	UL30	T480M		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			09/10/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
881	HSV1	Clinical isolate	UL30	G495V		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			10/10/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
882	HSV1	Clinical isolate	UL30	V498G		Polymorphism	Polymorphism	Polymorphism			Polymorphism	Polymorphism						Novel resistance-associated mutations of thymidine kinase and DNA polymerase genes of herpes simplex virus type 1 and type 2	https://pubmed.ncbi.nlm.nih.gov/22155911/	 doi.org/10.3851/IMP1870	Isolated strain 	dye uptake assay			11/10/2021	OJCharles			A
883	HSV1	Clinical isolate	UL30	V498M		Polymorphism		Polymorphism										Gene polymorphism of thymidine kinase and DNA polymerase in clinical strains of herpes simplex virus	http://pdfs.semanticscholar.org/273d/230d2dc0f09225c569b99871ac2aa4e3da70.pdf	doi.org/10.3851/IMP1852	Isolated strain 	dye uptake assay			12/10/2021	OJCharles	unkown co-mutations		A
884	HSV1	Clinical isolate	UL30	G505D		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			13/10/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
885	HSV1	Clinical isolate	UL30	S507R		Polymorphism		Polymorphism										Gene polymorphism of thymidine kinase and DNA polymerase in clinical strains of herpes simplex virus	http://pdfs.semanticscholar.org/273d/230d2dc0f09225c569b99871ac2aa4e3da70.pdf	doi.org/10.3851/IMP1852	Isolated strain 	dye uptake assay			14/10/2021	OJCharles	unkown co-mutations		A
886	HSV1	Clinical isolate	UL30	V521M		Polymorphism	Polymorphism	Polymorphism			Polymorphism	Polymorphism						Single nucleotide polymorphisms of thymidine kinase and DNA polymerase genes in clinical herpes simplex virus type 1 isolates associated with different resistance phenotypes	https://www.sciencedirect.com/science/article/pii/S0166354214000898?via%3Dihub	doi.org/10.1016/j.antiviral.2014.03.015	Isolated strain 	dye uptake assay			15/10/2021	OJCharles			A
887	HSV1	Clinical isolate	UL30	N522S		Polymorphism		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PCR DNA hybridization assay			16/10/2021	OJCharles			A
888	HSV1	Clinical isolate	UL30	A562T		Polymorphism		Polymorphism										Gene polymorphism of thymidine kinase and DNA polymerase in clinical strains of herpes simplex virus	http://pdfs.semanticscholar.org/273d/230d2dc0f09225c569b99871ac2aa4e3da70.pdf	doi.org/10.3851/IMP1852	Isolated strain 	dye uptake assay			17/10/2021	OJCharles	unkown co-mutations		A
889	HSV1	Clinical isolate	UL30	A566T		Polymorphism		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PCR DNA hybridization assay			18/10/2021	OJCharles			A
890	HSV1	Clinical isolate	UL30	K591R		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			19/10/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
891	HSV1	Clinical isolate	UL30	D630A		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			20/10/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
892	HSV1	Clinical isolate	UL30	G633D		Polymorphism		Polymorphism										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			21/10/2021	OJCharles			A
893	HSV1	Clinical isolate	UL30	T639I		Polymorphism		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PCR DNA hybridization assay			22/10/2021	OJCharles			A
894	HSV1	Clinical isolate	UL30	A646T		Polymorphism		Polymorphism										Genotypic and phenotypic characterization of acyclovir-resistant herpes simplex viruses isolated from haematopoietic stem cell transplant recipients.	https://journals.sagepub.com/doi/10.1177/135965350400900413	doi.org/10.1177/135965350400900413	Isolated strain 	yield reduction assay (ELVIRA)			23/10/2021	OJCharles			A
895	HSV1	Clinical isolate	UL30	E649D		0.8		0.5										Rapid susceptibility testing for herpes simplex virus type 1 using real-time PCR	https://www.sciencedirect.com/science/article/pii/S1386653212003502?via%3Dihub	doi.org/10.1016/j.jcv.2012.09.004	Isolated strain 	PCR DNA hybridization assay			24/10/2021	OJCharles			A
896	HSV1	Clinical isolate	UL30	E659D		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			25/10/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
897	HSV1	Clinical isolate	UL30	D660E		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			26/10/2021	OJCharles		KOS	A
898	HSV1	Clinical isolate	UL30	E661K		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			27/10/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
899	HSV1	Clinical isolate	UL30	E662D		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			28/10/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
900	HSV1	Clinical isolate	UL30	P664T		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			29/10/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
901	HSV1	Clinical isolate	UL30	del667		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			30/10/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
902	HSV1	Clinical isolate	UL30	del668		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			31/10/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
903	HSV1	Clinical isolate	UL30	G668E		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			01/11/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
904	HSV1	Clinical isolate	UL30	E669D		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			02/11/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
905	HSV1	Clinical isolate	UL30	E669G		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			03/11/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
906	HSV1	Clinical isolate	UL30	E671K		Polymorphism												Resistance of herpes simplex viruses to acyclovir: An update from a ten-year survey in France	https://www.sciencedirect.com/science/article/pii/S0166354214002502	doi.org/10.1016/j.antiviral.2014.08.013	Isolated strain 	dye uptake assay			04/11/2021	OJCharles		sc16	A
907	HSV1	Clinical isolate	UL30	D672N		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			05/11/2021	OJCharles		KOS	A
908	HSV1	Clinical isolate	UL30	E673K		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			06/11/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
909	HSV1	Clinical isolate	UL30	R674H		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			07/11/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
910	HSV1	Clinical isolate	UL30	E675A		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			08/11/2021	OJCharles		KOS	A
911	HSV1	Clinical isolate	UL30	E675K		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			09/11/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
912	HSV1	Clinical isolate	UL30	E684A		Polymorphism		Polymorphism										Gene polymorphism of thymidine kinase and DNA polymerase in clinical strains of herpes simplex virus	http://pdfs.semanticscholar.org/273d/230d2dc0f09225c569b99871ac2aa4e3da70.pdf	doi.org/10.3851/IMP1852	Isolated strain 	dye uptake assay			10/11/2021	OJCharles	unkown co-mutations		A
913	HSV1	Clinical isolate	UL30	E684D		Polymorphism		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PCR DNA hybridization assay			11/11/2021	OJCharles			A
914	HSV1	Clinical isolate	UL30	E688K		Polymorphism		Polymorphism										Gene polymorphism of thymidine kinase and DNA polymerase in clinical strains of herpes simplex virus	http://pdfs.semanticscholar.org/273d/230d2dc0f09225c569b99871ac2aa4e3da70.pdf	doi.org/10.3851/IMP1852	Isolated strain 	dye uptake assay			12/11/2021	OJCharles	unkown co-mutations		A
915	HSV1	Clinical isolate	UL30	D703N		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			13/11/2021	OJCharles		KOS	A
916	HSV1	Clinical isolate	UL30	N711K		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			14/11/2021	OJCharles		KOS	A
917	HSV1	Clinical isolate	UL30	R739S		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			15/11/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
918	HSV1	Clinical isolate	UL30	A740S		Polymorphism		Polymorphism										Gene polymorphism of thymidine kinase and DNA polymerase in clinical strains of herpes simplex virus	http://pdfs.semanticscholar.org/273d/230d2dc0f09225c569b99871ac2aa4e3da70.pdf	doi.org/10.3851/IMP1852	Isolated strain 	dye uptake assay			16/11/2021	OJCharles	unkown co-mutations		A
919	HSV1	Clinical isolate	UL30	V743M		Polymorphism	Polymorphism	Polymorphism			Polymorphism	Polymorphism						Genotypic and phenotypic characterization of acyclovir-resistant herpes simplex viruses isolated from haematopoietic stem cell transplant recipients.	https://journals.sagepub.com/doi/10.1177/135965350400900413	doi.org/10.1177/135965350400900413	Isolated strain 	yield reduction assay (ELVIRA)			17/11/2021	OJCharles	Cannot be inferred		O
920	HSV1	Clinical isolate	UL30	E747K		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			18/11/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
921	HSV1	Clinical isolate	UL30	G749D		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			19/11/2021	OJCharles		KOS	A
922	HSV1	Clinical isolate	UL30	L753M		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			20/11/2021	OJCharles		KOS	A
923	HSV1	Clinical isolate	UL30	Q794H		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			21/11/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
924	HSV1	Clinical isolate	UL30	A857V		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			22/11/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
925	HSV1	Clinical isolate	UL30	E860K		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			23/11/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
926	HSV1	Clinical isolate	UL30	Q861R		Polymorphism		Polymorphism										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			24/11/2021	OJCharles			A
927	HSV1	Clinical isolate	UL30	L862F		Polymorphism		Polymorphism										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			25/11/2021	OJCharles			A
928	HSV1	Clinical isolate	UL30	E868G		Polymorphism		Polymorphism										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			26/11/2021	OJCharles			A
929	HSV1	Clinical isolate	UL30	A870G		Polymorphism	Polymorphism	Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			27/11/2021	OJCharles		KOS	A
930	HSV1	Clinical isolate	UL30	A870V		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			28/11/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
931	HSV1	Clinical isolate	UL30	D871N		Polymorphism	Polymorphism	Polymorphism			Polymorphism	Polymorphism						Novel resistance-associated mutations of thymidine kinase and DNA polymerase genes of herpes simplex virus type 1 and type 2	https://pubmed.ncbi.nlm.nih.gov/22155911/	 doi.org/10.3851/IMP1870	Isolated strain 	dye uptake assay			29/11/2021	OJCharles			A
932	HSV1	Clinical isolate	UL30	R873C		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			30/11/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
933	HSV1	Clinical isolate	UL30	A874T		Polymorphism												Resistance of herpes simplex viruses to acyclovir: An update from a ten-year survey in France	https://www.sciencedirect.com/science/article/pii/S0166354214002502	doi.org/10.1016/j.antiviral.2014.08.013	Isolated strain 	dye uptake assay			01/12/2021	OJCharles		sc16	A
934	HSV1	Clinical isolate	UL30	P875S		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			02/12/2021	OJCharles		KOS	A
935	HSV1	Clinical isolate	UL30	V905M		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			03/12/2021	OJCharles		KOS	A
936	HSV1	Clinical isolate	UL30	V905M		Polymorphism												Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PCR DNA hybridization assay			04/02/2021	OJCharles	paper erronsously described this as position 906		A
937	HSV1	Clinical isolate	UL30	K908R		Polymorphism		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PCR DNA hybridization assay			04/12/2021	OJCharles			A
938	HSV1	TAS	UL30	A910V		Polymorphism	Polymorphism	Polymorphism										Genotypic Characterization of the DNA Polymerase and Sensitivity to Antiviral Compounds of Foscarnet-Resistant Herpes Simplex Virus Type 1 (HSV-1) Derived from a Foscarnet-Sensitive HSV-1 Strain	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC547286/	doi.org/10.1128/AAC.49.2.606-611.2005	Lab induced strain 	PRA			04/02/2021	OJCharles			A
939	HSV1	Clinical isolate	UL30	A916T		Polymorphism		Polymorphism										Gene polymorphism of thymidine kinase and DNA polymerase in clinical strains of herpes simplex virus	http://pdfs.semanticscholar.org/273d/230d2dc0f09225c569b99871ac2aa4e3da70.pdf	doi.org/10.3851/IMP1852	Isolated strain 	dye uptake assay			06/12/2021	OJCharles	unkown co-mutations		A
940	HSV1	Clinical isolate	UL30	P920F		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			07/12/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
941	HSV1	Clinical isolate	UL30	I922T		Polymorphism	Polymorphism	Polymorphism				Polymorphism						Heterogeneity and Evolution of Thymidine Kinase and DNA Polymerase Mutants of Herpes Simplex Virus Type 1: Implications for Antiviral Therapy	https://pubmed.ncbi.nlm.nih.gov/23315323/	doi.org/10.1093/infdis/jit019	Isolated strain 	PRA			09/12/2021	OJCharles	co-occurs with resmut		O
942	HSV1	Clinical isolate	UL30	E927D		Polymorphism		Polymorphism										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			10/12/2021	OJCharles			A
943	HSV1	Clinical isolate	UL30	T931A		Polymorphism												Resistance of herpes simplex viruses to acyclovir: An update from a ten-year survey in France	https://www.sciencedirect.com/science/article/pii/S0166354214002502	doi.org/10.1016/j.antiviral.2014.08.013	Isolated strain 	dye uptake assay			11/12/2021	OJCharles		sc16	A
944	HSV1	Clinical isolate	UL30	T931I		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			12/12/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
945	HSV1	Clinical isolate	UL30	I942L		Polymorphism		Polymorphism										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			13/12/2021	OJCharles			A
946	HSV1	Clinical isolate	UL30	Y946F		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			14/12/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
947	HSV1	Clinical isolate	UL30	G948C		Polymorphism	Polymorphism	Polymorphism			Polymorphism	Polymorphism						Novel resistance-associated mutations of thymidine kinase and DNA polymerase genes of herpes simplex virus type 1 and type 2	https://pubmed.ncbi.nlm.nih.gov/22155911/	 doi.org/10.3851/IMP1870	Isolated strain 	dye uptake assay			15/12/2021	OJCharles			A
948	HSV1	Clinical isolate	UL30	R993L		Polymorphism		Polymorphism										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			17/12/2021	OJCharles			A
949	HSV1	Clinical isolate	UL30	A995T		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			18/12/2021	OJCharles		KOS	A
950	HSV1	Clinical isolate	UL30	E1005K		0.5		0.7										Genotypic and phenotypic characterization of acyclovir-resistant herpes simplex viruses isolated from haematopoietic stem cell transplant recipients.	https://journals.sagepub.com/doi/10.1177/135965350400900413	doi.org/10.1177/135965350400900413	Isolated strain 	yield reduction assay (ELVIRA)			19/12/2021	OJCharles	unkown co-mutations		A
951	HSV1	Clinical isolate	UL30	A1012V		Polymorphism		Polymorphism										Gene polymorphism of thymidine kinase and DNA polymerase in clinical strains of herpes simplex virus	http://pdfs.semanticscholar.org/273d/230d2dc0f09225c569b99871ac2aa4e3da70.pdf	doi.org/10.3851/IMP1852	Isolated strain 	dye uptake assay			20/12/2021	OJCharles	unkown co-mutations		A
952	HSV1	Clinical isolate	UL30	R1019G		Polymorphism		Polymorphism										Gene polymorphism of thymidine kinase and DNA polymerase in clinical strains of herpes simplex virus	http://pdfs.semanticscholar.org/273d/230d2dc0f09225c569b99871ac2aa4e3da70.pdf	doi.org/10.3851/IMP1852	Isolated strain 	dye uptake assay			21/12/2021	OJCharles	unkown co-mutations		A
953	HSV1	Clinical isolate	UL30	R1020C		Polymorphism	Polymorphism	Polymorphism			Polymorphism	Polymorphism						Novel resistance-associated mutations of thymidine kinase and DNA polymerase genes of herpes simplex virus type 1 and type 2	https://pubmed.ncbi.nlm.nih.gov/22155911/	 doi.org/10.3851/IMP1870	Isolated strain 	dye uptake assay			22/12/2021	OJCharles			A
954	HSV1	Clinical isolate	UL30	R1020H		Polymorphism		Polymorphism										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			23/12/2021	OJCharles			A
955	HSV1	Clinical isolate	UL30	T1022A		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			24/12/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
956	HSV1	Clinical isolate	UL30	V1077L		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			25/12/2021	OJCharles		KOS	A
957	HSV1	Clinical isolate	UL30	Q1079K		Polymorphism		Polymorphism										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			26/12/2021	OJCharles	co-occurs with unknwon mutation phenotype		O
958	HSV1	Clinical isolate	UL30	E1082K		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			27/12/2021	OJCharles		KOS	A
959	HSV1	Clinical isolate	UL30	E1084A		Polymorphism		Polymorphism										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			28/12/2021	OJCharles	co-occurs with unknwon mutation phenotype		O
960	HSV1	Clinical isolate	UL30	E1084K		Polymorphism		Polymorphism										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			29/12/2021	OJCharles	occurs with C336Y known res		O
961	HSV1	Clinical isolate	UL30	E1085D		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			30/12/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
962	HSV1	Clinical isolate	UL30	E1085K		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			31/12/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
963	HSV1	Clinical isolate	UL30	T1086M		Polymorphism		Polymorphism										Gene polymorphism of thymidine kinase and DNA polymerase in clinical strains of herpes simplex virus	http://pdfs.semanticscholar.org/273d/230d2dc0f09225c569b99871ac2aa4e3da70.pdf	doi.org/10.3851/IMP1852	Isolated strain 	dye uptake assay			01/01/2022	OJCharles	unkown co-mutations		A
964	HSV1	Clinical isolate	UL30	A1099T		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			02/01/2022	OJCharles		KOS	A
965	HSV1	Clinical isolate	UL30	A1100T		Polymorphism		Polymorphism										Gene polymorphism of thymidine kinase and DNA polymerase in clinical strains of herpes simplex virus	http://pdfs.semanticscholar.org/273d/230d2dc0f09225c569b99871ac2aa4e3da70.pdf	doi.org/10.3851/IMP1852	Isolated strain 	dye uptake assay			03/01/2022	OJCharles	unkown co-mutations		A
966	HSV1	Clinical isolate	UL30	D1103H		Polymorphism	Polymorphism	Polymorphism			Polymorphism	Polymorphism						Genotypic and phenotypic characterization of acyclovir-resistant herpes simplex viruses isolated from haematopoietic stem cell transplant recipients.	https://journals.sagepub.com/doi/10.1177/135965350400900413	doi.org/10.1177/135965350400900413	Isolated strain 	yield reduction assay (ELVIRA)			04/01/2022	OJCharles	Cannot be inferred		O
967	HSV1	Clinical isolate	UL30	E1104D		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			05/01/2022	OJCharles		KOS	A
968	HSV1	Clinical isolate	UL30	E1104K		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			06/01/2022	OJCharles	mutations not resolved by sequence	MacIntyre	A
969	HSV1	Clinical isolate	UL30	A1109T		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			07/01/2022	OJCharles	mutations not resolved by sequence	MacIntyre	A
970	HSV1	Clinical isolate	UL30	P1112L		Polymorphism		Polymorphism										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			08/01/2022	OJCharles			A
971	HSV1	Clinical isolate	UL30	S1113C		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			09/01/2022	OJCharles		KOS	A
972	HSV1	Clinical isolate	UL30	P1114A		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			10/01/2022	OJCharles	mutations not resolved by sequence	MacIntyre	A
973	HSV1	Clinical isolate	UL30	P1114L		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			11/01/2022	OJCharles	mutations not resolved by sequence	MacIntyre	A
974	HSV1	Clinical isolate	UL30	R1117I		Polymorphism		Polymorphism										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			12/01/2022	OJCharles			A
975	HSV1	Clinical isolate	UL30	R1117L		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			13/01/2022	OJCharles	mutations not resolved by sequence	MacIntyre	A
976	HSV1	Clinical isolate	UL30	R1117S		Polymorphism		Polymorphism										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			14/01/2022	OJCharles			A
977	HSV1	Clinical isolate	UL30	T1121M		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			15/01/2022	OJCharles	mutations not resolved by sequence	MacIntyre	A
978	HSV1	Clinical isolate	UL30	S1123A		Polymorphism		Polymorphism										Gene polymorphism of thymidine kinase and DNA polymerase in clinical strains of herpes simplex virus	http://pdfs.semanticscholar.org/273d/230d2dc0f09225c569b99871ac2aa4e3da70.pdf	doi.org/10.3851/IMP1852	Isolated strain 	dye uptake assay			16/01/2022	OJCharles	unkown co-mutations		A
979	HSV1	Clinical isolate	UL30	S1123L		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			17/01/2022	OJCharles		KOS	A
980	HSV1	Clinical isolate	UL30	P1124H		Polymorphism		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PCR DNA hybridization assay			18/01/2022	OJCharles			A
981	HSV1	Clinical isolate	UL30	P1128L		Polymorphism		Polymorphism										Gene polymorphism of thymidine kinase and DNA polymerase in clinical strains of herpes simplex virus	http://pdfs.semanticscholar.org/273d/230d2dc0f09225c569b99871ac2aa4e3da70.pdf	doi.org/10.3851/IMP1852	Isolated strain 	dye uptake assay			19/01/2022	OJCharles	unkown co-mutations		A
982	HSV1	Clinical isolate	UL30	G1129R		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			20/01/2022	OJCharles	mutations not resolved by sequence	MacIntyre	A
983	HSV1	Clinical isolate	UL30	G1129V		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			21/01/2022	OJCharles		KOS	A
984	HSV1	Clinical isolate	UL30	A1147T		Polymorphism	Polymorphism	Polymorphism			Polymorphism	Polymorphism						Novel resistance-associated mutations of thymidine kinase and DNA polymerase genes of herpes simplex virus type 1 and type 2	https://pubmed.ncbi.nlm.nih.gov/22155911/	 doi.org/10.3851/IMP1870	Isolated strain 	dye uptake assay			22/01/2022	OJCharles			A
985	HSV1	Clinical isolate	UL30	A1147V		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			23/01/2022	OJCharles	mutations not resolved by sequence	MacIntyre	A
986	HSV1	Clinical isolate	UL30	H1152N		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			24/01/2022	OJCharles	mutations not resolved by sequence	MacIntyre	A
987	HSV1	Clinical isolate	UL30	D1159A		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			25/01/2022	OJCharles	mutations not resolved by sequence	MacIntyre	A
988	HSV1	Clinical isolate	UL30	L1166W		Polymorphism	Polymorphism	Polymorphism			Polymorphism	Polymorphism						Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay			26/01/2022	OJCharles			A
989	HSV1	Clinical isolate	UL30	A1168V		Polymorphism	Polymorphism	Polymorphism			Polymorphism	Polymorphism						Testing of herpes simplex virus for resistance to antiviral drugs	https://www.tandfonline.com/doi/abs/10.4161/viru.1.6.13806	doi.org/10.4161/viru.1.6.13806	Isolated strain 	dye uptake assay			27/01/2022	OJCharles	no data		O
990	HSV1	Clinical isolate	UL30	A1175D		Polymorphism		Polymorphism										Testing of herpes simplex virus for resistance to antiviral drugs	https://www.tandfonline.com/doi/abs/10.4161/viru.1.6.13806	doi.org/10.4161/viru.1.6.13806	Isolated strain 	dye uptake assay			28/01/2022	OJCharles	no data		O
991	HSV1	Clinical isolate	UL30	A1181T		Polymorphism		Polymorphism										Gene polymorphism of thymidine kinase and DNA polymerase in clinical strains of herpes simplex virus	http://pdfs.semanticscholar.org/273d/230d2dc0f09225c569b99871ac2aa4e3da70.pdf	doi.org/10.3851/IMP1852	Isolated strain 	dye uptake assay			29/01/2022	OJCharles	unkown co-mutations		A
992	HSV1	Clinical isolate	UL30	E1194D		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			30/01/2022	OJCharles		KOS	A
993	HSV1	Clinical isolate	UL30	P1199L		Polymorphism		Polymorphism										Longitudinal Characterization of Herpes Simplex Virus (HSV) Isolates Acquired From Different Sites in an Immune-Compromised Child: A New HSV Thymidine Kinase Mutation Associated With Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656553/	doi.org/10.1093/jpids/pis009	Isolated strain 	PRA			31/01/2022	OJCharles	unkown co-mutations	strain 17	O
994	HSV1	Clinical isolate	UL30	P1199Q		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			01/02/2022	OJCharles		KOS	A
995	HSV1	Clinical isolate	UL30	V1202M		Polymorphism		Polymorphism										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			02/02/2022	OJCharles			A
996	HSV1	Clinical isolate	UL30	A1203T		Polymorphism		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PCR DNA hybridization assay			03/02/2022	OJCharles			A
997	HSV1	Clinical isolate	UL30	A1204T		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			04/02/2022	OJCharles		KOS	A
998	HSV1	Clinical isolate	UL30	T1208A		Polymorphism		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PCR DNA hybridization assay			05/02/2022	OJCharles			A
999	HSV1	Clinical isolate	UL30	A1209T		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			06/02/2022	OJCharles		KOS	A
1000	HSV1	Clinical isolate	UL30	A1218S		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			07/02/2022	OJCharles	mutations not resolved by sequence	MacIntyre	A
1001	HSV1	Clinical isolate	UL30	T1219M		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			08/02/2022	OJCharles		KOS	A
1002	HSV1	Clinical isolate	UL30	A1220V		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			09/02/2022	OJCharles	mutations not resolved by sequence	MacIntyre	A
1003	HSV1	Clinical isolate	UL30	M1226I		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			10/02/2022	OJCharles	mutations not resolved by sequence	MacIntyre	A
1004	HSV1	Clinical isolate	UL30	R1229I		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			11/02/2022	OJCharles		KOS	A
1005	HSV1	Clinical isolate	UL30	L1234I		Polymorphism		Polymorphism										Gene polymorphism of thymidine kinase and DNA polymerase in clinical strains of herpes simplex virus	http://pdfs.semanticscholar.org/273d/230d2dc0f09225c569b99871ac2aa4e3da70.pdf	doi.org/10.3851/IMP1852	Isolated strain 	dye uptake assay			12/02/2022	OJCharles	unkown co-mutations		A
1006	HSV1	Clinical isolate	UL30	A1235T		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			13/02/2022	OJCharles	mutations not resolved by sequence	MacIntyre	A
1007	HSV1		UL30	D368A		Resistant		Resistant										Impaired Mismatch Extension by a Herpes Simplex DNA Polymerase Mutant with an Editing Nuclease Defect	https://www.sciencedirect.com/science/article/pii/S0021925819602449	doi.org/10.1074/jbc.273.37.24075	lab induced strain 	PCR DNA hybridization assay			15/02/2022	OJCharles			A
1008	HSV1	Clinical isolate	UL30	I529M		Resistant					Polymorphism							Mutations in the DNA Polymerase and Thymidine Kinase Genes of Herpes Simplex Virus Clinical Isolates Resistant to Antiherpetic Drugs	https://link.springer.com/article/10.1134/S0026893310030118		Isolated strain 	PRA			16/02/2022	OJCharles	co-occurs with resistant M880T and unknown mutations	L2	O
1009	HSV1	Clinical isolate	UL30	K532T		Resistant	Polymorphism											Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PCR DNA hybridization assay			17/02/2022	OJCharles	Cannot be inferred		O
1010	HSV1	Clinical isolate	UL30	E545D		10					1.3							Mutations in the DNA Polymerase and Thymidine Kinase Genes of Herpes Simplex Virus Clinical Isolates Resistant to Antiherpetic Drugs	https://link.springer.com/article/10.1134/S0026893310030118		Isolated strain 	PRA			18/02/2022	OJCharles	co-occurs with unknwon mutations	L2	O
1011	HSV1		UL30	Y557S				Resistant										Herpes Simplex Virus Type 1 DNA Polymerase: MUTATIONAL ANALYSIS OF THE 3?-5?-EXONUCLEASE DOMAIN	https://www.sciencedirect.com/science/article/pii/S0021925818350592	doi.org/10.1074/jbc.271.46.29245	Marker transfer 	PCR DNA hybridization assay			19/02/2022	OJCharles			A
1012	HSV1	Clinical isolate	UL30	Q570R		3.7		0.2										Genotypic and phenotypic characterization of acyclovir-resistant herpes simplex viruses isolated from haematopoietic stem cell transplant recipients.	https://journals.sagepub.com/doi/10.1177/135965350400900413	doi.org/10.1177/135965350400900413	Isolated strain 	yield reduction assay (ELVIRA)			20/02/2022	OJCharles			A
1013	HSV1		UL30	V573M		0.5		0.25										Resistance of herpes simplex virus type 1 against different phosphonylmethoxyalkyl derivatives of purines and pyrimidines due to specific mutations in the viral DNA polymerase gene	https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-81-3-639#tab2	doi.org/10.1099/0022-1317-81-3-639	Lab induced strain 	PRA			21/02/2022	OJCharles			A
1014	HSV1	Clinical isolate	UL30	D581A		Resistant												Phenotypic and genotypic characterization of clinical isolates of herpes simplex virus resistant to aciclovir	https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.18880-0#tab2	doi.org/10.1099/vir.0.18880-0	Isolated strain 	TK functional kinetic assay			22/02/2022	OJCharles			A
1015	HSV1	Clinical isolate	UL30	L583V		Resistant		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PCR DNA hybridization assay			23/02/2022	OJCharles	Cannot be inferred		O
1016	HSV1	SC16	UL30	E597D		10		8										Related functional domains in virus DNA polymerases	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC553373/pdf/emboj00241-0168.pdf		Lab induced strain 	PRA			24/02/2022	OJCharles			A
1017	HSV1	TAS	UL30	A605V		5	0.3	10				1.7						Genotypic Characterization of the DNA Polymerase and Sensitivity to Antiviral Compounds of Foscarnet-Resistant Herpes Simplex Virus Type 1 (HSV-1) Derived from a Foscarnet-Sensitive HSV-1 Strain	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC547286/	doi.org/10.1128/AAC.49.2.606-611.2005	Lab induced strain 	PRA			04/02/2021	OJCharles			A
1018	HSV1	Clinical isolate	UL30	Y608*		Resistant												Phenotypic and genotypic characterization of induced acyclovir-resistant clinical isolates of herpes simplex virus type 1	https://www.sciencedirect.com/science/article/pii/S0166354213002544?via%3Dihub	doi.org/10.1016/j.antiviral.2013.09.008	Isolated strain 	PRA			26/02/2022	OJCharles	cannot see in paper		O
1019	HSV1	KOS	UL30	Q618H		9	Polymorphism	1.9			Polymorphism							DNA polymerase mutations in drug-resistant herpes simplex virus mutants determine in vivo neurovirulence and drug-enzyme interactions	https://journals.sagepub.com/doi/abs/10.1177/135965350701200502	doi.org/10.1177/1359653507012005	Lab induced strain 	Cytopathic effect			27/02/2022	OJCharles		KOS	A
1020	HSV1	Clinical isolate	UL30	V621S		Resistant												Phenotypic and genotypic characterization of induced acyclovir-resistant clinical isolates of herpes simplex virus type 1	https://www.sciencedirect.com/science/article/pii/S0166354213002544?via%3Dihub	doi.org/10.1016/j.antiviral.2013.09.008	Isolated strain 	PRA			28/02/2022	OJCharles	co-occuring resistant mutant		O
1021	HSV1	Clinical isolate	UL30	A657T		Resistant	Polymorphism	Polymorphism			Resistant	Resistant						Novel resistance-associated mutations of thymidine kinase and DNA polymerase genes of herpes simplex virus type 1 and type 2	https://pubmed.ncbi.nlm.nih.gov/22155911/	 doi.org/10.3851/IMP1870	Isolated strain 	dye uptake assay			01/03/2022	OJCharles			A
1022	HSV1	Clinical isolate	UL30	D672N		Resistant	Polymorphism	Resistant			Resistant	Resistant						Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay			02/03/2022	OJCharles			A
1023	HSV1	KOS	UL30	R700G		2		6				Polymorphism						Penciclovir and pathogenesis phenotypes of drug-resistant Herpes simplex virus mutants	https://www.sciencedirect.com/science/article/pii/S0166354297000545?via%3Dihub	doi.org/10.1016/S0166-3542(97)00054-5	Lab induced strain 	PRA			03/03/2022	OJCharles		KOS	A
1024	HSV1		UL30	R700M		1.4	Resistant	Polymorphism			0.4							Resistance of herpes simplex virus type 1 against different phosphonylmethoxyalkyl derivatives of purines and pyrimidines due to specific mutations in the viral DNA polymerase gene	https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-81-3-639#tab2	doi.org/10.1099/0022-1317-81-3-639	Lab induced strain 	PRA			04/03/2022	OJCharles			A
1025	HSV1		UL30	L702H		Resistant	Polymorphism	Resistant				Resistant						Differential Mutation Patterns in Thymidine Kinase and DNA Polymerase Genes of Herpes Simplex Virus Type 1 Clones Passaged in the Presence of Acyclovir or Penciclovir	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC153316/	doi.org/10.1128/AAC.47.5.1707-1713.2003	Lab induced strain 	PRA			05/03/2022	OJCharles	ref wrong		E
1026	HSV1	Clinical isolate	UL30	L702P		128					257							Mutations in the DNA Polymerase and Thymidine Kinase Genes of Herpes Simplex Virus Clinical Isolates Resistant to Antiherpetic Drugs	https://link.springer.com/article/10.1134/S0026893310030118		Isolated strain 	PRA			06/03/2022	OJCharles	co-occurs with unknwon mutations	L2	O
1027	HSV1	KOS	UL30	V714M		2.7	Polymorphism	3.8			Polymorphism							DNA polymerase mutations in drug-resistant herpes simplex virus mutants determine in vivo neurovirulence and drug-enzyme interactions	https://journals.sagepub.com/doi/abs/10.1177/135965350701200502	doi.org/10.1177/1359653507012005	Lab induced strain 	Cytopathic effect			07/03/2022	OJCharles		KOS	A
1028	HSV1	Clinical isolate	UL30	V715G		Resistant	Polymorphism	Resistant				Resistant						Bone Marrow Transplantation in a ChildWith Wiskott-Aldrich Syndrome Latently InfectedWith Acyclovir-Resistant (ACVr) Herpes SimplexVirus Type 1: Emergence of Foscarnet-ResistantVirus Originating From the ACVrVirus	https://onlinelibrary.wiley.com/doi/epdf/10.1002/jmv.10175	 doi.org/10.1002/jmv.10175	Isolated strain 	PRA			08/03/2022	OJCharles		TAS	A
1029	HSV1	Clinical isolate	UL30	F716L		1.8	2.9	2.9										Mutations in the DNA Polymerase and Thymidine Kinase Genes of Herpes Simplex Virus Clinical Isolates Resistant to Antiherpetic Drugs	https://link.springer.com/article/10.1134/S0026893310030118		Isolated strain 	PRA			10/03/2022	OJCharles	co-occurs with unknwon mutations	L2	O
1030	HSV1	Clinical isolate	UL30	F733C		Resistant		Polymorphism										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			15/03/2022	OJCharles	co-occurs with large deletion		O
1031	HSV1	Clinical isolate	UL30	E771Q		Resistant		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PCR DNA hybridization assay			16/03/2022	OJCharles			A
1032	HSV1	KOS	UL30	L774F		3.7		3.2										A Point Mutation within Conserved Region VI of Herpes Simplex Virus Type 1 DNA Polymerase Confers Altered Drug Sensitivity and Enhances Replication Fidelity	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC368862/	doi.org/10.1128/JVI.78.2.650-657.2004	Marker Transfer 	PRA			17/03/2022	OJCharles		KOS	A
1033	HSV1	Clinical isolate	UL30	S775N		Resistant		Polymorphism										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			18/03/2022	OJCharles			A
1034	HSV1		UL30	W781V	3	14		3										Contrasting Effects of W781V and W780V Mutations in Helix N of Herpes Simplex Virus 1 and Human Cytomegalovirus DNA Polymerases on Antiviral Drug Susceptibility	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442382/	doi.org/10.1128/JVI.03360-14	Marker Transfer 	PRA			21/03/2022	OJCharles			A
1035	HSV1	KOS	UL30	P797T		Resistant												Identification of amino acids in herpes simplex virus DNA polymerase involved in substrate and drug recognition	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC282039/	doi.org/10.1073/pnas.85.18.6672	lab induced strain 	PRA			23/03/2022	OJCharles	infer pol mutation phenotype using virus phenotype assay ignorant of tk genotype	KOS	O
1036	HSV1	Clinical isolate	UL30	E798K		Resistant	Polymorphism	Resistant			Polymorphism	Resistant						Heterogeneity and Evolution of Thymidine Kinase and DNA Polymerase Mutants of Herpes Simplex Virus Type 1: Implications for Antiviral Therapy	https://pubmed.ncbi.nlm.nih.gov/23315323/	doi.org/10.1093/infdis/jit019	Isolated strain 	PRA			24/03/2022	OJCharles	co-occurs with resmut		O
1037	HSV1	KOS	UL30	L802F		7.4	Resistant	Resistant			Polymorphism							DNA polymerase mutations in drug-resistant herpes simplex virus mutants determine in vivo neurovirulence and drug-enzyme interactions	https://journals.sagepub.com/doi/abs/10.1177/135965350701200502	doi.org/10.1177/1359653507012005	Lab induced strain 	Cytopathic effect			25/03/2022	OJCharles		KOS	A
1038	HSV1	KOS	UL30	V813M		5	4	3				Resistant						Penciclovir and pathogenesis phenotypes of drug-resistant Herpes simplex virus mutants	https://www.sciencedirect.com/science/article/pii/S0166354297000545?via%3Dihub	doi.org/10.1016/S0166-3542(97)00054-5	Lab induced strain 	PRA			26/03/2022	OJCharles		KOS	A
1039	HSV1	SC16	UL30	N815S		150	Polymorphism	0.4			Polymorphism	Resistant						Related functional domains in virus DNA polymerases	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC553373/pdf/emboj00241-0168.pdf		Lab induced strain 	PRA			27/03/2022	OJCharles	redundant		O
1040	HSV1		UL30	G841C		Resistant	Resistant	Resistant				Resistant						Differential Mutation Patterns in Thymidine Kinase and DNA Polymerase Genes of Herpes Simplex Virus Type 1 Clones Passaged in the Presence of Acyclovir or Penciclovir	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC153316/	doi.org/10.1128/AAC.47.5.1707-1713.2003	Lab induced strain 	PRA			30/03/2022	OJCharles	ref wrong		E
1041	HSV1	SC16	UL30	G841S		29		2.6										Related functional domains in virus DNA polymerases	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC553373/pdf/emboj00241-0168.pdf		Lab induced strain 	PRA			31/03/2022	OJCharles			A
1042	HSV1	KOS	UL30	R842S		150						4						Penciclovir and pathogenesis phenotypes of drug-resistant Herpes simplex virus mutants	https://www.sciencedirect.com/science/article/pii/S0166354297000545?via%3Dihub	doi.org/10.1016/S0166-3542(97)00054-5	Lab induced strain 	PRA			01/04/2022	OJCharles		KOS	A
1043	HSV1	Clinical isolate	UL30	M880T		10					1.3							Mutations in the DNA Polymerase and Thymidine Kinase Genes of Herpes Simplex Virus Clinical Isolates Resistant to Antiherpetic Drugs	https://link.springer.com/article/10.1134/S0026893310030118		Isolated strain 	PRA			02/04/2022	OJCharles	co-occurs with unknwon mutations	L2	O
1044	HSV1		UL30	S889A		10		225										Resistance to Antiviral Inhibitors Caused by the Mutation S889A in the Highly-Conserved 885-GDTDS Motif of the Herpes Simplex Virus Type 1 DNA Polymerase	https://www.sciencedirect.com/science/article/pii/S004268228371439X?via%3Dihub	doi.org/10.1006/viro.1993.1439	Marker transfer 	PCR DNA hybridization assay			03/04/2022	OJCharles			A
1045	HSV1		UL30	F891Y		Resistant		Resistant										Engineered Herpes Simplex Virus DNA Polymerase Point Mutants: the Most Highly Conserved Region Shared among oL-Like DNA Polymerases Is Involved in Substrate Recognition	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC248752/pdf/jvirol00067-0201.pdf		Marker Transfer 	PRA			05/04/2022	OJCharles			A
1046	HSV1		UL30	V892M		Resistant		Resistant										Engineered Herpes Simplex Virus DNA Polymerase Point Mutants: the Most Highly Conserved Region Shared among oL-Like DNA Polymerases Is Involved in Substrate Recognition	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC248752/pdf/jvirol00067-0201.pdf		Marker Transfer 	PRA			06/04/2022	OJCharles			A
1047	HSV1	Clinical isolate	UL30	G901V		25		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			07/04/2022	OJCharles	mutations not resolved by sequence	MacIntyre	A
1048	HSV1		UL30	I922N			Polymorphism	Resistant										Differential Mutation Patterns in Thymidine Kinase and DNA Polymerase Genes of Herpes Simplex Virus Type 1 Clones Passaged in the Presence of Acyclovir or Penciclovir	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC153316/	doi.org/10.1128/AAC.47.5.1707-1713.2003	Lab induced strain 	PRA			09/04/2022	OJCharles	ref wrong		E
1049	HSV1	TAS	UL30	V958L		Resistant	Polymorphism	Resistant				Resistant						Genotypic Characterization of the DNA Polymerase and Sensitivity to Antiviral Compounds of Foscarnet-Resistant Herpes Simplex Virus Type 1 (HSV-1) Derived from a Foscarnet-Sensitive HSV-1 Strain	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC547286/	doi.org/10.1128/AAC.49.2.606-611.2005	Lab induced strain 	PRA			04/02/2021	OJCharles			A
1050	HSV1		UL30	R959H		3.4	Resistant	Resistant			Polymorphism							DNA polymerase mutations in drug-resistant herpes simplex virus mutants determine in vivo neurovirulence and drug-enzyme interactions	https://journals.sagepub.com/doi/abs/10.1177/135965350701200502	doi.org/10.1177/1359653507012005	Lab induced strain 	Cytopathic effect			12/04/2022	OJCharles			A
1051	HSV1	KOS	UL30	K960R		2.5	Resistant	Polymorphism			Polymorphism							DNA polymerase mutations in drug-resistant herpes simplex virus mutants determine in vivo neurovirulence and drug-enzyme interactions	https://journals.sagepub.com/doi/abs/10.1177/135965350701200502	doi.org/10.1177/1359653507012005	Lab induced strain 	Cytopathic effect			13/04/2022	OJCharles		KOS	A
1052	HSV1	KOS	UL30	W998L		1.5	Resistant	Polymorphism			Polymorphism							DNA polymerase mutations in drug-resistant herpes simplex virus mutants determine in vivo neurovirulence and drug-enzyme interactions	https://journals.sagepub.com/doi/abs/10.1177/135965350701200502	doi.org/10.1177/1359653507012005	Lab induced strain 	Cytopathic effect			15/04/2022	OJCharles		KOS	A
1053	HSV1	Clinical isolate	UL30	H1228D		3												Phenotypic and genotypic characterization of induced acyclovir-resistant clinical isolates of herpes simplex virus type 1	https://www.sciencedirect.com/science/article/pii/S0166354213002544?via%3Dihub	doi.org/10.1016/j.antiviral.2013.09.008	Isolated strain 	PRA			18/04/2022	OJCharles			A
1054	HSV2	Clinical isolate	UL30	A9T		Polymorphism		Polymorphism										Resistance testing of clinical herpes simplex virus type 2 isolates collected over 4 decades	https://www.sciencedirect.com/science/article/pii/S1438422115000776?via%3Dihub	doi.org/10.1016/j.ijmm.2015.08.014	Isolated strain 	dye uptake assay			01/11/2020	OJCharles			A
1055	HSV2	Clinical isolate	UL30	A9T		Polymorphism		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			01/11/2020	OJCharles			A
1056	HSV2	Clinical isolate	UL30	G12R		Polymorphism												Impact of novel mutations of herpes simplex virus 1 and 2 thymidine kinases on acyclovir phosphorylation activity	https://www.sciencedirect.com/science/article/pii/S0166354212002239?via%3Dihub#b0010	doi.org/10.1016/j.antiviral.2012.09.016	Isolated strain 	dye uptake assay			01/11/2020	OJCharles			A
1057	HSV2	Clinical isolate	UL30	P15S		Polymorphism		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			01/11/2020	OJCharles			A
1058	HSV2	Clinical isolate	UL30	P15R		Polymorphism	Polymorphism	Polymorphism			Polymorphism	Polymorphism						Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay			01/11/2020	OJCharles			A
1059	HSV2	Clinical isolate	UL30	Q34H		Resistant												Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay			01/11/2020	OJCharles	Y133F is polymorphic in subsequent studies		A
1060	HSV2	Clinical isolate	UL30	A36G		Polymorphism		Polymorphism										Impact of novel mutations of herpes simplex virus 1 and 2 thymidine kinases on acyclovir phosphorylation activity	https://www.sciencedirect.com/science/article/pii/S0166354212002239?via%3Dihub#b0010	doi.org/10.1016/j.antiviral.2012.09.016	Isolated strain 	dye uptake assay			01/11/2020	OJCharles			A
1061	HSV2	Clinical isolate	UL30	P37L		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			01/11/2020	OJCharles		KOS	A
1062	HSV2	Clinical isolate	UL30	C40W		Polymorphism		Polymorphism										Gene polymorphism of thymidine kinase and DNA polymerase in clinical strains of herpes simplex virus	http://pdfs.semanticscholar.org/273d/230d2dc0f09225c569b99871ac2aa4e3da70.pdf	doi.org/10.3851/IMP1852	Isolated strain 	dye uptake assay			01/11/2020	OJCharles	unkown co-mutations		A
1063	HSV2	Clinical isolate	UL30	R41H		Polymorphism	Polymorphism	Polymorphism			Polymorphism	Polymorphism						Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay			01/11/2020	OJCharles	Cannot be inferred		O
1064	HSV2	Clinical isolate	UL30	Q43R		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			01/11/2020	OJCharles		KOS	A
1065	HSV2	Clinical isolate	UL30	H49Y		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			01/11/2020	OJCharles		KOS	A
1066	HSV2	Clinical isolate	UL30	T53A		Polymorphism		Polymorphism										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub#tblfn8	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			01/11/2020	OJCharles	co occurs with unknown mut		O
1067	HSV2	Clinical isolate	UL30	L60P		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			01/11/2020	OJCharles		KOS	A
1068	HSV2	Clinical isolate	UL30	Q64R		Polymorphism		Polymorphism										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub#tblfn8	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			01/11/2020	OJCharles	co occurs with unknown mut		O
1069	HSV2	Clinical isolate	UL30	R101W		Polymorphism		Polymorphism										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub#tblfn8	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			01/11/2020	OJCharles	co occurs with unknown mut		O
1070	HSV2	Clinical isolate	UL30	L128S		Polymorphism		Polymorphism										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub#tblfn8	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			01/11/2020	OJCharles	co occurs with unknown mut		O
1071	HSV2	Clinical isolate	UL30	E139K		Polymorphism		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			01/11/2020	OJCharles			A
1072	HSV2	Clinical isolate	UL30	T144P		Polymorphism		Polymorphism										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub#tblfn8	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			01/11/2020	OJCharles	co occurs with unknown mut		O
1073	HSV2	Clinical isolate	UL30	I153T		Polymorphism		Polymorphism										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub#tblfn8	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			01/11/2020	OJCharles	co occurs with unknown mut		O
1074	HSV2	Clinical isolate	UL30	T202M		Polymorphism		Polymorphism										Impact of novel mutations of herpes simplex virus 1 and 2 thymidine kinases on acyclovir phosphorylation activity	https://www.sciencedirect.com/science/article/pii/S0166354212002239?via%3Dihub#b0010	doi.org/10.1016/j.antiviral.2012.09.016	Isolated strain 	dye uptake assay			01/11/2020	OJCharles			A
1075	HSV2	Clinical isolate	UL30	R203Q		Polymorphism		Polymorphism										Gene polymorphism of thymidine kinase and DNA polymerase in clinical strains of herpes simplex virus	http://pdfs.semanticscholar.org/273d/230d2dc0f09225c569b99871ac2aa4e3da70.pdf	doi.org/10.3851/IMP1852	Isolated strain 	dye uptake assay			01/11/2020	OJCharles	unkown co-mutations		A
1076	HSV2	Clinical isolate	UL30	L229M		Polymorphism		Polymorphism										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub#tblfn8	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			01/11/2020	OJCharles	co occurs with unknown mut		O
1077	HSV2	Clinical isolate	UL30	A232T		Polymorphism	Polymorphism	Polymorphism			Polymorphism	Polymorphism						Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay			01/11/2020	OJCharles	Cannot be inferred		O
1078	HSV2	Clinical isolate	UL30	A251V		Polymorphism		Polymorphism										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub#tblfn8	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			01/11/2020	OJCharles	co occurs with unknown mut		O
1079	HSV2	Clinical isolate	UL30	N286Y		Polymorphism	Polymorphism	Polymorphism				Polymorphism						Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay			01/11/2020	OJCharles			A
1080	HSV2	Clinical isolate	UL30	I291V		Polymorphism		Polymorphism										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub#tblfn8	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			01/11/2020	OJCharles	co occurs with unknown mut		O
1081	HSV2	Clinical isolate	UL30	A300T		Polymorphism		Polymorphism										Impact of novel mutations of herpes simplex virus 1 and 2 thymidine kinases on acyclovir phosphorylation activity	https://www.sciencedirect.com/science/article/pii/S0166354212002239?via%3Dihub#b0010	doi.org/10.1016/j.antiviral.2012.09.016	Isolated strain 	dye uptake assay			01/11/2020	OJCharles			A
1082	HSV2	Clinical isolate	UL30	G324E		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			01/11/2020	OJCharles		KOS	A
1083	HSV2	Clinical isolate	UL30	F336L		Polymorphism		Polymorphism										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub#tblfn8	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			01/11/2020	OJCharles	co occurs with unknown mut		O
1084	HSV2	Clinical isolate	UL30	T347M		Polymorphism		Polymorphism										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub#tblfn8	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			01/11/2020	OJCharles	co occurs with unknown mut		O
1085	HSV2	Clinical isolate	UL30	Q507H		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			01/11/2020	OJCharles		KOS	A
1086	HSV2	Clinical isolate	UL30	A547V		Polymorphism		Polymorphism										Impact of novel mutations of herpes simplex virus 1 and 2 thymidine kinases on acyclovir phosphorylation activity	https://www.sciencedirect.com/science/article/pii/S0166354212002239?via%3Dihub#b0010	doi.org/10.1016/j.antiviral.2012.09.016	Isolated strain 	dye uptake assay			01/11/2020	OJCharles			A
1087	HSV2	Clinical isolate	UL30	R628C		Resistant												Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			01/11/2020	OJCharles	Only publshed with known resistance mutations, not given is any un-previously identified mutations in pol / tk. So this is problematic		O
1088	HSV2	Clinical isolate	UL30	G646S		Polymorphism		Polymorphism										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub#tblfn8	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			01/11/2020	OJCharles	co occurs with unknown mut		O
1089	HSV2	Clinical isolate	UL30	D671N		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			01/11/2020	OJCharles		KOS	A
1090	HSV2	Clinical isolate	UL30	D676G		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			01/11/2020	OJCharles		KOS	A
1091	HSV2	Clinical isolate	UL30	D676N		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			01/11/2020	OJCharles		KOS	A
1092	HSV2	Clinical isolate	UL30	del676-677		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			01/11/2020	OJCharles		KOS	A
1093	HSV2	Clinical isolate	UL30	del677-679		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			01/11/2020	OJCharles		KOS	A
1094	HSV2	Clinical isolate	UL30	E678G		Polymorphism		Polymorphism				Polymorphism						Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			01/11/2020	OJCharles		KOS	A
1095	HSV2	Clinical isolate	UL30	G680R		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			01/11/2020	OJCharles		KOS	A
1096	HSV2	Clinical isolate	UL30	G680D		Polymorphism		Polymorphism										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub#tblfn8	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			01/11/2020	OJCharles	mutations not resolved by sequence & unsure which sequences also / did not have a pol genotype		O
1097	HSV2	Clinical isolate	UL30	del681-682		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			01/11/2020	OJCharles		KOS	A
1098	HSV2	Clinical isolate	UL30	E682G		Polymorphism		Polymorphism										Impact of novel mutations of herpes simplex virus 1 and 2 thymidine kinases on acyclovir phosphorylation activity	https://www.sciencedirect.com/science/article/pii/S0166354212002239?via%3Dihub#b0010	doi.org/10.1016/j.antiviral.2012.09.016	Isolated strain 	dye uptake assay			01/11/2020	OJCharles			A
1099	HSV2	Clinical isolate	UL30	E682K		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			01/11/2020	OJCharles		KOS	A
1100	HSV2	Clinical isolate	UL30	del682-683		Polymorphism		Polymorphism										Impact of novel mutations of herpes simplex virus 1 and 2 thymidine kinases on acyclovir phosphorylation activity	https://www.sciencedirect.com/science/article/pii/S0166354212002239?via%3Dihub#b0010	doi.org/10.1016/j.antiviral.2012.09.016	Isolated strain 	dye uptake assay			01/11/2020	OJCharles			A
1101	HSV2	Clinical isolate	UL30	del683-686		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			01/11/2020	OJCharles		KOS	A
1102	HSV2	Clinical isolate	UL30	E686+		Polymorphism		Polymorphism										Impact of novel mutations of herpes simplex virus 1 and 2 thymidine kinases on acyclovir phosphorylation activity	https://www.sciencedirect.com/science/article/pii/S0166354212002239?via%3Dihub#b0010	doi.org/10.1016/j.antiviral.2012.09.016	Isolated strain 	dye uptake assay			01/11/2020	OJCharles			A
1103	HSV2	Clinical isolate	UL30	D708N		Polymorphism		Polymorphism										Impact of novel mutations of herpes simplex virus 1 and 2 thymidine kinases on acyclovir phosphorylation activity	https://www.sciencedirect.com/science/article/pii/S0166354212002239?via%3Dihub#b0010	doi.org/10.1016/j.antiviral.2012.09.016	Isolated strain 	dye uptake assay			01/11/2020	OJCharles			A
1104	HSV2	Clinical isolate	UL30	D716N		Polymorphism	Polymorphism	Polymorphism			Polymorphism	Polymorphism						Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			01/11/2020	OJCharles			A
1105	HSV2	Clinical isolate	UL30	E746K		Polymorphism		Polymorphism										Novel resistance-associated mutations of thymidine kinase and DNA polymerase genes of herpes simplex virus type 1 and type 2	https://pubmed.ncbi.nlm.nih.gov/22155911/	 doi.org/10.3851/IMP1870	Isolated strain 	dye uptake assay			01/11/2020	OJCharles			A
1106	HSV2	Clinical isolate	UL30	Q799R		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			01/11/2020	OJCharles		KOS	A
1107	HSV2	Clinical isolate	UL30	T801P		Polymorphism	Polymorphism	Polymorphism			Polymorphism	Polymorphism						Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			01/11/2020	OJCharles			A
1108	HSV2	Clinical isolate	UL30	E803K		Polymorphism		Polymorphism										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub#tblfn8	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			01/11/2020	OJCharles	co occurs with unknown mut		O
1109	HSV2	Clinical isolate	UL30	A869D		Polymorphism		Polymorphism										Impact of novel mutations of herpes simplex virus 1 and 2 thymidine kinases on acyclovir phosphorylation activity	https://www.sciencedirect.com/science/article/pii/S0166354212002239?via%3Dihub#b0010	doi.org/10.1016/j.antiviral.2012.09.016	Isolated strain 	dye uptake assay			01/11/2020	OJCharles			A
1110	HSV2	Clinical isolate	UL30	A879V		Polymorphism		Polymorphism										Impact of novel mutations of herpes simplex virus 1 and 2 thymidine kinases on acyclovir phosphorylation activity	https://www.sciencedirect.com/science/article/pii/S0166354212002239?via%3Dihub#b0010	doi.org/10.1016/j.antiviral.2012.09.016	Isolated strain 	dye uptake assay			01/11/2020	OJCharles			A
1111	HSV2	Clinical isolate	UL30	P880H		Polymorphism	Polymorphism	Polymorphism				Polymorphism						Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay			01/11/2020	OJCharles			A
1112	HSV2	Clinical isolate	UL30	T903M		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			01/11/2020	OJCharles		KOS	A
1113	HSV2	Clinical isolate	UL30	A904G		Polymorphism		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			01/11/2020	OJCharles			A
1114	HSV2	Clinical isolate	UL30	A905E		Polymorphism		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			01/11/2020	OJCharles			A
1115	HSV2	Clinical isolate	UL30	M910I		Polymorphism		Polymorphism										Impact of novel mutations of herpes simplex virus 1 and 2 thymidine kinases on acyclovir phosphorylation activity	https://www.sciencedirect.com/science/article/pii/S0166354212002239?via%3Dihub#b0010	doi.org/10.1016/j.antiviral.2012.09.016	Isolated strain 	dye uptake assay			01/11/2020	OJCharles			A
1116	HSV2	Clinical isolate	UL30	K913M		Polymorphism		Polymorphism										Impact of novel mutations of herpes simplex virus 1 and 2 thymidine kinases on acyclovir phosphorylation activity	https://www.sciencedirect.com/science/article/pii/S0166354212002239?via%3Dihub#b0010	doi.org/10.1016/j.antiviral.2012.09.016	Isolated strain 	dye uptake assay			01/11/2020	OJCharles			A
1117	HSV2	Clinical isolate	UL30	T987S		Polymorphism		Polymorphism										Gene polymorphism of thymidine kinase and DNA polymerase in clinical strains of herpes simplex virus	http://pdfs.semanticscholar.org/273d/230d2dc0f09225c569b99871ac2aa4e3da70.pdf	doi.org/10.3851/IMP1852	Isolated strain 	dye uptake assay			01/11/2020	OJCharles	unkown co-mutations		A
1118	HSV2	Clinical isolate	UL30	L995F		Polymorphism	Polymorphism	Polymorphism			Polymorphism	Polymorphism						Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay			01/11/2020	OJCharles	Cannot be inferred		O
1119	HSV2	Clinical isolate	UL30	A1000T		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			01/11/2020	OJCharles		KOS	A
1120	HSV2	Clinical isolate	UL30	R1025H		Polymorphism		Polymorphism										Impact of novel mutations of herpes simplex virus 1 and 2 thymidine kinases on acyclovir phosphorylation activity	https://www.sciencedirect.com/science/article/pii/S0166354212002239?via%3Dihub#b0010	doi.org/10.1016/j.antiviral.2012.09.016	Isolated strain 	dye uptake assay			01/11/2020	OJCharles			A
1121	HSV2	Clinical isolate	UL30	I1026S		Polymorphism	Polymorphism	Polymorphism			Polymorphism	Polymorphism						Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay			01/11/2020	OJCharles	Cannot be inferred		O
1122	HSV2	Clinical isolate	UL30	A1083T		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			01/11/2020	OJCharles		KOS	A
1123	HSV2	Clinical isolate	UL30	del1106-1111		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			01/11/2020	OJCharles		KOS	A
1124	HSV2	Clinical isolate	UL30	P1112+		Polymorphism		Polymorphism										Impact of novel mutations of herpes simplex virus 1 and 2 thymidine kinases on acyclovir phosphorylation activity	https://www.sciencedirect.com/science/article/pii/S0166354212002239?via%3Dihub#b0010	doi.org/10.1016/j.antiviral.2012.09.016	Isolated strain 	dye uptake assay			01/11/2020	OJCharles			A
1125	HSV2	Clinical isolate	UL30	A1114V		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			01/11/2020	OJCharles		KOS	A
1126	HSV2	Clinical isolate	UL30	E1149G		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			01/11/2020	OJCharles	problematic theres never data shown to prove this	KOS	O
1127	HSV2	Clinical isolate	UL30	A1156T		Polymorphism		Polymorphism										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub#tblfn8	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			01/11/2020	OJCharles	co occurs with unknown mut		O
1128	HSV2	Clinical isolate	UL30	A1209V		Polymorphism		Polymorphism										Impact of novel mutations of herpes simplex virus 1 and 2 thymidine kinases on acyclovir phosphorylation activity	https://www.sciencedirect.com/science/article/pii/S0166354212002239?via%3Dihub#b0010	doi.org/10.1016/j.antiviral.2012.09.016	Isolated strain 	dye uptake assay			01/11/2020	OJCharles			A
1129	HSV2	Clinical isolate	UL30	A1223V		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			01/11/2020	OJCharles		KOS	A
1130	HSV2	Clinical isolate	UL30	R1230Q		Polymorphism		Polymorphism										Impact of novel mutations of herpes simplex virus 1 and 2 thymidine kinases on acyclovir phosphorylation activity	https://www.sciencedirect.com/science/article/pii/S0166354212002239?via%3Dihub#b0010	doi.org/10.1016/j.antiviral.2012.09.016	Isolated strain 	dye uptake assay			01/11/2020	OJCharles			A
1131	HSV2	Clinical isolate	UL23	A19V		Polymorphism		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			01/11/2020	OJCharles	Cannot be inferred		O
1132	HSV2	Clinical isolate	UL23	R26H		Polymorphism		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			01/11/2020	OJCharles			A
1133	HSV2	Clinical isolate	UL23	A27T		Polymorphism		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			01/11/2020	OJCharles	Cannot be inferred		O
1134	HSV2	Clinical isolate	UL23	S29A		Polymorphism		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			01/11/2020	OJCharles	Cannot be inferred		O
1135	HSV2		UL23	G39E		1.2												Impact of novel mutations of herpes simplex virus 1 and 2 thymidine kinases on acyclovir phosphorylation activity	https://www.sciencedirect.com/science/article/pii/S0166354212002239?via%3Dihub#b0010	doi.org/10.1016/j.antiviral.2012.09.016	Marker Transfer 	TK functional kinetic assay			01/11/2020	OJCharles			A
1136	HSV2	Clinical isolate	UL23	N78D		Polymorphism		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			01/11/2020	OJCharles			A
1137	HSV2	Clinical isolate	UL23	E96D		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			01/11/2020	OJCharles		KOS	A
1138	HSV2	Clinical isolate	UL23	A119T		Polymorphism		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			01/11/2020	OJCharles			A
1139	HSV2	Clinical isolate	UL23	T131M		Polymorphism		Polymorphism										Resistance testing of clinical herpes simplex virus type 2 isolates collected over 4 decades	https://www.sciencedirect.com/science/article/pii/S1438422115000776?via%3Dihub#bib0120	doi.org/10.1016/j.ijmm.2015.08.014	Isolated strain 	dye uptake assay			01/11/2020	OJCharles			A
1140	HSV2	Clinical isolate	UL23	A135P		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			01/11/2020	OJCharles		KOS	A
1141	HSV2	Clinical isolate	UL23	D137E		Polymorphism		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			01/11/2020	OJCharles		KOS	A
1142	HSV2	Clinical isolate	UL23	L140F		Polymorphism		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			01/11/2020	OJCharles			A
1143	HSV2	Clinical isolate	UL23	G150D		Polymorphism		Polymorphism										Resistance testing of clinical herpes simplex virus type 2 isolates collected over 4 decades	https://www.sciencedirect.com/science/article/pii/S1438422115000776?via%3Dihub#bib0120	doi.org/10.1016/j.ijmm.2015.08.014	Isolated strain 	dye uptake assay			01/11/2020	OJCharles			A
1144	HSV2	Clinical isolate	UL23	A157T		Polymorphism		Polymorphism										Resistance testing of clinical herpes simplex virus type 2 isolates collected over 4 decades	https://www.sciencedirect.com/science/article/pii/S1438422115000776?via%3Dihub#bib0120	doi.org/10.1016/j.ijmm.2015.08.014	Isolated strain 	dye uptake assay			01/11/2020	OJCharles			A
1145	HSV2	Clinical isolate	UL23	T159I		Polymorphism		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			01/11/2020	OJCharles	Cannot be inferred		O
1146	HSV2	Clinical isolate	UL23	G201D		Polymorphism		Polymorphism										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub#tblfn8	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			01/11/2020	OJCharles	co occurs with unknown mut		O
1147	HSV2	Clinical isolate	UL23	A215T		Polymorphism		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			01/11/2020	OJCharles			A
1148	HSV2	Clinical isolate	UL23	R220K		Polymorphism		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			01/11/2020	OJCharles			A
1149	HSV2	Clinical isolate	UL23	N245S		Polymorphism		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			01/11/2020	OJCharles	Cannot be inferred		O
1150	HSV2	Clinical isolate	UL23	R248W		Polymorphism		Polymorphism										Resistance testing of clinical herpes simplex virus type 2 isolates collected over 4 decades	https://www.sciencedirect.com/science/article/pii/S1438422115000776?via%3Dihub#bib0120	doi.org/10.1016/j.ijmm.2015.08.014	Isolated strain 	dye uptake assay			01/11/2020	OJCharles			A
1151	HSV2	Clinical isolate	UL23	Q251R		Polymorphism		Polymorphism										Gene polymorphism of thymidine kinase and DNA polymerase in clinical strains of herpes simplex virus	http://pdfs.semanticscholar.org/273d/230d2dc0f09225c569b99871ac2aa4e3da70.pdf	doi.org/10.3851/IMP1852	Isolated strain 	dye uptake assay			01/11/2020	OJCharles	unkown co-mutations		A
1152	HSV2	Clinical isolate	UL23	R284S		Polymorphism		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			01/11/2020	OJCharles	Cannot be inferred		O
1153	HSV2	Clinical isolate	UL23	L342W		Polymorphism		Polymorphism										Resistance testing of clinical herpes simplex virus type 2 isolates collected over 4 decades	https://www.sciencedirect.com/science/article/pii/S1438422115000776?via%3Dihub#bib0120	doi.org/10.1016/j.ijmm.2015.08.014	Isolated strain 	dye uptake assay			01/11/2020	OJCharles			A
1154	HSV2		UL23	S32stop*		161	0.7	0.4			2.6	133						Characterization of Herpes Simplex Viruses Selected in Culture for Resistance to Penciclovir or Acyclovir	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC114085/	doi.org/10.1128/JVI.75.4.1761-1769.2001	Lab induced strain 	PRA			01/11/2020	OJCharles			A
1155	HSV2	Clinical isolate	UL23	R34C		Resistant		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			01/11/2020	OJCharles	Cannot be inferred		O
1156	HSV2	Clinical isolate	UL23	R51W		Resistant												Journal of Medical Virology 73:60-64 (2004)Case ReportCharacterisation of Penciclovir Resistant AcyclovirSensitive Herpes Simplex Virus Type 2 IsolatedFrom an AIDS Patient	https://onlinelibrary.wiley.com/doi/epdf/10.1002/jmv.20061	doi.org/10.1002/jmv.20061	Isolated strain 	PRA			16/01/2021	OJCharles			A
1157	HSV2	Clinical isolate	UL23	Y53N		Resistant	Resistant	Polymorphism			Resistant	Resistant						Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay			01/11/2020	OJCharles	Cannot be inferred		A
1158	HSV2		UL23	I54stop*		200	2.8	1.4			1.2	133.8						Characterization of Herpes Simplex Viruses Selected in Culture for Resistance to Penciclovir or Acyclovir	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC114085/	doi.org/10.1128/JVI.75.4.1761-1769.2001	Lab induced strain 	PRA			01/11/2020	OJCharles			A
1159	HSV2		UL23	I54stop*		150	1.7	0.7			3.1	115						Characterization of Herpes Simplex Viruses Selected in Culture for Resistance to Penciclovir or Acyclovir	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC114085/	doi.org/10.1128/JVI.75.4.1761-1769.2001	Lab induced strain 	PRA			01/11/2020	OJCharles			A
1160	HSV2	Clinical isolate	UL23	G61W		Resistant		Polymorphism										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub#tblfn8	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			01/11/2020	OJCharles	co occurs with unknown mut		O
1161	HSV2	Clinical isolate	UL23	K62N		Resistant												Phenotypic and Genotypic Characterization of Acyclovir-Resistant Herpes Simplex Viruses from Immunocompromised Patients	https://academic.oup.com/jid/article/178/2/297/904713	doi.org/10.1086/515626	Isolated strain 	PCR DNA hybridization assay			01/11/2020	OJCharles	duplicate	A2	O
1162	HSV2		UL23	S66P		Resistant												Impact of novel mutations of herpes simplex virus 1 and 2 thymidine kinases on acyclovir phosphorylation activity	https://www.sciencedirect.com/science/article/pii/S0166354212002239?via%3Dihub#b0010	doi.org/10.1016/j.antiviral.2012.09.016	Marker Transfer 	TK functional kinetic assay			01/11/2020	OJCharles	Hard to interpret as double mutant is sensetive		O
1163	HSV2		UL23	A72S		Resistant												Impact of novel mutations of herpes simplex virus 1 and 2 thymidine kinases on acyclovir phosphorylation activity	https://www.sciencedirect.com/science/article/pii/S0166354212002239?via%3Dihub#b0010	doi.org/10.1016/j.antiviral.2012.09.016	Marker Transfer 	TK functional kinetic assay			01/11/2020	OJCharles	Hard to interpret as double mutant is sensetive		O
1164	HSV2	Clinical isolate	UL23	M86stop		Resistant		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			01/11/2020	OJCharles			A
1165	HSV2	Clinical isolate	UL23	A94V		Resistant		Resistant										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub#tblfn8	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			01/11/2020	OJCharles			A
1166	HSV2	Clinical isolate	UL23	L98stop		Resistant		Polymorphism										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub#tblfn8	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			01/11/2020	OJCharles	co occurs with unknown mut		O
1167	HSV2		UL23	I101S		4												Impact of novel mutations of herpes simplex virus 1 and 2 thymidine kinases on acyclovir phosphorylation activity	https://www.sciencedirect.com/science/article/pii/S0166354212002239?via%3Dihub#b0010	doi.org/10.1016/j.antiviral.2012.09.016	Marker Transfer 	TK functional kinetic assay			01/11/2020	OJCharles			A
1168	HSV2	Clinical isolate	UL23	Q105P		Resistant												Analysis of the thymidine kinase gene from clinically isolated acyclovir-resistant herpes simplex viruses	https://www.sciencedirect.com/science/article/pii/004268229190093Q?via%3Dihub	doi.org/10.1016/0042-6822(91)90093-Q	Isolated strain 	PRA			01/11/2020	OJCharles	ignores potential pol mutants		O
1169	HSV2	Clinical isolate	UL23	T131P		10												Phenotypic and Genotypic Characterization of Acyclovir-Resistant Herpes Simplex Viruses from Immunocompromised Patients	https://academic.oup.com/jid/article/178/2/297/904713	doi.org/10.1086/515626	Isolated strain 	PCR DNA hybridization assay			01/11/2020	OJCharles		A2	A
1170	HSV2	Clinical isolate	UL23	Y133F		Resistant	Resistant	Polymorphism			Resistant	Resistant						Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay			01/11/2020	OJCharles	Cannot be inferred		A
1171	HSV2	Clinical isolate	UL23	D137stop		Resistant		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			01/11/2020	OJCharles		KOS	A
1172	HSV2	Clinical isolate	UL23	L158P		Resistant												Phenotypic and genotypic characterization of clinical isolates of herpes simplex virus resistant to aciclovir	https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.18880-0#tab2	doi.org/10.1099/vir.0.18880-0	Isolated strain 	TK functional kinetic assay			01/11/2020	OJCharles			A
1173	HSV2	Clinical isolate	UL23	R177W		Resistant		Polymorphism										Recurrent Acyclovir-Resistant Genital Herpes in an Immunocompetent Patient	https://www.nejm.org/doi/10.1056/NEJM199312093292405?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200www.ncbi.nlm.nih.gov	doi.org/10.1056/NEJM199312093292405	Isolated strain 	PRA			01/11/2020	OJCharles	co-occuring mutations have been subsequently characterised		A
1174	HSV2	Clinical isolate	UL23	S182D		Resistant												Analysis of the thymidine kinase gene from clinically isolated acyclovir-resistant herpes simplex viruses	https://www.sciencedirect.com/science/article/pii/004268229190093Q?via%3Dihub	doi.org/10.1016/0042-6822(91)90093-Q	Isolated strain 	PRA			01/11/2020	OJCharles	ignores potential pol mutants		O
1175	HSV2	Clinical isolate	UL23	S182R		Resistant												Analysis of the thymidine kinase gene from clinically isolated acyclovir-resistant herpes simplex viruses	https://www.sciencedirect.com/science/article/pii/004268229190093Q?via%3Dihub	doi.org/10.1016/0042-6822(91)90093-Q	Isolated strain 	PRA			01/11/2020	OJCharles	ignores potential pol mutants		O
1176	HSV2		UL23	S182N		Resistant												Molecular analysis of a neurovirulent herpes simplex virus type 2 strain with reduced thymidine kinase activity 	https://link.springer.com/article/10.1007/BF01379080		Lab induced strain 	PRA			01/11/2020	OJCharles			A
1177	HSV2		UL23	M183I		5												Impact of novel mutations of herpes simplex virus 1 and 2 thymidine kinases on acyclovir phosphorylation activity	https://www.sciencedirect.com/science/article/pii/S0166354212002239?via%3Dihub#b0010	doi.org/10.1016/j.antiviral.2012.09.016	Marker Transfer 	TK functional kinetic assay			01/11/2020	OJCharles			A
1178	HSV2	Clinical isolate	UL23	M183stop		Resistant		Polymorphism										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub#tblfn8	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			01/11/2020	OJCharles	co occurs with unknown mut		O
1179	HSV2		UL23	M183stop*		Resistant	Polymorphism	Polymorphism			Resistant	Resistant						Characterization of Herpes Simplex Viruses Selected in Culture for Resistance to Penciclovir or Acyclovir	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC114085/	doi.org/10.1128/JVI.75.4.1761-1769.2001	Lab induced strain 	PRA			01/11/2020	OJCharles			A
1180	HSV2		UL23	M183stop*		130	2.4	0.3			6.2	133						Characterization of Herpes Simplex Viruses Selected in Culture for Resistance to Penciclovir or Acyclovir	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC114085/	doi.org/10.1128/JVI.75.4.1761-1769.2001	Lab induced strain 	PRA			01/11/2020	OJCharles			A
1181	HSV2	Clinical isolate	UL23	M183stop		Resistant		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			01/11/2020	OJCharles			A
1182	HSV2		UL23	M183stop*		500	0.7	11			81	1.2						Characterization of Herpes Simplex Viruses Selected in Culture for Resistance to Penciclovir or Acyclovir	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC114085/	doi.org/10.1128/JVI.75.4.1761-1769.2001	Lab induced strain 	PRA			01/11/2020	OJCharles			A
1183	HSV2		UL23	M183stop*		130	2.4	0.3			133	6.2						Characterization of Herpes Simplex Viruses Selected in Culture for Resistance to Penciclovir or Acyclovir	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC114085/	doi.org/10.1128/JVI.75.4.1761-1769.2001	Lab induced strain 	PRA			01/11/2020	OJCharles			A
1184	HSV2	Clinical isolate	UL23	T184stop		Resistant												Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			01/11/2020	OJCharles		KOS	A
1185	HSV2	Clinical isolate	UL23	G201D		Resistant												Phenotypic and genotypic characterization of clinical isolates of herpes simplex virus resistant to aciclovir	https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.18880-0#tab2	doi.org/10.1099/vir.0.18880-0	Isolated strain 	TK functional kinetic assay			01/11/2020	OJCharles			A
1186	HSV2	Clinical isolate	UL23	R221C		Resistant												Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub#tblfn8	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			01/11/2020	OJCharles			A
1187	HSV2	Clinical isolate	UL23	R221H		Resistant	Resistant				Resistant	Resistant						Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay			01/11/2020	OJCharles	Cannot be inferred		A
1188	HSV2	Clinical isolate	UL23	Q222stop		Resistant												Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			01/11/2020	OJCharles		KOS	A
1189	HSV2	Clinical isolate	UL23	R223H		Resistant												Nucleotide sequence changes in thymidine kinase gene of herpes simplex virus type 2 clones from an isolate of a patient treated with acyclovir.	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC174976/	doi.org/10.1128/aac.31.10.1483	Isolated strain 	PRA			01/11/2020	OJCharles			A
1190	HSV2		UL23	D229stop*		500	0.4	0.3			133	1.2						Characterization of Herpes Simplex Viruses Selected in Culture for Resistance to Penciclovir or Acyclovir	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC114085/	doi.org/10.1128/JVI.75.4.1761-1769.2001	Lab induced strain 	PRA			01/11/2020	OJCharles			A
1191	HSV2		UL23	D229stop*		200	1.6	0.5			133	2						Characterization of Herpes Simplex Viruses Selected in Culture for Resistance to Penciclovir or Acyclovir	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC114085/	doi.org/10.1128/JVI.75.4.1761-1769.2001	Lab induced strain 	PRA			01/11/2020	OJCharles			A
1192	HSV2	Clinical isolate	UL23	D229stop		Resistant												Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			01/11/2020	OJCharles			A
1193	HSV2	Clinical isolate	UL23	D229stop		Resistant												Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			01/11/2020	OJCharles			A
1194	HSV2	Clinical isolate	UL23	D229stop		Resistant												Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub#tblfn8	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			01/11/2020	OJCharles	co occurs with unknown mut		O
1195	HSV2	Clinical isolate	UL23	D229stop		Resistant												Phenotypic and Genotypic Characterization of Acyclovir-Resistant Herpes Simplex Viruses from Immunocompromised Patients	https://academic.oup.com/jid/article/178/2/297/904713	doi.org/10.1086/515626	Isolated strain 	PCR DNA hybridization assay			01/11/2020	OJCharles		A2	A
1196	HSV2	Clinical isolate	UL23	D229stop		Resistant												Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub#tblfn8	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			01/11/2020	OJCharles	co occurs with unknown mut		O
1197	HSV2	Clinical isolate	UL23	D229stop		Resistant												Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			01/11/2020	OJCharles			A
1198	HSV2	Clinical isolate	UL23	Y239*		Resistant												Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			01/11/2020	OJCharles	V239 or Y240?		O
1199	HSV2		UL23	D259frameshift*		200	1	0.8			133	1.2						Characterization of Herpes Simplex Viruses Selected in Culture for Resistance to Penciclovir or Acyclovir	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC114085/	doi.org/10.1128/JVI.75.4.1761-1769.2001	Lab induced strain 	PRA			01/11/2020	OJCharles			A
1200	HSV2	Clinical isolate	UL23	R262stop		Resistant												Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			01/11/2020	OJCharles			A
1201	HSV2	Clinical isolate	UL23	L263stop		Resistant												Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub#tblfn8	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			01/11/2020	OJCharles	co occurs with unknown mut		O
1202	HSV2	Clinical isolate	UL23	L263stop		Resistant												Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub#tblfn8	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			01/11/2020	OJCharles	co occurs with unknown mut		O
1203	HSV2	Clinical isolate	UL23	R271V		Resistant												Phenotypic and Genotypic Characterization of Acyclovir-Resistant Herpes Simplex Viruses from Immunocompromised Patients	https://academic.oup.com/jid/article/178/2/297/904713	doi.org/10.1086/515626	Isolated strain 	PCR DNA hybridization assay			01/11/2020	OJCharles	three mutations, 1 measure	A2	O
1204	HSV2	Clinical isolate	UL23	P272S		Resistant												Phenotypic and Genotypic Characterization of Acyclovir-Resistant Herpes Simplex Viruses from Immunocompromised Patients	https://academic.oup.com/jid/article/178/2/297/904713	doi.org/10.1086/515626	Isolated strain 	PCR DNA hybridization assay			01/11/2020	OJCharles	three mutations, 1 measure	A2	O
1205	HSV2	Clinical isolate	UL23	D273R		Resistant												Phenotypic and Genotypic Characterization of Acyclovir-Resistant Herpes Simplex Viruses from Immunocompromised Patients	https://academic.oup.com/jid/article/178/2/297/904713	doi.org/10.1086/515626	Isolated strain 	PCR DNA hybridization assay			01/11/2020	OJCharles	three mutations, 1 measure	A2	O
1206	HSV2	Clinical isolate	UL23	T288M		Resistant												Phenotypic and Genotypic Characterization of Acyclovir-Resistant Herpes Simplex Viruses from Immunocompromised Patients	https://academic.oup.com/jid/article/178/2/297/904713	doi.org/10.1086/515626	Isolated strain 	PCR DNA hybridization assay			01/11/2020	OJCharles		A2	A
1207	HSV2		UL23	T288frameshift*		200	1	0.8			1.5	133						Characterization of Herpes Simplex Viruses Selected in Culture for Resistance to Penciclovir or Acyclovir	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC114085/	doi.org/10.1128/JVI.75.4.1761-1769.2001	Lab induced strain 	PRA			01/11/2020	OJCharles			A
1208	HSV2		UL23	I308frameshift*		60	4.3	0.9			5.6	133						Characterization of Herpes Simplex Viruses Selected in Culture for Resistance to Penciclovir or Acyclovir	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC114085/	doi.org/10.1128/JVI.75.4.1761-1769.2001	Lab induced strain 	PRA			01/11/2020	OJCharles			A
1209	HSV2		UL23	V335frameshift*		200	1.3	1.2			6.2	133						Characterization of Herpes Simplex Viruses Selected in Culture for Resistance to Penciclovir or Acyclovir	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC114085/	doi.org/10.1128/JVI.75.4.1761-1769.2001	Lab induced strain 	PRA			01/11/2020	OJCharles			A
1210	HSV2	Clinical isolate	UL23	C336Y		Resistant												Phenotypic and Genotypic Characterization of Acyclovir-Resistant Herpes Simplex Viruses from Immunocompromised Patients	https://academic.oup.com/jid/article/178/2/297/904713	doi.org/10.1086/515626	Isolated strain 	PCR DNA hybridization assay			01/11/2020	OJCharles	C is 337 G is 336 - followup	A2	O
1211	HSV2	Clinical isolate	UL23	M348stop		Resistant												Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub#tblfn8	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			01/11/2020	OJCharles	co occurs with unknown mut		O
1212	HSV2	Clinical isolate	UL23	M348stop		Resistant												Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			01/11/2020	OJCharles			A
1213	HSV2		UL23	M348stop		Resistant												Genital Herpes Due to Acyclovir-SensitiveHerpes Simplex Virus Caused Secondary andRecurrent Herpetic Whitlows Due to ThymidineKinase-De?cient/Temperature-Sensitive Virus	https://onlinelibrary.wiley.com/doi/epdf/10.1002/jmv.20990	doi.org/10.1002/jmv.20990	Isolated strain 	PRA			01/11/2020	OJCharles			A
1214	HSV2	Clinical isolate	UL23	M348stop		Resistant												Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub#tblfn8	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			01/11/2020	OJCharles	co occurs with unknown mut		O
1215	HSV2	Clinical isolate	UL23	M348stop		Resistant												Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			01/11/2020	OJCharles		KOS	A
1216	HSV2		UL23	M348stop		Resistant					Resistant	Resistant						Characterization of Herpes Simplex Viruses Selected in Culture for Resistance to Penciclovir or Acyclovir	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC114085/	doi.org/10.1128/JVI.75.4.1761-1769.2001	Lab induced strain 	PRA			01/11/2020	OJCharles			A
1217	HSV2	Clinical isolate	UL30	E250Q		Resistant		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			01/11/2020	OJCharles			O
1218	HSV2	Clinical isolate	UL30	D307N		Resistant		Polymorphism										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub#tblfn8	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			01/11/2020	OJCharles			A
1219	HSV2	Clinical isolate	UL30	E678G		Resistant		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			01/11/2020	OJCharles	Copies a susceptible mutant falsely as resistant from here https://aac.asm.org/content/aac/54/11/4833.full.pdf		O
1220	HSV2	Clinical isolate	UL30	G684+		Resistant		Polymorphism										Impact of novel mutations of herpes simplex virus 1 and 2 thymidine kinases on acyclovir phosphorylation activity	https://www.sciencedirect.com/science/article/pii/S0166354212002239?via%3Dihub#b0010	doi.org/10.1016/j.antiviral.2012.09.016	Isolated strain 	dye uptake assay			01/11/2020	OJCharles			A
1221	HSV2	Clinical isolate	UL30	A724T		0.8	3.1	3.4										Characterization of the DNA Polymerase and Thymidine Kinase Genes of Herpes Simplex Virus Isolates from AIDS Patients in whom Acyclovir and Foscarnet Therapy Sequentially Failed	https://academic.oup.com/jid/article/180/2/487/881212	doi.org/10.1086/314900	Isolated strain 	PRA			01/11/2020	OJCharles	Only pol conserved was sequenced		A
1222	HSV2	Clinical isolate	UL30	A724V		Resistant		Polymorphism										Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals	https://aac.asm.org/content/54/11/4833	doi.org/10.1128/AAC.00669-10	Isolated strain 	PRA			01/11/2020	OJCharles	redundant	KOS	O
1223	HSV2	Clinical isolate	UL30	S725G				Resistant										Novel mutations in the thymidine kinase and DNA polymerase genes of acyclovir and foscarnet resistant herpes simplex viruses infecting an immunocompromised patient	https://www.sciencedirect.com/science/article/pii/S1386653202000057?via%3Dihub	doi.org/10.1016/S1386-6532(02)00005-7	Isolated strain 	PRA			01/11/2020	OJCharles	redundant		O
1224	HSV2	Clinical isolate	UL30	S729N		2.4	1.4	5.9										Characterization of the DNA Polymerase and Thymidine Kinase Genes of Herpes Simplex Virus Isolates from AIDS Patients in whom Acyclovir and Foscarnet Therapy Sequentially Failed	https://academic.oup.com/jid/article/180/2/487/881212	doi.org/10.1086/314900	Isolated strain 	PRA			01/11/2020	OJCharles	Only pol conserved was sequenced		A
1225	HSV2	Clinical isolate	UL30	Q732R		Resistant		Resistant										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub#tblfn8	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			01/11/2020	OJCharles	co occurs with unknown mut		O
1226	HSV2	Clinical isolate	UL30	L783M		0.8	1.9	8										Characterization of the DNA Polymerase and Thymidine Kinase Genes of Herpes Simplex Virus Isolates from AIDS Patients in whom Acyclovir and Foscarnet Therapy Sequentially Failed	https://academic.oup.com/jid/article/180/2/487/881212	doi.org/10.1086/314900	Isolated strain 	PRA			01/11/2020	OJCharles	Only pol conserved was sequenced		A
1227	HSV2	Clinical isolate	UL30	D785N		1.3	0.7	3.9										Characterization of the DNA Polymerase and Thymidine Kinase Genes of Herpes Simplex Virus Isolates from AIDS Patients in whom Acyclovir and Foscarnet Therapy Sequentially Failed	https://academic.oup.com/jid/article/180/2/487/881212	doi.org/10.1086/314900	Isolated strain 	PRA			01/11/2020	OJCharles	Only pol conserved was sequenced		A
1228	HSV2	Clinical isolate	UL30	Q829R		Resistant		Polymorphism										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub#tblfn8	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			01/11/2020	OJCharles			A
1229	HSV2	Clinical isolate	UL30	L850I		0.8	0.3	9.2										Characterization of the DNA Polymerase and Thymidine Kinase Genes of Herpes Simplex Virus Isolates from AIDS Patients in whom Acyclovir and Foscarnet Therapy Sequentially Failed	https://academic.oup.com/jid/article/180/2/487/881212	doi.org/10.1086/314900	Isolated strain 	PRA			01/11/2020	OJCharles	Only pol conserved was sequenced		A
1230	HSV2	Clinical isolate	UL30	M910T		Resistant		Polymorphism										Impact of novel mutations of herpes simplex virus 1 and 2 thymidine kinases on acyclovir phosphorylation activity	https://www.sciencedirect.com/science/article/pii/S0166354212002239?via%3Dihub#b0010	doi.org/10.1016/j.antiviral.2012.09.016	Isolated strain 	dye uptake assay			01/11/2020	OJCharles			A
1231	HSV2	Clinical isolate	UL30	D912N		Resistant		Polymorphism										Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			01/11/2020	OJCharles	does not list all mutations so cant infer backward!		O
1232	HSV2	Clinical isolate	UL30	D912V		Resistant	Polymorphism	Resistant										Characterization of the DNA Polymerase and Thymidine Kinase Genes of Herpes Simplex Virus Isolates from AIDS Patients in whom Acyclovir and Foscarnet Therapy Sequentially Failed	https://academic.oup.com/jid/article/180/2/487/881212	doi.org/10.1086/314900	Isolated strain 	PRA	TK	28*	01/11/2020	OJCharles	Only pol conserved was sequenced		A
1233	HSV2	Clinical isolate	UL30	A915V		Resistant		Polymorphism										Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub#tblfn8	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			01/11/2020	OJCharles	co occurs with unknown mut		O
1234	VZV	HJO	ORF36	L73I		1.3	0.7	2.7			1	0.9						Drug Resistance of Clinical Varicella-Zoster Virus Strains Confirmed by Recombinant Thymidine Kinase Expression and by Targeted Resistance Mutagenesis of a Cloned Wild-Type Isolate	https://aac.asm.org/content/aac/59/5/2726.full.pdf	doi.org/10.1128/AAC.05115-14	Recombinant BAC 	PRA			01/12/2020	OJCharles			A
1235	VZV	HJO	ORF36	A163*		5.7	0.9	0.2			133	10						Drug Resistance of Clinical Varicella-Zoster Virus Strains Confirmed by Recombinant Thymidine Kinase Expression and by Targeted Resistance Mutagenesis of a Cloned Wild-Type Isolate	https://aac.asm.org/content/aac/59/5/2726.full.pdf	doi.org/10.1128/AAC.05115-14	Recombinant BAC 	PRA			01/12/2020	OJCharles			A
1236	VZV	HJO	ORF36	W225R		5.7	2.1	1.5			133	10						Drug Resistance of Clinical Varicella-Zoster Virus Strains Confirmed by Recombinant Thymidine Kinase Expression and by Targeted Resistance Mutagenesis of a Cloned Wild-Type Isolate	https://aac.asm.org/content/aac/59/5/2726.full.pdf	doi.org/10.1128/AAC.05115-14	Recombinant BAC 	PRA			01/12/2020	OJCharles			A
1237	VZV	HJO	ORF36	T256M		5.7	0.3	0.8			133	10						Drug Resistance of Clinical Varicella-Zoster Virus Strains Confirmed by Recombinant Thymidine Kinase Expression and by Targeted Resistance Mutagenesis of a Cloned Wild-Type Isolate	https://aac.asm.org/content/aac/59/5/2726.full.pdf	doi.org/10.1128/AAC.05115-14	Recombinant BAC 	PRA			01/12/2020	OJCharles			A
1238	VZV	HJO	ORF36	Q303*		5.7	0.4	0.9			133	10						Drug Resistance of Clinical Varicella-Zoster Virus Strains Confirmed by Recombinant Thymidine Kinase Expression and by Targeted Resistance Mutagenesis of a Cloned Wild-Type Isolate	https://aac.asm.org/content/aac/59/5/2726.full.pdf	doi.org/10.1128/AAC.05115-14	Recombinant BAC 	PRA	Pol	A955T	01/12/2020	OJCharles			A
1239	VZV	HJO	ORF36	N334*		5.7	0.8	0.6			133	10						Drug Resistance of Clinical Varicella-Zoster Virus Strains Confirmed by Recombinant Thymidine Kinase Expression and by Targeted Resistance Mutagenesis of a Cloned Wild-Type Isolate	https://aac.asm.org/content/aac/59/5/2726.full.pdf	doi.org/10.1128/AAC.05115-14	Recombinant BAC 	PRA			01/12/2020	OJCharles			A
1240	VZV	HJO	ORF36	del7-74		5.7	1.3	0.7			133	10						Drug Resistance of Clinical Varicella-Zoster Virus Strains Confirmed by Recombinant Thymidine Kinase Expression and by Targeted Resistance Mutagenesis of a Cloned Wild-Type Isolate	https://aac.asm.org/content/aac/59/5/2726.full.pdf	doi.org/10.1128/AAC.05115-14	Recombinant BAC 	PRA			01/12/2020	OJCharles			A
1241	VZV	HJO	ORF28	T237K		1.1	3.4	2.9			133	1.1						Drug Resistance of Clinical Varicella-Zoster Virus Strains Confirmed by Recombinant Thymidine Kinase Expression and by Targeted Resistance Mutagenesis of a Cloned Wild-Type Isolate	https://aac.asm.org/content/aac/59/5/2726.full.pdf	doi.org/10.1128/AAC.05115-14	Recombinant BAC 	PRA			01/12/2020	OJCharles			A
1242	VZV	HJO	ORF28	A955T		0.9	0.6	0.8			133	0.8						Drug Resistance of Clinical Varicella-Zoster Virus Strains Confirmed by Recombinant Thymidine Kinase Expression and by Targeted Resistance Mutagenesis of a Cloned Wild-Type Isolate	https://aac.asm.org/content/aac/59/5/2726.full.pdf	doi.org/10.1128/AAC.05115-14	Recombinant BAC 	PRA			01/12/2020	OJCharles			A
1243	VZV	Clinical isolate	ORF36	L332P		5.8												Clinical and Virologic Characterization of Acyclovir-Resistant Varicella-Zoster Viruses Isolated from 11 Patients with Acquired Immunodeficiency Syndrome	https://academic.oup.com/cid/article/33/12/2061/365806	doi.org/10.1086/324503	Isolated strain 	PRA			01/12/2020	OJCharles		Cha/Oka	A
1244	VZV	Clinical isolate	ORF36	R183*		12												Clinical and Virologic Characterization of Acyclovir-Resistant Varicella-Zoster Viruses Isolated from 11 Patients with Acquired Immunodeficiency Syndrome	https://academic.oup.com/cid/article/33/12/2061/365806	doi.org/10.1086/324503	Isolated strain 	PRA			01/12/2020	OJCharles		Cha/Oka	A
1245	VZV	Clinical isolate	ORF36	E192*		14		1			36	12						In Vitro-Selected Drug-Resistant Varicella-Zoster Virus Mutants in the Thymidine Kinase and DNA Polymerase Genes Yield Novel Phenotype-Genotype Associations and Highlight Differences between Antiherpesvirus Drugs	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302250/	doi.org/10.1128/JVI.06620-11	Isolated strain 	PRA			12/01/2020	OJCharles		Oka	A
1246	VZV	Clinical isolate	ORF36	T86A		12		1			38	15						In Vitro-Selected Drug-Resistant Varicella-Zoster Virus Mutants in the Thymidine Kinase and DNA Polymerase Genes Yield Novel Phenotype-Genotype Associations and Highlight Differences between Antiherpesvirus Drugs	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302250/	doi.org/10.1128/JVI.06620-11	Isolated strain 	PRA			12/01/2020	OJCharles		Oka	A
1247	VZV	Clinical isolate	ORF36	G24R		15		1			40	13						In Vitro-Selected Drug-Resistant Varicella-Zoster Virus Mutants in the Thymidine Kinase and DNA Polymerase Genes Yield Novel Phenotype-Genotype Associations and Highlight Differences between Antiherpesvirus Drugs	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302250/	doi.org/10.1128/JVI.06620-11	Isolated strain 	PRA			12/01/2020	OJCharles		Oka	A
1248	VZV	Clinical isolate	ORF28	K662E		4		8			2	4						In Vitro-Selected Drug-Resistant Varicella-Zoster Virus Mutants in the Thymidine Kinase and DNA Polymerase Genes Yield Novel Phenotype-Genotype Associations and Highlight Differences between Antiherpesvirus Drugs	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302250/	doi.org/10.1128/JVI.06620-11	Isolated strain 	PRA			12/01/2020	OJCharles		Oka	A
1249	VZV	Clinical isolate	ORF28	V666L		9		8			1	8						In Vitro-Selected Drug-Resistant Varicella-Zoster Virus Mutants in the Thymidine Kinase and DNA Polymerase Genes Yield Novel Phenotype-Genotype Associations and Highlight Differences between Antiherpesvirus Drugs	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302250/	doi.org/10.1128/JVI.06620-11	Isolated strain 	PRA			12/01/2020	OJCharles		Oka	A
1250	VZV	Clinical isolate	ORF28	L767S		12		5			1	10						In Vitro-Selected Drug-Resistant Varicella-Zoster Virus Mutants in the Thymidine Kinase and DNA Polymerase Genes Yield Novel Phenotype-Genotype Associations and Highlight Differences between Antiherpesvirus Drugs	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302250/	doi.org/10.1128/JVI.06620-11	Isolated strain 	PRA			12/01/2020	OJCharles		Oka	A
1251	VZV	Clinical isolate	ORF28	D668Y		4		1			1	2						In Vitro-Selected Drug-Resistant Varicella-Zoster Virus Mutants in the Thymidine Kinase and DNA Polymerase Genes Yield Novel Phenotype-Genotype Associations and Highlight Differences between Antiherpesvirus Drugs	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302250/	doi.org/10.1128/JVI.06620-11	Isolated strain 	PRA			12/01/2020	OJCharles		Oka	A
1252	VZV	Clinical isolate	ORF28	D668Y		10		4			1	1.4						In Vitro-Selected Drug-Resistant Varicella-Zoster Virus Mutants in the Thymidine Kinase and DNA Polymerase Genes Yield Novel Phenotype-Genotype Associations and Highlight Differences between Antiherpesvirus Drugs	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302250/	doi.org/10.1128/JVI.06620-11	Isolated strain 	PRA	pol	M808V	12/01/2020	OJCharles		Oka	A
1253	VZV	Clinical isolate	ORF36	G24E		36												Phenotypic and Genotypic Characterization of Acyclovir-Resistant Varicella-Zoster Viruses Isolated from Persons with AIDS	https://academic.oup.com/jid/article/170/1/68/863472	doi.org/10.1093/infdis/170.1.68	Isolated strain 	PRA			12/01/2020	OJCharles		Oka	A
1254	VZV	Clinical isolate	ORF36	C231*		17.5												Phenotypic and Genotypic Characterization of Acyclovir-Resistant Varicella-Zoster Viruses Isolated from Persons with AIDS	https://academic.oup.com/jid/article/170/1/68/863472	doi.org/10.1093/infdis/170.1.68	Isolated strain 	PRA			12/01/2020	OJCharles		Oka	A
1255	VZV	Clinical isolate	ORF36	E308Q		1.2												Phenotypic and Genotypic Characterization of Acyclovir-Resistant Varicella-Zoster Viruses Isolated from Persons with AIDS	https://academic.oup.com/jid/article/170/1/68/863472	doi.org/10.1093/infdis/170.1.68	Isolated strain 	PRA			12/01/2020	OJCharles		Oka	A
1256	VZV	Clinical isolate	ORF36	I38*		37												Phenotypic and Genotypic Characterization of Acyclovir-Resistant Varicella-Zoster Viruses Isolated from Persons with AIDS	https://academic.oup.com/jid/article/170/1/68/863472	doi.org/10.1093/infdis/170.1.68	Isolated strain 	PRA			12/01/2020	OJCharles		Oka	A
1257	VZV	Clinical isolate	ORF36	V194*		19												Phenotypic and Genotypic Characterization of Acyclovir-Resistant Varicella-Zoster Viruses Isolated from Persons with AIDS	https://academic.oup.com/jid/article/170/1/68/863472	doi.org/10.1093/infdis/170.1.68	Isolated strain 	PRA			12/01/2020	OJCharles		Oka	A
1258	VZV	Clinical isolate	ORF36	L298*		20												Phenotypic and Genotypic Characterization of Acyclovir-Resistant Varicella-Zoster Viruses Isolated from Persons with AIDS	https://academic.oup.com/jid/article/170/1/68/863472	doi.org/10.1093/infdis/170.1.68	Isolated strain 	PRA			12/01/2020	OJCharles		Oka	A
1259	VZV	Clinical isolate	ORF36	R54*		21.3	 											Phenotypic and Genotypic Characterization of Acyclovir-Resistant Varicella-Zoster Viruses Isolated from Persons with AIDS	https://academic.oup.com/jid/article/170/1/68/863472	doi.org/10.1093/infdis/170.1.68	Isolated strain 	PRA			12/01/2020	OJCharles		Oka	A
1260	VZV	Clinical isolate	ORF36	V171*		23.8												Phenotypic and Genotypic Characterization of Acyclovir-Resistant Varicella-Zoster Viruses Isolated from Persons with AIDS	https://academic.oup.com/jid/article/170/1/68/863472	doi.org/10.1093/infdis/170.1.68	Isolated strain 	PRA			12/01/2020	OJCharles		Oka	A
1261	VZV	Clinical isolate	ORF36	V333*		11.3												Phenotypic and Genotypic Characterization of Acyclovir-Resistant Varicella-Zoster Viruses Isolated from Persons with AIDS	https://academic.oup.com/jid/article/170/1/68/863472	doi.org/10.1093/infdis/170.1.68	Isolated strain 	PRA			12/01/2020	OJCharles		Oka	A
1262	VZV	Clinical isolate	ORF36	C138R		16						15						Analysis of the thymidine kinase genes from acyclovir-resistant mutants of varicella-zoster virus isolated from patients with AIDS	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC237457/		Isolated strain 	PRA	TK	S242F	12/01/2020	OJCharles		Oka	A
1263	VZV	Clinical isolate	ORF36	R143G		16						15						Analysis of the thymidine kinase genes from acyclovir-resistant mutants of varicella-zoster virus isolated from patients with AIDS	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC237457/		Isolated strain 	PRA			12/01/2020	OJCharles		Oka	A
1264	VZV	Clinical isolate	ORF36	D129N		8.7						15						Analysis of the thymidine kinase genes from acyclovir-resistant mutants of varicella-zoster virus isolated from patients with AIDS	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC237457/		Isolated strain 	PRA			12/01/2020	OJCharles		Oka	A
1265	VZV	Clinical isolate	ORF36	K25R		16						15						Analysis of the thymidine kinase genes from acyclovir-resistant mutants of varicella-zoster virus isolated from patients with AIDS	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC237457/		Isolated strain 	PRA			12/01/2020	OJCharles		Oka	A
1266	VZV	Clinical isolate	ORF36	R143K		16						1.5						Analysis of the thymidine kinase genes from acyclovir-resistant mutants of varicella-zoster virus isolated from patients with AIDS	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC237457/		Isolated strain 	PRA			12/01/2020	OJCharles		Oka	A
1267	VZV	Clinical isolate	ORF36	E59G		10						11						Analysis of the thymidine kinase genes from acyclovir-resistant mutants of varicella-zoster virus isolated from patients with AIDS	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC237457/		Isolated strain 	PRA			12/01/2020	OJCharles		Oka	A
1268	VZV	Clinical isolate	ORF36	E48G		26	4.8	42			1.2	61						Phenotypic and Genetic Characterization of Thymidine Kinase from Clinical Strains of Varicella-Zoster Virus Resistant to Acyclovir	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC89493/		Isolated strain 	TK functional kinetic assay			12/01/2020	OJCharles		Oka	A
1269	VZV	Clinical isolate	ORF36	R130Q		5												Mutant Varicella-Zoster Virus Thymidine Kinase: Correlation of Clinical Resistance and Enzyme Impairment	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC250677		Isolated strain 	TK functional kinetic assay			12/01/2020	OJCharles		Oka	A
1270	VZV	Clinical isolate	ORF36	L154P		38												Molecular Analysis of the Pyrimidine Deoxyribonucleoside Kinase Gene of Wild-type and Acyclovir-resistant Strains of Varicella-Zoster Virus	https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-69-10-2585#tab2	doi.org/10.1099/0022-1317-69-10-2585	Isolated strain 	PRA			12/01/2020	OJCharles		Oka	A
1271	VZV	Clinical isolate	ORF36	T256A		19	1.2	1				6.7						ACYCLOVIR-RESISTANT CHRONIC VERRUCOUS VACCINE STRAIN VARICELLA IN A PATIENT WITH NEUROBLASTOMA	https://journals.lww.com/pidj/Fulltext/2008/10000/ACYCLOVIR_RESISTANT_CHRONIC_VERRUCOUS_VACCINE.24.aspx	doi.org/10.1097/INF.0b013e318175d85c	Isolated strain 	PRA			12/01/2020	OJCharles		Oka	A
1272	VZV	Clinical isolate	ORF36	S51L		1.5					2	0.7						Genetic polymorphism of thymidine kinase (TK) and DNA polymerase (pol) of clinical varicella-zoster virus (VZV) isolates collected over three decades	https://www.sciencedirect.com/science/article/pii/S1386653217302433?via%3Dihub#tbl0005	doi.org/10.1016/j.jcv.2017.08.011	Isolated strain 	PRA			12/01/2020	OJCharles		Oka	A
1273	VZV	Clinical isolate	ORF36	N119D		2					1.2	0.92						Genetic polymorphism of thymidine kinase (TK) and DNA polymerase (pol) of clinical varicella-zoster virus (VZV) isolates collected over three decades	https://www.sciencedirect.com/science/article/pii/S1386653217302433?via%3Dihub#tbl0005	doi.org/10.1016/j.jcv.2017.08.011	Isolated strain 	PRA			12/01/2020	OJCharles		Oka	A
1274	VZV	Clinical isolate	ORF36	V194A		1					1.2	0.5						Genetic polymorphism of thymidine kinase (TK) and DNA polymerase (pol) of clinical varicella-zoster virus (VZV) isolates collected over three decades	https://www.sciencedirect.com/science/article/pii/S1386653217302433?via%3Dihub#tbl0005	doi.org/10.1016/j.jcv.2017.08.011	Isolated strain 	PRA			12/01/2020	OJCharles		Oka	A
1275	VZV	Clinical isolate	ORF28	T39A		1					1.2	1.5						Genetic polymorphism of thymidine kinase (TK) and DNA polymerase (pol) of clinical varicella-zoster virus (VZV) isolates collected over three decades	https://www.sciencedirect.com/science/article/pii/S1386653217302433?via%3Dihub#tbl0005	doi.org/10.1016/j.jcv.2017.08.011	Isolated strain 	PRA			12/01/2020	OJCharles		Oka	A
1276	VZV	Clinical isolate	ORF28	M201I		1					0.8	1.1						Genetic polymorphism of thymidine kinase (TK) and DNA polymerase (pol) of clinical varicella-zoster virus (VZV) isolates collected over three decades	https://www.sciencedirect.com/science/article/pii/S1386653217302433?via%3Dihub#tbl0005	doi.org/10.1016/j.jcv.2017.08.011	Isolated strain 	PRA			12/01/2020	OJCharles		Oka	A
1277	VZV	Clinical isolate	ORF28	M201I		1.5					1.2	1.8						Genetic polymorphism of thymidine kinase (TK) and DNA polymerase (pol) of clinical varicella-zoster virus (VZV) isolates collected over three decades	https://www.sciencedirect.com/science/article/pii/S1386653217302433?via%3Dihub#tbl0005	doi.org/10.1016/j.jcv.2017.08.011	Isolated strain 	PRA	 		12/01/2020	OJCharles		Oka	A
1278	VZV	Clinical isolate	ORF28	G218D		1.6					1	1.9						Genetic polymorphism of thymidine kinase (TK) and DNA polymerase (pol) of clinical varicella-zoster virus (VZV) isolates collected over three decades	https://www.sciencedirect.com/science/article/pii/S1386653217302433?via%3Dihub#tbl0005	doi.org/10.1016/j.jcv.2017.08.011	Isolated strain 	PRA			12/01/2020	OJCharles		Oka	A
1279	VZV	Clinical isolate	ORF28	S386A		2					1	0.9						Genetic polymorphism of thymidine kinase (TK) and DNA polymerase (pol) of clinical varicella-zoster virus (VZV) isolates collected over three decades	https://www.sciencedirect.com/science/article/pii/S1386653217302433?via%3Dihub#tbl0005	doi.org/10.1016/j.jcv.2017.08.011	Isolated strain 	PRA			12/01/2020	OJCharles		Oka	A
1280	VZV	Clinical isolate	ORF28	S386A		2.6					1.2	1.5						Genetic polymorphism of thymidine kinase (TK) and DNA polymerase (pol) of clinical varicella-zoster virus (VZV) isolates collected over three decades	https://www.sciencedirect.com/science/article/pii/S1386653217302433?via%3Dihub#tbl0005	doi.org/10.1016/j.jcv.2017.08.011	Isolated strain 	PRA			12/01/2020	OJCharles		Oka	A
1281	VZV	Clinical isolate	ORF28	Q402P		1.1					1.2	1.9						Genetic polymorphism of thymidine kinase (TK) and DNA polymerase (pol) of clinical varicella-zoster virus (VZV) isolates collected over three decades	https://www.sciencedirect.com/science/article/pii/S1386653217302433?via%3Dihub#tbl0005	doi.org/10.1016/j.jcv.2017.08.011	Isolated strain 	PRA			12/01/2020	OJCharles		Oka	A
1282	VZV	Clinical isolate	ORF28	T417I		2					1.2	2.5						Genetic polymorphism of thymidine kinase (TK) and DNA polymerase (pol) of clinical varicella-zoster virus (VZV) isolates collected over three decades	https://www.sciencedirect.com/science/article/pii/S1386653217302433?via%3Dihub#tbl0005	doi.org/10.1016/j.jcv.2017.08.011	Isolated strain 	PRA			12/01/2020	OJCharles		Oka	A
1283	VZV	Clinical isolate	ORF28	G723R		1.1					1.2	1.5						Genetic polymorphism of thymidine kinase (TK) and DNA polymerase (pol) of clinical varicella-zoster virus (VZV) isolates collected over three decades	https://www.sciencedirect.com/science/article/pii/S1386653217302433?via%3Dihub#tbl0005	doi.org/10.1016/j.jcv.2017.08.011	Isolated strain 	PRA			12/01/2020	OJCharles		Oka	A
1284	VZV	Clinical isolate	ORF28	R753K		1.1					1.2	1.5						Genetic polymorphism of thymidine kinase (TK) and DNA polymerase (pol) of clinical varicella-zoster virus (VZV) isolates collected over three decades	https://www.sciencedirect.com/science/article/pii/S1386653217302433?via%3Dihub#tbl0005	doi.org/10.1016/j.jcv.2017.08.011	Isolated strain 	PRA			12/01/2020	OJCharles		Oka	A
1285	VZV	Clinical isolate	ORF28	V777I		0.7					1.2	1.4						Genetic polymorphism of thymidine kinase (TK) and DNA polymerase (pol) of clinical varicella-zoster virus (VZV) isolates collected over three decades	https://www.sciencedirect.com/science/article/pii/S1386653217302433?via%3Dihub#tbl0005	doi.org/10.1016/j.jcv.2017.08.011	Isolated strain 	PRA			12/01/2020	OJCharles		Oka	A
1286	VZV	Clinical isolate	ORF28	R950C		1.2					1.2	1.3						Genetic polymorphism of thymidine kinase (TK) and DNA polymerase (pol) of clinical varicella-zoster virus (VZV) isolates collected over three decades	https://www.sciencedirect.com/science/article/pii/S1386653217302433?via%3Dihub#tbl0005	doi.org/10.1016/j.jcv.2017.08.011	Isolated strain 	PRA			12/01/2020	OJCharles		Oka	A
1287	VZV	Clinical isolate	ORF28	T1066S		1.9					0.8	2						Genetic polymorphism of thymidine kinase (TK) and DNA polymerase (pol) of clinical varicella-zoster virus (VZV) isolates collected over three decades	https://www.sciencedirect.com/science/article/pii/S1386653217302433?via%3Dihub#tbl0005	doi.org/10.1016/j.jcv.2017.08.011	Isolated strain 	PRA			12/01/2020	OJCharles		Oka	A
1288	VZV	Clinical isolate	ORF28	R1076C		1.1					1.5	1.6						Genetic polymorphism of thymidine kinase (TK) and DNA polymerase (pol) of clinical varicella-zoster virus (VZV) isolates collected over three decades	https://www.sciencedirect.com/science/article/pii/S1386653217302433?via%3Dihub#tbl0005	doi.org/10.1016/j.jcv.2017.08.011	Isolated strain 	PRA			12/01/2020	OJCharles		Oka	A
1289	VZV	Clinical isolate	ORF28	C1185Y		2.9					1.8	2						Genetic polymorphism of thymidine kinase (TK) and DNA polymerase (pol) of clinical varicella-zoster virus (VZV) isolates collected over three decades	https://www.sciencedirect.com/science/article/pii/S1386653217302433?via%3Dihub#tbl0005	doi.org/10.1016/j.jcv.2017.08.011	Isolated strain 	PRA			12/01/2020	OJCharles		Oka	A
1290	VZV	Clinical isolate	ORF28	G186C		Polymorphism	Polymorphism	Polymorphism			Polymorphism	Polymorphism						Complementary assays for monitoring susceptibility of varicella-zoster virus resistance to antivirals	https://www.sciencedirect.com/science/article/pii/S0166093416300787	doi.org/10.1016/j.jviromet.2016.03.006	Isolated strain 	PRA			12/01/2020	OJCharles		Oka	A
1291	VZV	Clinical isolate	ORF28	S863G		Polymorphism	Polymorphism	Polymorphism			Polymorphism	Polymorphism						Complementary assays for monitoring susceptibility of varicella-zoster virus resistance to antivirals	https://www.sciencedirect.com/science/article/pii/S0166093416300787	doi.org/10.1016/j.jviromet.2016.03.006	Isolated strain 	PRA			12/01/2020	OJCharles		Oka	A
1292	VZV	Clinical isolate	ORF28	C1159R		Polymorphism	Polymorphism	Polymorphism			Polymorphism	Polymorphism						Complementary assays for monitoring susceptibility of varicella-zoster virus resistance to antivirals	https://www.sciencedirect.com/science/article/pii/S0166093416300787	doi.org/10.1016/j.jviromet.2016.03.006	Isolated strain 	PRA			12/01/2020	OJCharles		Oka	A
1293	VZV	Clinical isolate	ORF28	I3L		0.9												Complementary assays for monitoring susceptibility of varicella-zoster virus resistance to antivirals	https://www.sciencedirect.com/science/article/pii/S0166093416300787	doi.org/10.1016/j.jviromet.2016.03.006	Isolated strain 	PRA			12/01/2020	OJCharles		Oka	A
1294	VZV	Clinical isolate	ORF28	V638I		0.6												Complementary assays for monitoring susceptibility of varicella-zoster virus resistance to antivirals	https://www.sciencedirect.com/science/article/pii/S0166093416300787	doi.org/10.1016/j.jviromet.2016.03.006	Isolated strain 	PRA			12/01/2020	OJCharles		Oka	A
1295	VZV	Clinical isolate	ORF36	R143G		14												Complementary assays for monitoring susceptibility of varicella-zoster virus resistance to antivirals	https://www.sciencedirect.com/science/article/pii/S0166093416300787	doi.org/10.1016/j.jviromet.2016.03.006	Isolated strain 	PRA			12/01/2020	OJCharles		Oka	A
1296	HSV1		UL30	L802F		2.4	2.2	2.2			0.9	2.8						The Anti-Human Immunodeficiency Virus Drug Tenofovir, a Reverse Transcriptase Inhibitor, Also Targets the Herpes Simplex Virus DNA Polymerase	https://academic.oup.com/jid/article/217/5/790/4653578	doi.org/10.1093/infdis/jix605	Marker Transfer 	PRA			04/02/2021	OJCharles			A
1297	HSV1		UL30	Q618H		3.4	0.6	1			0.3	2.9						The Anti-Human Immunodeficiency Virus Drug Tenofovir, a Reverse Transcriptase Inhibitor, Also Targets the Herpes Simplex Virus DNA Polymerase	https://academic.oup.com/jid/article/217/5/790/4653578	doi.org/10.1093/infdis/jix605	Marker Transfer 	PRA			04/02/2021	OJCharles			A
1298	HSV1		UL30	A605V		6.1	1.6	6.7			0.2	1.2						The Anti-Human Immunodeficiency Virus Drug Tenofovir, a Reverse Transcriptase Inhibitor, Also Targets the Herpes Simplex Virus DNA Polymerase	https://academic.oup.com/jid/article/217/5/790/4653578	doi.org/10.1093/infdis/jix605	Marker Transfer 	PRA			04/02/2021	OJCharles			A
1299	HSV1		UL30	A719V		7	0.7	3.6			0.5	2.8						The Anti-Human Immunodeficiency Virus Drug Tenofovir, a Reverse Transcriptase Inhibitor, Also Targets the Herpes Simplex Virus DNA Polymerase	https://academic.oup.com/jid/article/217/5/790/4653578	doi.org/10.1093/infdis/jix605	Marker Transfer 	PRA			04/02/2021	OJCharles			A
1300	HSV1		UL30	A719T		5.4	1	2.1			1	1.4						The Anti-Human Immunodeficiency Virus Drug Tenofovir, a Reverse Transcriptase Inhibitor, Also Targets the Herpes Simplex Virus DNA Polymerase	https://academic.oup.com/jid/article/217/5/790/4653578	doi.org/10.1093/infdis/jix605	Marker Transfer 	PRA			04/02/2021	OJCharles			A
1301	HSV1		UL30	S724N		4.1	2.8	3.1			0.4	6.6						The Anti-Human Immunodeficiency Virus Drug Tenofovir, a Reverse Transcriptase Inhibitor, Also Targets the Herpes Simplex Virus DNA Polymerase	https://academic.oup.com/jid/article/217/5/790/4653578	doi.org/10.1093/infdis/jix605	Marker Transfer 	PRA			04/02/2021	OJCharles			A
1302	HSV1		UL30	S724N		8.6	2.6	4.9			0.2	2.3						The Anti-Human Immunodeficiency Virus Drug Tenofovir, a Reverse Transcriptase Inhibitor, Also Targets the Herpes Simplex Virus DNA Polymerase	https://academic.oup.com/jid/article/217/5/790/4653578	doi.org/10.1093/infdis/jix605	Marker Transfer 	PRA			04/02/2021	OJCharles			A
1303	HSV1		UL30	N815S		77.8	2.2	2.2			0.9	2.8						The Anti-Human Immunodeficiency Virus Drug Tenofovir, a Reverse Transcriptase Inhibitor, Also Targets the Herpes Simplex Virus DNA Polymerase	https://academic.oup.com/jid/article/217/5/790/4653578	doi.org/10.1093/infdis/jix605	Marker Transfer 	PRA			04/02/2021	OJCharles			A
1304	HSV1		UL30	T821M		3.3	1.5	2.6			1	2.9						The Anti-Human Immunodeficiency Virus Drug Tenofovir, a Reverse Transcriptase Inhibitor, Also Targets the Herpes Simplex Virus DNA Polymerase	https://academic.oup.com/jid/article/217/5/790/4653578	doi.org/10.1093/infdis/jix605	Marker Transfer 	PRA			04/02/2021	OJCharles			A
1305	HSV1		UL30	R959H		3.3	1.8	3.5			1	2.6						The Anti-Human Immunodeficiency Virus Drug Tenofovir, a Reverse Transcriptase Inhibitor, Also Targets the Herpes Simplex Virus DNA Polymerase	https://academic.oup.com/jid/article/217/5/790/4653578	doi.org/10.1093/infdis/jix605	Marker Transfer 	PRA			04/02/2021	OJCharles			A
1306	HSV2		UL30	K533E		3.8	1.4	4.2				2.5						The Anti-Human Immunodeficiency Virus Drug Tenofovir, a Reverse Transcriptase Inhibitor, Also Targets the Herpes Simplex Virus DNA Polymerase	https://academic.oup.com/jid/article/217/5/790/4653578	doi.org/10.1093/infdis/jix605	Marker Transfer 	PRA			04/02/2021	OJCharles			A
1307	HSV2		UL30	A606V		6.2	1.7	6.2				2.6						The Anti-Human Immunodeficiency Virus Drug Tenofovir, a Reverse Transcriptase Inhibitor, Also Targets the Herpes Simplex Virus DNA Polymerase	https://academic.oup.com/jid/article/217/5/790/4653578	doi.org/10.1093/infdis/jix605	Marker Transfer 	PRA			04/02/2021	OJCharles			A
1308	HSV2		UL30	C625R		3.3	1.4	4.4				3.4						The Anti-Human Immunodeficiency Virus Drug Tenofovir, a Reverse Transcriptase Inhibitor, Also Targets the Herpes Simplex Virus DNA Polymerase	https://academic.oup.com/jid/article/217/5/790/4653578	doi.org/10.1093/infdis/jix605	Marker Transfer 	PRA			04/02/2021	OJCharles			A
1309	HSV2		UL30	R628C		2	1.3	2.5				2.2						The Anti-Human Immunodeficiency Virus Drug Tenofovir, a Reverse Transcriptase Inhibitor, Also Targets the Herpes Simplex Virus DNA Polymerase	https://academic.oup.com/jid/article/217/5/790/4653578	doi.org/10.1093/infdis/jix605	Marker Transfer 	PRA			04/02/2021	OJCharles			A
1310	HSV2		UL30	R628C		2	1.2	2.4				1.8						The Anti-Human Immunodeficiency Virus Drug Tenofovir, a Reverse Transcriptase Inhibitor, Also Targets the Herpes Simplex Virus DNA Polymerase	https://academic.oup.com/jid/article/217/5/790/4653578	doi.org/10.1093/infdis/jix605	Marker Transfer 	PRA			04/02/2021	OJCharles			A
1311	HSV2		UL30	A724V		3.6	1	2.7				1.6						The Anti-Human Immunodeficiency Virus Drug Tenofovir, a Reverse Transcriptase Inhibitor, Also Targets the Herpes Simplex Virus DNA Polymerase	https://academic.oup.com/jid/article/217/5/790/4653578	doi.org/10.1093/infdis/jix605	Marker Transfer 	PRA			04/02/2021	OJCharles			A
1312	HSV2		UL30	S725G		2.7	0.7	4				1.7						The Anti-Human Immunodeficiency Virus Drug Tenofovir, a Reverse Transcriptase Inhibitor, Also Targets the Herpes Simplex Virus DNA Polymerase	https://academic.oup.com/jid/article/217/5/790/4653578	doi.org/10.1093/infdis/jix605	Marker Transfer 	PRA			04/02/2021	OJCharles			A
1313	HSV2		UL30	S729N		6.9	1.6	6.9				3.8						The Anti-Human Immunodeficiency Virus Drug Tenofovir, a Reverse Transcriptase Inhibitor, Also Targets the Herpes Simplex Virus DNA Polymerase	https://academic.oup.com/jid/article/217/5/790/4653578	doi.org/10.1093/infdis/jix605	Marker Transfer 	PRA			04/02/2021	OJCharles			A
1314	HSV2		UL30	I731F		2.9	2.3	6				1.7						The Anti-Human Immunodeficiency Virus Drug Tenofovir, a Reverse Transcriptase Inhibitor, Also Targets the Herpes Simplex Virus DNA Polymerase	https://academic.oup.com/jid/article/217/5/790/4653578	doi.org/10.1093/infdis/jix605	Marker Transfer 	PRA			04/02/2021	OJCharles			A
1315	HSV2		UL30	Q732R		3.8	1.8	4.1				2.7						The Anti-Human Immunodeficiency Virus Drug Tenofovir, a Reverse Transcriptase Inhibitor, Also Targets the Herpes Simplex Virus DNA Polymerase	https://academic.oup.com/jid/article/217/5/790/4653578	doi.org/10.1093/infdis/jix605	Marker Transfer 	PRA			04/02/2021	OJCharles			A
1316	HSV2		UL30	M789T		3.3	1.4	3.2				2.7						The Anti-Human Immunodeficiency Virus Drug Tenofovir, a Reverse Transcriptase Inhibitor, Also Targets the Herpes Simplex Virus DNA Polymerase	https://academic.oup.com/jid/article/217/5/790/4653578	doi.org/10.1093/infdis/jix605	Marker Transfer 	PRA			04/02/2021	OJCharles			A
1317	HSV2		UL30	M789K		3.4	1.6	3.3				2.7						The Anti-Human Immunodeficiency Virus Drug Tenofovir, a Reverse Transcriptase Inhibitor, Also Targets the Herpes Simplex Virus DNA Polymerase	https://academic.oup.com/jid/article/217/5/790/4653578	doi.org/10.1093/infdis/jix605	Marker Transfer 	PRA			04/02/2021	OJCharles			A
1318	HSV2		UL30	V818A		4.6	1.1	5.1				2.8						The Anti-Human Immunodeficiency Virus Drug Tenofovir, a Reverse Transcriptase Inhibitor, Also Targets the Herpes Simplex Virus DNA Polymerase	https://academic.oup.com/jid/article/217/5/790/4653578	doi.org/10.1093/infdis/jix605	Marker Transfer 	PRA			04/02/2021	OJCharles			A
1319	HSV2		UL30	N820S		68	1	0.2				5.9						The Anti-Human Immunodeficiency Virus Drug Tenofovir, a Reverse Transcriptase Inhibitor, Also Targets the Herpes Simplex Virus DNA Polymerase	https://academic.oup.com/jid/article/217/5/790/4653578	doi.org/10.1093/infdis/jix605	Marker Transfer 	PRA			04/02/2021	OJCharles			A
1320	HSV2		UL30	Y823C		3.4	1.3	2				1.6						The Anti-Human Immunodeficiency Virus Drug Tenofovir, a Reverse Transcriptase Inhibitor, Also Targets the Herpes Simplex Virus DNA Polymerase	https://academic.oup.com/jid/article/217/5/790/4653578	doi.org/10.1093/infdis/jix605	Marker Transfer 	PRA			04/02/2021	OJCharles			A
1321	HSV2		UL30	R847C		6.6	1.6	6.1				2.4						The Anti-Human Immunodeficiency Virus Drug Tenofovir, a Reverse Transcriptase Inhibitor, Also Targets the Herpes Simplex Virus DNA Polymerase	https://academic.oup.com/jid/article/217/5/790/4653578	doi.org/10.1093/infdis/jix605	Marker Transfer 	PRA			04/02/2021	OJCharles			A
1322	HSV2		UL30	F923L		7.5	1.4	4.7				3.2						The Anti-Human Immunodeficiency Virus Drug Tenofovir, a Reverse Transcriptase Inhibitor, Also Targets the Herpes Simplex Virus DNA Polymerase	https://academic.oup.com/jid/article/217/5/790/4653578	doi.org/10.1093/infdis/jix605	Marker Transfer 	PRA			04/02/2021	OJCharles			A
1323	HSV2		UL30	T934A		5	1.1	5.4				2.8						The Anti-Human Immunodeficiency Virus Drug Tenofovir, a Reverse Transcriptase Inhibitor, Also Targets the Herpes Simplex Virus DNA Polymerase	https://academic.oup.com/jid/article/217/5/790/4653578	doi.org/10.1093/infdis/jix605	Marker Transfer 	PRA			04/02/2021	OJCharles			A
1324	HSV2		UL30	R964H		4.9	1	4.8				1.2						The Anti-Human Immunodeficiency Virus Drug Tenofovir, a Reverse Transcriptase Inhibitor, Also Targets the Herpes Simplex Virus DNA Polymerase	https://academic.oup.com/jid/article/217/5/790/4653578	doi.org/10.1093/infdis/jix605	Marker Transfer 	PRA			04/02/2021	OJCharles			A
1325	HSV2	Clinical isolate	UL23	G39E		25.6					0.66	100						Novel resistance-associated mutations of thymidine kinase and DNA polymerase genes of herpes simplex virus type 1 and type 2	https://pubmed.ncbi.nlm.nih.gov/22155911/	 doi.org/10.3851/IMP1870	Isolated strain 	dye uptake assay			04/02/2021	OJCharles	Ambigious		O
1326	HSV2	Clinical isolate	UL30	L60P		Polymorphism												Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			14/01/2021	OJCharles			A
1327	HSV2	Clinical isolate	UL30	G906A		Polymorphism												Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354203002122?via%3Dihub#TBL6	doi.org/10.1016/j.antiviral.2003.08.018	Isolated strain 	PRA			14/01/2021	OJCharles			A
1328	HSV1		UL23	R41H		1		2.3			1	1.1						Recombinant herpes simplex virus type 1 strains with targeted mutations relevant for aciclovir susceptibility	https://www.nature.com/articles/srep29903	doi.org/10.1038/srep29903	Recombinant BAC 	dye uptake assay			04/02/2021	OJCharles			A
1329	HSV1		UL23	G61A		46		2.9			60	27						Recombinant herpes simplex virus type 1 strains with targeted mutations relevant for aciclovir susceptibility	https://www.nature.com/articles/srep29903	doi.org/10.1038/srep29903	Recombinant BAC 	dye uptake assay			04/02/2021	OJCharles			A
1330	HSV1		UL23	P84L		95		4.4			225	8.9						Recombinant herpes simplex virus type 1 strains with targeted mutations relevant for aciclovir susceptibility	https://www.nature.com/articles/srep29903	doi.org/10.1038/srep29903	Recombinant BAC 	dye uptake assay			04/02/2021	OJCharles			A
1331	HSV1		UL23	R106H		1		3.1			1	1						Recombinant herpes simplex virus type 1 strains with targeted mutations relevant for aciclovir susceptibility	https://www.nature.com/articles/srep29903	doi.org/10.1038/srep29903	Recombinant BAC 	dye uptake assay			04/02/2021	OJCharles			A
1332	HSV1		UL23	A118V		1		4.8			1	1						Recombinant herpes simplex virus type 1 strains with targeted mutations relevant for aciclovir susceptibility	https://www.nature.com/articles/srep29903	doi.org/10.1038/srep29903	Recombinant BAC 	dye uptake assay			04/02/2021	OJCharles			A
1333	HSV1		UL23	L139V		1		1.2			1	0.5						Recombinant herpes simplex virus type 1 strains with targeted mutations relevant for aciclovir susceptibility	https://www.nature.com/articles/srep29903	doi.org/10.1038/srep29903	Recombinant BAC 	dye uptake assay			04/02/2021	OJCharles			A
1334	HSV1		UL23	K219T		1		1.6			1	0.8						Recombinant herpes simplex virus type 1 strains with targeted mutations relevant for aciclovir susceptibility	https://www.nature.com/articles/srep29903	doi.org/10.1038/srep29903	Recombinant BAC 	dye uptake assay			04/02/2021	OJCharles			A
1335	HSV1		UL23	S276R		1		3.8			1	0.9						Recombinant herpes simplex virus type 1 strains with targeted mutations relevant for aciclovir susceptibility	https://www.nature.com/articles/srep29903	doi.org/10.1038/srep29903	Recombinant BAC 	dye uptake assay			04/02/2021	OJCharles			A
1336	HSV1		UL23	L298R		1		2.5			1	1.1						Recombinant herpes simplex virus type 1 strains with targeted mutations relevant for aciclovir susceptibility	https://www.nature.com/articles/srep29903	doi.org/10.1038/srep29903	Recombinant BAC 	dye uptake assay			04/02/2021	OJCharles			A
1337	HSV1		UL23	S345P		1		1.7			1	0.7						Recombinant herpes simplex virus type 1 strains with targeted mutations relevant for aciclovir susceptibility	https://www.nature.com/articles/srep29903	doi.org/10.1038/srep29903	Recombinant BAC 	dye uptake assay			04/02/2021	OJCharles			A
1338	HSV1		UL23	V238I		1		1.6			1	1						Recombinant herpes simplex virus type 1 strains with targeted mutations relevant for aciclovir susceptibility	https://www.nature.com/articles/srep29903	doi.org/10.1038/srep29903	Recombinant BAC 	dye uptake assay			04/02/2021	OJCharles			A
1339	HSV2	MS	UL23	G25A		1.1						0.3						Relevance of non-synonymous thymidine kinase mutations for antiviral resistance of recombinant herpes simplex virus type 2 strains	https://www.sciencedirect.com/science/article/pii/S0166354217307490?via%3Dihub	doi.org/10.1016/j.antiviral.2018.02.004	Recombinant BAC 	PRA			04/02/2021	OJCharles			A
1340	HSV2	MS	UL23	G39E		0.7						0.5						Relevance of non-synonymous thymidine kinase mutations for antiviral resistance of recombinant herpes simplex virus type 2 strains	https://www.sciencedirect.com/science/article/pii/S0166354217307490?via%3Dihub	doi.org/10.1016/j.antiviral.2018.02.004	Recombinant BAC 	PRA			04/02/2021	OJCharles			A
1341	HSV2	MS	UL23	Y53N		13						6.8						Relevance of non-synonymous thymidine kinase mutations for antiviral resistance of recombinant herpes simplex virus type 2 strains	https://www.sciencedirect.com/science/article/pii/S0166354217307490?via%3Dihub	doi.org/10.1016/j.antiviral.2018.02.004	Recombinant BAC 	PRA			04/02/2021	OJCharles			A
1342	HSV2	MS	UL23	T131M		1.5						1.2						Relevance of non-synonymous thymidine kinase mutations for antiviral resistance of recombinant herpes simplex virus type 2 strains	https://www.sciencedirect.com/science/article/pii/S0166354217307490?via%3Dihub	doi.org/10.1016/j.antiviral.2018.02.004	Recombinant BAC 	PRA			04/02/2021	OJCharles			A
1343	HSV2	MS	UL23	Y133F		0.4						1.2						Relevance of non-synonymous thymidine kinase mutations for antiviral resistance of recombinant herpes simplex virus type 2 strains	https://www.sciencedirect.com/science/article/pii/S0166354217307490?via%3Dihub	doi.org/10.1016/j.antiviral.2018.02.004	Recombinant BAC 	PRA			04/02/2021	OJCharles			A
1344	HSV2	MS	UL23	G150D		0.7						0.3						Relevance of non-synonymous thymidine kinase mutations for antiviral resistance of recombinant herpes simplex virus type 2 strains	https://www.sciencedirect.com/science/article/pii/S0166354217307490?via%3Dihub	doi.org/10.1016/j.antiviral.2018.02.004	Recombinant BAC 	PRA			04/02/2021	OJCharles			A
1345	HSV2	MS	UL23	A157T		0.5						0.3						Relevance of non-synonymous thymidine kinase mutations for antiviral resistance of recombinant herpes simplex virus type 2 strains	https://www.sciencedirect.com/science/article/pii/S0166354217307490?via%3Dihub	doi.org/10.1016/j.antiviral.2018.02.004	Recombinant BAC 	PRA			04/02/2021	OJCharles			A
1346	HSV2	MS	UL23	R221H		12.9						7.8						Relevance of non-synonymous thymidine kinase mutations for antiviral resistance of recombinant herpes simplex virus type 2 strains	https://www.sciencedirect.com/science/article/pii/S0166354217307490?via%3Dihub	doi.org/10.1016/j.antiviral.2018.02.004	Recombinant BAC 	PRA			04/02/2021	OJCharles			A
1347	HSV2	MS	UL23	R248W		0.9						1.3						Relevance of non-synonymous thymidine kinase mutations for antiviral resistance of recombinant herpes simplex virus type 2 strains	https://www.sciencedirect.com/science/article/pii/S0166354217307490?via%3Dihub	doi.org/10.1016/j.antiviral.2018.02.004	Recombinant BAC 	PRA			04/02/2021	OJCharles			A
1348	HSV2	MS	UL23	L342W		0.3						1.3						Relevance of non-synonymous thymidine kinase mutations for antiviral resistance of recombinant herpes simplex virus type 2 strains	https://www.sciencedirect.com/science/article/pii/S0166354217307490?via%3Dihub	doi.org/10.1016/j.antiviral.2018.02.004	Recombinant BAC 	PRA			04/02/2021	OJCharles			A
1349	HSV2	MS	UL23	G25A		1.8						2.4						Relevance of non-synonymous thymidine kinase mutations for antiviral resistance of recombinant herpes simplex virus type 2 strains	https://www.sciencedirect.com/science/article/pii/S0166354217307490?via%3Dihub	doi.org/10.1016/j.antiviral.2018.02.004	Recombinant BAC 	dye uptake assay			04/02/2021	OJCharles			A
1350	HSV2	MS	UL23	G39E		1.8						2.4						Relevance of non-synonymous thymidine kinase mutations for antiviral resistance of recombinant herpes simplex virus type 2 strains	https://www.sciencedirect.com/science/article/pii/S0166354217307490?via%3Dihub	doi.org/10.1016/j.antiviral.2018.02.004	Recombinant BAC 	dye uptake assay			04/02/2021	OJCharles			A
1351	HSV2	MS	UL23	Y53N		24.1						7.8						Relevance of non-synonymous thymidine kinase mutations for antiviral resistance of recombinant herpes simplex virus type 2 strains	https://www.sciencedirect.com/science/article/pii/S0166354217307490?via%3Dihub	doi.org/10.1016/j.antiviral.2018.02.004	Recombinant BAC 	dye uptake assay			04/02/2021	OJCharles			A
1352	HSV2	MS	UL23	T131M		0.2						1.4						Relevance of non-synonymous thymidine kinase mutations for antiviral resistance of recombinant herpes simplex virus type 2 strains	https://www.sciencedirect.com/science/article/pii/S0166354217307490?via%3Dihub	doi.org/10.1016/j.antiviral.2018.02.004	Recombinant BAC 	dye uptake assay			04/02/2021	OJCharles			A
1353	HSV2	MS	UL23	Y133F		0.6						2.5						Relevance of non-synonymous thymidine kinase mutations for antiviral resistance of recombinant herpes simplex virus type 2 strains	https://www.sciencedirect.com/science/article/pii/S0166354217307490?via%3Dihub	doi.org/10.1016/j.antiviral.2018.02.004	Recombinant BAC 	dye uptake assay			04/02/2021	OJCharles			A
1354	HSV2	MS	UL23	G150D		0.6						2						Relevance of non-synonymous thymidine kinase mutations for antiviral resistance of recombinant herpes simplex virus type 2 strains	https://www.sciencedirect.com/science/article/pii/S0166354217307490?via%3Dihub	doi.org/10.1016/j.antiviral.2018.02.004	Recombinant BAC 	dye uptake assay			04/02/2021	OJCharles			A
1355	HSV2	MS	UL23	A157T		0.5						1.7						Relevance of non-synonymous thymidine kinase mutations for antiviral resistance of recombinant herpes simplex virus type 2 strains	https://www.sciencedirect.com/science/article/pii/S0166354217307490?via%3Dihub	doi.org/10.1016/j.antiviral.2018.02.004	Recombinant BAC 	dye uptake assay			04/02/2021	OJCharles			A
1356	HSV2	MS	UL23	R221H		24.1						4.7						Relevance of non-synonymous thymidine kinase mutations for antiviral resistance of recombinant herpes simplex virus type 2 strains	https://www.sciencedirect.com/science/article/pii/S0166354217307490?via%3Dihub	doi.org/10.1016/j.antiviral.2018.02.004	Recombinant BAC 	dye uptake assay			04/02/2021	OJCharles			A
1357	HSV2	MS	UL23	R248W		1.9						2.3						Relevance of non-synonymous thymidine kinase mutations for antiviral resistance of recombinant herpes simplex virus type 2 strains	https://www.sciencedirect.com/science/article/pii/S0166354217307490?via%3Dihub	doi.org/10.1016/j.antiviral.2018.02.004	Recombinant BAC 	dye uptake assay			04/02/2021	OJCharles			A
1358	HSV2	MS	UL23	L342W		0.6						2						Relevance of non-synonymous thymidine kinase mutations for antiviral resistance of recombinant herpes simplex virus type 2 strains	https://www.sciencedirect.com/science/article/pii/S0166354217307490?via%3Dihub	doi.org/10.1016/j.antiviral.2018.02.004	Recombinant BAC 	dye uptake assay			04/02/2021	OJCharles			A
1359	HSV1	HSV1-17	UL30	P561S		0.85	1.48	0.91										Drug Resistance Patterns of Recombinant Herpes Simplex Virus DNA Polymerase Mutants Generated with a Set of Overlapping Cosmids and Plasmids	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC161916/	doi.org/10.1128/JVI.77.14.7820-7829.2003	Marker Transfer 	PRA			04/02/2021	OJCharles		HSV1-17	A
1360	HSV1	HSV1-17	UL30	V573M		1.9	1.16	0.87										Drug Resistance Patterns of Recombinant Herpes Simplex Virus DNA Polymerase Mutants Generated with a Set of Overlapping Cosmids and Plasmids	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC161916/	doi.org/10.1128/JVI.77.14.7820-7829.2003	Marker Transfer 	PRA			04/02/2021	OJCharles		HSV1-17	A
1361	HSV1	HSV1-17	UL30	R700M		0.98	3.67	0.14										Drug Resistance Patterns of Recombinant Herpes Simplex Virus DNA Polymerase Mutants Generated with a Set of Overlapping Cosmids and Plasmids	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC161916/	doi.org/10.1128/JVI.77.14.7820-7829.2003	Marker Transfer 	PRA			04/02/2021	OJCharles		HSV1-17	A
1362	HSV1	HSV1-17	UL30	V715M		2.86	0.35	0.81										Drug Resistance Patterns of Recombinant Herpes Simplex Virus DNA Polymerase Mutants Generated with a Set of Overlapping Cosmids and Plasmids	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC161916/	doi.org/10.1128/JVI.77.14.7820-7829.2003	Marker Transfer 	PRA			04/02/2021	OJCharles		HSV1-17	A
1363	HSV1	HSV1-17	UL30	A719T		5.94	1.85	2.18										Drug Resistance Patterns of Recombinant Herpes Simplex Virus DNA Polymerase Mutants Generated with a Set of Overlapping Cosmids and Plasmids	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC161916/	doi.org/10.1128/JVI.77.14.7820-7829.2003	Marker Transfer 	PRA			04/02/2021	OJCharles		HSV1-17	A
1364	HSV1	HSV1-17	UL30	S724N		9.87	2.05	2.69										Drug Resistance Patterns of Recombinant Herpes Simplex Virus DNA Polymerase Mutants Generated with a Set of Overlapping Cosmids and Plasmids	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC161916/	doi.org/10.1128/JVI.77.14.7820-7829.2003	Marker Transfer 	PRA			04/02/2021	OJCharles		HSV1-17	A
1365	HSV1	HSV1-17	UL30	L778M		5.53	2.04	2.03										Drug Resistance Patterns of Recombinant Herpes Simplex Virus DNA Polymerase Mutants Generated with a Set of Overlapping Cosmids and Plasmids	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC161916/	doi.org/10.1128/JVI.77.14.7820-7829.2003	Marker Transfer 	PRA			04/02/2021	OJCharles		HSV1-17	A
1366	HSV1	HSV1-17	UL30	D780N		6.1	1.21	2.17										Drug Resistance Patterns of Recombinant Herpes Simplex Virus DNA Polymerase Mutants Generated with a Set of Overlapping Cosmids and Plasmids	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC161916/	doi.org/10.1128/JVI.77.14.7820-7829.2003	Marker Transfer 	PRA			04/02/2021	OJCharles		HSV1-17	A
1367	HSV1	HSV1-17	UL30	L782I		6.43	1.76	2.29										Drug Resistance Patterns of Recombinant Herpes Simplex Virus DNA Polymerase Mutants Generated with a Set of Overlapping Cosmids and Plasmids	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC161916/	doi.org/10.1128/JVI.77.14.7820-7829.2003	Marker Transfer 	PRA			04/02/2021	OJCharles		HSV1-17	A
1368	HSV1	HSV1-17	UL30	K805Q		0.64	1.82	0.34										Drug Resistance Patterns of Recombinant Herpes Simplex Virus DNA Polymerase Mutants Generated with a Set of Overlapping Cosmids and Plasmids	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC161916/	doi.org/10.1128/JVI.77.14.7820-7829.2003	Marker Transfer 	PRA			04/02/2021	OJCharles		HSV1-17	A
1369	HSV1	HSV1-17	UL30	T821M		6.25	2.11	1.48										Drug Resistance Patterns of Recombinant Herpes Simplex Virus DNA Polymerase Mutants Generated with a Set of Overlapping Cosmids and Plasmids	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC161916/	doi.org/10.1128/JVI.77.14.7820-7829.2003	Marker Transfer 	PRA			04/02/2021	OJCharles		HSV1-17	A
1370	HSV1	HSV1-17	UL30	L846I		1.52	1.26	0.7										Drug Resistance Patterns of Recombinant Herpes Simplex Virus DNA Polymerase Mutants Generated with a Set of Overlapping Cosmids and Plasmids	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC161916/	doi.org/10.1128/JVI.77.14.7820-7829.2003	Marker Transfer 	PRA			04/02/2021	OJCharles		HSV1-17	A
1371	HSV1	HSV1-17	UL30	F891C		34.99	1.74	3.91										Drug Resistance Patterns of Recombinant Herpes Simplex Virus DNA Polymerase Mutants Generated with a Set of Overlapping Cosmids and Plasmids	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC161916/	doi.org/10.1128/JVI.77.14.7820-7829.2003	Marker Transfer 	PRA			04/02/2021	OJCharles		HSV1-17	A
1372	HSV1	HSV1-17	UL30	D907V		3.78	1.59	2.27										Drug Resistance Patterns of Recombinant Herpes Simplex Virus DNA Polymerase Mutants Generated with a Set of Overlapping Cosmids and Plasmids	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC161916/	doi.org/10.1128/JVI.77.14.7820-7829.2003	Marker Transfer 	PRA			04/02/2021	OJCharles		HSV1-17	A
1373	HSV1	HSV1-17	UL30	P920S		1.05	0.65	0.73										Drug Resistance Patterns of Recombinant Herpes Simplex Virus DNA Polymerase Mutants Generated with a Set of Overlapping Cosmids and Plasmids	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC161916/	doi.org/10.1128/JVI.77.14.7820-7829.2003	Marker Transfer 	PRA			04/02/2021	OJCharles		HSV1-17	A
1374	HSV1	HSV1-17	UL30	Y941H		9.39	0.39	1.38										Drug Resistance Patterns of Recombinant Herpes Simplex Virus DNA Polymerase Mutants Generated with a Set of Overlapping Cosmids and Plasmids	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC161916/	doi.org/10.1128/JVI.77.14.7820-7829.2003	Marker Transfer 	PRA			04/02/2021	OJCharles		HSV1-17	A
1375	HSV1	HSV1-17	UL30	N961K		5.34	1.41	0.83										Drug Resistance Patterns of Recombinant Herpes Simplex Virus DNA Polymerase Mutants Generated with a Set of Overlapping Cosmids and Plasmids	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC161916/	doi.org/10.1128/JVI.77.14.7820-7829.2003	Marker Transfer 	PRA			04/02/2021	OJCharles		HSV1-17	A
1376	HSV1	HSV1-17	UL30	L1007M		1.84	1.22	0.59										Drug Resistance Patterns of Recombinant Herpes Simplex Virus DNA Polymerase Mutants Generated with a Set of Overlapping Cosmids and Plasmids	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC161916/	doi.org/10.1128/JVI.77.14.7820-7829.2003	Marker Transfer 	PRA			04/02/2021	OJCharles		HSV1-17	A
1377	HSV1	HSV1-17	UL30	I1028T		1.74	2.28	0.58										Drug Resistance Patterns of Recombinant Herpes Simplex Virus DNA Polymerase Mutants Generated with a Set of Overlapping Cosmids and Plasmids	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC161916/	doi.org/10.1128/JVI.77.14.7820-7829.2003	Marker Transfer 	PRA			04/02/2021	OJCharles		HSV1-17	A
1378	HSV1	HSV1-17	UL30	S724N		11.61	2.38	2.53										Drug Resistance Patterns of Recombinant Herpes Simplex Virus DNA Polymerase Mutants Generated with a Set of Overlapping Cosmids and Plasmids	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC161916/	doi.org/10.1128/JVI.77.14.7820-7829.2003	Marker Transfer 	PRA			04/02/2021	OJCharles		HSV1-17	A
1379	HSV2	Clinical isolate	UL23	G59P		61												Highly Reliable Heterologous System for Evaluating Resistance of Clinical Herpes Simplex Virus Isolates to Nucleoside Analogues	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC114104/	doi.org/10.1128/JVI.75.7.3105-3110.2001	Isolated strain 	PRA			04/02/2021	OJCharles			A
1380	VZV	Clinical isolate	ORF36	S179N		1		1.4			0.7	1						Phenotypic and Genetic Characterization of Thymidine Kinase from Clinical Strains of Varicella-Zoster Virus Resistant to Acyclovir	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC89493/		Isolated strain 	TK functional kinetic assay			04/02/2021	OJCharles		Oka	A
1381	HSV1		UL23	R51W		10												Herpes Simplex Virus Thymidine Kinase Mutations Associated with Resistance to Acyclovir: a Site-Directed Mutagenesis Study	https://aac.asm.org/content/aac/49/3/1055.full.pdf	doi.org/10.1128/AAC.49.3.1055-1059.2005	Marker Transfer 	TK functional kinetic assay			04/02/2021	OJCharles	inferred fc		A
1382	HSV1		UL23	E83K		10												Herpes Simplex Virus Thymidine Kinase Mutations Associated with Resistance to Acyclovir: a Site-Directed Mutagenesis Study	https://aac.asm.org/content/aac/49/3/1055.full.pdf	doi.org/10.1128/AAC.49.3.1055-1059.2005	Marker Transfer 	TK functional kinetic assay			04/02/2021	OJCharles	inferred fc		A
1383	HSV1		UL23	A175V		10												Herpes Simplex Virus Thymidine Kinase Mutations Associated with Resistance to Acyclovir: a Site-Directed Mutagenesis Study	https://aac.asm.org/content/aac/49/3/1055.full.pdf	doi.org/10.1128/AAC.49.3.1055-1059.2005	Marker Transfer 	TK functional kinetic assay			04/02/2021	OJCharles	inferred fc		A
1384	HSV1		UL23	D77N		Polymorphism												Herpes Simplex Virus Thymidine Kinase Mutations Associated with Resistance to Acyclovir: a Site-Directed Mutagenesis Study	https://aac.asm.org/content/aac/49/3/1055.full.pdf	doi.org/10.1128/AAC.49.3.1055-1059.2005	Marker Transfer 	TK functional kinetic assay			04/02/2021	OJCharles			A
1385	Adeno	ad5	pol	L883S	trust		Resistant											Sequence changes in the human adenovirus type 5 DNA polymerase associated with resistance to the broad spectrum antiviral cidofovir	https://www.sciencedirect.com/science/article/pii/S0166354202000980	doi.org/10.1016/S0166-3542(02)00098-0	Isolated strain 	PRA			04/02/2021	OJCharles	L741S originally		A
1386	Adeno	ad5	pol	S1183R			Resistant											Sequence changes in the human adenovirus type 5 DNA polymerase associated with resistance to the broad spectrum antiviral cidofovir	https://www.sciencedirect.com/science/article/pii/S0166354202000980	doi.org/10.1016/S0166-3542(02)00098-0	Isolated strain 	PRA	pol	L883S	04/02/2021	OJCharles	co-occuring uncharacterised mutations S1041R		O
1387	Adeno	ad5	pol	F882I			Resistant											Sequence changes in the human adenovirus type 5 DNA polymerase associated with resistance to the broad spectrum antiviral cidofovir	https://www.sciencedirect.com/science/article/pii/S0166354202000980	doi.org/10.1016/S0166-3542(02)00098-0	Isolated strain 	PRA	pol	V180I	04/02/2021	OJCharles	co-occuring uncharacterised mutations - oringally F740I		O
1388	Adeno	ad5	pol	V180I			Resistant											Sequence changes in the human adenovirus type 5 DNA polymerase associated with resistance to the broad spectrum antiviral cidofovir	https://www.sciencedirect.com/science/article/pii/S0166354202000980	doi.org/10.1016/S0166-3542(02)00098-0	Isolated strain 	PRA	pol	F882I	04/02/2021	OJCharles	co-occuring uncharacterised mutations - and cannot find homolog in the refseq		O
1389	Adeno	ad5	pol	A501E	trust		4.6											Sequence changes in the human adenovirus type 5 DNA polymerase associated with resistance to the broad spectrum antiviral cidofovir	https://www.sciencedirect.com/science/article/pii/S0166354202000980	doi.org/10.1016/S0166-3542(02)00098-0	Isolated strain 	PRA			04/02/2021	OJCharles	originally  A359E		A
1390	Adeno	ad5	pol	L554F			Resistant											Sequence changes in the human adenovirus type 5 DNA polymerase associated with resistance to the broad spectrum antiviral cidofovir	https://www.sciencedirect.com/science/article/pii/S0166354202000980	doi.org/10.1016/S0166-3542(02)00098-0	Isolated strain 	PRA	pol	A501E,V817L	04/02/2021	OJCharles	co-occuring uncharacterised mutations - cannot find refseq homolog		O
1391	Adeno	ad5	pol	V817L			Resistant											Sequence changes in the human adenovirus type 5 DNA polymerase associated with resistance to the broad spectrum antiviral cidofovir	https://www.sciencedirect.com/science/article/pii/S0166354202000980	doi.org/10.1016/S0166-3542(02)00098-0	Isolated strain 	PRA	pol	A501E, L554F	04/02/2021	OJCharles	co-occuring uncharacterised mutations		O
1392	Adeno	ad5	pol	T87I			1.9		2.1									"Cidofovir Diphosphate Inhibits Adenovirus 5 DNA Polymerase
via both Nonobligate Chain Termination and Direct Inhibition, and Polymerase Mutations Confer Cidofovir Resistance on Intact Virus" https://aac.asm.org/content/aac/63/1/e01925-18.full.pdf	doi.org/10.1128/AAC.01925-18.	Lab induced strain 		pol	V303I	04/02/2021	OJCharles	co-occuring uncharacterised mutations		O
1393	Adeno	ad5	pol	M689V	nucleotide generic	4	4					4						Selective Modification of Adenovirus Replication Can Be Achieved through Rational Mutagenesis of the Adenovirus Type 5 DNA Polymerase	https://jvi.asm.org/content/jvi/86/19/10484.full.pdf	doi.org/10.1128/JVI.00739-12	Marker Transfer 	TK functional kinetic assay			04/02/2021	OJCharles	this is not resistance data		O
1394	Adeno	ad5	pol	C687S	nucleotide generic	4	4					4						Selective Modification of Adenovirus Replication Can Be Achieved through Rational Mutagenesis of the Adenovirus Type 5 DNA Polymerase	https://jvi.asm.org/content/jvi/86/19/10484.full.pdf	doi.org/10.1128/JVI.00739-12	Marker Transfer 	TK functional kinetic assay			04/02/2021	OJCharles	this is not resistance data		O
1395	Adeno	ad5	pol	R665K	nucleotide generic	4	4					4						Selective Modification of Adenovirus Replication Can Be Achieved through Rational Mutagenesis of the Adenovirus Type 5 DNA Polymerase	https://jvi.asm.org/content/jvi/86/19/10484.full.pdf	doi.org/10.1128/JVI.00739-12	Marker Transfer 	TK functional kinetic assay			04/02/2021	OJCharles	this is not resistance data		O
1396	Adeno	ad5	pol	I664V	nucleotide generic	2.5	2.5					2.5						Selective Modification of Adenovirus Replication Can Be Achieved through Rational Mutagenesis of the Adenovirus Type 5 DNA Polymerase	https://jvi.asm.org/content/jvi/86/19/10484.full.pdf	doi.org/10.1128/JVI.00739-12	Marker Transfer 	TK functional kinetic assay			04/02/2021	OJCharles	this is not resistance data - Don’t trust this it was not repruceable between cell lines		O
1397	Adeno	ad5	pol	I664M	nucleotide generic	1.7	1.7					1.7						Selective Modification of Adenovirus Replication Can Be Achieved through Rational Mutagenesis of the Adenovirus Type 5 DNA Polymerase	https://jvi.asm.org/content/jvi/86/19/10484.full.pdf	doi.org/10.1128/JVI.00739-12	Marker Transfer 	TK functional kinetic assay			04/02/2021	OJCharles	this is not resistance data		O
1398	HSV1		UL23	E83K		37						71						Intracellular uptake of thymidine and antiherpetic drugs for thymidine kinase-deficient mutants of herpes simplex virus type 1	https://www.sciencedirect.com/science/article/pii/S0166354206000313?via%3Dihub	doi.org/10.1016/j.antiviral.2006.01.010	Marker Transfer 	TK functional kinetic assay			29/01/2021	OJCharles			A
1399	HSV1		UL23	A189V		48						6.8						Intracellular uptake of thymidine and antiherpetic drugs for thymidine kinase-deficient mutants of herpes simplex virus type 1	https://www.sciencedirect.com/science/article/pii/S0166354206000313?via%3Dihub	doi.org/10.1016/j.antiviral.2006.01.010	Marker Transfer 	TK functional kinetic assay			29/01/2021	OJCharles			A
1400	HSV1		UL23	R216C		37						21						Intracellular uptake of thymidine and antiherpetic drugs for thymidine kinase-deficient mutants of herpes simplex virus type 1	https://www.sciencedirect.com/science/article/pii/S0166354206000313?via%3Dihub	doi.org/10.1016/j.antiviral.2006.01.010	Marker Transfer 	TK functional kinetic assay			29/01/2021	OJCharles			A
1401	HSV1		UL23	R163H		42						10						Intracellular uptake of thymidine and antiherpetic drugs for thymidine kinase-deficient mutants of herpes simplex virus type 1	https://www.sciencedirect.com/science/article/pii/S0166354206000313?via%3Dihub	doi.org/10.1016/j.antiviral.2006.01.010	Marker Transfer 	TK functional kinetic assay			29/01/2021	OJCharles			A
1402	HSV1	Clinical isolate	UL23	P57H		42												Phenotypic and Genotypic Characterization of Acyclovir-Resistant Herpes Simplex Viruses from Immunocompromised Patients	https://academic.oup.com/jid/article/178/2/297/904713	doi.org/10.1086/515626	Isolated strain 	dye uptake assay			04/02/2021	OJCharles		A2	A
1403	HSV1	Clinical isolate	UL23	K62N		12												Phenotypic and Genotypic Characterization of Acyclovir-Resistant Herpes Simplex Viruses from Immunocompromised Patients	https://academic.oup.com/jid/article/178/2/297/904713	doi.org/10.1086/515626	Isolated strain 	PCR DNA hybridization assay			04/02/2021	OJCharles		A2	A
1404	HSV1	Clinical isolate	UL23	K62N		21												Phenotypic and Genotypic Characterization of Acyclovir-Resistant Herpes Simplex Viruses from Immunocompromised Patients	https://academic.oup.com/jid/article/178/2/297/904713	doi.org/10.1086/515626	Isolated strain 	dye uptake assay			04/02/2021	OJCharles		A2	A
1405	HSV1	Clinical isolate	UL23	K62N		34												Phenotypic and Genotypic Characterization of Acyclovir-Resistant Herpes Simplex Viruses from Immunocompromised Patients	https://academic.oup.com/jid/article/178/2/297/904713	doi.org/10.1086/515626	Isolated strain 	dye uptake assay			04/02/2021	OJCharles		A2	A
1406	HSV1	Clinical isolate	UL23	T63I		11												Phenotypic and Genotypic Characterization of Acyclovir-Resistant Herpes Simplex Viruses from Immunocompromised Patients	https://academic.oup.com/jid/article/178/2/297/904713	doi.org/10.1086/515626	Isolated strain 	dye uptake assay			04/02/2021	OJCharles		A2	A
1407	HSV1	Clinical isolate	UL23	D228stop		36												Phenotypic and Genotypic Characterization of Acyclovir-Resistant Herpes Simplex Viruses from Immunocompromised Patients	https://academic.oup.com/jid/article/178/2/297/904713	doi.org/10.1086/515626	Isolated strain 	dye uptake assay			04/02/2021	OJCharles		A2	A
1408	HSV1	Clinical isolate	UL23	D228stop		24												Phenotypic and Genotypic Characterization of Acyclovir-Resistant Herpes Simplex Viruses from Immunocompromised Patients	https://academic.oup.com/jid/article/178/2/297/904713	doi.org/10.1086/515626	Isolated strain 	PCR DNA hybridization assay			04/02/2021	OJCharles		A2	A
1409	HSV2	Clinical isolate	UL23	T131P		25												Phenotypic and Genotypic Characterization of Acyclovir-Resistant Herpes Simplex Viruses from Immunocompromised Patients	https://academic.oup.com/jid/article/178/2/297/904713	doi.org/10.1086/515626	Isolated strain 	dye uptake assay			04/02/2021	OJCharles		A2	A
1410	HSV1	Clinical isolate	UL23	T201P		22												Phenotypic and Genotypic Characterization of Acyclovir-Resistant Herpes Simplex Viruses from Immunocompromised Patients	https://academic.oup.com/jid/article/178/2/297/904713	doi.org/10.1086/515626	Isolated strain 	dye uptake assay			04/02/2021	OJCharles		A2	A
1411	HSV1	Clinical isolate	UL23	R216C		16												Phenotypic and Genotypic Characterization of Acyclovir-Resistant Herpes Simplex Viruses from Immunocompromised Patients	https://academic.oup.com/jid/article/178/2/297/904713	doi.org/10.1086/515626	Isolated strain 	PCR DNA hybridization assay			04/02/2021	OJCharles		A2	A
1412	HSV1	Clinical isolate	UL23	R216C		27												Phenotypic and Genotypic Characterization of Acyclovir-Resistant Herpes Simplex Viruses from Immunocompromised Patients	https://academic.oup.com/jid/article/178/2/297/904713	doi.org/10.1086/515626	Isolated strain 	dye uptake assay			04/02/2021	OJCharles		A2	A
1413	HSV1	Clinical isolate	UL23	R222C		7.1												Phenotypic and Genotypic Characterization of Acyclovir-Resistant Herpes Simplex Viruses from Immunocompromised Patients	https://academic.oup.com/jid/article/178/2/297/904713	doi.org/10.1086/515626	Isolated strain 	PCR DNA hybridization assay			04/02/2021	OJCharles		A2	A
1414	HSV1	Clinical isolate	UL23	R222C		9.8												Phenotypic and Genotypic Characterization of Acyclovir-Resistant Herpes Simplex Viruses from Immunocompromised Patients	https://academic.oup.com/jid/article/178/2/297/904713	doi.org/10.1086/515626	Isolated strain 	dye uptake assay			04/02/2021	OJCharles		A2	A
1415	HSV1	Clinical isolate	UL23	A156T		Polymorphism		Polymorphism										Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			07/01/2021	OJCharles	mutations not resolved by sequence	MacIntyre	A
1416	HSV1	Clinical isolate	UL23	C336Y		14												Highly Reliable Heterologous System for Evaluating Resistance of Clinical Herpes Simplex Virus Isolates to Nucleoside Analogues	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC114104/	doi.org/10.1128/JVI.75.7.3105-3110.2001	Isolated strain 	PRA			04/02/2021	OJCharles			A
1417	HSV1	Clinical isolate	UL23	R222C		25												Highly Reliable Heterologous System for Evaluating Resistance of Clinical Herpes Simplex Virus Isolates to Nucleoside Analogues	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC114104/	doi.org/10.1128/JVI.75.7.3105-3110.2001	Isolated strain 	PRA			04/02/2021	OJCharles			A
1418	HSV2	Clinical isolate	UL23	T131P		21												Highly Reliable Heterologous System for Evaluating Resistance of Clinical Herpes Simplex Virus Isolates to Nucleoside Analogues	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC114104/	doi.org/10.1128/JVI.75.7.3105-3110.2001	Isolated strain 	PRA			04/02/2021	OJCharles			A
1419	HSV1	Clinical isolate	UL23	R176Q		8.9												Highly Reliable Heterologous System for Evaluating Resistance of Clinical Herpes Simplex Virus Isolates to Nucleoside Analogues	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC114104/	doi.org/10.1128/JVI.75.7.3105-3110.2001	Isolated strain 	PRA			04/02/2021	OJCharles			A
1420	HSV1	Clinical isolate	UL23	Y172C		Resistant												Screening of herpes simplex virus type 1 isolates for acyclovir resistance using DiviTum assay	https://www.sciencedirect.com/science/article/pii/S0166093412004351?via%3Dihub	doi.org/10.1016/j.jviromet.2012.12.001	Isolated strain 	indirect ELISA			04/02/2021	OJCharles			A
1421	HSV1	Clinical isolate	UL23	L315S		Resistant												Screening of herpes simplex virus type 1 isolates for acyclovir resistance using DiviTum assay	https://www.sciencedirect.com/science/article/pii/S0166093412004351?via%3Dihub	doi.org/10.1016/j.jviromet.2012.12.001	Isolated strain 	indirect ELISA			04/02/2021	OJCharles			A
1422	HSV1	Clinical isolate	UL23	A174P		Resistant												Screening of herpes simplex virus type 1 isolates for acyclovir resistance using DiviTum assay	https://www.sciencedirect.com/science/article/pii/S0166093412004351?via%3Dihub	doi.org/10.1016/j.jviromet.2012.12.001	Isolated strain 	indirect ELISA			04/02/2021	OJCharles			A
1423	HSV1	Clinical isolate	UL23	Y53C		Resistant												Screening of herpes simplex virus type 1 isolates for acyclovir resistance using DiviTum assay	https://www.sciencedirect.com/science/article/pii/S0166093412004351?via%3Dihub	doi.org/10.1016/j.jviromet.2012.12.001	Isolated strain 	indirect ELISA			04/02/2021	OJCharles			A
1424	HSV1	Clinical isolate	UL23	E83N		Resistant												Screening of herpes simplex virus type 1 isolates for acyclovir resistance using DiviTum assay	https://www.sciencedirect.com/science/article/pii/S0166093412004351?via%3Dihub	doi.org/10.1016/j.jviromet.2012.12.001	Isolated strain 	indirect ELISA			04/02/2021	OJCharles	assumed typo in wt aa not position was Y83N		A
1425	HSV1	Clinical isolate	UL23	T245M		Resistant												Screening of herpes simplex virus type 1 isolates for acyclovir resistance using DiviTum assay	https://www.sciencedirect.com/science/article/pii/S0166093412004351?via%3Dihub	doi.org/10.1016/j.jviromet.2012.12.001	Isolated strain 	indirect ELISA			04/02/2021	OJCharles			A
1426	HSV1	Clinical isolate	UL23	L208H		Resistant												Screening of herpes simplex virus type 1 isolates for acyclovir resistance using DiviTum assay	https://www.sciencedirect.com/science/article/pii/S0166093412004351?via%3Dihub	doi.org/10.1016/j.jviromet.2012.12.001	Isolated strain 	indirect ELISA			04/02/2021	OJCharles			A
1427	HSV1	Clinical isolate	UL23	A156V		Resistant												Screening of herpes simplex virus type 1 isolates for acyclovir resistance using DiviTum assay	https://www.sciencedirect.com/science/article/pii/S0166093412004351?via%3Dihub	doi.org/10.1016/j.jviromet.2012.12.001	Isolated strain 	indirect ELISA			04/02/2021	OJCharles			A
1428	HSV1	Clinical isolate	UL23	V348I		Resistant												Screening of herpes simplex virus type 1 isolates for acyclovir resistance using DiviTum assay	https://www.sciencedirect.com/science/article/pii/S0166093412004351?via%3Dihub	doi.org/10.1016/j.jviromet.2012.12.001	Isolated strain 	indirect ELISA			04/02/2021	OJCharles			A
1429	HSV1	Clinical isolate	UL23	M121R		Resistant												Screening of herpes simplex virus type 1 isolates for acyclovir resistance using DiviTum assay	https://www.sciencedirect.com/science/article/pii/S0166093412004351?via%3Dihub	doi.org/10.1016/j.jviromet.2012.12.001	Isolated strain 	indirect ELISA			04/02/2021	OJCharles			A
1430	HSV1	Clinical isolate	UL23	G200C		Resistant												Screening of herpes simplex virus type 1 isolates for acyclovir resistance using DiviTum assay	https://www.sciencedirect.com/science/article/pii/S0166093412004351?via%3Dihub	doi.org/10.1016/j.jviromet.2012.12.001	Isolated strain 	indirect ELISA			04/02/2021	OJCharles			A
1431	HSV1	Clinical isolate	UL23	T103P		Resistant												Screening of herpes simplex virus type 1 isolates for acyclovir resistance using DiviTum assay	https://www.sciencedirect.com/science/article/pii/S0166093412004351?via%3Dihub	doi.org/10.1016/j.jviromet.2012.12.001	Isolated strain 	indirect ELISA			04/02/2021	OJCharles			A
1432	HSV1	Clinical isolate	UL23	T287M		Resistant												Screening of herpes simplex virus type 1 isolates for acyclovir resistance using DiviTum assay	https://www.sciencedirect.com/science/article/pii/S0166093412004351?via%3Dihub	doi.org/10.1016/j.jviromet.2012.12.001	Isolated strain 	indirect ELISA			04/02/2021	OJCharles			A
1433	HSV1	AB047358	UL23	T65N		4.7												Association between sensitivity of viral thymidine kinase-associated acyclovir-resistant herpes simplex virus type 1 and virulence	https://virologyj.biomedcentral.com/articles/10.1186/s12985-017-0728-2	doi.org/10.1186/s12985-017-0728-2	Marker Transfer 	PRA			04/02/2021	OJCharles			A
1434	HSV1	AB047358	UL23	P84S		10												Association between sensitivity of viral thymidine kinase-associated acyclovir-resistant herpes simplex virus type 1 and virulence	https://virologyj.biomedcentral.com/articles/10.1186/s12985-017-0728-2	doi.org/10.1186/s12985-017-0728-2	Marker Transfer 	PRA			04/02/2021	OJCharles			A
1435	HSV1	AB047358	UL23	T245M		6.5												Association between sensitivity of viral thymidine kinase-associated acyclovir-resistant herpes simplex virus type 1 and virulence	https://virologyj.biomedcentral.com/articles/10.1186/s12985-017-0728-2	doi.org/10.1186/s12985-017-0728-2	Marker Transfer 	PRA			04/02/2021	OJCharles			A
1436	HSV1	AB047358	UL23	C336Y		4.7												Association between sensitivity of viral thymidine kinase-associated acyclovir-resistant herpes simplex virus type 1 and virulence	https://virologyj.biomedcentral.com/articles/10.1186/s12985-017-0728-2	doi.org/10.1186/s12985-017-0728-2	Marker Transfer 	PRA			04/02/2021	OJCharles			A
1437	HSV1	Clinical isolate	UL23	H105P		131		0.8										Rapid susceptibility testing for herpes simplex virus type 1 using real-time PCR	https://www.sciencedirect.com/science/article/pii/S1386653212003502?via%3Dihub	doi.org/10.1016/j.jcv.2012.09.004	Isolated strain 	PRA			04/02/2021	OJCharles			A
1438	HSV1	Clinical isolate	UL30	S724N		72		4										Rapid susceptibility testing for herpes simplex virus type 1 using real-time PCR	https://www.sciencedirect.com/science/article/pii/S1386653212003502?via%3Dihub	doi.org/10.1016/j.jcv.2012.09.004	Isolated strain 	PRA			04/02/2021	OJCharles			A
1439	HSV1	Clinical isolate	UL23	N376H		Polymorphism												Acyclovir Susceptibility and Genetic Characteristics of Sequential Herpes Simplex Virus Type 1 Corneal Isolates from Patients with Recurrent Herpetic Keratitis	https://academic.oup.com/jid/article/200/9/1402/851413	doi.org/10.1086/606028	Isolated strain 	PCR DNA hybridization assay			04/02/2021	OJCharles	Only sequences TK, so any Pol mutations are unnacounted for	KOS	A
1440	HSV1	Clinical isolate	UL23	L170P		Resistant												Single nucleotide polymorphisms of thymidine kinase and DNA polymerase genes in clinical herpes simplex virus type 1 isolates associated with different resistance phenotypes	https://www.sciencedirect.com/science/article/pii/S0166354214000898?via%3Dihub	doi.org/10.1016/j.antiviral.2014.03.015	Isolated strain 	dye uptake assay			04/02/2021	OJCharles			A
1441	HSV1	Clinical isolate	UL23	R89Q		Polymorphism												Acyclovir-resistant herpes simplex virus type 1 in intra-ocular fluid samples of herpetic uveitis patients	https://www.sciencedirect.com/science/article/pii/S1386653213001157?via%3Dihub	doi.org/10.1016/j.jcv.2013.03.014	Isolated strain 	TK functional kinetic assay			04/02/2021	OJCharles	co-ocurs with 138vi and 322ml which are polymorphisms	KOS	A
1442	HSV1	Clinical isolate	UL23	V138I		Polymorphism												Acyclovir-resistant herpes simplex virus type 1 in intra-ocular fluid samples of herpetic uveitis patients	https://www.sciencedirect.com/science/article/pii/S1386653213001157?via%3Dihub	doi.org/10.1016/j.jcv.2013.03.014	Isolated strain 	TK functional kinetic assay			04/02/2021	OJCharles		KOS	A
1443	HSV1	Clinical isolate	UL23	G240E		Polymorphism												Acyclovir-resistant herpes simplex virus type 1 in intra-ocular fluid samples of herpetic uveitis patients	https://www.sciencedirect.com/science/article/pii/S1386653213001157?via%3Dihub	doi.org/10.1016/j.jcv.2013.03.014	Isolated strain 	TK functional kinetic assay			04/02/2021	OJCharles		KOS	A
1444	HSV1	Clinical isolate	UL23	S345P		Polymorphism												Acyclovir-resistant herpes simplex virus type 1 in intra-ocular fluid samples of herpetic uveitis patients	https://www.sciencedirect.com/science/article/pii/S1386653213001157?via%3Dihub	doi.org/10.1016/j.jcv.2013.03.014	Isolated strain 	TK functional kinetic assay			04/02/2021	OJCharles		KOS	A
1445	HSV1	Clinical isolate	UL23	D162N		Resistant												Acyclovir-resistant herpes simplex virus type 1 in intra-ocular fluid samples of herpetic uveitis patients	https://www.sciencedirect.com/science/article/pii/S1386653213001157?via%3Dihub	doi.org/10.1016/j.jcv.2013.03.014	Isolated strain 	TK functional kinetic assay			04/02/2021	OJCharles		KOS	A
1446	HSV1	Clinical isolate	UL23	P173L		Resistant												Acyclovir-resistant herpes simplex virus type 1 in intra-ocular fluid samples of herpetic uveitis patients	https://www.sciencedirect.com/science/article/pii/S1386653213001157?via%3Dihub	doi.org/10.1016/j.jcv.2013.03.014	Isolated strain 	TK functional kinetic assay			04/02/2021	OJCharles	many co occuring mutations	KOS	O
1447	HSV1	Clinical isolate	UL23	M182stop		Resistant												Acyclovir-resistant herpes simplex virus type 1 in intra-ocular fluid samples of herpetic uveitis patients	https://www.sciencedirect.com/science/article/pii/S1386653213001157?via%3Dihub	doi.org/10.1016/j.jcv.2013.03.014	Isolated strain 	TK functional kinetic assay			04/02/2021	OJCharles		KOS	A
1448	HSV1	Clinical isolate	UL23	R216H		Resistant												Acyclovir-resistant herpes simplex virus type 1 in intra-ocular fluid samples of herpetic uveitis patients	https://www.sciencedirect.com/science/article/pii/S1386653213001157?via%3Dihub	doi.org/10.1016/j.jcv.2013.03.014	Isolated strain 	TK functional kinetic assay			04/02/2021	OJCharles		KOS	A
1449	HSV1	Clinical isolate	UL23	R220H		Resistant												Acyclovir-resistant herpes simplex virus type 1 in intra-ocular fluid samples of herpetic uveitis patients	https://www.sciencedirect.com/science/article/pii/S1386653213001157?via%3Dihub	doi.org/10.1016/j.jcv.2013.03.014	Isolated strain 	TK functional kinetic assay			04/02/2021	OJCharles		KOS	A
1450	HSV1		UL30	Y818C		50	2.3	2.3			0.8	2.9						Characterization of DNA Polymerase-Associated Acyclovir-Resistant Herpes Simplex Virus Type 1: Mutations, Sensitivity to Antiviral Compounds, Neurovirulence, and In-Vivo Sensitivity to Treatment	https://www.jstage.jst.go.jp/article/yoken/66/5/66_404/_pdf/-char/en	doi.org/10.7883/yoken.66.404	Lab induced strain 	PRA			04/02/2021	OJCharles			A
1451	HSV1		UL30	N815S		600	0.5	2.3			2.5	2.9						Characterization of DNA Polymerase-Associated Acyclovir-Resistant Herpes Simplex Virus Type 1: Mutations, Sensitivity to Antiviral Compounds, Neurovirulence, and In-Vivo Sensitivity to Treatment	https://www.jstage.jst.go.jp/article/yoken/66/5/66_404/_pdf/-char/en	doi.org/10.7883/yoken.66.404	Lab induced strain 	PRA			04/02/2021	OJCharles			A
1452	HSV1		UL30	V817M		36	0.8	2.3			0.8	1.5						Characterization of DNA Polymerase-Associated Acyclovir-Resistant Herpes Simplex Virus Type 1: Mutations, Sensitivity to Antiviral Compounds, Neurovirulence, and In-Vivo Sensitivity to Treatment	https://www.jstage.jst.go.jp/article/yoken/66/5/66_404/_pdf/-char/en	doi.org/10.7883/yoken.66.404	Lab induced strain 	PRA			04/02/2021	OJCharles			A
1453	HSV1		UL30	G841C		24	1	2.3			0.3	1.4						Characterization of DNA Polymerase-Associated Acyclovir-Resistant Herpes Simplex Virus Type 1: Mutations, Sensitivity to Antiviral Compounds, Neurovirulence, and In-Vivo Sensitivity to Treatment	https://www.jstage.jst.go.jp/article/yoken/66/5/66_404/_pdf/-char/en	doi.org/10.7883/yoken.66.404	Lab induced strain 	PRA			04/02/2021	OJCharles			A
1454	HSV1		UL30	L702H		56	0.5	2.3			0.5	1.2						Characterization of DNA Polymerase-Associated Acyclovir-Resistant Herpes Simplex Virus Type 1: Mutations, Sensitivity to Antiviral Compounds, Neurovirulence, and In-Vivo Sensitivity to Treatment	https://www.jstage.jst.go.jp/article/yoken/66/5/66_404/_pdf/-char/en	doi.org/10.7883/yoken.66.404	Lab induced strain 	PRA			04/02/2021	OJCharles			A
1455	HSV1	Clinical isolate	UL23	P268T		Polymorphism												Genetic Characterization of Thymidine Kinase from Acyclovir-Resistant and -Susceptible Herpes Simplex Virus Type 1 Isolated from Bone Marrow Transplant Recipients	https://academic.oup.com/jid/article/182/1/290/883239	doi.org/10.1086/315696	Isolated strain 	dye uptake assay			04/02/2021	OJCharles			A
1456	HSV1	Clinical isolate	UL23	D286E		Polymorphism												Genetic Characterization of Thymidine Kinase from Acyclovir-Resistant and -Susceptible Herpes Simplex Virus Type 1 Isolated from Bone Marrow Transplant Recipients	https://academic.oup.com/jid/article/182/1/290/883239	doi.org/10.1086/315696	Isolated strain 	dye uptake assay			04/02/2021	OJCharles			A
1457	HSV1	Clinical isolate	UL23	N376H		Polymorphism												Genetic Characterization of Thymidine Kinase from Acyclovir-Resistant and -Susceptible Herpes Simplex Virus Type 1 Isolated from Bone Marrow Transplant Recipients	https://academic.oup.com/jid/article/182/1/290/883239	doi.org/10.1086/315696	Isolated strain 	dye uptake assay			04/02/2021	OJCharles			A
1458	HSV1	Clinical isolate	UL23	N376H		Polymorphism												Genetic Characterization of Thymidine Kinase from Acyclovir-Resistant and -Susceptible Herpes Simplex Virus Type 1 Isolated from Bone Marrow Transplant Recipients	https://academic.oup.com/jid/article/182/1/290/883239	doi.org/10.1086/315696	Isolated strain 	dye uptake assay			04/02/2021	OJCharles			A
1459	HSV1		UL30	R881G		1.3		1										Resistance to Antiviral Inhibitors Caused by the Mutation S889A in the Highly-Conserved 885-GDTDS Motif of the Herpes Simplex Virus Type 1 DNA Polymerase	https://www.sciencedirect.com/science/article/pii/S004268228371439X?via%3Dihub	doi.org/10.1006/viro.1993.1439	Marker transfer 	PCR DNA hybridization assay			04/02/2021	OJCharles			A
1460	HSV1	KOS	UL23	R51W		Resistant	Polymorphism	Polymorphism			 	Resistant						Characterization of Herpes Simplex Virus Type 1 Thymidine Kinase Mutants Selected under a Single Round of High-Dose Brivudin	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1082774/#r5	doi.org/10.1128/JVI.79.9.5863-5869.2005	Lab induced strain 	PRA			04/02/2021	OJCharles		KOS	A
1480	HSV1	Clinical isolate	UL23	M130I		5												Phenotypic and genotypic characterization of induced acyclovir-resistant clinical isolates of herpes simplex virus type 1	https://www.sciencedirect.com/science/article/pii/S0166354213002544?via%3Dihub	doi.org/10.1016/j.antiviral.2013.09.008	Isolated strain 	PRA			04/02/2021	OJCharles			A
1481	HSV1	TAS	UL23	C336Y		120	0.2											Genotypic and phenotypic characterization of the thymidine kinase of ACV-resistant HSV-1 derived from an acyclovir-sensitive herpes simplex virus type 1 strain	https://www.sciencedirect.com/science/article/pii/S0166354202001316?via%3Dihub	doi.org/10.1016/S0166-3542(02)00131-6	Lab induced strain 	PRA			04/02/2021	OJCharles			A
1482	HSV1		UL23	T287M		500	1	0.3			1670	300						Characterization of Herpes Simplex Viruses Selected in Culture for Resistance to Penciclovir or Acyclovir	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC114085/	doi.org/10.1128/JVI.75.4.1761-1769.2001	Lab induced strain 	PRA			04/02/2021	OJCharles			A
1483	HSV1	SC16	UL30	A719V		19		10										Related functional domains in virus DNA polymerases	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC553373/pdf/emboj00241-0168.pdf		Lab induced strain 	PRA			04/02/2021	OJCharles			A
1484	HSV1	SC16	UL30	G355D		Polymorphism												Related functional domains in virus DNA polymerases	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC553373/pdf/emboj00241-0168.pdf		Lab induced strain 	PRA			04/02/2021	OJCharles	Occurs only along with a co-resistant mutation		O
1485	HSV1	Clinical isolate	UL23	D162H		Resistant												Survey of acyclovir-resistant herpes simplex virus in the Netherlands: prevalence and characterization	https://www.sciencedirect.com/science/article/pii/S1386653204001246?via%3Dihub	doi.org/10.1016/j.jcv.2004.04.002	Isolated strain 	yield reduction assay (ELVIRA)			04/02/2021	OJCharles			A
1486	HSV1		UL23	R176Q		4.1												Survey of acyclovir-resistant herpes simplex virus in the Netherlands: prevalence and characterization	https://www.sciencedirect.com/science/article/pii/S1386653204001246?via%3Dihub	doi.org/10.1016/j.jcv.2004.04.002	Isolated strain 	yield reduction assay (ELVIRA)			04/02/2021	OJCharles			A
1487	HSV2		UL23	D229H		181												Survey of acyclovir-resistant herpes simplex virus in the Netherlands: prevalence and characterization	https://www.sciencedirect.com/science/article/pii/S1386653204001246?via%3Dihub	doi.org/10.1016/j.jcv.2004.04.002	Isolated strain 	yield reduction assay (ELVIRA)			04/02/2021	OJCharles			A
1488	HSV2		UL23	T288M		30												Survey of acyclovir-resistant herpes simplex virus in the Netherlands: prevalence and characterization	https://www.sciencedirect.com/science/article/pii/S1386653204001246?via%3Dihub	doi.org/10.1016/j.jcv.2004.04.002	Isolated strain 	yield reduction assay (ELVIRA)			04/02/2021	OJCharles			A
1489	HSV2		UL23	G56E		Resistant												Survey of acyclovir-resistant herpes simplex virus in the Netherlands: prevalence and characterization	https://www.sciencedirect.com/science/article/pii/S1386653204001246?via%3Dihub	doi.org/10.1016/j.jcv.2004.04.002	Isolated strain 	yield reduction assay (ELVIRA)			04/02/2021	OJCharles			A
1490	HSV1		UL23	R222H		20												Survey of acyclovir-resistant herpes simplex virus in the Netherlands: prevalence and characterization	https://www.sciencedirect.com/science/article/pii/S1386653204001246?via%3Dihub	doi.org/10.1016/j.jcv.2004.04.002	Isolated strain 	yield reduction assay (ELVIRA)	UL23	R363C	04/02/2021	OJCharles	unknwon comut		O
1491	HSV2		UL23	T202A		70		0.3										Survey of acyclovir-resistant herpes simplex virus in the Netherlands: prevalence and characterization	https://www.sciencedirect.com/science/article/pii/S1386653204001246?via%3Dihub	doi.org/10.1016/j.jcv.2004.04.002	Isolated strain 	yield reduction assay (ELVIRA)			04/02/2021	OJCharles			A
1492	HSV1		UL30	S724N		11												Resistance of herpes simplex virus type 1 against different phosphonylmethoxyalkyl derivatives of purines and pyrimidines due to specific mutations in the viral DNA polymerase gene	https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-81-3-639#tab2	doi.org/10.1099/0022-1317-81-3-639	Lab induced strain 	PRA			04/02/2021	OJCharles			A
1493	HSV1		UL30	A136T		Polymorphism		Polymorphism										Resistance of herpes simplex virus type 1 against different phosphonylmethoxyalkyl derivatives of purines and pyrimidines due to specific mutations in the viral DNA polymerase gene	https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-81-3-639#tab2	doi.org/10.1099/0022-1317-81-3-639	Lab induced strain 	PRA			04/02/2021	OJCharles	R700M is poly in followup papers		A
1494	HSV1		UL30	L1007M		3.2												Resistance of herpes simplex virus type 1 against different phosphonylmethoxyalkyl derivatives of purines and pyrimidines due to specific mutations in the viral DNA polymerase gene	https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-81-3-639#tab2	doi.org/10.1099/0022-1317-81-3-639	Lab induced strain 	PRA			04/02/2021	OJCharles			A
1495	HSV1		UL30	I1028T		1.6		1.5										Resistance of herpes simplex virus type 1 against different phosphonylmethoxyalkyl derivatives of purines and pyrimidines due to specific mutations in the viral DNA polymerase gene	https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-81-3-639#tab2	doi.org/10.1099/0022-1317-81-3-639	Lab induced strain 	PRA			04/02/2021	OJCharles			A
1496	HSV1	KOS	UL30	A719V		4.2		2.3										DNA polymerase mutations in drug-resistant herpes simplex virus mutants determine in vivo neurovirulence and drug-enzyme interactions	https://journals.sagepub.com/doi/abs/10.1177/135965350701200502	doi.org/10.1177/1359653507012005	Lab induced strain 	Cytopathic effect			04/02/2021	OJCharles		KOS	A
1497	HSV1	KOS	UL30	S724N		6		4.7										DNA polymerase mutations in drug-resistant herpes simplex virus mutants determine in vivo neurovirulence and drug-enzyme interactions	https://journals.sagepub.com/doi/abs/10.1177/135965350701200502	doi.org/10.1177/1359653507012005	Lab induced strain 	Cytopathic effect			04/02/2021	OJCharles		KOS	A
1498	HSV1	KOS	UL30	T821M		4.7		2.9										DNA polymerase mutations in drug-resistant herpes simplex virus mutants determine in vivo neurovirulence and drug-enzyme interactions	https://journals.sagepub.com/doi/abs/10.1177/135965350701200502	doi.org/10.1177/1359653507012005	Lab induced strain 	Cytopathic effect			04/02/2021	OJCharles		KOS	A
1499	HSV1	KOS	UL30	L1007M		2												DNA polymerase mutations in drug-resistant herpes simplex virus mutants determine in vivo neurovirulence and drug-enzyme interactions	https://journals.sagepub.com/doi/abs/10.1177/135965350701200502	doi.org/10.1177/1359653507012005	Lab induced strain 	Cytopathic effect			04/02/2021	OJCharles		KOS	A
1500	HSV1	KOS	UL30	I1028T		1.5												DNA polymerase mutations in drug-resistant herpes simplex virus mutants determine in vivo neurovirulence and drug-enzyme interactions	https://journals.sagepub.com/doi/abs/10.1177/135965350701200502	doi.org/10.1177/1359653507012005	Lab induced strain 	Cytopathic effect			04/02/2021	OJCharles		KOS	A
1501	HSV1	KOS	UL30	A605V		4		10										Penciclovir and pathogenesis phenotypes of drug-resistant Herpes simplex virus mutants	https://www.sciencedirect.com/science/article/pii/S0166354297000545?via%3Dihub	doi.org/10.1016/S0166-3542(97)00054-5	Lab induced strain 	PRA			04/02/2021	OJCharles		KOS	A
1502	HSV1	KOS	UL30	S724N		8		6										Penciclovir and pathogenesis phenotypes of drug-resistant Herpes simplex virus mutants	https://www.sciencedirect.com/science/article/pii/S0166354297000545?via%3Dihub	doi.org/10.1016/S0166-3542(97)00054-5	Lab induced strain 	PRA			04/02/2021	OJCharles		KOS	A
1503	HSV1	KOS	UL30	F891C		10		10										Penciclovir and pathogenesis phenotypes of drug-resistant Herpes simplex virus mutants	https://www.sciencedirect.com/science/article/pii/S0166354297000545?via%3Dihub	doi.org/10.1016/S0166-3542(97)00054-5	Lab induced strain 	PRA			04/02/2021	OJCharles		KOS	A
1504	HSV1	KOS	UL30	N961K		4												Penciclovir and pathogenesis phenotypes of drug-resistant Herpes simplex virus mutants	https://www.sciencedirect.com/science/article/pii/S0166354297000545?via%3Dihub	doi.org/10.1016/S0166-3542(97)00054-5	Lab induced strain 	PRA			04/02/2021	OJCharles		KOS	A
1505	HSV1	TAS	UL30	N494S		Polymorphism												Genotypic Characterization of the DNA Polymerase and Sensitivity to Antiviral Compounds of Foscarnet-Resistant Herpes Simplex Virus Type 1 (HSV-1) Derived from a Foscarnet-Sensitive HSV-1 Strain	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC547286/	doi.org/10.1128/AAC.49.2.606-611.2005	Lab induced strain 	PRA			04/02/2021	OJCharles			A
1506	HSV1	TAS	UL30	L702I		1	0.1	3				1						Genotypic Characterization of the DNA Polymerase and Sensitivity to Antiviral Compounds of Foscarnet-Resistant Herpes Simplex Virus Type 1 (HSV-1) Derived from a Foscarnet-Sensitive HSV-1 Strain	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC547286/	doi.org/10.1128/AAC.49.2.606-611.2005	Lab induced strain 	PRA			04/02/2021	OJCharles			A
1507	HSV1	TAS	UL30	F716L		6	0.1	10				2.2						Genotypic Characterization of the DNA Polymerase and Sensitivity to Antiviral Compounds of Foscarnet-Resistant Herpes Simplex Virus Type 1 (HSV-1) Derived from a Foscarnet-Sensitive HSV-1 Strain	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC547286/	doi.org/10.1128/AAC.49.2.606-611.2005	Lab induced strain 	PRA			04/02/2021	OJCharles			A
1508	HSV1	TAS	UL30	A719V		5.5	0.3	8				2.5						Genotypic Characterization of the DNA Polymerase and Sensitivity to Antiviral Compounds of Foscarnet-Resistant Herpes Simplex Virus Type 1 (HSV-1) Derived from a Foscarnet-Sensitive HSV-1 Strain	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC547286/	doi.org/10.1128/AAC.49.2.606-611.2005	Lab induced strain 	PRA			04/02/2021	OJCharles			A
1509	HSV1	TAS	UL30	S724N		3	1	10				4						Genotypic Characterization of the DNA Polymerase and Sensitivity to Antiviral Compounds of Foscarnet-Resistant Herpes Simplex Virus Type 1 (HSV-1) Derived from a Foscarnet-Sensitive HSV-1 Strain	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC547286/	doi.org/10.1128/AAC.49.2.606-611.2005	Lab induced strain 	PRA			04/02/2021	OJCharles			A
1510	HSV1	TAS	UL30	L778M		2.6	1	5				2.5						Genotypic Characterization of the DNA Polymerase and Sensitivity to Antiviral Compounds of Foscarnet-Resistant Herpes Simplex Virus Type 1 (HSV-1) Derived from a Foscarnet-Sensitive HSV-1 Strain	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC547286/	doi.org/10.1128/AAC.49.2.606-611.2005	Lab induced strain 	PRA			04/02/2021	OJCharles			A
1511	HSV1	TAS	UL30	E798K		3												Genotypic Characterization of the DNA Polymerase and Sensitivity to Antiviral Compounds of Foscarnet-Resistant Herpes Simplex Virus Type 1 (HSV-1) Derived from a Foscarnet-Sensitive HSV-1 Strain	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC547286/	doi.org/10.1128/AAC.49.2.606-611.2005	Lab induced strain 	PRA			04/02/2021	OJCharles			A
1512	HSV1	TAS	UL30	A834S		2												Genotypic Characterization of the DNA Polymerase and Sensitivity to Antiviral Compounds of Foscarnet-Resistant Herpes Simplex Virus Type 1 (HSV-1) Derived from a Foscarnet-Sensitive HSV-1 Strain	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC547286/	doi.org/10.1128/AAC.49.2.606-611.2005	Lab induced strain 	PRA			04/02/2021	OJCharles			A
1513	HSV1	TAS	UL30	T839I		2.3												Genotypic Characterization of the DNA Polymerase and Sensitivity to Antiviral Compounds of Foscarnet-Resistant Herpes Simplex Virus Type 1 (HSV-1) Derived from a Foscarnet-Sensitive HSV-1 Strain	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC547286/	doi.org/10.1128/AAC.49.2.606-611.2005	Lab induced strain 	PRA			04/02/2021	OJCharles			A
1514	HSV1	TAS	UL30	A910V		4												Genotypic Characterization of the DNA Polymerase and Sensitivity to Antiviral Compounds of Foscarnet-Resistant Herpes Simplex Virus Type 1 (HSV-1) Derived from a Foscarnet-Sensitive HSV-1 Strain	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC547286/	doi.org/10.1128/AAC.49.2.606-611.2005	Lab induced strain 	PRA			04/02/2021	OJCharles			A
1515	HSV1	TAS	UL30	V958L		12												Genotypic Characterization of the DNA Polymerase and Sensitivity to Antiviral Compounds of Foscarnet-Resistant Herpes Simplex Virus Type 1 (HSV-1) Derived from a Foscarnet-Sensitive HSV-1 Strain	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC547286/	doi.org/10.1128/AAC.49.2.606-611.2005	Lab induced strain 	PRA			04/02/2021	OJCharles			A
1516	HSV1	TAS	UL30	R959H		4.6												Genotypic Characterization of the DNA Polymerase and Sensitivity to Antiviral Compounds of Foscarnet-Resistant Herpes Simplex Virus Type 1 (HSV-1) Derived from a Foscarnet-Sensitive HSV-1 Strain	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC547286/	doi.org/10.1128/AAC.49.2.606-611.2005	Lab induced strain 	PRA			04/02/2021	OJCharles			A
1517	HSV1		UL23	Y53D		Resistant												Impact of novel mutations of herpes simplex virus 1 and 2 thymidine kinases on acyclovir phosphorylation activity	https://www.sciencedirect.com/science/article/pii/S0166354212002239?via%3Dihub#b0010	doi.org/10.1016/j.antiviral.2012.09.016	Marker Transfer 	TK functional kinetic assay			04/02/2021	OJCharles			A
1518	HSV1		UL23	L170P		Resistant												Impact of novel mutations of herpes simplex virus 1 and 2 thymidine kinases on acyclovir phosphorylation activity	https://www.sciencedirect.com/science/article/pii/S0166354212002239?via%3Dihub#b0010	doi.org/10.1016/j.antiviral.2012.09.016	Marker Transfer 	TK functional kinetic assay			04/02/2021	OJCharles			A
1519	HSV1		UL23	A207P		Resistant												Impact of novel mutations of herpes simplex virus 1 and 2 thymidine kinases on acyclovir phosphorylation activity	https://www.sciencedirect.com/science/article/pii/S0166354212002239?via%3Dihub#b0010	doi.org/10.1016/j.antiviral.2012.09.016	Marker Transfer 	TK functional kinetic assay			04/02/2021	OJCharles			A
1520	HSV1	Clinical isolate	UL23	Y172C		80												Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay			04/02/2021	OJCharles			A
1521	HSV1	Clinical isolate	UL30	S724N		5												Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505214/	doi.org/10.1128/AAC.00977-15	Isolated strain 	PRA			04/02/2021	OJCharles		MacIntyre	A
1522	HSV1	Clinical isolate	UL23	N23S		Polymorphism												Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay			14/04/2021	OJCharles		Mackityre	A
1523	HSV1	Clinical isolate	UL23	K36E		Polymorphism												Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay			14/04/2021	OJCharles		Mackityre	A
1524	HSV1	Clinical isolate	UL23	L42P		Polymorphism												Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay			14/04/2021	OJCharles		Mackityre	A
1525	HSV1	Clinical isolate	UL23	G251C		Polymorphism												Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay			14/04/2021	OJCharles		Mackityre	A
1526	HSV1	Clinical isolate	UL23	A265T		Polymorphism												Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay			14/04/2021	OJCharles		Mackityre	A
1527	HSV1	Clinical isolate	UL23	V267L		Polymorphism												Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay			14/04/2021	OJCharles		Mackityre	A
1528	HSV1	Clinical isolate	UL23	P268T		Polymorphism												Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay			14/04/2021	OJCharles		Mackityre	A
1529	HSV1	Clinical isolate	UL23	D286E		Polymorphism												Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay			14/04/2021	OJCharles		Mackityre	A
1530	HSV1	Clinical isolate	UL23	N376H		Polymorphism												Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay			14/04/2021	OJCharles		Mackityre	A
1531	HSV1	Clinical isolate	UL23	V348I		Polymorphism												Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay			14/04/2021	OJCharles		Mackityre	A
1532	HSV1	Clinical isolate	UL30	F248L		Polymorphism												Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay			14/04/2021	OJCharles		Mackityre	A
1533	HSV1	Clinical isolate	UL30	A1203T		Polymorphism												Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay			14/04/2021	OJCharles		Mackityre	A
1534	HSV1	Clinical isolate	UL30	R330A		Polymorphism												Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay			14/04/2021	OJCharles		Mackityre	A
1535	HSV1	Clinical isolate	UL23	I143V		Resistant												Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay			04/02/2021	OJCharles	only co-occurs with unknown R256W	Mackityre	O
1536	HSV1	Clinical isolate	UL23	R256W		Resistant												Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay			04/02/2021	OJCharles	only co-occurs with unknown I143V	Mackityre	O
1537	HSV1	Clinical isolate	UL23	Y172C		Resistant	Polymorphism	Polymorphism			Resistant	Resistant						Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay			04/05/2021	OJCharles			A
1538	HSV1	Clinical isolate	UL23	A174P		Resistant												Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay	UL30	D1103H	04/02/2021	OJCharles	only co-occurs with unknown mutation		O
1539	HSV1	Clinical isolate	UL23	L315S		Resistant												Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay			04/02/2021	OJCharles			A
1540	HSV1	Clinical isolate	UL30	P1124H		Polymorphism												Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay			04/02/2021	OJCharles			A
1541	HSV1	Clinical isolate	UL30	T1208A		Polymorphism												Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay			04/02/2021	OJCharles			A
1542	HSV1	Clinical isolate	UL30	A566T		Polymorphism		Polymorphism										Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay			04/02/2021	OJCharles	Cannot be inferred		O
1543	HSV1	Clinical isolate	UL30	D1103H		Polymorphism	Polymorphism	Polymorphism			Polymorphism	Polymorphism						Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S0166354210003864?via%3Dihub	doi.org/10.1016/j.antiviral.2010.03.002	Isolated strain 	dye uptake assay			04/02/2021	OJCharles	Cannot be inferred		O
1544	HSV1	Clinical isolate	UL23	R222C		Resistant												Single nucleotide polymorphisms of thymidine kinase and DNA polymerase genes in clinical herpes simplex virus type 1 isolates associated with different resistance phenotypes	https://www.sciencedirect.com/science/article/pii/S0166354214000898?via%3Dihub	doi.org/10.1016/j.antiviral.2014.03.015	Isolated strain 	dye uptake assay			04/02/2021	OJCharles			A
1545	HSV1	Clinical isolate	UL23	G200D		25												Single nucleotide polymorphisms of thymidine kinase and DNA polymerase genes in clinical herpes simplex virus type 1 isolates associated with different resistance phenotypes	https://www.sciencedirect.com/science/article/pii/S0166354214000898?via%3Dihub	doi.org/10.1016/j.antiviral.2014.03.015	Isolated strain 	dye uptake assay			04/02/2021	OJCharles			A
1546	HSV1		UL23	P131S		20												Thymidine Kinase Mutations Conferring Acyclovir Resistance in Herpes Simplex Type 1 Recombinant Viruses	https://aac.asm.org/content/aac/50/11/3889.full.pdf	 doi.org/10.1128/AAC.00889-06	Marker transfer 	PRA			04/02/2021	OJCharles			A
1547	HSV1		UL23	C336Y		30												Thymidine Kinase Mutations Conferring Acyclovir Resistance in Herpes Simplex Type 1 Recombinant Viruses	https://aac.asm.org/content/aac/50/11/3889.full.pdf	 doi.org/10.1128/AAC.00889-06	Marker transfer 	PRA			04/02/2021	OJCharles			A
1548	HSV1	F	UL23	Q125H		13.3						5.3						Acyclovir Sensitivity and Neurovirulence of Herpes Simplex Virus Type 1 with Amino Acid Substitutions in the Viral Thymidine Kinase Gene, Which Were Detected in the Patients with Intractable Herpes Simplex Encephalitis Previously Reported	https://www.jstage.jst.go.jp/article/yoken/71/5/71_JJID.2018.176/_pdf/-char/en		Recombinant BAC 	PRA			04/02/2021	OJCharles		F	A
1549	HSV1	F	UL23	R41H		0.8												Acyclovir Sensitivity and Neurovirulence of Herpes Simplex Virus Type 1 with Amino Acid Substitutions in the Viral Thymidine Kinase Gene, Which Were Detected in the Patients with Intractable Herpes Simplex Encephalitis Previously Reported	https://www.jstage.jst.go.jp/article/yoken/71/5/71_JJID.2018.176/_pdf/-char/en		Recombinant BAC 	PRA			04/02/2021	OJCharles		F	A
1550	HSV1	F	UL23	A156V		0.9												Acyclovir Sensitivity and Neurovirulence of Herpes Simplex Virus Type 1 with Amino Acid Substitutions in the Viral Thymidine Kinase Gene, Which Were Detected in the Patients with Intractable Herpes Simplex Encephalitis Previously Reported	https://www.jstage.jst.go.jp/article/yoken/71/5/71_JJID.2018.176/_pdf/-char/en		Recombinant BAC 	PRA			04/02/2021	OJCharles		F	A
1551	HSV1	Clinical isolate	UL23	A37V		Polymorphism												HSV susceptibility to acyclovir - genotypic and phenotypic characterization	https://journals.sagepub.com/doi/10.3851/IMP3279	doi.org/10.3851/IMP3279	Isolated strain 	PRA			04/02/2021	OJCharles			A
1552	HSV1	Clinical isolate	UL23	H283N		Polymorphism												HSV susceptibility to acyclovir - genotypic and phenotypic characterization	https://journals.sagepub.com/doi/10.3851/IMP3279	doi.org/10.3851/IMP3279	Isolated strain 	PRA			04/02/2021	OJCharles			A
1553	HSV1	Clinical isolate	UL30	G641R		1		Polymorphism										UL23, UL30, and UL5 characterization of HSV1 clinical strains isolated from hematology department patients	https://www.sciencedirect.com/science/article/pii/S0166354219300452?via%3Dihub	doi.org/10.1016/j.antiviral.2019.05.012	Isolated strain 	dye uptake assay			04/02/2021	OJCharles			A
1554	HSV1	Clinical isolate	UL30	G645D		1		Polymorphism										UL23, UL30, and UL5 characterization of HSV1 clinical strains isolated from hematology department patients	https://www.sciencedirect.com/science/article/pii/S0166354219300452?via%3Dihub	doi.org/10.1016/j.antiviral.2019.05.012	Isolated strain 	dye uptake assay			04/02/2021	OJCharles			A
1555	HSV1	Clinical isolate	UL30	E649G		1.3		Polymorphism										UL23, UL30, and UL5 characterization of HSV1 clinical strains isolated from hematology department patients	https://www.sciencedirect.com/science/article/pii/S0166354219300452?via%3Dihub	doi.org/10.1016/j.antiviral.2019.05.012	Isolated strain 	dye uptake assay			04/02/2021	OJCharles			A
1556	HSV1	Clinical isolate	UL30	G679D		1		Polymorphism										UL23, UL30, and UL5 characterization of HSV1 clinical strains isolated from hematology department patients	https://www.sciencedirect.com/science/article/pii/S0166354219300452?via%3Dihub	doi.org/10.1016/j.antiviral.2019.05.012	Isolated strain 	dye uptake assay			04/02/2021	OJCharles			A
1557	HSV1	Clinical isolate	UL30	R681L		1		Polymorphism										UL23, UL30, and UL5 characterization of HSV1 clinical strains isolated from hematology department patients	https://www.sciencedirect.com/science/article/pii/S0166354219300452?via%3Dihub	doi.org/10.1016/j.antiviral.2019.05.012	Isolated strain 	dye uptake assay			04/02/2021	OJCharles			A
1558	HSV1	Clinical isolate	UL30	I966M		2.5		Polymorphism										UL23, UL30, and UL5 characterization of HSV1 clinical strains isolated from hematology department patients	https://www.sciencedirect.com/science/article/pii/S0166354219300452?via%3Dihub	doi.org/10.1016/j.antiviral.2019.05.012	Isolated strain 	dye uptake assay			04/02/2021	OJCharles			A
1559	HSV1	Clinical isolate	UL23	E43A		1.3												UL23, UL30, and UL5 characterization of HSV1 clinical strains isolated from hematology department patients	https://www.sciencedirect.com/science/article/pii/S0166354219300452?via%3Dihub	doi.org/10.1016/j.antiviral.2019.05.012	Isolated strain 	dye uptake assay			04/02/2021	OJCharles	methodology is not explicit, were these individually transferred, or simply the experimentalists feeling?		O
1560	HSV1	Clinical isolate	UL23	L50M		1												UL23, UL30, and UL5 characterization of HSV1 clinical strains isolated from hematology department patients	https://www.sciencedirect.com/science/article/pii/S0166354219300452?via%3Dihub	doi.org/10.1016/j.antiviral.2019.05.012	Isolated strain 	dye uptake assay			04/02/2021	OJCharles	methodology is not explicit, were these individually transferred, or simply the experimentalists feeling?		O
1561	HSV1	Clinical isolate	UL23	L68R		1.2												UL23, UL30, and UL5 characterization of HSV1 clinical strains isolated from hematology department patients	https://www.sciencedirect.com/science/article/pii/S0166354219300452?via%3Dihub	doi.org/10.1016/j.antiviral.2019.05.012	Isolated strain 	dye uptake assay			04/02/2021	OJCharles	methodology is not explicit, were these individually transferred, or simply the experimentalists feeling?		O
1562	HSV1	Clinical isolate	UL23	E43A		1.3												UL23, UL30, and UL5 characterization of HSV1 clinical strains isolated from hematology department patients	https://www.sciencedirect.com/science/article/pii/S0166354219300452?via%3Dihub	doi.org/10.1016/j.antiviral.2019.05.012	Isolated strain 	dye uptake assay			04/02/2021	OJCharles			A
1563	HSV1	Clinical isolate	UL23	L50M		1												UL23, UL30, and UL5 characterization of HSV1 clinical strains isolated from hematology department patients	https://www.sciencedirect.com/science/article/pii/S0166354219300452?via%3Dihub	doi.org/10.1016/j.antiviral.2019.05.012	Isolated strain 	dye uptake assay			04/02/2021	OJCharles			A
1564	HSV1	Clinical isolate	UL23	L68R		1.5												UL23, UL30, and UL5 characterization of HSV1 clinical strains isolated from hematology department patients	https://www.sciencedirect.com/science/article/pii/S0166354219300452?via%3Dihub	doi.org/10.1016/j.antiviral.2019.05.012	Isolated strain 	dye uptake assay			04/02/2021	OJCharles			A
1565	HSV1	Clinical isolate	UL23	S74L		39		1										UL23, UL30, and UL5 characterization of HSV1 clinical strains isolated from hematology department patients	https://www.sciencedirect.com/science/article/pii/S0166354219300452?via%3Dihub	doi.org/10.1016/j.antiviral.2019.05.012	Isolated strain 	dye uptake assay			04/02/2021	OJCharles	co-occurs with known resmut or other unknown mutant		O
1566	HSV1	Clinical isolate	UL23	Q109K		1		1.6										UL23, UL30, and UL5 characterization of HSV1 clinical strains isolated from hematology department patients	https://www.sciencedirect.com/science/article/pii/S0166354219300452?via%3Dihub	doi.org/10.1016/j.antiviral.2019.05.012	Isolated strain 	dye uptake assay			04/02/2021	OJCharles			A
1567	HSV1	Clinical isolate	UL23	A133V		1												UL23, UL30, and UL5 characterization of HSV1 clinical strains isolated from hematology department patients	https://www.sciencedirect.com/science/article/pii/S0166354219300452?via%3Dihub	doi.org/10.1016/j.antiviral.2019.05.012	Isolated strain 	dye uptake assay			04/02/2021	OJCharles			A
1568	HSV1	Clinical isolate	UL23	A136N		1												UL23, UL30, and UL5 characterization of HSV1 clinical strains isolated from hematology department patients	https://www.sciencedirect.com/science/article/pii/S0166354219300452?via%3Dihub	doi.org/10.1016/j.antiviral.2019.05.012	Isolated strain 	dye uptake assay			04/02/2021	OJCharles	A is not the tk wt AA have emailed author		O
1569	HSV1	Clinical isolate	UL23	S150L		1												UL23, UL30, and UL5 characterization of HSV1 clinical strains isolated from hematology department patients	https://www.sciencedirect.com/science/article/pii/S0166354219300452?via%3Dihub	doi.org/10.1016/j.antiviral.2019.05.012	Isolated strain 	dye uptake assay			04/02/2021	OJCharles			A
1570	HSV1	Clinical isolate	UL23	P154S		84		1.1										UL23, UL30, and UL5 characterization of HSV1 clinical strains isolated from hematology department patients	https://www.sciencedirect.com/science/article/pii/S0166354219300452?via%3Dihub	doi.org/10.1016/j.antiviral.2019.05.012	Isolated strain 	dye uptake assay			04/02/2021	OJCharles	co-occurs with known resmut or other unknown mutant		O
1571	HSV1	Clinical isolate	UL23	L159R		56		1.4										UL23, UL30, and UL5 characterization of HSV1 clinical strains isolated from hematology department patients	https://www.sciencedirect.com/science/article/pii/S0166354219300452?via%3Dihub	doi.org/10.1016/j.antiviral.2019.05.012	Isolated strain 	dye uptake assay			04/02/2021	OJCharles	co-occurs with known resmut or other unknown mutant		O
1572	HSV1	Clinical isolate	UL23	E225L		25		2.2										UL23, UL30, and UL5 characterization of HSV1 clinical strains isolated from hematology department patients	https://www.sciencedirect.com/science/article/pii/S0166354219300452?via%3Dihub	doi.org/10.1016/j.antiviral.2019.05.012	Isolated strain 	dye uptake assay			04/02/2021	OJCharles	co-occurs with known resmut or other unknown mutant		O
1573	HSV1	Clinical isolate	UL23	L242P		18		1										UL23, UL30, and UL5 characterization of HSV1 clinical strains isolated from hematology department patients	https://www.sciencedirect.com/science/article/pii/S0166354219300452?via%3Dihub	doi.org/10.1016/j.antiviral.2019.05.012	Isolated strain 	dye uptake assay			04/02/2021	OJCharles			A
1574	HSV1	Clinical isolate	UL23	Y248H		53		0.85										UL23, UL30, and UL5 characterization of HSV1 clinical strains isolated from hematology department patients	https://www.sciencedirect.com/science/article/pii/S0166354219300452?via%3Dihub	doi.org/10.1016/j.antiviral.2019.05.012	Isolated strain 	dye uptake assay			04/02/2021	OJCharles	co-occurs with known resmut or other unknown mutant		O
1575	HSV1	Clinical isolate	UL23	D258N		1.3												UL23, UL30, and UL5 characterization of HSV1 clinical strains isolated from hematology department patients	https://www.sciencedirect.com/science/article/pii/S0166354219300452?via%3Dihub	doi.org/10.1016/j.antiviral.2019.05.012	Isolated strain 	dye uptake assay			04/02/2021	OJCharles			A
1576	HSV1	Clinical isolate	UL23	S263L		1.6												UL23, UL30, and UL5 characterization of HSV1 clinical strains isolated from hematology department patients	https://www.sciencedirect.com/science/article/pii/S0166354219300452?via%3Dihub	doi.org/10.1016/j.antiviral.2019.05.012	Isolated strain 	dye uptake assay			04/02/2021	OJCharles			A
1577	HSV1	Clinical isolate	UL23	P280S		1.3												UL23, UL30, and UL5 characterization of HSV1 clinical strains isolated from hematology department patients	https://www.sciencedirect.com/science/article/pii/S0166354219300452?via%3Dihub	doi.org/10.1016/j.antiviral.2019.05.012	Isolated strain 	dye uptake assay			04/02/2021	OJCharles			A
1578	HSV1	Clinical isolate	UL23	N301S		1												UL23, UL30, and UL5 characterization of HSV1 clinical strains isolated from hematology department patients	https://www.sciencedirect.com/science/article/pii/S0166354219300452?via%3Dihub	doi.org/10.1016/j.antiviral.2019.05.012	Isolated strain 	dye uptake assay			04/02/2021	OJCharles			A
1579	HSV1	Clinical isolate	UL23	A316S		1												UL23, UL30, and UL5 characterization of HSV1 clinical strains isolated from hematology department patients	https://www.sciencedirect.com/science/article/pii/S0166354219300452?via%3Dihub	doi.org/10.1016/j.antiviral.2019.05.012	Isolated strain 	dye uptake assay			04/02/2021	OJCharles			A
1580	HSV1	Clinical isolate	UL23	M322L		1												UL23, UL30, and UL5 characterization of HSV1 clinical strains isolated from hematology department patients	https://www.sciencedirect.com/science/article/pii/S0166354219300452?via%3Dihub	doi.org/10.1016/j.antiviral.2019.05.012	Isolated strain 	dye uptake assay			04/02/2021	OJCharles			A
1581	HSV1	Clinical isolate	UL23	I326V		1.3												UL23, UL30, and UL5 characterization of HSV1 clinical strains isolated from hematology department patients	https://www.sciencedirect.com/science/article/pii/S0166354219300452?via%3Dihub	doi.org/10.1016/j.antiviral.2019.05.012	Isolated strain 	dye uptake assay			04/02/2021	OJCharles			A
1582	HSV1	Clinical isolate	UL23	D330A		1												UL23, UL30, and UL5 characterization of HSV1 clinical strains isolated from hematology department patients	https://www.sciencedirect.com/science/article/pii/S0166354219300452?via%3Dihub	doi.org/10.1016/j.antiviral.2019.05.012	Isolated strain 	dye uptake assay			04/02/2021	OJCharles	methodology is not explicit, were these individually transferred, or simply the experimentalists feeling?		O
1583	HSV1	Clinical isolate	UL23	D338H		1												UL23, UL30, and UL5 characterization of HSV1 clinical strains isolated from hematology department patients	https://www.sciencedirect.com/science/article/pii/S0166354219300452?via%3Dihub	doi.org/10.1016/j.antiviral.2019.05.012	Isolated strain 	dye uptake assay			04/02/2021	OJCharles			A
1584	HSV1	Clinical isolate	UL23	Q342H		1												UL23, UL30, and UL5 characterization of HSV1 clinical strains isolated from hematology department patients	https://www.sciencedirect.com/science/article/pii/S0166354219300452?via%3Dihub	doi.org/10.1016/j.antiviral.2019.05.012	Isolated strain 	dye uptake assay			04/02/2021	OJCharles			A
1585	HSV1	Clinical isolate	UL23	T344I		1												UL23, UL30, and UL5 characterization of HSV1 clinical strains isolated from hematology department patients	https://www.sciencedirect.com/science/article/pii/S0166354219300452?via%3Dihub	doi.org/10.1016/j.antiviral.2019.05.012	Isolated strain 	dye uptake assay			04/02/2021	OJCharles			A
1586	HSV1	Clinical isolate	UL23	Q349R		1												UL23, UL30, and UL5 characterization of HSV1 clinical strains isolated from hematology department patients	https://www.sciencedirect.com/science/article/pii/S0166354219300452?via%3Dihub	doi.org/10.1016/j.antiviral.2019.05.012	Isolated strain 	dye uptake assay			04/02/2021	OJCharles			A
1587	HSV1	Clinical isolate	UL23	V352L		1.9												UL23, UL30, and UL5 characterization of HSV1 clinical strains isolated from hematology department patients	https://www.sciencedirect.com/science/article/pii/S0166354219300452?via%3Dihub	doi.org/10.1016/j.antiviral.2019.05.012	Isolated strain 	dye uptake assay			04/02/2021	OJCharles			A
1588	HSV1	Clinical isolate	UL23	R370W		1.9												UL23, UL30, and UL5 characterization of HSV1 clinical strains isolated from hematology department patients	https://www.sciencedirect.com/science/article/pii/S0166354219300452?via%3Dihub	doi.org/10.1016/j.antiviral.2019.05.012	Isolated strain 	dye uptake assay			04/02/2021	OJCharles			A
1589	HSV1	Clinical isolate	UL23	E371D		1.9												UL23, UL30, and UL5 characterization of HSV1 clinical strains isolated from hematology department patients	https://www.sciencedirect.com/science/article/pii/S0166354219300452?via%3Dihub	doi.org/10.1016/j.antiviral.2019.05.012	Isolated strain 	dye uptake assay			04/02/2021	OJCharles			A
1590	HSV1	Clinical isolate	UL5	L49I		20		10										UL23, UL30, and UL5 characterization of HSV1 clinical strains isolated from hematology department patients	https://www.sciencedirect.com/science/article/pii/S0166354219300452?via%3Dihub	doi.org/10.1016/j.antiviral.2019.05.012	Isolated strain 	dye uptake assay			04/02/2021	OJCharles	co-occurs with other unknown mutants		O
1591	HSV1	Clinical isolate	UL5	L138V		19		8.6										UL23, UL30, and UL5 characterization of HSV1 clinical strains isolated from hematology department patients	https://www.sciencedirect.com/science/article/pii/S0166354219300452?via%3Dihub	doi.org/10.1016/j.antiviral.2019.05.012	Isolated strain 	dye uptake assay			04/02/2021	OJCharles	co-occurs with other unknown mutants		O
1592	HSV1	Clinical isolate	UL5	S173L		53		1.5										UL23, UL30, and UL5 characterization of HSV1 clinical strains isolated from hematology department patients	https://www.sciencedirect.com/science/article/pii/S0166354219300452?via%3Dihub	doi.org/10.1016/j.antiviral.2019.05.012	Isolated strain 	dye uptake assay			04/02/2021	OJCharles	co-occurs with other unknown mutants		O
1593	HSV1	Clinical isolate	UL5	A280T		39		1										UL23, UL30, and UL5 characterization of HSV1 clinical strains isolated from hematology department patients	https://www.sciencedirect.com/science/article/pii/S0166354219300452?via%3Dihub	doi.org/10.1016/j.antiviral.2019.05.012	Isolated strain 	dye uptake assay			04/02/2021	OJCharles	co-occurs with other unknown mutants		O
1594	HSV1	Clinical isolate	UL5	A575V		39		1										UL23, UL30, and UL5 characterization of HSV1 clinical strains isolated from hematology department patients	https://www.sciencedirect.com/science/article/pii/S0166354219300452?via%3Dihub	doi.org/10.1016/j.antiviral.2019.05.012	Isolated strain 	dye uptake assay			04/02/2021	OJCharles	co-occurs with other unknown mutants		O
1595	HSV1	Clinical isolate	UL5	V600A		19		8.6										UL23, UL30, and UL5 characterization of HSV1 clinical strains isolated from hematology department patients	https://www.sciencedirect.com/science/article/pii/S0166354219300452?via%3Dihub	doi.org/10.1016/j.antiviral.2019.05.012	Isolated strain 	dye uptake assay			04/02/2021	OJCharles	co-occurs with other unknown mutants		O
1596	HSV1	Clinical isolate	UL5	A602T		19		8.6										UL23, UL30, and UL5 characterization of HSV1 clinical strains isolated from hematology department patients	https://www.sciencedirect.com/science/article/pii/S0166354219300452?via%3Dihub	doi.org/10.1016/j.antiviral.2019.05.012	Isolated strain 	dye uptake assay			04/02/2021	OJCharles	methodology is not explicit, were these individually transferred, or simply the experimentalists feeling?		O
1597	HSV1	Clinical isolate	UL5	D862N		20		10										UL23, UL30, and UL5 characterization of HSV1 clinical strains isolated from hematology department patients	https://www.sciencedirect.com/science/article/pii/S0166354219300452?via%3Dihub	doi.org/10.1016/j.antiviral.2019.05.012	Isolated strain 	dye uptake assay			04/02/2021	OJCharles	co-occurs with other unknown mutants		O
1598	HSV1	Clinical isolate	UL23	L340R		14												Input of recombinant phenotyping for the characterization of a novel acyclovir-resistance mutation identified in a patient with recurrent herpetic keratitis	https://www.sciencedirect.com/science/article/pii/S0166354219302700?via%3Dihub	doi.org/10.1016/j.antiviral.2019.06.007	Isolated strain 	PRA			04/02/2021	OJCharles		KOS	A
1599	HSV1		UL23	L340R		34												Input of recombinant phenotyping for the characterization of a novel acyclovir-resistance mutation identified in a patient with recurrent herpetic keratitis	https://www.sciencedirect.com/science/article/pii/S0166354219302700?via%3Dihub	doi.org/10.1016/j.antiviral.2019.06.007	Recombinant BAC 	PRA			04/02/2021	OJCharles		KOS	A
1600	HSV1		UL23	R216H		Resistant												Stepwise characterization of non-synonymous mutations in the HSV-1 thymidine kinase gene by different functional assays	https://www.sciencedirect.com/science/article/pii/S016609341730071X?via%3Dihub	doi.org/10.1016/j.jviromet.2017.05.013	Lab induced strain 	TK functional kinetic assay			04/02/2021	OJCharles			A
1601	HSV1		UL23	L170P		Resistant												Stepwise characterization of non-synonymous mutations in the HSV-1 thymidine kinase gene by different functional assays	https://www.sciencedirect.com/science/article/pii/S016609341730071X?via%3Dihub	doi.org/10.1016/j.jviromet.2017.05.013	Lab induced strain 	TK functional kinetic assay			04/02/2021	OJCharles		JQ352247.1	A
1602	HSV1		UL23	S181N		Resistant												Stepwise characterization of non-synonymous mutations in the HSV-1 thymidine kinase gene by different functional assays	https://www.sciencedirect.com/science/article/pii/S016609341730071X?via%3Dihub	doi.org/10.1016/j.jviromet.2017.05.013	Lab induced strain 	TK functional kinetic assay			04/02/2021	OJCharles		JQ352247.1	A
1603	HSV1		UL23	Q15K		Polymorphism												Stepwise characterization of non-synonymous mutations in the HSV-1 thymidine kinase gene by different functional assays	https://www.sciencedirect.com/science/article/pii/S016609341730071X?via%3Dihub	doi.org/10.1016/j.jviromet.2017.05.013	Lab induced strain 	TK functional kinetic assay			04/02/2021	OJCharles		JQ352247.1	A
1604	HSV1		UL23	R20C		Polymorphism												Stepwise characterization of non-synonymous mutations in the HSV-1 thymidine kinase gene by different functional assays	https://www.sciencedirect.com/science/article/pii/S016609341730071X?via%3Dihub	doi.org/10.1016/j.jviromet.2017.05.013	Lab induced strain 	TK functional kinetic assay			04/02/2021	OJCharles		JQ352247.1	A
1605	HSV1		UL23	R32H		Polymorphism												Stepwise characterization of non-synonymous mutations in the HSV-1 thymidine kinase gene by different functional assays	https://www.sciencedirect.com/science/article/pii/S016609341730071X?via%3Dihub	doi.org/10.1016/j.jviromet.2017.05.013	Lab induced strain 	TK functional kinetic assay			04/02/2021	OJCharles		JQ352247.1	A
1606	HSV1		UL23	E43A		Polymorphism												Stepwise characterization of non-synonymous mutations in the HSV-1 thymidine kinase gene by different functional assays	https://www.sciencedirect.com/science/article/pii/S016609341730071X?via%3Dihub	doi.org/10.1016/j.jviromet.2017.05.013	Lab induced strain 	TK functional kinetic assay			04/02/2021	OJCharles		JQ352247.1	A
1607	HSV1		UL23	E43D		Polymorphism												Stepwise characterization of non-synonymous mutations in the HSV-1 thymidine kinase gene by different functional assays	https://www.sciencedirect.com/science/article/pii/S016609341730071X?via%3Dihub	doi.org/10.1016/j.jviromet.2017.05.013	Lab induced strain 	TK functional kinetic assay			04/02/2021	OJCharles		JQ352247.1	A
1608	HSV1		UL23	G61E		Resistant												Stepwise characterization of non-synonymous mutations in the HSV-1 thymidine kinase gene by different functional assays	https://www.sciencedirect.com/science/article/pii/S016609341730071X?via%3Dihub	doi.org/10.1016/j.jviromet.2017.05.013	Lab induced strain 	TK functional kinetic assay			04/02/2021	OJCharles		JQ352247.1	A
1609	HSV1		UL23	R89H		Polymorphism												Stepwise characterization of non-synonymous mutations in the HSV-1 thymidine kinase gene by different functional assays	https://www.sciencedirect.com/science/article/pii/S016609341730071X?via%3Dihub	doi.org/10.1016/j.jviromet.2017.05.013	Lab induced strain 	TK functional kinetic assay			04/02/2021	OJCharles		JQ352247.1	A
1610	HSV1		UL23	A93V		Resistant												Stepwise characterization of non-synonymous mutations in the HSV-1 thymidine kinase gene by different functional assays	https://www.sciencedirect.com/science/article/pii/S016609341730071X?via%3Dihub	doi.org/10.1016/j.jviromet.2017.05.013	Lab induced strain 	TK functional kinetic assay			04/02/2021	OJCharles		JQ352247.1	A
1611	HSV1		UL23	M121K		Resistant												Stepwise characterization of non-synonymous mutations in the HSV-1 thymidine kinase gene by different functional assays	https://www.sciencedirect.com/science/article/pii/S016609341730071X?via%3Dihub	doi.org/10.1016/j.jviromet.2017.05.013	Lab induced strain 	TK functional kinetic assay			04/02/2021	OJCharles		JQ352247.1	A
1612	HSV1		UL23	A156V		Polymorphism												Stepwise characterization of non-synonymous mutations in the HSV-1 thymidine kinase gene by different functional assays	https://www.sciencedirect.com/science/article/pii/S016609341730071X?via%3Dihub	doi.org/10.1016/j.jviromet.2017.05.013	Lab induced strain 	TK functional kinetic assay			04/02/2021	OJCharles		JQ352247.1	A
1613	HSV1		UL23	R163G		Resistant												Stepwise characterization of non-synonymous mutations in the HSV-1 thymidine kinase gene by different functional assays	https://www.sciencedirect.com/science/article/pii/S016609341730071X?via%3Dihub	doi.org/10.1016/j.jviromet.2017.05.013	Lab induced strain 	TK functional kinetic assay			04/02/2021	OJCharles		JQ352247.1	A
1614	HSV1		UL23	del173		Resistant												Stepwise characterization of non-synonymous mutations in the HSV-1 thymidine kinase gene by different functional assays	https://www.sciencedirect.com/science/article/pii/S016609341730071X?via%3Dihub	doi.org/10.1016/j.jviromet.2017.05.013	Lab induced strain 	TK functional kinetic assay			04/02/2021	OJCharles		JQ352247.1	A
1615	HSV1		UL23	V238F		Resistant												Stepwise characterization of non-synonymous mutations in the HSV-1 thymidine kinase gene by different functional assays	https://www.sciencedirect.com/science/article/pii/S016609341730071X?via%3Dihub	doi.org/10.1016/j.jviromet.2017.05.013	Lab induced strain 	TK functional kinetic assay			04/02/2021	OJCharles		JQ352247.1	A
1616	HSV1		UL23	N244H		Polymorphism												Stepwise characterization of non-synonymous mutations in the HSV-1 thymidine kinase gene by different functional assays	https://www.sciencedirect.com/science/article/pii/S016609341730071X?via%3Dihub	doi.org/10.1016/j.jviromet.2017.05.013	Lab induced strain 	TK functional kinetic assay			04/02/2021	OJCharles		JQ352247.1	A
1617	HSV1		UL23	G264V		Resistant												Stepwise characterization of non-synonymous mutations in the HSV-1 thymidine kinase gene by different functional assays	https://www.sciencedirect.com/science/article/pii/S016609341730071X?via%3Dihub	doi.org/10.1016/j.jviromet.2017.05.013	Lab induced strain 	TK functional kinetic assay			04/02/2021	OJCharles		JQ352247.1	A
1618	HSV1		UL23	P269S		Polymorphism												Stepwise characterization of non-synonymous mutations in the HSV-1 thymidine kinase gene by different functional assays	https://www.sciencedirect.com/science/article/pii/S016609341730071X?via%3Dihub	doi.org/10.1016/j.jviromet.2017.05.013	Lab induced strain 	TK functional kinetic assay			04/02/2021	OJCharles		JQ352247.1	A
1619	HSV1		UL23	G271V		Polymorphism												Stepwise characterization of non-synonymous mutations in the HSV-1 thymidine kinase gene by different functional assays	https://www.sciencedirect.com/science/article/pii/S016609341730071X?via%3Dihub	doi.org/10.1016/j.jviromet.2017.05.013	Lab induced strain 	TK functional kinetic assay			04/02/2021	OJCharles		JQ352247.1	A
1620	HSV1		UL23	S276N		Polymorphism												Stepwise characterization of non-synonymous mutations in the HSV-1 thymidine kinase gene by different functional assays	https://www.sciencedirect.com/science/article/pii/S016609341730071X?via%3Dihub	doi.org/10.1016/j.jviromet.2017.05.013	Lab induced strain 	TK functional kinetic assay			04/02/2021	OJCharles		JQ352247.1	A
1621	HSV1		UL23	I326V		Polymorphism												Stepwise characterization of non-synonymous mutations in the HSV-1 thymidine kinase gene by different functional assays	https://www.sciencedirect.com/science/article/pii/S016609341730071X?via%3Dihub	doi.org/10.1016/j.jviromet.2017.05.013	Lab induced strain 	TK functional kinetic assay			04/02/2021	OJCharles		JQ352247.1	A
1622	HSV1		UL23	N376*		Resistant												Stepwise characterization of non-synonymous mutations in the HSV-1 thymidine kinase gene by different functional assays	https://www.sciencedirect.com/science/article/pii/S016609341730071X?via%3Dihub	doi.org/10.1016/j.jviromet.2017.05.013	Lab induced strain 	TK functional kinetic assay			04/02/2021	OJCharles		JQ352247.1	A
1623	HSV2		UL23	R220T		Polymorphism												Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub#tblfn8	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			04/02/2021	OJCharles			A
1624	HSV2		UL30	A1213T		Polymorphism												Surveillance of herpes simplex virus resistance to antivirals: A 4-year survey	https://www.sciencedirect.com/science/article/pii/S0166354213002581?via%3Dihub#tblfn8	doi.org/10.1016/j.antiviral.2013.09.012	Isolated strain 	PRA			04/02/2021	OJCharles	M1213 original have inferred type		A
1625	HHV6b		U38	R798I	4.2		118	1.2										Characterization of a cidofovir-resistant HHV-6 mutant obtained by in vitro selection	https://www.sciencedirect.com/science/article/pii/S0166354207005001?via%3Dihub	doi.org/10.1016/j.antiviral.2007.12.004	Lab induced strain 	qPCR			04/02/2021	OJCharles		http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=nucleotide&doptcmdl=genbank&term=AB021506	A
1626	HHV6b		U38	A961V	Resistant													Selection of the same mutation in the U69 protein kinase gene of human herpesvirus-6 after prolonged exposure to ganciclovir in vitro and in vivo	https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-82-11-2767	doi.org/10.1099/0022-1317-82-11-2767	Lab induced strain 	ELISA			04/02/2021	OJCharles	cannot infer		O
1627	HHV6b		U69	M318V	Resistant													Selection of the same mutation in the U69 protein kinase gene of human herpesvirus-6 after prolonged exposure to ganciclovir in vitro and in vivo	https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-82-11-2767	doi.org/10.1099/0022-1317-82-11-2767	Lab induced strain 				04/02/2021	OJCharles	cannot infer		O
1628	HHV6b	Z29	U69	M318V	Resistant													Mapping ganciclovir resistance in the human herpesvirus?6 U69 protein kinase	https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.10510	doi.org/10.1002/jmv.10510	Marker transfer 	PRA			04/02/2021	OJCharles		Z29	A
1629	HHV6b	Z29	U69	L213I	Polymorphism													Mapping ganciclovir resistance in the human herpesvirus?6 U69 protein kinase	https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.10510	doi.org/10.1002/jmv.10510	Marker transfer 	PRA			04/02/2021	OJCharles		Z29	A
1630	HHV6b	Z29	U69	C448G	Resistant													Mapping ganciclovir resistance in the human herpesvirus?6 U69 protein kinase	https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.10510	doi.org/10.1002/jmv.10510	Marker transfer 	PRA			04/02/2021	OJCharles		Z29	A
1631	HHV6b	Z29	U69	C463Y	Resistant													Mapping ganciclovir resistance in the human herpesvirus?6 U69 protein kinase	https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.10510	doi.org/10.1002/jmv.10510	Marker transfer 	PRA			04/02/2021	OJCharles		Z29	A
1632	HHV6b	Z29	U69	M318V	Resistant													Detection and identification of U69 gene mutations encoded by ganciclovir-resistant human herpesvirus 6 using denaturing high-performance liquid chromatography	https://www.sciencedirect.com/science/article/pii/S0166093409003012	doi.org/10.1016/j.jviromet.2009.06.016	Marker transfer 	qPCR			04/02/2021	OJCharles		Z29	A
1633	HHV6b	Z29	U69	A447D	Resistant													Detection and identification of U69 gene mutations encoded by ganciclovir-resistant human herpesvirus 6 using denaturing high-performance liquid chromatography	https://www.sciencedirect.com/science/article/pii/S0166093409003012	doi.org/10.1016/j.jviromet.2009.06.016	Marker transfer 	qPCR			04/02/2021	OJCharles		Z29	A
1634	HHV6b	Z29	U69	C448G	Resistant													Detection and identification of U69 gene mutations encoded by ganciclovir-resistant human herpesvirus 6 using denaturing high-performance liquid chromatography	https://www.sciencedirect.com/science/article/pii/S0166093409003012	doi.org/10.1016/j.jviromet.2009.06.016	Marker transfer 	qPCR			04/02/2021	OJCharles		Z29	A
1635	HHV6b	Z29	U69	L450S	Resistant													Detection and identification of U69 gene mutations encoded by ganciclovir-resistant human herpesvirus 6 using denaturing high-performance liquid chromatography	https://www.sciencedirect.com/science/article/pii/S0166093409003012	doi.org/10.1016/j.jviromet.2009.06.016	Marker transfer 	qPCR			04/02/2021	OJCharles		Z29	A
1636	HHV6b	Z29	U69	A462D	Resistant													Detection and identification of U69 gene mutations encoded by ganciclovir-resistant human herpesvirus 6 using denaturing high-performance liquid chromatography	https://www.sciencedirect.com/science/article/pii/S0166093409003012	doi.org/10.1016/j.jviromet.2009.06.016	Marker transfer 	qPCR			04/02/2021	OJCharles		Z29	A
1637	HHV6b	Z29	U69	C463Y	Resistant													Detection and identification of U69 gene mutations encoded by ganciclovir-resistant human herpesvirus 6 using denaturing high-performance liquid chromatography	https://www.sciencedirect.com/science/article/pii/S0166093409003012	doi.org/10.1016/j.jviromet.2009.06.016	Marker transfer 	qPCR			04/02/2021	OJCharles		Z29	A
1638	HHV6b	Z29	U69	L202I	Polymorphism													Detection and identification of U69 gene mutations encoded by ganciclovir-resistant human herpesvirus 6 using denaturing high-performance liquid chromatography	https://www.sciencedirect.com/science/article/pii/S0166093409003012	doi.org/10.1016/j.jviromet.2009.06.016	Marker transfer 	qPCR			04/02/2021	OJCharles		Z29	A
1639	HHV6b	Z29	U69	L213I	Polymorphism													Detection and identification of U69 gene mutations encoded by ganciclovir-resistant human herpesvirus 6 using denaturing high-performance liquid chromatography	https://www.sciencedirect.com/science/article/pii/S0166093409003012	doi.org/10.1016/j.jviromet.2009.06.016	Marker transfer 	qPCR			04/02/2021	OJCharles		Z29	A
1640	HHV6b	HST	U38	R798I	4		213	1.2										Characterization of a cidofovir-resistant HHV-6 mutant obtained by in vitro selection	https://www.sciencedirect.com/science/article/pii/S0166354207005001?via%3Dihub	doi.org/10.1016/j.antiviral.2007.12.004	Lab induced strain 	qPCR			04/02/2021	OJCharles		HST	A
1641	HHV6b	HST	U38	H507Y	0.84		1.1	24										Different mutations in the HHV-6 DNA polymerase gene accounting for resistance to foscarnet	https://pubmed.ncbi.nlm.nih.gov/17926642/		Lab induced strain 	qPCR			04/02/2021	OJCharles		HST	A
1642	HHV6b	HST	U38	A961V				0.7										Different mutations in the HHV-6 DNA polymerase gene accounting for resistance to foscarnet	https://pubmed.ncbi.nlm.nih.gov/17926642/		Lab induced strain 	Polymerase kinetic assay			04/02/2021	OJCharles		HST	A
1643	HHV6b	HST	U38	F292S				6										Different mutations in the HHV-6 DNA polymerase gene accounting for resistance to foscarnet	https://pubmed.ncbi.nlm.nih.gov/17926642/		Lab induced strain 	Polymerase kinetic assay			04/02/2021	OJCharles		HST	A
1644	HHV6b	HST	U38	H507Y				2.6										Different mutations in the HHV-6 DNA polymerase gene accounting for resistance to foscarnet	https://pubmed.ncbi.nlm.nih.gov/17926642/		Lab induced strain 	Polymerase kinetic assay			04/02/2021	OJCharles		HST	A
1645	HHV6b	HST	U38	T435R				1.8										Different mutations in the HHV-6 DNA polymerase gene accounting for resistance to foscarnet	https://pubmed.ncbi.nlm.nih.gov/17926642/		Lab induced strain 	Polymerase kinetic assay			04/02/2021	OJCharles		HST	A
1646	HHV6b	HST	U38	C525S				3.4										Different mutations in the HHV-6 DNA polymerase gene accounting for resistance to foscarnet	https://pubmed.ncbi.nlm.nih.gov/17926642/		Lab induced strain 	Polymerase kinetic assay			04/02/2021	OJCharles		HST	A
1647	VZV	Clinical isolate	ORF36	Q90*		Resistant												Development of Resistance to Acyclovir during Chronic Infection with the Oka Vaccine Strain of Varicella-Zoster Virus, in an Immunosuppressed Child	https://academic.oup.com/jid/article/188/7/954/820206	doi.org/10.1086/378502	Isolated strain 	TK functional kinetic assay			28/05/2021	OJCharles	Resistant Phenotype not established this was effect on TK activity (which is hand in hand) but not directly a resistance measurement	Oka	A
1648	VZV	Clinical isolate	ORF36	L92P		Resistant												Analysis of mutations in the thymidine kinase genes of drug-resistant varicella-zoster virus populations using the polymerase chain reaction	https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-72-3-623#tab2	doi.org/10.1099/0022-1317-72-3-623		TK functional kinetic assay			28/05/2021	OJCharles		9883	A
1649	VZV	Clinical isolate	ORF36	L92P		Resistant												Analysis of mutations in the thymidine kinase genes of drug-resistant varicella-zoster virus populations using the polymerase chain reaction	https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-72-3-623#tab2	doi.org/10.1099/0022-1317-72-3-623		TK functional kinetic assay			28/05/2021	OJCharles		9883	A
1651	VZV	Oka	ORF36	A29T		1												Complementary assays for monitoring susceptibility of varicella-zoster virus resistance to antivirals	https://www.sciencedirect.com/science/article/pii/S0166093416300787	doi.org/10.1016/j.jviromet.2016.03.006	Isolated strain 	PRA			18/11/2021	OJCharles		Oka	A
1652	VZV	Clinical isolate	ORF36	S288L		Polymorphism												Resistance testing of clinical varicella-zoster virus strains	https://www.sciencedirect.com/science/article/pii/S0166354211002841?via%3Dihub	doi.org/10.1016/j.antiviral.2011.04.005	Isolated strain 	PRA			18/11/2021	OJCharles		Oka	A
1653	VZV	Clinical isolate	ORF36	K186R		1		1			1	1						Genetic polymorphism of thymidine kinase (TK) and DNA polymerase (pol) of clinical varicella-zoster virus (VZV) isolates collected over three decades	https://www.sciencedirect.com/science/article/pii/S1386653217302433?via%3Dihub#tbl0005	doi.org/10.1016/j.jcv.2017.08.011	Isolated strain 	PRA			18/11/2021	OJCharles	Co-occurs with D545Y , needs to be tested indep	Oka	O
1654	VZV	Clinical isolate	ORF36	A319V		Polymorphism												Molecular Analysis of the Pyrimidine Deoxyribonucleoside Kinase Gene of Wild-type and Acyclovir-resistant Strains of Varicella-Zoster Virus	https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-69-10-2585#tab2	doi.org/10.1099/0022-1317-69-10-2585	Isolated strain 	PRA			18/11/2021	OJCharles		Oka	A
1655	HCMV	AD169	UL97	C592G	3.1													Ganciclovir and maribavir susceptibility phenotypes of cytomegalovirus UL97 ATP binding region mutations detected by expanded genotypic testing	https://www.sciencedirect.com/science/article/pii/S0166354221001297?via%3Dihub	doi.org/10.1016/j.antiviral.2021.105139	Lab induced strain 	SEAP			21/12/2021	OJCharles		AD169	A
1656	HCMV	AD169	UL97	F342Y	5.9									4.2				Ganciclovir and maribavir susceptibility phenotypes of cytomegalovirus UL97 ATP binding region mutations detected by expanded genotypic testing	https://www.sciencedirect.com/science/article/pii/S0166354221001297?via%3Dihub	doi.org/10.1016/j.antiviral.2021.105139	Lab induced strain 	SEAP			21/12/2021	OJCharles		AD169	A
1657	HCMV	AD169	UL97	Y335H	0.9									1				Ganciclovir and maribavir susceptibility phenotypes of cytomegalovirus UL97 ATP binding region mutations detected by expanded genotypic testing	https://www.sciencedirect.com/science/article/pii/S0166354221001297?via%3Dihub	doi.org/10.1016/j.antiviral.2021.105139	Lab induced strain 	SEAP			21/12/2021	OJCharles		AD169	A
1658	HCMV	AD169	UL97	V345I	1.3									0.4				Ganciclovir and maribavir susceptibility phenotypes of cytomegalovirus UL97 ATP binding region mutations detected by expanded genotypic testing	https://www.sciencedirect.com/science/article/pii/S0166354221001297?via%3Dihub	doi.org/10.1016/j.antiviral.2021.105139	Lab induced strain 	SEAP			21/12/2021	OJCharles		AD169	A
1659	HCMV	AD169	UL97	L348V	0.9									1.6				Ganciclovir and maribavir susceptibility phenotypes of cytomegalovirus UL97 ATP binding region mutations detected by expanded genotypic testing	https://www.sciencedirect.com/science/article/pii/S0166354221001297?via%3Dihub	doi.org/10.1016/j.antiviral.2021.105139	Lab induced strain 	SEAP			21/12/2021	OJCharles		AD169	A
1660	HCMV	AD169	UL97	K359N	2.1									0.7				Ganciclovir and maribavir susceptibility phenotypes of cytomegalovirus UL97 ATP binding region mutations detected by expanded genotypic testing	https://www.sciencedirect.com/science/article/pii/S0166354221001297?via%3Dihub	doi.org/10.1016/j.antiviral.2021.105139	Lab induced strain 	SEAP			21/12/2021	OJCharles		AD169	A
1661	HCMV	AD169	UL97	E362D	3.8									0.1				Ganciclovir and maribavir susceptibility phenotypes of cytomegalovirus UL97 ATP binding region mutations detected by expanded genotypic testing	https://www.sciencedirect.com/science/article/pii/S0166354221001297?via%3Dihub	doi.org/10.1016/j.antiviral.2021.105139	Lab induced strain 	SEAP			21/12/2021	OJCharles		AD169	A
1662	HCMV	AD169	UL97	A378T	1									1.1				Ganciclovir and maribavir susceptibility phenotypes of cytomegalovirus UL97 ATP binding region mutations detected by expanded genotypic testing	https://www.sciencedirect.com/science/article/pii/S0166354221001297?via%3Dihub	doi.org/10.1016/j.antiviral.2021.105139	Lab induced strain 	SEAP			21/12/2021	OJCharles		AD169	A
1663	HCMV	AD169	UL97	V388M	1.2									1.1				Ganciclovir and maribavir susceptibility phenotypes of cytomegalovirus UL97 ATP binding region mutations detected by expanded genotypic testing	https://www.sciencedirect.com/science/article/pii/S0166354221001297?via%3Dihub	doi.org/10.1016/j.antiviral.2021.105139	Lab induced strain 	SEAP			21/12/2021	OJCharles		AD169	A
1664	HCMV	AD169	UL97	H415Y	1.1									0.6				Ganciclovir and maribavir susceptibility phenotypes of cytomegalovirus UL97 ATP binding region mutations detected by expanded genotypic testing	https://www.sciencedirect.com/science/article/pii/S0166354221001297?via%3Dihub	doi.org/10.1016/j.antiviral.2021.105139	Lab induced strain 	SEAP			21/12/2021	OJCharles		AD169	A
1665	HCMV	AD169	UL97	A435V	1									0.6				Ganciclovir and maribavir susceptibility phenotypes of cytomegalovirus UL97 ATP binding region mutations detected by expanded genotypic testing	https://www.sciencedirect.com/science/article/pii/S0166354221001297?via%3Dihub	doi.org/10.1016/j.antiviral.2021.105139	Lab induced strain 	SEAP			21/12/2021	OJCharles		AD169	A
1666	HCMV	AD169	UL97	C437Y	0.9									0.9				Ganciclovir and maribavir susceptibility phenotypes of cytomegalovirus UL97 ATP binding region mutations detected by expanded genotypic testing	https://www.sciencedirect.com/science/article/pii/S0166354221001297?via%3Dihub	doi.org/10.1016/j.antiviral.2021.105139	Lab induced strain 	SEAP			21/12/2021	OJCharles		AD169	A
1667	HCMV	AD169	UL54	D301N		0.2	14											Opposite effects of cytomegalovirus UL54 exonuclease domain mutations on acyclovir and cidofovir susceptibility	https://www.sciencedirect.com/science/article/pii/S0166354221001716?via%3Dihub	doi.org/10.1016/j.antiviral.2021.105181	Recombinant BAC 	SEAP			21/12/2021	OJCharles		AD169	A
1668	HCMV	AD169	UL54	N408D		0.2	3.3											Opposite effects of cytomegalovirus UL54 exonuclease domain mutations on acyclovir and cidofovir susceptibility	https://www.sciencedirect.com/science/article/pii/S0166354221001716?via%3Dihub	doi.org/10.1016/j.antiviral.2021.105181	Recombinant BAC 	SEAP			21/12/2021	OJCharles		AD169	A
1669	HCMV	AD169	UL54	N408K		0.1	32											Opposite effects of cytomegalovirus UL54 exonuclease domain mutations on acyclovir and cidofovir susceptibility	https://www.sciencedirect.com/science/article/pii/S0166354221001716?via%3Dihub	doi.org/10.1016/j.antiviral.2021.105181	Recombinant BAC 	SEAP			21/12/2021	OJCharles		AD169	A
1670	HCMV	AD169	UL54	N410K		0.7	2.5											Opposite effects of cytomegalovirus UL54 exonuclease domain mutations on acyclovir and cidofovir susceptibility	https://www.sciencedirect.com/science/article/pii/S0166354221001716?via%3Dihub	doi.org/10.1016/j.antiviral.2021.105181	Recombinant BAC 	SEAP			21/12/2021	OJCharles		AD169	A
1671	HCMV	AD169	UL54	F412C		0.2	17											Opposite effects of cytomegalovirus UL54 exonuclease domain mutations on acyclovir and cidofovir susceptibility	https://www.sciencedirect.com/science/article/pii/S0166354221001716?via%3Dihub	doi.org/10.1016/j.antiviral.2021.105181	Recombinant BAC 	SEAP			21/12/2021	OJCharles		AD169	A
1672	HCMV	AD169	UL54	F412L		0.2	12											Opposite effects of cytomegalovirus UL54 exonuclease domain mutations on acyclovir and cidofovir susceptibility	https://www.sciencedirect.com/science/article/pii/S0166354221001716?via%3Dihub	doi.org/10.1016/j.antiviral.2021.105181	Recombinant BAC 	SEAP			21/12/2021	OJCharles		AD169	A
1673	HCMV	AD169	UL54	K513R		3.6	14											Opposite effects of cytomegalovirus UL54 exonuclease domain mutations on acyclovir and cidofovir susceptibility	https://www.sciencedirect.com/science/article/pii/S0166354221001716?via%3Dihub	doi.org/10.1016/j.antiviral.2021.105181	Recombinant BAC 	SEAP			21/12/2021	OJCharles		AD169	A
1674	HCMV	AD169	UL54	D515Y		0.6	2.2											Opposite effects of cytomegalovirus UL54 exonuclease domain mutations on acyclovir and cidofovir susceptibility	https://www.sciencedirect.com/science/article/pii/S0166354221001716?via%3Dihub	doi.org/10.1016/j.antiviral.2021.105181	Recombinant BAC 	SEAP			21/12/2021	OJCharles		AD169	A
1675	HCMV	AD169	UL54	L516P		0.2	5.3											Opposite effects of cytomegalovirus UL54 exonuclease domain mutations on acyclovir and cidofovir susceptibility	https://www.sciencedirect.com/science/article/pii/S0166354221001716?via%3Dihub	doi.org/10.1016/j.antiviral.2021.105181	Recombinant BAC 	SEAP			21/12/2021	OJCharles		AD169	A
1676	HCMV	AD169	UL54	P522S		0.2	4.4											Opposite effects of cytomegalovirus UL54 exonuclease domain mutations on acyclovir and cidofovir susceptibility	https://www.sciencedirect.com/science/article/pii/S0166354221001716?via%3Dihub	doi.org/10.1016/j.antiviral.2021.105181	Recombinant BAC 	SEAP			21/12/2021	OJCharles		AD169	A
1677	HCMV	AD169	UL54	L545W		0.3	6.4											Opposite effects of cytomegalovirus UL54 exonuclease domain mutations on acyclovir and cidofovir susceptibility	https://www.sciencedirect.com/science/article/pii/S0166354221001716?via%3Dihub	doi.org/10.1016/j.antiviral.2021.105181	Recombinant BAC 	SEAP			21/12/2021	OJCharles		AD169	A
1678	HCMV	AD169	UL54	Q578H		8.6	2.9	Resistant										Opposite effects of cytomegalovirus UL54 exonuclease domain mutations on acyclovir and cidofovir susceptibility	https://www.sciencedirect.com/science/article/pii/S0166354221001716?via%3Dihub	doi.org/10.1016/j.antiviral.2021.105181	Recombinant BAC 	SEAP			21/12/2021	OJCharles		AD169	A
1679	HCMV	AD169	UL54	T700A		4.6	1.7	Resistant										Opposite effects of cytomegalovirus UL54 exonuclease domain mutations on acyclovir and cidofovir susceptibility	https://www.sciencedirect.com/science/article/pii/S0166354221001716?via%3Dihub	doi.org/10.1016/j.antiviral.2021.105181	Recombinant BAC 	SEAP			21/12/2021	OJCharles		AD169	A
1680	HCMV	AD169	UL54	A809V		5.2	2	Resistant										Opposite effects of cytomegalovirus UL54 exonuclease domain mutations on acyclovir and cidofovir susceptibility	https://www.sciencedirect.com/science/article/pii/S0166354221001716?via%3Dihub	doi.org/10.1016/j.antiviral.2021.105181	Recombinant BAC 	SEAP			21/12/2021	OJCharles		AD169	A
1681	HCMV	AD169	UL54	D981del2		0.8	3.3	Resistant										Opposite effects of cytomegalovirus UL54 exonuclease domain mutations on acyclovir and cidofovir susceptibility	https://www.sciencedirect.com/science/article/pii/S0166354221001716?via%3Dihub	doi.org/10.1016/j.antiviral.2021.105181	Recombinant BAC 	SEAP			21/12/2021	OJCharles		AD169	A
1682	HCMV	AD169	UL54	A987G		0.4	7.7											Opposite effects of cytomegalovirus UL54 exonuclease domain mutations on acyclovir and cidofovir susceptibility	https://www.sciencedirect.com/science/article/pii/S0166354221001716?via%3Dihub	doi.org/10.1016/j.antiviral.2021.105181	Recombinant BAC 	SEAP			21/12/2021	OJCharles		AD169	A
1683	HCMV	AD169	UL54	A987V		1.6	0.9	Resistant										Opposite effects of cytomegalovirus UL54 exonuclease domain mutations on acyclovir and cidofovir susceptibility	https://www.sciencedirect.com/science/article/pii/S0166354221001716?via%3Dihub	doi.org/10.1016/j.antiviral.2021.105181	Recombinant BAC 	SEAP			21/12/2021	OJCharles		AD169	A
1684	HSV1	HSV1-17	UL30	L49I		1	1.6	0.6										Antiviral susceptibility of recombinant Herpes simplex virus 1 strains with specific polymerase amino acid changes	https://www.sciencedirect.com/science/article/pii/S016635422100156X?via%3Dihub	doi.org/10.1016/j.antiviral.2021.105166	Recombinant BAC 	GFP fluorescence reduction assay			22/12/2021	OJCharles	Could incorporate metabolic data too but reps are worse	HSV1-17	A
1685	HSV1	HSV1-17	UL30	E70K		1.9		0.7										Antiviral susceptibility of recombinant Herpes simplex virus 1 strains with specific polymerase amino acid changes	https://www.sciencedirect.com/science/article/pii/S016635422100156X?via%3Dihub	doi.org/10.1016/j.antiviral.2021.105166	Recombinant BAC 	GFP fluorescence reduction assay			22/12/2021	OJCharles		HSV1-17	A
1686	HSV1	HSV1-17	UL30	L359I		1.4	1	0.8										Antiviral susceptibility of recombinant Herpes simplex virus 1 strains with specific polymerase amino acid changes	https://www.sciencedirect.com/science/article/pii/S016635422100156X?via%3Dihub	doi.org/10.1016/j.antiviral.2021.105166	Recombinant BAC 	GFP fluorescence reduction assay			22/12/2021	OJCharles		HSV1-17	A
1687	HSV1	HSV1-17	UL30	E421V		1.4	1	0.7										Antiviral susceptibility of recombinant Herpes simplex virus 1 strains with specific polymerase amino acid changes	https://www.sciencedirect.com/science/article/pii/S016635422100156X?via%3Dihub	doi.org/10.1016/j.antiviral.2021.105166	Recombinant BAC 	GFP fluorescence reduction assay			22/12/2021	OJCharles		HSV1-17	A
1688	HSV1	HSV1-17	UL30	P829S		1.5	1.2	0.7										Antiviral susceptibility of recombinant Herpes simplex virus 1 strains with specific polymerase amino acid changes	https://www.sciencedirect.com/science/article/pii/S016635422100156X?via%3Dihub	doi.org/10.1016/j.antiviral.2021.105166	Recombinant BAC 	GFP fluorescence reduction assay			22/12/2021	OJCharles		HSV1-17	A
1689	HSV1	HSV1-17	UL30	T1121M		0.8	1.6	1.1										Antiviral susceptibility of recombinant Herpes simplex virus 1 strains with specific polymerase amino acid changes	https://www.sciencedirect.com/science/article/pii/S016635422100156X?via%3Dihub	doi.org/10.1016/j.antiviral.2021.105166	Recombinant BAC 	GFP fluorescence reduction assay			22/12/2021	OJCharles		HSV1-17	A
1690	HSV1	HSV1-17	UL30	M1226I		1.5		1.5										Antiviral susceptibility of recombinant Herpes simplex virus 1 strains with specific polymerase amino acid changes	https://www.sciencedirect.com/science/article/pii/S016635422100156X?via%3Dihub	doi.org/10.1016/j.antiviral.2021.105166	Recombinant BAC 	GFP fluorescence reduction assay			22/12/2021	OJCharles		HSV1-17	A
1691	HSV1	HSV1-17	UL23	G61A		26	1.1	1										Antiviral susceptibility of recombinant Herpes simplex virus 1 strains with specific polymerase amino acid changes	https://www.sciencedirect.com/science/article/pii/S016635422100156X?via%3Dihub	doi.org/10.1016/j.antiviral.2021.105166	Recombinant BAC 	GFP fluorescence reduction assay			22/12/2021	OJCharles		HSV1-17	A
1692	HSV1	HSV1-17	UL30	S724N		22	4.1	11.2										Antiviral susceptibility of recombinant Herpes simplex virus 1 strains with specific polymerase amino acid changes	https://www.sciencedirect.com/science/article/pii/S016635422100156X?via%3Dihub	doi.org/10.1016/j.antiviral.2021.105166	Recombinant BAC 	GFP fluorescence reduction assay			22/12/2021	OJCharles		HSV1-17	A
1693	HSV1	HSV1-17	UL30	Q618I		1.5		0.2										Impact of Amino Acid Substitutions in Region II and Helix K of Herpes Simplex Virus 1 and Human Cytomegalovirus DNA Polymerases on Resistance to Foscarnet	https://journals.asm.org/doi/10.1128/AAC.00390-21?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed	doi.org/10.1128/AAC.00390-21	Recombinant BAC 	PRA			22/12/2021	OJCharles		HSV1-17	A
1694	HSV1	HSV1-17	UL30	I619K		2.1		2.5										Impact of Amino Acid Substitutions in Region II and Helix K of Herpes Simplex Virus 1 and Human Cytomegalovirus DNA Polymerases on Resistance to Foscarnet	https://journals.asm.org/doi/10.1128/AAC.00390-21?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed	doi.org/10.1128/AAC.00390-21	Recombinant BAC 	PRA			22/12/2021	OJCharles		HSV1-17	A
1695	HSV1	HSV1-17	UL30	T623A		1.4		1										Impact of Amino Acid Substitutions in Region II and Helix K of Herpes Simplex Virus 1 and Human Cytomegalovirus DNA Polymerases on Resistance to Foscarnet	https://journals.asm.org/doi/10.1128/AAC.00390-21?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed	doi.org/10.1128/AAC.00390-21	Recombinant BAC 	PRA			22/12/2021	OJCharles		HSV1-17	A
1696	HSV1	HSV1-17	UL30	L625I		2.4		1.6										Impact of Amino Acid Substitutions in Region II and Helix K of Herpes Simplex Virus 1 and Human Cytomegalovirus DNA Polymerases on Resistance to Foscarnet	https://journals.asm.org/doi/10.1128/AAC.00390-21?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed	doi.org/10.1128/AAC.00390-21	Recombinant BAC 	PRA			22/12/2021	OJCharles		HSV1-17	A
1697	HSV1	HSV1-17	UL30	V694Q		1.3		1.7										Impact of Amino Acid Substitutions in Region II and Helix K of Herpes Simplex Virus 1 and Human Cytomegalovirus DNA Polymerases on Resistance to Foscarnet	https://journals.asm.org/doi/10.1128/AAC.00390-21?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed	doi.org/10.1128/AAC.00390-21	Recombinant BAC 	PRA			22/12/2021	OJCharles		HSV1-17	A
1698	HSV1	HSV1-17	UL30	Q697P		1.5		1.3										Impact of Amino Acid Substitutions in Region II and Helix K of Herpes Simplex Virus 1 and Human Cytomegalovirus DNA Polymerases on Resistance to Foscarnet	https://journals.asm.org/doi/10.1128/AAC.00390-21?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed	doi.org/10.1128/AAC.00390-21	Recombinant BAC 	PRA			22/12/2021	OJCharles		HSV1-17	A
1699	HSV1	HSV1-17	UL30	P712Y		3.7		0.6										Impact of Amino Acid Substitutions in Region II and Helix K of Herpes Simplex Virus 1 and Human Cytomegalovirus DNA Polymerases on Resistance to Foscarnet	https://journals.asm.org/doi/10.1128/AAC.00390-21?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed	doi.org/10.1128/AAC.00390-21	Recombinant BAC 	PRA			22/12/2021	OJCharles		HSV1-17	A
1700	HSV1	HSV1-17	UL30	A719T		3.5		2										Impact of Amino Acid Substitutions in Region II and Helix K of Herpes Simplex Virus 1 and Human Cytomegalovirus DNA Polymerases on Resistance to Foscarnet	https://journals.asm.org/doi/10.1128/AAC.00390-21?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed	doi.org/10.1128/AAC.00390-21	Recombinant BAC 	PRA			22/12/2021	OJCharles		HSV1-17	A
1701	HCMV	AD169	UL54	I580K	2.1			1.1										Impact of Amino Acid Substitutions in Region II and Helix K of Herpes Simplex Virus 1 and Human Cytomegalovirus DNA Polymerases on Resistance to Foscarnet	https://journals.asm.org/doi/10.1128/AAC.00390-21?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed	doi.org/10.1128/AAC.00390-21	Recombinant BAC 	GLuc reporter assay			22/12/2021	OJCharles		AD169	A
1702	HCMV	AD169	UL54	T584A	1			1										Impact of Amino Acid Substitutions in Region II and Helix K of Herpes Simplex Virus 1 and Human Cytomegalovirus DNA Polymerases on Resistance to Foscarnet	https://journals.asm.org/doi/10.1128/AAC.00390-21?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed	doi.org/10.1128/AAC.00390-21	Recombinant BAC 	GLuc reporter assay			22/12/2021	OJCharles		AD169	A
1703	HCMV	AD169	UL54	L586I	0.6			1										Impact of Amino Acid Substitutions in Region II and Helix K of Herpes Simplex Virus 1 and Human Cytomegalovirus DNA Polymerases on Resistance to Foscarnet	https://journals.asm.org/doi/10.1128/AAC.00390-21?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed	doi.org/10.1128/AAC.00390-21	Recombinant BAC 	GLuc reporter assay			22/12/2021	OJCharles		AD169	A
1704	HCMV	AD169	UL54	V694Q	0.5			1.6										Impact of Amino Acid Substitutions in Region II and Helix K of Herpes Simplex Virus 1 and Human Cytomegalovirus DNA Polymerases on Resistance to Foscarnet	https://journals.asm.org/doi/10.1128/AAC.00390-21?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed	doi.org/10.1128/AAC.00390-21	Recombinant BAC 	GLuc reporter assay			22/12/2021	OJCharles		AD169	A
1705	HCMV	AD169	UL54	Q697P	0.7			3.8										Impact of Amino Acid Substitutions in Region II and Helix K of Herpes Simplex Virus 1 and Human Cytomegalovirus DNA Polymerases on Resistance to Foscarnet	https://journals.asm.org/doi/10.1128/AAC.00390-21?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed	doi.org/10.1128/AAC.00390-21	Recombinant BAC 	GLuc reporter assay			22/12/2021	OJCharles		AD169	A
1706	HCMV	AD169	UL54	A719T	2.4			2.5										Impact of Amino Acid Substitutions in Region II and Helix K of Herpes Simplex Virus 1 and Human Cytomegalovirus DNA Polymerases on Resistance to Foscarnet	https://journals.asm.org/doi/10.1128/AAC.00390-21?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed	doi.org/10.1128/AAC.00390-21	Recombinant BAC 	GLuc reporter assay			22/12/2021	OJCharles		AD169	A
1707	HSV1	VR-3	UL5	K356N		1		1								261		Characteristics of Helicase-Primase Inhibitor Amenamevir-Resistant Herpes Simplex Virus	https://journals.asm.org/doi/10.1128/AAC.00494-21?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed	doi.org/10.1128/AAC.00494-21	Recombinant BAC 	PRA			22/12/2021	OJCharles		VR-3	A
1708	HSV1	VR-3	UL5	G352C		1		1								25		Characteristics of Helicase-Primase Inhibitor Amenamevir-Resistant Herpes Simplex Virus	https://journals.asm.org/doi/10.1128/AAC.00494-21?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed	doi.org/10.1128/AAC.00494-21	Recombinant BAC 	PRA			22/12/2021	OJCharles		VR-3	A
1709	HSV1	VR-3	UL5	G352V		1		1								3		Characteristics of Helicase-Primase Inhibitor Amenamevir-Resistant Herpes Simplex Virus	https://journals.asm.org/doi/10.1128/AAC.00494-21?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed	doi.org/10.1128/AAC.00494-21	Recombinant BAC 	PRA			22/12/2021	OJCharles		VR-3	A
1710	HSV1	VR-3	UL5	M355T		1		1								6		Characteristics of Helicase-Primase Inhibitor Amenamevir-Resistant Herpes Simplex Virus	https://journals.asm.org/doi/10.1128/AAC.00494-21?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed	doi.org/10.1128/AAC.00494-21	Recombinant BAC 	PRA			22/12/2021	OJCharles		VR-3	A
1711	HSV1	VR-3	UL5	E34K		1		1								1.5		Characteristics of Helicase-Primase Inhibitor Amenamevir-Resistant Herpes Simplex Virus	https://journals.asm.org/doi/10.1128/AAC.00494-21?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed	doi.org/10.1128/AAC.00494-21	Recombinant BAC 	PRA			22/12/2021	OJCharles		VR-3	A
1712	HSV1	VR-3	UL5	I341S		1		1								1.5		Characteristics of Helicase-Primase Inhibitor Amenamevir-Resistant Herpes Simplex Virus	https://journals.asm.org/doi/10.1128/AAC.00494-21?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed	doi.org/10.1128/AAC.00494-21	Recombinant BAC 	PRA			22/12/2021	OJCharles		VR-3	A
1713	HSV1	VR-3	UL5	C477D		1		1								1.5		Characteristics of Helicase-Primase Inhibitor Amenamevir-Resistant Herpes Simplex Virus	https://journals.asm.org/doi/10.1128/AAC.00494-21?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed	doi.org/10.1128/AAC.00494-21	Recombinant BAC 	PRA			22/12/2021	OJCharles		VR-3	A
1714	HSV1	VR-3	UL52	F360V		1		1								158		Characteristics of Helicase-Primase Inhibitor Amenamevir-Resistant Herpes Simplex Virus	https://journals.asm.org/doi/10.1128/AAC.00494-21?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed	doi.org/10.1128/AAC.00494-21	Recombinant BAC 	PRA			22/12/2021	OJCharles		VR-3	A
1715	HSV1	VR-3	UL52	F360C		1		1								25		Characteristics of Helicase-Primase Inhibitor Amenamevir-Resistant Herpes Simplex Virus	https://journals.asm.org/doi/10.1128/AAC.00494-21?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed	doi.org/10.1128/AAC.00494-21	Recombinant BAC 	PRA			22/12/2021	OJCharles		VR-3	A
1716	HSV1	VR-3	UL52	N902T		1		1								6		Characteristics of Helicase-Primase Inhibitor Amenamevir-Resistant Herpes Simplex Virus	https://journals.asm.org/doi/10.1128/AAC.00494-21?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed	doi.org/10.1128/AAC.00494-21	Recombinant BAC 	PRA			22/12/2021	OJCharles		VR-3	A
1717	HSV1	VR-3	UL52	Y222C		1		1								1.5		Characteristics of Helicase-Primase Inhibitor Amenamevir-Resistant Herpes Simplex Virus	https://journals.asm.org/doi/10.1128/AAC.00494-21?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed	doi.org/10.1128/AAC.00494-21	Recombinant BAC 	PRA			22/12/2021	OJCharles		VR-3	A
1718	HSV1	VR-3	UL52	F294L		1		1								1.5		Characteristics of Helicase-Primase Inhibitor Amenamevir-Resistant Herpes Simplex Virus	https://journals.asm.org/doi/10.1128/AAC.00494-21?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed	doi.org/10.1128/AAC.00494-21	Recombinant BAC 	PRA			22/12/2021	OJCharles		VR-3	A
1719	HSV1	VR-3	UL52	S364G		1		1								1		Characteristics of Helicase-Primase Inhibitor Amenamevir-Resistant Herpes Simplex Virus	https://journals.asm.org/doi/10.1128/AAC.00494-21?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed	doi.org/10.1128/AAC.00494-21	Recombinant BAC 	PRA			22/12/2021	OJCharles		VR-3	A
1720	HSV2	UW-268	UL5	K355N												2800		Characteristics of Helicase-Primase Inhibitor Amenamevir-Resistant Herpes Simplex Virus	https://journals.asm.org/doi/10.1128/AAC.00494-21?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed	doi.org/10.1128/AAC.00494-21	Lab induced strain 	PRA			22/12/2021	OJCharles		VR-3	A
1721	HSV2	UW-268	UL5	G351R												2196		Characteristics of Helicase-Primase Inhibitor Amenamevir-Resistant Herpes Simplex Virus	https://journals.asm.org/doi/10.1128/AAC.00494-21?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed	doi.org/10.1128/AAC.00494-21	Lab induced strain 	PRA			22/12/2021	OJCharles		UW-268	A
1722	HSV2	UW-268	UL5	K355E												8		Characteristics of Helicase-Primase Inhibitor Amenamevir-Resistant Herpes Simplex Virus	https://journals.asm.org/doi/10.1128/AAC.00494-21?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed	doi.org/10.1128/AAC.00494-21	Lab induced strain 	PRA			22/12/2021	OJCharles		UW-268	A
1723	HSV2	UW-268	UL5	I340V												2.1		Characteristics of Helicase-Primase Inhibitor Amenamevir-Resistant Herpes Simplex Virus	https://journals.asm.org/doi/10.1128/AAC.00494-21?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed	doi.org/10.1128/AAC.00494-21	Lab induced strain 	PRA			22/12/2021	OJCharles		UW-268	A
1724	HCMV	Toledo	UL54	T700A	0.9		0.7	7.6										Analysis of Novel Drug-Resistant Human Cytomegalovirus DNA Polymerase Mutations Reveals the Role of a DNA-Binding Loop in Phosphonoformic Acid Resistance	https://www.frontiersin.org/articles/10.3389/fmicb.2022.771978/full	doi.org/10.3389/fmicb.2022.771978	Recombinant BAC 	PRA			04/03/2022	OJCharles		Toledo	A
1725	HCMV	Toledo	UL54	H600L	11.1		4.9	5.2										Analysis of Novel Drug-Resistant Human Cytomegalovirus DNA Polymerase Mutations Reveals the Role of a DNA-Binding Loop in Phosphonoformic Acid Resistance	https://www.frontiersin.org/articles/10.3389/fmicb.2022.771978/full	doi.org/10.3389/fmicb.2022.771978	Recombinant BAC 	PRA			04/03/2022	OJCharles		Toledo	A
1726	HCMV	Toledo	UL54	E756G	1		1.8	8.8										Analysis of Novel Drug-Resistant Human Cytomegalovirus DNA Polymerase Mutations Reveals the Role of a DNA-Binding Loop in Phosphonoformic Acid Resistance	https://www.frontiersin.org/articles/10.3389/fmicb.2022.771978/full	doi.org/10.3389/fmicb.2022.771978	Recombinant BAC 	PRA			04/03/2022	OJCharles		Toledo	A
1727	HCMV	Toledo	UL54	H600L	1.4		0.7	37										Analysis of Novel Drug-Resistant Human Cytomegalovirus DNA Polymerase Mutations Reveals the Role of a DNA-Binding Loop in Phosphonoformic Acid Resistance	https://www.frontiersin.org/articles/10.3389/fmicb.2022.771978/full	doi.org/10.3389/fmicb.2022.771978	Recombinant BAC 	PRA	UL54	T700A	04/03/2022	OJCharles		Toledo	A
1729	Adeno	ad5	pol	V303I			1.9		2.1									Cidofovir Diphosphate Inhibits Adenovirus 5 DNA Polymerase via both Nonobligate Chain Termination and Direct Inhibition, and Polymerase Mutations Confer Cidofovir Resistance on Intact Virus	https://aac.asm.org/content/aac/63/1/e01925-18.full.pdf	doi.org/10.1128/AAC.01925-18	Lab induced strain 	Polymerase kinetic assay	pol	T87I	04/02/2022	OJCharles	co-occuring uncharacterised mutations		O
1730	HCMV	AD169	UL97	C480F	17.5			0.84						10				Phenotype and Genotype Study of Novel C480F Maribavir-Ganciclovir Cross-Resistance Mutation Detected in Hematopoietic Stem Cell and Solid Organ Transplant Recipients	https://academic.oup.com/jid/article/224/6/1024/6105173	doi.org/10.1093/infdis/jiab029	Recombinant BAC 	GFP fluorescence reduction assay			05/08/2023	OJCharles		AD169	A
1731	HSV1	F	UL23	T63A	10													Drug resistance of herpes simplex virus type 1Structural considerations at the molecular level of the thymidine kinase	https://febs.onlinelibrary.wiley.com/doi/abs/10.1046/j.1432-1327.1998.2550472.x?sid=nlm%3Apubmed	doi.org/10.1046/j.1432-1327.1998.2550472.x	Marker transfer 	TK functional kinetic assay			17/05/2022	OJCharles	fold change guessed, no tk activity	F	A
1732	HSV1	F	UL23	T63S	5													Drug resistance of herpes simplex virus type 1Structural considerations at the molecular level of the thymidine kinase	https://febs.onlinelibrary.wiley.com/doi/abs/10.1046/j.1432-1327.1998.2550472.x?sid=nlm%3Apubmed	doi.org/10.1046/j.1432-1327.1998.2550472.x	Marker transfer 	TK functional kinetic assay			17/05/2022	OJCharles		F	A
1733	HCMV	AD169	UL56	R246C	0.6		1.8	0.9		0.8				0.5				Assessment of UL56 Mutations before Letermovir Therapy in Refractory Cytomegalovirus Transplant Recipients	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9045154/	doi.org/10.1128/spectrum.00191-22	Recombinant BAC 	GFP fluorescence reduction assay			09/10/2022	OJCharles		AD169	A
1734	HCMV	AD169	UL51	D12E						1.4								First clinical description of letermovir resistance mutation in cytomegalovirus UL51 gene and potential impact on the terminase complex structure	https://www.sciencedirect.com/science/article/pii/S0166354222001309	doi.org/10.1016/j.antiviral.2022.105361	Recombinant BAC 	GFP fluorescence reduction assay			09/10/2022	OJCharles		AD169	A
1735	HCMV	AD169	UL51	A95V						13.8								First clinical description of letermovir resistance mutation in cytomegalovirus UL51 gene and potential impact on the terminase complex structure	https://www.sciencedirect.com/science/article/pii/S0166354222001309	doi.org/10.1016/j.antiviral.2022.105361	Recombinant BAC 	GFP fluorescence reduction assay			09/10/2022	OJCharles		AD169	A
1736	HCMV	AD169	UL51	V113L						1.5								First clinical description of letermovir resistance mutation in cytomegalovirus UL51 gene and potential impact on the terminase complex structure	https://www.sciencedirect.com/science/article/pii/S0166354222001309	doi.org/10.1016/j.antiviral.2022.105361	Recombinant BAC 	GFP fluorescence reduction assay			09/10/2022	OJCharles		AD169	A
1737	HCMV	AD169	UL51	A95V						128								First clinical description of letermovir resistance mutation in cytomegalovirus UL51 gene and potential impact on the terminase complex structure	https://www.sciencedirect.com/science/article/pii/S0166354222001309	doi.org/10.1016/j.antiviral.2022.105361	Recombinant BAC 	GFP fluorescence reduction assay	UL56	L257I	09/10/2022	OJCharles		AD169	A
1738	HCMV	AD169	UL56	V231L						8.8								Relative frequency of cytomegalovirus UL56 gene mutations detected in genotypic letermovir resistance testing	https://www.sciencedirect.com/science/article/pii/S0166354222001917?via%3Dihub#bib4	doi.org/10.1016/j.antiviral.2022.105422	Recombinant BAC 	SEAP			09/10/2022	OJCharles		AD169	A
1739	HCMV	AD169	UL56	Q234R						2								Relative frequency of cytomegalovirus UL56 gene mutations detected in genotypic letermovir resistance testing	https://www.sciencedirect.com/science/article/pii/S0166354222001917?via%3Dihub#bib4	doi.org/10.1016/j.antiviral.2022.105422	Recombinant BAC 	SEAP			09/10/2022	OJCharles		AD169	A
1740	HCMV	AD169	UL56	L243P						1								Relative frequency of cytomegalovirus UL56 gene mutations detected in genotypic letermovir resistance testing	https://www.sciencedirect.com/science/article/pii/S0166354222001917?via%3Dihub#bib4	doi.org/10.1016/j.antiviral.2022.105422	Recombinant BAC 	SEAP			09/10/2022	OJCharles		AD169	A
1741	HCMV	AD169	UL56	S262C						1								Relative frequency of cytomegalovirus UL56 gene mutations detected in genotypic letermovir resistance testing	https://www.sciencedirect.com/science/article/pii/S0166354222001917?via%3Dihub#bib4	doi.org/10.1016/j.antiviral.2022.105422	Recombinant BAC 	SEAP			09/10/2022	OJCharles		AD169	A
1742	HCMV	AD169	UL56	L328I						1.4								Relative frequency of cytomegalovirus UL56 gene mutations detected in genotypic letermovir resistance testing	https://www.sciencedirect.com/science/article/pii/S0166354222001917?via%3Dihub#bib4	doi.org/10.1016/j.antiviral.2022.105422	Recombinant BAC 	SEAP			09/10/2022	OJCharles		AD169	A
1743	HCMV	AD169	UL56	H335Y						0.8								Relative frequency of cytomegalovirus UL56 gene mutations detected in genotypic letermovir resistance testing	https://www.sciencedirect.com/science/article/pii/S0166354222001917?via%3Dihub#bib4	doi.org/10.1016/j.antiviral.2022.105422	Recombinant BAC 	SEAP			09/10/2022	OJCharles		AD169	A
1744	HCMV	AD169	UL56	E339G						1.2								Relative frequency of cytomegalovirus UL56 gene mutations detected in genotypic letermovir resistance testing	https://www.sciencedirect.com/science/article/pii/S0166354222001917?via%3Dihub#bib4	doi.org/10.1016/j.antiviral.2022.105422	Recombinant BAC 	SEAP			09/10/2022	OJCharles		AD169	A
1745	HCMV	AD169	UL56	K350R						1								Relative frequency of cytomegalovirus UL56 gene mutations detected in genotypic letermovir resistance testing	https://www.sciencedirect.com/science/article/pii/S0166354222001917?via%3Dihub#bib4	doi.org/10.1016/j.antiviral.2022.105422	Recombinant BAC 	SEAP			09/10/2022	OJCharles		AD169	A
1746	HCMV	AD169	UL56	V363I						3.7								Relative frequency of cytomegalovirus UL56 gene mutations detected in genotypic letermovir resistance testing	https://www.sciencedirect.com/science/article/pii/S0166354222001917?via%3Dihub#bib4	doi.org/10.1016/j.antiviral.2022.105422	Recombinant BAC 	SEAP			09/10/2022	OJCharles		AD169	A
1747	HCMV	AD169	UL56	N368I						1.3								Relative frequency of cytomegalovirus UL56 gene mutations detected in genotypic letermovir resistance testing	https://www.sciencedirect.com/science/article/pii/S0166354222001917?via%3Dihub#bib4	doi.org/10.1016/j.antiviral.2022.105422	Recombinant BAC 	SEAP			09/10/2022	OJCharles		AD169	A
1748	HCMV	AD169	UL56	R369K						4.9								Relative frequency of cytomegalovirus UL56 gene mutations detected in genotypic letermovir resistance testing	https://www.sciencedirect.com/science/article/pii/S0166354222001917?via%3Dihub#bib4	doi.org/10.1016/j.antiviral.2022.105422	Recombinant BAC 	SEAP			09/10/2022	OJCharles		AD169	A
1749	HCMV	AD169	UL56	T399I						0.8								Relative frequency of cytomegalovirus UL56 gene mutations detected in genotypic letermovir resistance testing	https://www.sciencedirect.com/science/article/pii/S0166354222001917?via%3Dihub#bib4	doi.org/10.1016/j.antiviral.2022.105422	Recombinant BAC 	SEAP			09/10/2022	OJCharles		AD169	A
1750	HCMV	AD169	UL54	G441S	Polymorphism		Polymorphism	Polymorphism										Genotypic and Phenotypic Study of Antiviral Resistance Mutations in Refractory Cytomegalovirus Infection	https://academic.oup.com/jid/article-abstract/226/9/1528/6672993	doi.org/10.1093/infdis/jiac349	Isolated strain 	PRA			05/08/2023	OJCharles		AD169	A
1751	HCMV	AD169	UL54	A543V			Resistant											Genotypic and Phenotypic Study of Antiviral Resistance Mutations in Refractory Cytomegalovirus Infection	https://academic.oup.com/jid/article-abstract/226/9/1528/6672993	doi.org/10.1093/infdis/jiac349	Isolated strain 	PRA	UL54	M460I	05/08/2023	OJCharles	co-occurs with M460I which causes GCVr and has not been tested against CDV but given GCVr it is more likely it causes CDVr and A543V is therefore hard to determine	AD169	O
1752	HCMV	AD169	UL54	F460S	Polymorphism		Polymorphism	Polymorphism										Genotypic and Phenotypic Study of Antiviral Resistance Mutations in Refractory Cytomegalovirus Infection	https://academic.oup.com/jid/article-abstract/226/9/1528/6672993	doi.org/10.1093/infdis/jiac349	Isolated strain 	PRA			05/08/2023	OJCharles		AD169	A
1753	HCMV	AD169	UL54	R512C	Polymorphism		Polymorphism	Polymorphism										Genotypic and Phenotypic Study of Antiviral Resistance Mutations in Refractory Cytomegalovirus Infection	https://academic.oup.com/jid/article-abstract/226/9/1528/6672993	doi.org/10.1093/infdis/jiac349	Isolated strain 	PRA			05/08/2023	OJCharles		AD169	A
1754	HCMV	AD169	UL54	A928T	Resistant		Resistant	Resistant										Genotypic and Phenotypic Study of Antiviral Resistance Mutations in Refractory Cytomegalovirus Infection	https://academic.oup.com/jid/article-abstract/226/9/1528/6672993	doi.org/10.1093/infdis/jiac349	Isolated strain 	PRA			05/08/2023	OJCharles	no other mutations noted	AD169	A
1755	HCMV	AD169	UL56	F345L	1.42		1.67	1		1								Genotypic and Phenotypic Study of Antiviral Resistance Mutations in Refractory Cytomegalovirus Infection	https://academic.oup.com/jid/article-abstract/226/9/1528/6672993	doi.org/10.1093/infdis/jiac349	Isolated strain 	PRA			05/08/2023	OJCharles		AD169	A
1756	HCMV	AD169	UL56	P800L	0.23		0.13	1		1.1								Genotypic and Phenotypic Study of Antiviral Resistance Mutations in Refractory Cytomegalovirus Infection	https://academic.oup.com/jid/article-abstract/226/9/1528/6672993	doi.org/10.1093/infdis/jiac349	Isolated strain 	PRA			05/08/2023	OJCharles		AD169	A
1757	HSV1	KOS	UL30	Q727R		Resistant		Resistant										A Herpes Simplex Virus 1 DNA Polymerase Multidrug Resistance Mutation Identified in a Patient With Immunodeficiency and Confirmed by Gene Editing	https://academic.oup.com/jid/advance-article-abstract/doi/10.1093/infdis/jiad184/7177683?redirectedFrom=fulltext	doi.org/10.1093/infdis/jiad184	Marker transfer 	Cytopathic effect			05/08/2023	OJCharles		KOS	A
1758	HSV1	Clinical isolate	UL30	R264C	1.9	0.6	1.2	0.7			1.2	2						A Herpes Simplex Virus 1 DNA Polymerase Multidrug Resistance Mutation Identified in a Patient With Immunodeficiency and Confirmed by Gene Editing	https://academic.oup.com/jid/advance-article-abstract/doi/10.1093/infdis/jiad184/7177683?redirectedFrom=fulltext	doi.org/10.1093/infdis/jiad184	Isolated strain 	Cytopathic effect			05/08/2023	OJCharles	lost ref	KOS	P
1759	HSV1	Clinical isolate	UL30	T245M	199	297	1.2	0.9			545	467						A Herpes Simplex Virus 1 DNA Polymerase Multidrug Resistance Mutation Identified in a Patient With Immunodeficiency and Confirmed by Gene Editing	https://academic.oup.com/jid/advance-article-abstract/doi/10.1093/infdis/jiad184/7177683?redirectedFrom=fulltext	doi.org/10.1093/infdis/jiad184	Isolated strain 	Cytopathic effect			05/08/2023	OJCharles	lost ref	KOS	O
1760	HCMV	AD169	UL56	V231L						5.6								A third component of the human cytomegalovirus terminase complex is involved in letermovir resistance	https://www.sciencedirect.com/science/article/pii/S0166354217306393	doi.org/10.1016/j.antiviral.2017.10.019	Recombinant BAC 	SEAP			07/08/2023	OJCharles		AD169	A
1761	HCMV	AD169	UL56	L241P						173								A third component of the human cytomegalovirus terminase complex is involved in letermovir resistance	https://www.sciencedirect.com/science/article/pii/S0166354217306393	doi.org/10.1016/j.antiviral.2017.10.019	Recombinant BAC 	SEAP			07/08/2023	OJCharles		AD169	A
1762	HCMV	AD169	UL56	R369M						16								A third component of the human cytomegalovirus terminase complex is involved in letermovir resistance	https://www.sciencedirect.com/science/article/pii/S0166354217306393	doi.org/10.1016/j.antiviral.2017.10.019	Recombinant BAC 	SEAP			07/08/2023	OJCharles		AD169	A
1763	HCMV	AD169	UL89	D344E						1.6								A third component of the human cytomegalovirus terminase complex is involved in letermovir resistance	https://www.sciencedirect.com/science/article/pii/S0166354217306393	doi.org/10.1016/j.antiviral.2017.10.019	Recombinant BAC 	SEAP			07/08/2023	OJCharles		AD169	A
1764	HCMV	AD169	UL56	V231L						8.1								New Locus of Drug Resistance in the Human Cytomegalovirus UL56 Gene Revealed by In Vitro Exposure to Letermovir and Ganciclovir	https://aac.asm.org/content/aac/62/9/e00922-18.full.pdf	doi.org/10.1128/AAC.00922-18	Recombinant BAC 	SEAP			07/08/2023	OJCharles		AD169	A
1765	HCMV	AD169	UL56	V236M						49								New Locus of Drug Resistance in the Human Cytomegalovirus UL56 Gene Revealed by In Vitro Exposure to Letermovir and Ganciclovir	https://aac.asm.org/content/aac/62/9/e00922-18.full.pdf	doi.org/10.1128/AAC.00922-18	Recombinant BAC 	SEAP			07/08/2023	OJCharles		AD169	A
1766	HCMV	AD169	UL56	L257F						14								New Locus of Drug Resistance in the Human Cytomegalovirus UL56 Gene Revealed by In Vitro Exposure to Letermovir and Ganciclovir	https://aac.asm.org/content/aac/62/9/e00922-18.full.pdf	doi.org/10.1128/AAC.00922-18	Recombinant BAC 	SEAP			07/08/2023	OJCharles		AD169	A
1767	HCMV	AD169	UL56	C325Y						8800								New Locus of Drug Resistance in the Human Cytomegalovirus UL56 Gene Revealed by In Vitro Exposure to Letermovir and Ganciclovir	https://aac.asm.org/content/aac/62/9/e00922-18.full.pdf	doi.org/10.1128/AAC.00922-18	Recombinant BAC 	SEAP			07/08/2023	OJCharles		AD169	A
1768	HCMV	AD169	UL27	R448P										1.5				Effects on maribavir susceptibility of cytomegalovirus UL97 kinase ATP binding region mutations detected after drug exposure in vitro and in vivo	https://www.sciencedirect.com/science/article/pii/S0166354212001283	doi.org/10.1016/j.antiviral.2012.05.013	Recombinant BAC 	SEAP			07/08/2023	OJCharles		AD169	A
1769	HCMV	AD169	UL27	D534Y										1.4				Effects on maribavir susceptibility of cytomegalovirus UL97 kinase ATP binding region mutations detected after drug exposure in vitro and in vivo	https://www.sciencedirect.com/science/article/pii/S0166354212001283	doi.org/10.1016/j.antiviral.2012.05.013	Recombinant BAC 	SEAP			07/08/2023	OJCharles		AD169	A
1770	HCMV	AD169	UL97	I324V										0.6				Effects on maribavir susceptibility of cytomegalovirus UL97 kinase ATP binding region mutations detected after drug exposure in vitro and in vivo	https://www.sciencedirect.com/science/article/pii/S0166354212001283	doi.org/10.1016/j.antiviral.2012.05.013	Recombinant BAC 	SEAP			07/08/2023	OJCharles		AD169	A
1771	HCMV	AD169	UL97	S334G										1.1				Effects on maribavir susceptibility of cytomegalovirus UL97 kinase ATP binding region mutations detected after drug exposure in vitro and in vivo	https://www.sciencedirect.com/science/article/pii/S0166354212001283	doi.org/10.1016/j.antiviral.2012.05.013	Recombinant BAC 	SEAP			07/08/2023	OJCharles		AD169	A
1772	HCMV	AD169	UL27	R233S										2				Effects on maribavir susceptibility of cytomegalovirus UL97 kinase ATP binding region mutations detected after drug exposure in vitro and in vivo	https://www.sciencedirect.com/science/article/pii/S0166354212001283	doi.org/10.1016/j.antiviral.2012.05.013	Recombinant BAC 	SEAP	UL97	S334G	07/08/2023	OJCharles		AD169	A
1773	HCMV	AD169	UL97	L337M										7.2				Effects on maribavir susceptibility of cytomegalovirus UL97 kinase ATP binding region mutations detected after drug exposure in vitro and in vivo	https://www.sciencedirect.com/science/article/pii/S0166354212001283	doi.org/10.1016/j.antiviral.2012.05.013	Recombinant BAC 	SEAP	UL27	R233S	07/08/2023	OJCharles		AD169	A
1774	HCMV	AD169	UL97	V353A										12				Effects on maribavir susceptibility of cytomegalovirus UL97 kinase ATP binding region mutations detected after drug exposure in vitro and in vivo	https://www.sciencedirect.com/science/article/pii/S0166354212001283	doi.org/10.1016/j.antiviral.2012.05.013	Recombinant BAC 	SEAP			07/08/2023	OJCharles		AD169	A
1775	HCMV	AD169	UL97	S386L										0.9				Effects on maribavir susceptibility of cytomegalovirus UL97 kinase ATP binding region mutations detected after drug exposure in vitro and in vivo	https://www.sciencedirect.com/science/article/pii/S0166354212001283	doi.org/10.1016/j.antiviral.2012.05.013	Recombinant BAC 	SEAP			07/08/2023	OJCharles		AD169	A
1776	HCMV	Clinical isolate	UL97	M460V	6									1				Potent and Selective Inhibition of Human Cytomegalovirus Replication by 1263W94, a Benzimidazole l-Riboside with a Unique Mode of Action	https://journals.asm.org/doi/full/10.1128/aac.46.8.2365-2372.2002	doi.org/10.1128/aac.46.8.2365-2372.2002	Isolated strain 	PCR DNA hybridization assay			07/08/2023	OJCharles		AD169	A
1777	HCMV	Clinical isolate	UL97	H520E	5.2									1.6				Potent and Selective Inhibition of Human Cytomegalovirus Replication by 1263W94, a Benzimidazole l-Riboside with a Unique Mode of Action	https://journals.asm.org/doi/full/10.1128/aac.46.8.2365-2372.2002	doi.org/10.1128/aac.46.8.2365-2372.2002	Isolated strain 	PCR DNA hybridization assay			07/08/2023	OJCharles		AD169	A
1778	HCMV	Clinical isolate	UL97	A594V	6													Potent and Selective Inhibition of Human Cytomegalovirus Replication by 1263W94, a Benzimidazole l-Riboside with a Unique Mode of Action	https://journals.asm.org/doi/full/10.1128/aac.46.8.2365-2372.2002	doi.org/10.1128/aac.46.8.2365-2372.2002	Isolated strain 	PCR DNA hybridization assay			07/08/2023	OJCharles		AD169	A
1779	HCMV	Clinical isolate	UL54	T700A	2.2									0.8				Potent and Selective Inhibition of Human Cytomegalovirus Replication by 1263W94, a Benzimidazole l-Riboside with a Unique Mode of Action	https://journals.asm.org/doi/full/10.1128/aac.46.8.2365-2372.2002	doi.org/10.1128/aac.46.8.2365-2372.2002	Isolated strain 	PCR DNA hybridization assay			07/08/2023	OJCharles		AD169	A
1780	HCMV	Clinical isolate	UL97	L397R	1									34				Potent and Selective Inhibition of Human Cytomegalovirus Replication by 1263W94, a Benzimidazole l-Riboside with a Unique Mode of Action	https://journals.asm.org/doi/full/10.1128/aac.46.8.2365-2372.2002	doi.org/10.1128/aac.46.8.2365-2372.2002	Isolated strain 	PCR DNA hybridization assay			07/08/2023	OJCharles		AD169	A
1781	HCMV	AD169	UL27	V353A										16				Diverse Cytomegalovirus UL27 Mutations Adapt to Loss of Viral UL97 Kinase Activity under Maribavir	https://aac.asm.org/content/53/1/81	doi.org/10.1128/AAC.01177-08	Recombinant BAC 	SEAP			07/08/2023	OJCharles		AD169	A
1782	HCMV	AD169	UL97	V353A	1.7									15				Accelerated Evolution of Maribavir Resistance in a Cytomegalovirus Exonuclease Domain II Mutant	https://jvi.asm.org/content/82/1/246.short	doi.org/10.1128/JVI.01787-07	Marker transfer	SEAP			07/08/2023	OJCharles		AD169	A
1783	HCMV	AD169	UL97	H587Y	1									1				Accelerated Evolution of Maribavir Resistance in a Cytomegalovirus Exonuclease Domain II Mutant	https://jvi.asm.org/content/82/1/246.short	doi.org/10.1128/JVI.01787-07	Marker transfer	SEAP			07/08/2023	OJCharles		AD169	A
1784	HCMV	AD169	UL27	R233S										4.7				Mutations in the Human Cytomegalovirus UL27 Gene That Confer Resistance to Maribavir	https://journals.asm.org/doi/full/10.1128/jvi.78.13.7124-7130.2004	doi.org/10.1128/jvi.78.13.7124-7130.2004	Marker Transfer	PRA			07/08/2023	OJCharles		AD169	A
1785	HCMV	AD169	UL27	W362R										2				Mutations in the Human Cytomegalovirus UL27 Gene That Confer Resistance to Maribavir	https://journals.asm.org/doi/full/10.1128/jvi.78.13.7124-7130.2004	doi.org/10.1128/jvi.78.13.7124-7130.2004	Marker Transfer	PRA			07/08/2023	OJCharles		AD169	A
1786	HCMV	AD169	UL97	M460V	7									0.3				Cytomegalovirus UL97 Kinase Mutations That Confer Maribavir Resistance	https://academic.oup.com/jid/article-lookup/doi/10.1086/518514	doi.org/10.1086/518514	Marker Transfer 	SEAP			07/08/2023	OJCharles		AD169	A
1787	HCMV	AD169	UL97	V353A										10				Cytomegalovirus UL97 Kinase Catalytic Domain Mutations That Confer Multidrug Resistance	https://aac.asm.org/content/aac/57/7/3375.full.pdf		Recombinant BAC 	SEAP			07/08/2023	OJCharles		AD169	A
1788	HCMV	AD169	UL97	M460I											11			Cytomegalovirus UL97 Kinase Catalytic Domain Mutations That Confer Multidrug Resistance	https://aac.asm.org/content/aac/57/7/3375.full.pdf		Recombinant BAC 	SEAP			07/08/2023	OJCharles		AD169	A
1789	HCMV	AD169	UL97	C592G	2.7													Cytomegalovirus UL97 Kinase Catalytic Domain Mutations That Confer Multidrug Resistance	https://aac.asm.org/content/aac/57/7/3375.full.pdf		Recombinant BAC 	SEAP			07/08/2023	OJCharles		AD169	A
1790	HCMV	AD169	UL97	A594V	8.3													Recombinant Phenotyping of Cytomegalovirus UL97 Kinase Sequence Variants for Ganciclovir Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876423/	doi.org/10.1128/AAC.00186-10	Recombinant BAC 	SEAP			07/08/2023	OJCharles		AD169	A
1791	HCMV	AD169	UL97	C603R	8.3													Recombinant Phenotyping of Cytomegalovirus UL97 Kinase Sequence Variants for Ganciclovir Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876423/	doi.org/10.1128/AAC.00186-10	Recombinant BAC 	SEAP			07/08/2023	OJCharles		AD169	A
1792	HCMV	AD169	UL97	V665I	1.1													Recombinant Phenotyping of Cytomegalovirus UL97 Kinase Sequence Variants for Ganciclovir Resistance	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876423/	doi.org/10.1128/AAC.00186-10	Recombinant BAC 	SEAP			07/08/2023	OJCharles		AD169	A
1793	HCMV	AD169	UL97	K355M	25										13			Human Cytomegalovirus UL97 Kinase Is Involved in the Mechanism of Action of Methylenecyclopropane Analogs with 6-Ether and -Thioether Substitutions	https://journals.asm.org/doi/full/10.1128/aac.01726-13	doi.org/10.1128/aac.01726-13	Recombinant BAC 	PRA			07/08/2023	OJCharles		AD169	A
1794	HCMV	Towne	UL97	C592G	2.5													Cytomegalovirus UL97 Phosphotransferase Mutations That Affect Susceptibility to Ganciclovir	https://academic.oup.com/jid/article/185/2/162/2191141	doi.org/10.1086/338362	Marker Transfer 	PRA			07/08/2023	OJCharles		Towne	A
1795	HCMV	Towne	UL97	L634Q	1.1													Cytomegalovirus UL97 Phosphotransferase Mutations That Affect Susceptibility to Ganciclovir	https://academic.oup.com/jid/article/185/2/162/2191141	doi.org/10.1086/338362	Marker Transfer 	PRA			07/08/2023	OJCharles		Towne	A
1796	HCMV	Towne	UL97	C607F	1.6													Cytomegalovirus UL97 Phosphotransferase Mutations That Affect Susceptibility to Ganciclovir	https://academic.oup.com/jid/article/185/2/162/2191141	doi.org/10.1086/338362	Marker Transfer 	PRA			07/08/2023	OJCharles		Towne	A
1797	HCMV	AD169	UL97	L595S	4.9													Cytomegalovirus UL97 Phosphotransferase Mutations That Affect Susceptibility to Ganciclovir	https://academic.oup.com/jid/article/185/2/162/2191141	doi.org/10.1086/338362	Marker Transfer 	PRA			07/08/2023	OJCharles		AD169	A
1798	HCMV	AD169	UL97	C592G	2.6													Cytomegalovirus UL97 Phosphotransferase Mutations That Affect Susceptibility to Ganciclovir	https://academic.oup.com/jid/article/185/2/162/2191141	doi.org/10.1086/338362	Marker Transfer 	PRA			07/08/2023	OJCharles		AD169	A
1799	HCMV	Clinical Isolate	UL97	L595F	1		0.4	1.5										High-Level Resistance of Cytomegalovirus to Ganciclovir Is Associated with Alterations in Both the UL97 and DNA Polymerase Genes	https://academic.oup.com/jid/article/176/1/69/901024	doi.org/10.1086/514041	Isolated strain 	PRA			07/08/2023	OJCharles			A
1800	HCMV	Clinical Isolate	UL97	A594V	1.7		1.7	1.1										High-Level Resistance of Cytomegalovirus to Ganciclovir Is Associated with Alterations in Both the UL97 and DNA Polymerase Genes	https://academic.oup.com/jid/article/176/1/69/901024	doi.org/10.1086/514041	Isolated strain 	PRA			07/08/2023	OJCharles			A
1801	HCMV	Clinical Isolate	UL97	M460V	1.7		1.2	0.9										High-Level Resistance of Cytomegalovirus to Ganciclovir Is Associated with Alterations in Both the UL97 and DNA Polymerase Genes	https://academic.oup.com/jid/article/176/1/69/901024	doi.org/10.1086/514041	Isolated strain 	PRA			07/08/2023	OJCharles			A
1802	HCMV	Clinical Isolate	UL97	M460I	2.2		1	0.6										High-Level Resistance of Cytomegalovirus to Ganciclovir Is Associated with Alterations in Both the UL97 and DNA Polymerase Genes	https://academic.oup.com/jid/article/176/1/69/901024	doi.org/10.1086/514041	Isolated strain 	PRA			07/08/2023	OJCharles			A
1803	HCMV	Clinical Isolate	UL97	L595S	4		1	1										Analysis and Characterization of Antiviral Drug–Resistant Cytomegalovirus Isolates from Solid Organ Transplant Recipients	https://academic.oup.com/jid/article/186/6/760/2191110	doi.org/10.1086/342844	Isolated strain 	PRA			07/08/2023	OJCharles			A
1804	HCMV	Clinical Isolate	UL97	H520Q	3.2		0.5	1.5										Analysis and Characterization of Antiviral Drug–Resistant Cytomegalovirus Isolates from Solid Organ Transplant Recipients	https://academic.oup.com/jid/article/186/6/760/2191110	doi.org/10.1086/342844	Isolated strain 	PRA			07/08/2023	OJCharles			A
1805	HCMV	Clinical Isolate	UL97	A594P	2.6		2.5	0.7										Analysis and Characterization of Antiviral Drug–Resistant Cytomegalovirus Isolates from Solid Organ Transplant Recipients	https://academic.oup.com/jid/article/186/6/760/2191110	doi.org/10.1086/342844	Isolated strain 	PRA			07/08/2023	OJCharles			A
1806	HCMV	Clinical Isolate	UL54	F412S	2.3		16	1										Analysis and Characterization of Antiviral Drug–Resistant Cytomegalovirus Isolates from Solid Organ Transplant Recipients	https://academic.oup.com/jid/article/186/6/760/2191110	doi.org/10.1086/342844	Isolated strain 	PRA			07/08/2023	OJCharles			A
1807	HCMV	Clinical Isolate	UL97	A594V	1.8													Analysis and Characterization of Antiviral Drug–Resistant Cytomegalovirus Isolates from Solid Organ Transplant Recipients	https://academic.oup.com/jid/article/186/6/760/2191110	doi.org/10.1086/342844	Isolated strain 	PRA			07/08/2023	OJCharles	large discrepencies between reps		O
1808	HCMV	Clinical Isolate	UL97	C607Y	4													Analysis and Characterization of Antiviral Drug–Resistant Cytomegalovirus Isolates from Solid Organ Transplant Recipients	https://academic.oup.com/jid/article/186/6/760/2191110	doi.org/10.1086/342844	Isolated strain 	PRA			07/08/2023	OJCharles			A
1809	HCMV		UL97	L595F	7													Mutations in human cytomegalovirus UL97 gene confer clinical resistance to ganciclovir and can be detected directly in patient plasma	https://www.jci.org/articles/view/117648	doi.org/10.1172/jci117648	Isolated strain 	PRA			14/08/2023	OJCharles			A
1810	HCMV		UL97	T659I	4													Mutations in human cytomegalovirus UL97 gene confer clinical resistance to ganciclovir and can be detected directly in patient plasma	https://www.jci.org/articles/view/117648	doi.org/10.1172/jci117648	Isolated strain 	PRA			14/08/2023	OJCharles			A
1811	HCMV		UL54	V715M	1			5.5										Single amino acid changes in the DNA polymerase confer foscarnet resistance and slow-growth phenotype, while mutations in the UL97-encoded phosphotransferase confer ganciclovir resistance in three double-resistant human cytomegalovirus strains recovered from patients with AIDS	https://journals.asm.org/doi/10.1128/JVI.70.3.1390-1395.1996	doi.org/10.1128/jvi.70.3.1390-1395.1996	Marker Transfer	PRA			14/08/2023	OJCharles		AD169	A
1812	HCMV	AD169	UL54	N495K 	1		2.5	5.6										Rapid determination of antiviral drug susceptibility of human cytomegalovirus by real-time PCR	https://www.sciencedirect.com/science/article/pii/S0166354208004221	doi.org/10.1016/j.antiviral.2008.09.009	Marker Transfer	PRA			14/08/2023	OJCharles		AD169	A
1813	HCMV	AD169	UL54	L545S	8		10											Rapid determination of antiviral drug susceptibility of human cytomegalovirus by real-time PCR	https://www.sciencedirect.com/science/article/pii/S0166354208004221	doi.org/10.1016/j.antiviral.2008.09.009	Marker Transfer	PRA			14/08/2023	OJCharles		AD169	A
1814	HCMV		UL97	A594V	10													Antiviral Susceptibilities and Analysis of UL97 and DNA Polymerase Sequences of Clinical Cytomegalovirus Isolates from Immunocompromised Patients	https://academic.oup.com/jid/article/175/5/1087/853432	doi.org/10.1086/516446	Isolated strain 	PRA			14/08/2023	OJCharles			A
1815	HCMV		UL97	A594T	5													Antiviral Susceptibilities and Analysis of UL97 and DNA Polymerase Sequences of Clinical Cytomegalovirus Isolates from Immunocompromised Patients	https://academic.oup.com/jid/article/175/5/1087/853432	doi.org/10.1086/516446	Isolated strain 	PRA			14/08/2023	OJCharles			A
1816	HCMV		UL97	C603W	Resistant		Polymorphism	Polymorphism										Drug-resistant cytomegalovirus in transplant recipients: a French cohort study	https://academic.oup.com/jac/article/65/12/2628/755060#13268428	doi.org/10.1093/jac/dkq368	Isolated strain 	PCR DNA hybridization assa			14/08/2023	OJCharles		AD169	A
1817	HCMV		UL54	A834P	Resistant		Resistant	Resistant										Drug-resistant cytomegalovirus in transplant recipients: a French cohort study	https://academic.oup.com/jac/article/65/12/2628/755060#13268428	doi.org/10.1093/jac/dkq368	Isolated strain 	PCR DNA hybridization assa			14/08/2023	OJCharles		AD169	A
1818	HCMV		UL97	M460V	8.2													Development of new cytomegalovirus UL97 and DNA polymerase mutations conferring drug resistance after valganciclovir therapy in allogeneic stem cell recipients	https://www.sciencedirect.com/science/article/pii/S1386653206004161	www.sciencedirect.com/science/article/pii/S1386653206004161	Marker Transfer	SEAP			14/08/2023	OJCharles		AD169	A
1819	HCMV		UL54	D413A	6.5		10	0.8										Development of new cytomegalovirus UL97 and DNA polymerase mutations conferring drug resistance after valganciclovir therapy in allogeneic stem cell recipients	https://www.sciencedirect.com/science/article/pii/S1386653206004161	www.sciencedirect.com/science/article/pii/S1386653206004161	Marker Transfer	SEAP			14/08/2023	OJCharles		AD169	A
1820	HCMV	Towne	UL54	D588N	3.8		2.7	3.2										How Evolution of Mutations Conferring Drug Resistance Affects Viral Dynamics and Clinical Outcomes of Cytomegalovirus-Infected Hematopoietic Cell Transplant Recipients	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC540138/	doi.org/10.1128%2FJCM.43.1.208-213.2005	Marker Transfer 	PRA			14/08/2023	OJCharles		Towne	A
1821	HCMV		UL97	C592F	4	0.8	1.8	1.6										Aciclovir Selects for Ganciclovir-Cross-Resistance ofHuman Cytomegalovirus In Vitro That is Only in PartExplained by Known Mutations in the UL97 Protein	https://onlinelibrary.wiley.com/doi/epdf/10.1002/jmv.2003	doi.org/10.1002/jmv.2003	Lab derived mutant 	PRA			14/08/2023	OJCharles			A
1822	HCMV		UL97	K599M	1.5	1.6	1	3.8										Aciclovir Selects for Ganciclovir-Cross-Resistance ofHuman Cytomegalovirus In Vitro That is Only in PartExplained by Known Mutations in the UL97 Protein	https://onlinelibrary.wiley.com/doi/epdf/10.1002/jmv.2003	doi.org/10.1002/jmv.2003	Lab derived mutant 	PRA			14/08/2023	OJCharles	Reported as L599M compared to AD169 which has K599 and L600. Assuming the correct mutation is K599M		A
1823	HCMV		UL54	F412C	3.6		10	2.5										Evolution of Mutations Conferring Multidrug Resistance during Prophylaxis and Therapy for Cytomegalovirus Disease	https://academic.oup.com/jid/article/176/3/786/872103	doi.org/10.1086/517302	Lab derived mutant 	PRA			14/08/2023	OJCharles		AD169	A
1824	HCMV		UL54	L802M	3.6		1.8	11										Evolution of Mutations Conferring Multidrug Resistance during Prophylaxis and Therapy for Cytomegalovirus Disease	https://academic.oup.com/jid/article/176/3/786/872103	doi.org/10.1086/517302	Lab derived mutant 	PRA			14/08/2023	OJCharles		AD169	A
1825	HCMV	AD169	UL97	D605E	0.6													GCV resistance due to the mutation A594P in the cytomegalovirus protein UL97 is partially reconstituted by a second mutation at D605E	https://www.sciencedirect.com/science/article/pii/S0166354201002029	doi.org/10.1016/S0166-3542(01)00202-9	Marker Transfer	PRA			14/08/2023	OJCharles		AD169	A
1826	HCMV	AD169	UL97	A594P	4.6													GCV resistance due to the mutation A594P in the cytomegalovirus protein UL97 is partially reconstituted by a second mutation at D605E	https://www.sciencedirect.com/science/article/pii/S0166354201002029	doi.org/10.1016/S0166-3542(01)00202-9	Marker Transfer	PRA			14/08/2023	OJCharles		AD169	A
1827	HCMV	AD169	UL97	A594P	3.8													GCV resistance due to the mutation A594P in the cytomegalovirus protein UL97 is partially reconstituted by a second mutation at D605E	https://www.sciencedirect.com/science/article/pii/S0166354201002029	doi.org/10.1016/S0166-3542(01)00202-9	Marker Transfer	PRA	UL97	D605E	14/08/2023	OJCharles		AD169	A
1828	HCMV	TB40	UL97	M460V	5.9													Identification of newly detected, drug-related HCMV UL97- and UL54-mutations using a modified plaque reduction assay	https://www.sciencedirect.com/science/article/abs/pii/S1386653215002759	doi.org/10.1016/j.jcv.2015.06.090	Recombinant BAC	PRA			14/08/2023	OJCharles		TB40	A
1829	HCMV	TB40	UL97	I610T	2.6													Identification of newly detected, drug-related HCMV UL97- and UL54-mutations using a modified plaque reduction assay	https://www.sciencedirect.com/science/article/abs/pii/S1386653215002759	doi.org/10.1016/j.jcv.2015.06.090	Recombinant BAC	PRA			14/08/2023	OJCharles		TB40	A
1830	HCMV	TB40	UL97	E596D	1.3													Identification of newly detected, drug-related HCMV UL97- and UL54-mutations using a modified plaque reduction assay	https://www.sciencedirect.com/science/article/abs/pii/S1386653215002759	doi.org/10.1016/j.jcv.2015.06.090	Recombinant BAC	PRA			14/08/2023	OJCharles		TB40	A
1831	HCMV	TB40	UL54	D515E	2.4		1.6	1.1										Identification of newly detected, drug-related HCMV UL97- and UL54-mutations using a modified plaque reduction assay	https://www.sciencedirect.com/science/article/abs/pii/S1386653215002759	doi.org/10.1016/j.jcv.2015.06.090	Recombinant BAC	PRA			14/08/2023	OJCharles		TB40	A
1832	HCMV	TB40	UL54	I521T	2.1		4.9	1										Identification of newly detected, drug-related HCMV UL97- and UL54-mutations using a modified plaque reduction assay	https://www.sciencedirect.com/science/article/abs/pii/S1386653215002759	doi.org/10.1016/j.jcv.2015.06.090	Recombinant BAC	PRA			14/08/2023	OJCharles		TB40	A
1833	HCMV	TB40	UL54	L516M	1.3		1.1	1.2										"Generation and characterization of a GCV resistant HCMV UL97-mutation and a drug sensitive UL54-mutation"	https://www.sciencedirect.com/science/article/abs/pii/S0166354213002866	https://doi.org/10.1016/j.antiviral.2013.09.026	Recombinant BAC	PRA			14/08/2023	OJCharles		TB40	A
1834	HCMV	Clinical isolate	UL97	M460V	15.5													"Generation and characterization of a GCV resistant HCMV UL97-mutation and a drug sensitive UL54-mutation"	https://www.sciencedirect.com/science/article/abs/pii/S0166354213002866	https://doi.org/10.1016/j.antiviral.2013.09.026	Isolated strain	PRA			14/08/2023	OJCharles		TB40	A
1835	HCMV	Clinical isolate	UL97	M615V	1.1													Incidence and characterization of cytomegalovirus resistance mutations among pediatric solid organ transplant patients who received valganciclovir prophylaxis	https://www.sciencedirect.com/science/article/abs/pii/S1386653210000181	doi.org/10.1016/j.jcv.2010.01.009	Recombinant BAC 	PRA			14/08/2023	OJCharles			A
1836	HCMV		UL97	C603R	3.6													Incidence and characterization of cytomegalovirus resistance mutations among pediatric solid organ transplant patients who received valganciclovir prophylaxis	https://www.sciencedirect.com/science/article/abs/pii/S1386653210000181	doi.org/10.1016/j.jcv.2010.01.009	Recombinant BAC 	PRA			14/08/2023	OJCharles			A
1837	HCMV	AD169	UL97	C592G	3													Differentiated Levels of Ganciclovir Resistance Conferred by Mutations at Codons 591 to 603 of the Cytomegalovirus UL97 Kinase Gene	https://journals.asm.org/doi/10.1128/JCM.00391-17	doi.org/10.1128/jcm.00391-17	Recombinant BAC 	SEAP			14/08/2023	OJCharles		AD169	A
1838	HCMV	AD169	UL97	A594V	6.5													Differentiated Levels of Ganciclovir Resistance Conferred by Mutations at Codons 591 to 603 of the Cytomegalovirus UL97 Kinase Gene	https://journals.asm.org/doi/10.1128/JCM.00391-17	doi.org/10.1128/jcm.00391-17	Recombinant BAC 	SEAP			14/08/2023	OJCharles		AD169	A
1839	HCMV	AD169	UL97	A591V	3.8													Differentiated Levels of Ganciclovir Resistance Conferred by Mutations at Codons 591 to 603 of the Cytomegalovirus UL97 Kinase Gene	https://journals.asm.org/doi/10.1128/JCM.00391-17	doi.org/10.1128/jcm.00391-17	Recombinant BAC 	SEAP			14/08/2023	OJCharles		AD169	A
1840	HCMV	AD169	UL97	K599E	1.2													Differentiated Levels of Ganciclovir Resistance Conferred by Mutations at Codons 591 to 603 of the Cytomegalovirus UL97 Kinase Gene	https://journals.asm.org/doi/10.1128/JCM.00391-17	doi.org/10.1128/jcm.00391-17	Recombinant BAC 	SEAP			14/08/2023	OJCharles		AD169	A
1841	HCMV	AD169	UL97	T601M	1													Differentiated Levels of Ganciclovir Resistance Conferred by Mutations at Codons 591 to 603 of the Cytomegalovirus UL97 Kinase Gene	https://journals.asm.org/doi/10.1128/JCM.00391-17	doi.org/10.1128/jcm.00391-17	Recombinant BAC 	SEAP			14/08/2023	OJCharles		AD169	A
1842	HCMV	AD169	UL54	L897S	1		1	0.9										Phenotyping of Cytomegalovirus Drug Resistance Mutations by Using Recombinant Viruses Incorporating a Reporter Gene	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1168698/	doi.org/10.1128/AAC.49.7.2710-2715.2005	Lab derived mutant 	SEAP			15/08/2023	OJCharles	you can draw this as we know UL97H587Y has no impact		A
1843	HCMV	AD169	UL97	M460V	9													Phenotyping of Cytomegalovirus Drug Resistance Mutations by Using Recombinant Viruses Incorporating a Reporter Gene	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1168698/	doi.org/10.1128/AAC.49.7.2710-2715.2005	Lab derived mutant 	SEAP			15/08/2023	OJCharles			A
1844	HCMV	AD169	UL97	C592G	3		1.4	1										Phenotyping of Cytomegalovirus Drug Resistance Mutations by Using Recombinant Viruses Incorporating a Reporter Gene	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1168698/	doi.org/10.1128/AAC.49.7.2710-2715.2005	Lab derived mutant 	SEAP			15/08/2023	OJCharles			A
1845	HCMV	AD169	UL97	A594V	9													Phenotyping of Cytomegalovirus Drug Resistance Mutations by Using Recombinant Viruses Incorporating a Reporter Gene	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1168698/	doi.org/10.1128/AAC.49.7.2710-2715.2005	Lab derived mutant 	SEAP			15/08/2023	OJCharles			A
1846	HCMV	AD169	UL54	N408H	2		3.3	1.1										Drug Resistance Assessed in a Phase 3 Clinical Trial of Maribavir Therapy for Refractory or Resistant Cytomegalovirus Infection in Transplant Recipients	https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiad293/7233334	doi.org/10.1093/infdis/jiad293	Recombinant BAC 	SEAP			29/11/2023	OJCharles			A
1847	HCMV	AD169	UL54	L501F	2.6		3.8	1.3										Drug Resistance Assessed in a Phase 3 Clinical Trial of Maribavir Therapy for Refractory or Resistant Cytomegalovirus Infection in Transplant Recipients	https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiad293/7233334	doi.org/10.1093/infdis/jiad293	Recombinant BAC 	SEAP			29/11/2023	OJCharles		AD169	A
1848	HCMV	AD169	UL54	T503A	3.1		3.7	1.5										Drug Resistance Assessed in a Phase 3 Clinical Trial of Maribavir Therapy for Refractory or Resistant Cytomegalovirus Infection in Transplant Recipients	https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiad293/7233334	doi.org/10.1093/infdis/jiad293	Recombinant BAC 	SEAP			29/11/2023	OJCharles		AD169	A
1849	HCMV	AD169	UL54	K513Q	6.6		18	1										Drug Resistance Assessed in a Phase 3 Clinical Trial of Maribavir Therapy for Refractory or Resistant Cytomegalovirus Infection in Transplant Recipients	https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiad293/7233334	doi.org/10.1093/infdis/jiad293	Recombinant BAC 	SEAP			29/11/2023	OJCharles		AD169	A
1850	HCMV	AD169	UL54	P522T	2.1		2	1.4										Drug Resistance Assessed in a Phase 3 Clinical Trial of Maribavir Therapy for Refractory or Resistant Cytomegalovirus Infection in Transplant Recipients	https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiad293/7233334	doi.org/10.1093/infdis/jiad293	Recombinant BAC 	SEAP			29/11/2023	OJCharles		AD169	A
1851	HCMV	AD169	UL54	L545F	4		11	1.2										Drug Resistance Assessed in a Phase 3 Clinical Trial of Maribavir Therapy for Refractory or Resistant Cytomegalovirus Infection in Transplant Recipients	https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiad293/7233334	doi.org/10.1093/infdis/jiad293	Recombinant BAC 	SEAP			29/11/2023	OJCharles		AD169	A
1852	HCMV	AD169	UL54	C590F	1.6		1.6	2.3										Drug Resistance Assessed in a Phase 3 Clinical Trial of Maribavir Therapy for Refractory or Resistant Cytomegalovirus Infection in Transplant Recipients	https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiad293/7233334	doi.org/10.1093/infdis/jiad293	Recombinant BAC 	SEAP			29/11/2023	OJCharles		AD169	A
1853	HCMV	AD169	UL97	A594P	8.1													Drug Resistance Assessed in a Phase 3 Clinical Trial of Maribavir Therapy for Refractory or Resistant Cytomegalovirus Infection in Transplant Recipients	https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiad293/7233334	doi.org/10.1093/infdis/jiad293	Recombinant BAC 	SEAP			29/11/2023	OJCharles		AD169	A
1854	HCMV	AD169	UL97	E596Q	2.7													Drug Resistance Assessed in a Phase 3 Clinical Trial of Maribavir Therapy for Refractory or Resistant Cytomegalovirus Infection in Transplant Recipients	https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiad293/7233334	doi.org/10.1093/infdis/jiad293	Recombinant BAC 	SEAP			29/11/2023	OJCharles		AD169	A
1855	HSV2	Clinical isolate	UL30	L783M			2.7	7.6										Herpes simplex virus isolates with reduced adefovir susceptibility selected in vivo by foscarnet therapy	https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.2195	doi.org/10.1002/jmv.2195	Isolated strain	PRA			01/12/2023	OJCharles			A
1856	HSV2	Clinical isolate	UL30	A724T			1	3.1										Herpes simplex virus isolates with reduced adefovir susceptibility selected in vivo by foscarnet therapy	https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.2195	doi.org/10.1002/jmv.2195	Isolated strain	PRA			01/12/2023	OJCharles			A
1857	HSV2	Clinical isolate	UL30	S729N			1.6	3.2										Herpes simplex virus isolates with reduced adefovir susceptibility selected in vivo by foscarnet therapy	https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.2195	doi.org/10.1002/jmv.2195	Isolated strain	PRA			01/12/2023	OJCharles			A
1858	HSV2	Clinical isolate	UL30	D785N			0.3	3.9										Herpes simplex virus isolates with reduced adefovir susceptibility selected in vivo by foscarnet therapy	https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.2195	doi.org/10.1002/jmv.2195	Isolated strain	PRA			01/12/2023	OJCharles			A
1859	HSV2	Clinical isolate	UL30	L850I			0.3	9.2										Herpes simplex virus isolates with reduced adefovir susceptibility selected in vivo by foscarnet therapy	https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.2195	doi.org/10.1002/jmv.2195	Isolated strain	PRA			01/12/2023	OJCharles			A
1860	HSV1	PDK	UL52	A899T													43	A single drug-resistance mutation in HSV-1 UL52 primase points to a difference between two helicase-primase inhibitors in their mode of interaction with the antiviral target	https://academic.oup.com/jac/article/61/5/1044/847175	doi.org/10.1093/jac/dkn057	Lab derived mutant 	PRA			01/12/2023	OJCharles		PDK	A
1861	HSV1	PDK	UL52	A899T													2500	A single drug-resistance mutation in HSV-1 UL52 primase points to a difference between two helicase-primase inhibitors in their mode of interaction with the antiviral target	https://academic.oup.com/jac/article/61/5/1044/847175	doi.org/10.1093/jac/dkn057	Lab derived mutant 	PRA	UL5	K356T	01/12/2023	OJCharles		PDK	A
1862	HSV1	PDK	UL52	A899T													100	A single drug-resistance mutation in HSV-1 UL52 primase points to a difference between two helicase-primase inhibitors in their mode of interaction with the antiviral target	https://academic.oup.com/jac/article/61/5/1044/847175	doi.org/10.1093/jac/dkn057	Lab derived mutant 	PRA			01/12/2023	OJCharles		PDK	A
1863	HSV1	SC16	UL5	K356Q													100	A single drug-resistance mutation in HSV-1 UL52 primase points to a difference between two helicase-primase inhibitors in their mode of interaction with the antiviral target	https://academic.oup.com/jac/article/61/5/1044/847175	doi.org/10.1093/jac/dkn057	Lab derived mutant 	PRA			01/12/2023	OJCharles		SC16	A
1864	HSV1	SC16	UL5	G352R													3333	A single drug-resistance mutation in HSV-1 UL52 primase points to a difference between two helicase-primase inhibitors in their mode of interaction with the antiviral target	https://academic.oup.com/jac/article/61/5/1044/847175	doi.org/10.1093/jac/dkn057	Lab derived mutant 	PRA			01/12/2023	OJCharles		SC16	A
1865	HSV1	SC16	UL5	K356T													100	A single drug-resistance mutation in HSV-1 UL52 primase points to a difference between two helicase-primase inhibitors in their mode of interaction with the antiviral target	https://academic.oup.com/jac/article/61/5/1044/847175	doi.org/10.1093/jac/dkn057	Lab derived mutant 	PRA			01/12/2023	OJCharles		SC16	A
1866	HSV1	SC16	UL5	K356T													124	A single drug-resistance mutation in HSV-1 UL52 primase points to a difference between two helicase-primase inhibitors in their mode of interaction with the antiviral target	https://academic.oup.com/jac/article/61/5/1044/847175	doi.org/10.1093/jac/dkn057	Lab derived mutant 	PRA			01/12/2023	OJCharles		SC16	A
1867	HSV1	SC16	UL5	M355T													15	High Frequency of Spontaneous Helicaseprimase Inhibitor (BAY 57–1293) Drug-Resistant Variants in Certain Laboratory Isolates of HSV-1	https://journals.sagepub.com/doi/10.1177/095632020701800102	doi.org/10.1177/0956320207018001	Lab derived mutant 	PRA			01/12/2023	OJCharles	my concern with this paper is that they do not cover other important genes eg BAY-Pr1 is 50fold resistance with no ul5 mutations discard all?		A
1868	HSV1	SC16	UL5	K356T													125	High Frequency of Spontaneous Helicaseprimase Inhibitor (BAY 57–1293) Drug-Resistant Variants in Certain Laboratory Isolates of HSV-1	https://journals.sagepub.com/doi/10.1177/095632020701800102	doi.org/10.1177/0956320207018001	Lab derived mutant 	PRA			01/12/2023	OJCharles	my concern with this paper is that they do not cover other important genes eg BAY-Pr1 is 50fold resistance with no ul5 mutations discard all?		A
1869	HSV1	SC16	UL5	G352R													4000	High Frequency of Spontaneous Helicaseprimase Inhibitor (BAY 57–1293) Drug-Resistant Variants in Certain Laboratory Isolates of HSV-1	https://journals.sagepub.com/doi/10.1177/095632020701800102	doi.org/10.1177/0956320207018001	Lab derived mutant 	PRA			01/12/2023	OJCharles	my concern with this paper is that they do not cover other important genes eg BAY-Pr1 is 50fold resistance with no ul5 mutations discard all?		A
1870	HSV1	PDK	UL5	A199T													50	High Frequency of Spontaneous Helicaseprimase Inhibitor (BAY 57–1293) Drug-Resistant Variants in Certain Laboratory Isolates of HSV-1	https://journals.sagepub.com/doi/10.1177/095632020701800102	doi.org/10.1177/0956320207018001	Lab derived mutant 	PRA			01/12/2023	OJCharles	my concern with this paper is that they do not cover other important genes eg BAY-Pr1 is 50fold resistance with no ul5 mutations discard all?		A
1871	HSV1	PDK	UL5	K356T													2000	High Frequency of Spontaneous Helicaseprimase Inhibitor (BAY 57–1293) Drug-Resistant Variants in Certain Laboratory Isolates of HSV-1	https://journals.sagepub.com/doi/10.1177/095632020701800102	doi.org/10.1177/0956320207018001	Lab derived mutant 	PRA			01/12/2023	OJCharles	my concern with this paper is that they do not cover other important genes eg BAY-Pr1 is 50fold resistance with no ul5 mutations discard all?		A
1872	HSV2	Clinical isolate	UL5	H334R													Polymorphism	"No Evidence of Pritelivir Resistance Among Herpes
Simplex Virus Type 2 Isolates After 4 Weeks of Daily
Therapy"	https://academic.oup.com/jid/article/214/2/258/2572113	doi.org/10.1093/infdis/jiw129	Isolated strain	PRA			01/12/2023	OJCharles		Bry	A
1873	HSV1		UL5	N342K													40	Antiviral drug resistance and helicase–primase inhibitors of herpes simplex virus	https://www.sciencedirect.com/science/article/abs/pii/S1368764610000609?via%3Dihub	doi.org/10.1016/j.drup.2010.11.002	Lab derived mutant 	PRA			01/12/2023	OJCharles			A
1874	HSV1		UL5	G352V													400	Antiviral drug resistance and helicase–primase inhibitors of herpes simplex virus	https://www.sciencedirect.com/science/article/abs/pii/S1368764610000609?via%3Dihub	doi.org/10.1016/j.drup.2010.11.002	Lab derived mutant 	PRA			01/12/2023	OJCharles			A
1875	HSV1		UL5	G352R													3000	Antiviral drug resistance and helicase–primase inhibitors of herpes simplex virus	https://www.sciencedirect.com/science/article/abs/pii/S1368764610000609?via%3Dihub	doi.org/10.1016/j.drup.2010.11.002	Lab derived mutant 	PRA			01/12/2023	OJCharles			A
1876	HSV1		UL5	M355T													5	Antiviral drug resistance and helicase–primase inhibitors of herpes simplex virus	https://www.sciencedirect.com/science/article/abs/pii/S1368764610000609?via%3Dihub	doi.org/10.1016/j.drup.2010.11.002	Lab derived mutant 	PRA			01/12/2023	OJCharles			A
1877	HSV1		UL5	K356N													5000	Antiviral drug resistance and helicase–primase inhibitors of herpes simplex virus	https://www.sciencedirect.com/science/article/abs/pii/S1368764610000609?via%3Dihub	doi.org/10.1016/j.drup.2010.11.002	Lab derived mutant 	PRA			01/12/2023	OJCharles			A
1878	HSV1		UL5	K356Q													150	Antiviral drug resistance and helicase–primase inhibitors of herpes simplex virus	https://www.sciencedirect.com/science/article/abs/pii/S1368764610000609?via%3Dihub	doi.org/10.1016/j.drup.2010.11.002	Lab derived mutant 	PRA			01/12/2023	OJCharles			A
1879	HSV2		UL23	A190V		8												Genotypic testing improves detection of antiviral resistance in human herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S1386653223001774	doi.org/10.1016/j.jcv.2023.105554	Isolated strain	PRA			01/12/2023	OJCharles			A
1880	HSV2		UL30	T1200A		1												Genotypic testing improves detection of antiviral resistance in human herpes simplex virus	https://www.sciencedirect.com/science/article/pii/S1386653223001774	doi.org/10.1016/j.jcv.2023.105554	Isolated strain	PRA			01/12/2023	OJCharles			A
1881	HSV1	KOS	UL30	Y941H		10		Resistant										A Point Mutation within a Distinct Conserved Region of the Herpes Simplex Virus DNA Polymerase Gene Confers Drug Resistance	https://journals.asm.org/doi/10.1128/jvi.66.3.1774-1776.1992	doi.org/10.1128/jvi.66.3.1774-1776.1992	Marker Transfer	PRA			01/12/2023	OJCharles		KOS	A
1882	HSV1	Clinical isolate	UL30	L216I	1	1		1										Association of the Emergence of Acyclovir-Resistant Herpes Simplex Virus Type 1 With Prognosis in Hematopoietic Stem Cell Transplantation Patients	https://academic.oup.com/jid/article/215/6/865/2973094	doi.org/10.1093/infdis/jix042	Isolated strain	PRA			01/12/2023	OJCharles		TAS	A
1883	HSV1	Clinical isolate	UL30	I890M	1	3.5		5.7										Association of the Emergence of Acyclovir-Resistant Herpes Simplex Virus Type 1 With Prognosis in Hematopoietic Stem Cell Transplantation Patients	https://academic.oup.com/jid/article/215/6/865/2973094	doi.org/10.1093/infdis/jix042	Isolated strain	PRA			01/12/2023	OJCharles		TAS	A
1884	HSV1	Clinical isolate	UL23	L327R	4.2	10		0.6										Association of the Emergence of Acyclovir-Resistant Herpes Simplex Virus Type 1 With Prognosis in Hematopoietic Stem Cell Transplantation Patients	https://academic.oup.com/jid/article/215/6/865/2973094	doi.org/10.1093/infdis/jix042	Isolated strain	PRA			01/12/2023	OJCharles		TAS	A
1885	HSV1	Clinical isolate	UL30	R700G	0.1	0.8		1.2										Association of the Emergence of Acyclovir-Resistant Herpes Simplex Virus Type 1 With Prognosis in Hematopoietic Stem Cell Transplantation Patients	https://academic.oup.com/jid/article/215/6/865/2973094	doi.org/10.1093/infdis/jix042	Isolated strain	PRA			01/12/2023	OJCharles	many herpesdrgnovel mutations in strain but good repeated evidence mutations together are natural polymorphims	TAS	A
1886	HSV1	Clinical isolate	UL30	A748V	0.1	0.8		1.2										Association of the Emergence of Acyclovir-Resistant Herpes Simplex Virus Type 1 With Prognosis in Hematopoietic Stem Cell Transplantation Patients	https://academic.oup.com/jid/article/215/6/865/2973094	doi.org/10.1093/infdis/jix042	Isolated strain	PRA			01/12/2023	OJCharles	many herpesdrgnovel mutations in strain but good repeated evidence mutations together are natural polymorphims	TAS	A
1887	HSV1	Clinical isolate	UL30	K908Q	0.1	0.8		1.2										Association of the Emergence of Acyclovir-Resistant Herpes Simplex Virus Type 1 With Prognosis in Hematopoietic Stem Cell Transplantation Patients	https://academic.oup.com/jid/article/215/6/865/2973094	doi.org/10.1093/infdis/jix042	Isolated strain	PRA			01/12/2023	OJCharles	many herpesdrgnovel mutations in strain but good repeated evidence mutations together are natural polymorphims	TAS	A
1888	HSV1	Clinical isolate	UL30	A605V	0.1	3.1		3.5										Association of the Emergence of Acyclovir-Resistant Herpes Simplex Virus Type 1 With Prognosis in Hematopoietic Stem Cell Transplantation Patients	https://academic.oup.com/jid/article/215/6/865/2973094	doi.org/10.1093/infdis/jix042	Isolated strain	PRA			01/12/2023	OJCharles		TAS	A
1889	HSV1	Clinical isolate	UL23	G279D		0.8												Association of the Emergence of Acyclovir-Resistant Herpes Simplex Virus Type 1 With Prognosis in Hematopoietic Stem Cell Transplantation Patients	https://academic.oup.com/jid/article/215/6/865/2973094	doi.org/10.1093/infdis/jix042	Isolated strain	PRA			01/12/2023	OJCharles		TAS	A
1890	HSV1	Clinical isolate	UL23	G56D	10	4.7		1.7										Association of the Emergence of Acyclovir-Resistant Herpes Simplex Virus Type 1 With Prognosis in Hematopoietic Stem Cell Transplantation Patients	https://academic.oup.com/jid/article/215/6/865/2973094	doi.org/10.1093/infdis/jix042	Isolated strain	PRA			01/12/2023	OJCharles		TAS	A
1891	HSV1	Clinical isolate	UL30	V278A	0.1	0.3		0.3										Association of the Emergence of Acyclovir-Resistant Herpes Simplex Virus Type 1 With Prognosis in Hematopoietic Stem Cell Transplantation Patients	https://academic.oup.com/jid/article/215/6/865/2973094	doi.org/10.1093/infdis/jix042	Isolated strain	PRA			01/12/2023	OJCharles	many herpesdrgnovel mutations in strain but good repeated evidence mutations together are natural polymorphims	TAS	A
1892	HSV1	Clinical isolate	UL30	A1131T	0.1	0.3		0.3										Association of the Emergence of Acyclovir-Resistant Herpes Simplex Virus Type 1 With Prognosis in Hematopoietic Stem Cell Transplantation Patients	https://academic.oup.com/jid/article/215/6/865/2973094	doi.org/10.1093/infdis/jix042	Isolated strain	PRA			01/12/2023	OJCharles	many herpesdrgnovel mutations in strain but good repeated evidence mutations together are natural polymorphims	TAS	A
1893	HSV1	Clinical isolate	UL23	G200D	49	47		0.7										Association of the Emergence of Acyclovir-Resistant Herpes Simplex Virus Type 1 With Prognosis in Hematopoietic Stem Cell Transplantation Patients	https://academic.oup.com/jid/article/215/6/865/2973094	doi.org/10.1093/infdis/jix042	Isolated strain	PRA			01/12/2023	OJCharles		TAS	A
1894	HSV1	Clinical isolate	UL30	D672N	0.3	0.5		1.3										Association of the Emergence of Acyclovir-Resistant Herpes Simplex Virus Type 1 With Prognosis in Hematopoietic Stem Cell Transplantation Patients	https://academic.oup.com/jid/article/215/6/865/2973094	doi.org/10.1093/infdis/jix042	Isolated strain	PRA			01/12/2023	OJCharles	many herpesdrgnovel mutations in strain but good repeated evidence mutations together are natural polymorphims	TAS	A
1895	HSV1	Clinical isolate	UL23	L32P	0.3	0.5		1.3										Association of the Emergence of Acyclovir-Resistant Herpes Simplex Virus Type 1 With Prognosis in Hematopoietic Stem Cell Transplantation Patients	https://academic.oup.com/jid/article/215/6/865/2973094	doi.org/10.1093/infdis/jix042	Isolated strain	PRA			01/12/2023	OJCharles	this mutations makes no sense perhaps P31L but unsure ALSO many herpesdrgnovel mutations in strain but good repeated evidence mutations together are natural polymorphims	TAS	O
1896	HSV1	Clinical isolate	UL23	R89Q	Polymorphism	Polymorphism		Polymorphism										Association of the Emergence of Acyclovir-Resistant Herpes Simplex Virus Type 1 With Prognosis in Hematopoietic Stem Cell Transplantation Patients	https://academic.oup.com/jid/article/215/6/865/2973094	doi.org/10.1093/infdis/jix042	Isolated strain	PRA			01/12/2023	OJCharles	many herpesdrgnovel mutations in strain but good repeated evidence mutations together are natural polymorphims	TAS	A
1897	HSV1	Clinical isolate	UL30	S724N	0.3	3.9		5										Association of the Emergence of Acyclovir-Resistant Herpes Simplex Virus Type 1 With Prognosis in Hematopoietic Stem Cell Transplantation Patients	https://academic.oup.com/jid/article/215/6/865/2973094	doi.org/10.1093/infdis/jix042	Isolated strain	PRA			01/12/2023	OJCharles		TAS	A
1898	HSV1	Clinical isolate	UL30	"	A719V"	0.5	2.8		1.3										Association of the Emergence of Acyclovir-Resistant Herpes Simplex Virus Type 1 With Prognosis in Hematopoietic Stem Cell Transplantation Patients	https://academic.oup.com/jid/article/215/6/865/2973094	doi.org/10.1093/infdis/jix042	Isolated strain	PRA			01/12/2023	OJCharles		TAS	A
1899	HSV1	Clinical isolate	UL23	N23S		Polymorphism												Polymorphisms of thymidine kinase gene in herpes simplex virus type 1: Analysis of clinical isolates from herpetic keratitis patients and laboratory strains	https://onlinelibrary.wiley.com/doi/abs/10.1002/%28SICI%291096-9071%28199810%2956%3A2%3C151%3A%3AAID-JMV9%3E3.0.CO%3B2-7	doi.org/10.1002/(SICI)1096-9071(199810)56:2<151::AID-JMV9>3.0.CO;2-7	Isolated strain	PRA			01/12/2023	OJCharles		Strain 17	A
1900	HSV1	Clinical isolate	UL23	K36E		Polymorphism												Polymorphisms of thymidine kinase gene in herpes simplex virus type 1: Analysis of clinical isolates from herpetic keratitis patients and laboratory strains	https://onlinelibrary.wiley.com/doi/abs/10.1002/%28SICI%291096-9071%28199810%2956%3A2%3C151%3A%3AAID-JMV9%3E3.0.CO%3B2-7	doi.org/10.1002/(SICI)1096-9071(199810)56:2<151::AID-JMV9>3.0.CO;2-7	Isolated strain	PRA			01/12/2023	OJCharles		Strain 17	A
1901	HSV1	Clinical isolate	UL23	L42P		Polymorphism												Polymorphisms of thymidine kinase gene in herpes simplex virus type 1: Analysis of clinical isolates from herpetic keratitis patients and laboratory strains	https://onlinelibrary.wiley.com/doi/abs/10.1002/%28SICI%291096-9071%28199810%2956%3A2%3C151%3A%3AAID-JMV9%3E3.0.CO%3B2-7	doi.org/10.1002/(SICI)1096-9071(199810)56:2<151::AID-JMV9>3.0.CO;2-7	Isolated strain	PRA			01/12/2023	OJCharles		Strain 17	A
1902	HSV1	Clinical isolate	UL23	R89Q		Polymorphism												Polymorphisms of thymidine kinase gene in herpes simplex virus type 1: Analysis of clinical isolates from herpetic keratitis patients and laboratory strains	https://onlinelibrary.wiley.com/doi/abs/10.1002/%28SICI%291096-9071%28199810%2956%3A2%3C151%3A%3AAID-JMV9%3E3.0.CO%3B2-7	doi.org/10.1002/(SICI)1096-9071(199810)56:2<151::AID-JMV9>3.0.CO;2-7	Isolated strain	PRA			01/12/2023	OJCharles		Strain 17	A
1903	HSV1	Clinical isolate	UL23	G240E		Polymorphism												Polymorphisms of thymidine kinase gene in herpes simplex virus type 1: Analysis of clinical isolates from herpetic keratitis patients and laboratory strains	https://onlinelibrary.wiley.com/doi/abs/10.1002/%28SICI%291096-9071%28199810%2956%3A2%3C151%3A%3AAID-JMV9%3E3.0.CO%3B2-7	doi.org/10.1002/(SICI)1096-9071(199810)56:2<151::AID-JMV9>3.0.CO;2-7	Isolated strain	PRA			01/12/2023	OJCharles		Strain 17	A
1904	HSV1	Clinical isolate	UL23	A265T		Polymorphism												Polymorphisms of thymidine kinase gene in herpes simplex virus type 1: Analysis of clinical isolates from herpetic keratitis patients and laboratory strains	https://onlinelibrary.wiley.com/doi/abs/10.1002/%28SICI%291096-9071%28199810%2956%3A2%3C151%3A%3AAID-JMV9%3E3.0.CO%3B2-7	doi.org/10.1002/(SICI)1096-9071(199810)56:2<151::AID-JMV9>3.0.CO;2-7	Isolated strain	PRA			01/12/2023	OJCharles		Strain 17	A
1905	HSV1	Clinical isolate	UL23	V267L		Polymorphism												Polymorphisms of thymidine kinase gene in herpes simplex virus type 1: Analysis of clinical isolates from herpetic keratitis patients and laboratory strains	https://onlinelibrary.wiley.com/doi/abs/10.1002/%28SICI%291096-9071%28199810%2956%3A2%3C151%3A%3AAID-JMV9%3E3.0.CO%3B2-7	doi.org/10.1002/(SICI)1096-9071(199810)56:2<151::AID-JMV9>3.0.CO;2-7	Isolated strain	PRA			01/12/2023	OJCharles		Strain 17	A
1906	HSV1	Clinical isolate	UL23	P268T		Polymorphism												Polymorphisms of thymidine kinase gene in herpes simplex virus type 1: Analysis of clinical isolates from herpetic keratitis patients and laboratory strains	https://onlinelibrary.wiley.com/doi/abs/10.1002/%28SICI%291096-9071%28199810%2956%3A2%3C151%3A%3AAID-JMV9%3E3.0.CO%3B2-7	doi.org/10.1002/(SICI)1096-9071(199810)56:2<151::AID-JMV9>3.0.CO;2-7	Isolated strain	PRA			01/12/2023	OJCharles		Strain 17	A
1907	HSV1	Clinical isolate	UL23	R281Q		Polymorphism												Polymorphisms of thymidine kinase gene in herpes simplex virus type 1: Analysis of clinical isolates from herpetic keratitis patients and laboratory strains	https://onlinelibrary.wiley.com/doi/abs/10.1002/%28SICI%291096-9071%28199810%2956%3A2%3C151%3A%3AAID-JMV9%3E3.0.CO%3B2-7	doi.org/10.1002/(SICI)1096-9071(199810)56:2<151::AID-JMV9>3.0.CO;2-7	Isolated strain	PRA			01/12/2023	OJCharles		Strain 17	A
1908	HSV1	Clinical isolate	UL23	D286E		Polymorphism												Polymorphisms of thymidine kinase gene in herpes simplex virus type 1: Analysis of clinical isolates from herpetic keratitis patients and laboratory strains	https://onlinelibrary.wiley.com/doi/abs/10.1002/%28SICI%291096-9071%28199810%2956%3A2%3C151%3A%3AAID-JMV9%3E3.0.CO%3B2-7	doi.org/10.1002/(SICI)1096-9071(199810)56:2<151::AID-JMV9>3.0.CO;2-7	Isolated strain	PRA			01/12/2023	OJCharles		Strain 17	A
1909	HSV1	Clinical isolate	UL23	P355Q		Polymorphism												Polymorphisms of thymidine kinase gene in herpes simplex virus type 1: Analysis of clinical isolates from herpetic keratitis patients and laboratory strains	https://onlinelibrary.wiley.com/doi/abs/10.1002/%28SICI%291096-9071%28199810%2956%3A2%3C151%3A%3AAID-JMV9%3E3.0.CO%3B2-7	doi.org/10.1002/(SICI)1096-9071(199810)56:2<151::AID-JMV9>3.0.CO;2-7	Isolated strain	PRA			01/12/2023	OJCharles		Strain 17	A
1910	HSV1	Clinical isolate	UL23	N376P		Polymorphism												Polymorphisms of thymidine kinase gene in herpes simplex virus type 1: Analysis of clinical isolates from herpetic keratitis patients and laboratory strains	https://onlinelibrary.wiley.com/doi/abs/10.1002/%28SICI%291096-9071%28199810%2956%3A2%3C151%3A%3AAID-JMV9%3E3.0.CO%3B2-7	doi.org/10.1002/(SICI)1096-9071(199810)56:2<151::AID-JMV9>3.0.CO;2-7	Isolated strain	PRA			01/12/2023	OJCharles		Strain 17	A
1911	HSV1	Clinical isolate	UL23	N23S		1												Acyclovir-resistant HSV-1 isolates among immunocompromised patients in southern Taiwan: Low prevalence and novel mutations	https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.28985	doi.org/10.1002/jmv.28985	Isolated strain	PRA			01/12/2023	OJCharles	reported as S23N	KOS	A
1912	HSV1	Clinical isolate	UL30	E226D		1												Acyclovir-resistant HSV-1 isolates among immunocompromised patients in southern Taiwan: Low prevalence and novel mutations	https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.28985	doi.org/10.1002/jmv.28985	Isolated strain	PRA			01/12/2023	OJCharles		KOS	A
1913	HSV1	Clinical isolate	UL30	A566T		1												Acyclovir-resistant HSV-1 isolates among immunocompromised patients in southern Taiwan: Low prevalence and novel mutations	https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.28985	doi.org/10.1002/jmv.28985	Isolated strain	PRA			01/12/2023	OJCharles	reported as T566A	KOS	A
1914	HSV1	Clinical isolate	UL30	E676D		1												Acyclovir-resistant HSV-1 isolates among immunocompromised patients in southern Taiwan: Low prevalence and novel mutations	https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.28985	doi.org/10.1002/jmv.28985	Isolated strain	PRA			01/12/2023	OJCharles		KOS	A
1915	HSV1	Clinical isolate	UL23	Y248D		4												Acyclovir-resistant HSV-1 isolates among immunocompromised patients in southern Taiwan: Low prevalence and novel mutations	https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.28985	doi.org/10.1002/jmv.28985	Isolated strain	PRA			01/12/2023	OJCharles		KOS	A
1916	HSV1	Clinical isolate	UL23	K36E		1												Acyclovir-resistant HSV-1 isolates among immunocompromised patients in southern Taiwan: Low prevalence and novel mutations	https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.28985	doi.org/10.1002/jmv.28985	Isolated strain	PRA			01/12/2023	OJCharles		KOS	A
1917	HSV1	Clinical isolate	UL30	R227H		1												Acyclovir-resistant HSV-1 isolates among immunocompromised patients in southern Taiwan: Low prevalence and novel mutations	https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.28985	doi.org/10.1002/jmv.28985	Isolated strain	PRA			01/12/2023	OJCharles		KOS	A
1918	HSV1	Clinical isolate	UL30	A351D		1												Acyclovir-resistant HSV-1 isolates among immunocompromised patients in southern Taiwan: Low prevalence and novel mutations	https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.28985	doi.org/10.1002/jmv.28985	Isolated strain	PRA			01/12/2023	OJCharles		KOS	A
1919	HSV1	M13	UL23	G56V		100												Site-directed mutagenesis of a nucleotide-binding domain in HSV-1 thymidine kinase: Effects on catalytic activity	https://www.sciencedirect.com/science/article/abs/pii/004268228890308X	doi.org/10.1016/0042-6822(88)90308-X	Marker Transfer	TK functional kinetic assay			01/12/2023	OJCharles			A
1920	HSV1	M13	UL23	G59V		100												Site-directed mutagenesis of a nucleotide-binding domain in HSV-1 thymidine kinase: Effects on catalytic activity	https://www.sciencedirect.com/science/article/abs/pii/004268228890308X	doi.org/10.1016/0042-6822(88)90308-X	Marker Transfer	TK functional kinetic assay			01/12/2023	OJCharles			A
1921	HSV1	M13	UL23	G61V		100												Site-directed mutagenesis of a nucleotide-binding domain in HSV-1 thymidine kinase: Effects on catalytic activity	https://www.sciencedirect.com/science/article/abs/pii/004268228890308X	doi.org/10.1016/0042-6822(88)90308-X	Marker Transfer	TK functional kinetic assay			01/12/2023	OJCharles			A
1922	HSV1	M13	UL23	K62I		100												Site-directed mutagenesis of a nucleotide-binding domain in HSV-1 thymidine kinase: Effects on catalytic activity	https://www.sciencedirect.com/science/article/abs/pii/004268228890308X	doi.org/10.1016/0042-6822(88)90308-X	Marker Transfer	TK functional kinetic assay			01/12/2023	OJCharles			A
1923	HSV1	M13	UL23	T63S		0.8												Site-directed mutagenesis of a nucleotide-binding domain in HSV-1 thymidine kinase: Effects on catalytic activity	https://www.sciencedirect.com/science/article/abs/pii/004268228890308X	doi.org/10.1016/0042-6822(88)90308-X	Marker Transfer	TK functional kinetic assay			01/12/2023	OJCharles			A
1924	HSV1	M13	UL23	T63A		100												Site-directed mutagenesis of a nucleotide-binding domain in HSV-1 thymidine kinase: Effects on catalytic activity	https://www.sciencedirect.com/science/article/abs/pii/004268228890308X	doi.org/10.1016/0042-6822(88)90308-X	Marker Transfer	TK functional kinetic assay			01/12/2023	OJCharles			A
1925	HSV1	Clinical isolate	UL23	R527Q		200												Herpes Simplex Virus Isolates from an Immunocompromised Patient who Failed to Respond to Acyclovir Treatment Express Thymidine Kinase with Altered Substrate Specificity	https://journals.sagepub.com/doi/10.1177/095632029100200504	doi.org/10.1177/09563202910020050	Isolated strain	PRA			01/12/2023	OJCharles	polymerase was not sequenced	SC16	A
1926	HSV2	Clinical isolate	UL23	A27T		Polymorphism												Characterisation of penciclovir resistant acyclovir sensitive herpes simplex virus type 2 isolated from an AIDS patient	https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.20061	doi.org/10.1002/jmv.20061	Isolated strain	PRA			01/12/2023	OJCharles		333	A
1927	HSV2	Clinical isolate	UL23	S29A		Polymorphism												Characterisation of penciclovir resistant acyclovir sensitive herpes simplex virus type 2 isolated from an AIDS patient	https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.20061	doi.org/10.1002/jmv.20061	Isolated strain	PRA			01/12/2023	OJCharles		333	A
1928	HSV2	Clinical isolate	UL23	R51W		Resistant												Characterisation of penciclovir resistant acyclovir sensitive herpes simplex virus type 2 isolated from an AIDS patient	https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.20061	doi.org/10.1002/jmv.20061	Isolated strain	PRA			01/12/2023	OJCharles		333	A
1929	HSV2	Clinical isolate	UL23	N78D		Polymorphism												Characterisation of penciclovir resistant acyclovir sensitive herpes simplex virus type 2 isolated from an AIDS patient	https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.20061	doi.org/10.1002/jmv.20061	Isolated strain	PRA			01/12/2023	OJCharles		333	A
1930	HSV2	Clinical isolate	UL23	L140F		Polymorphism												Characterisation of penciclovir resistant acyclovir sensitive herpes simplex virus type 2 isolated from an AIDS patient	https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.20061	doi.org/10.1002/jmv.20061	Isolated strain	PRA			01/12/2023	OJCharles		333	A
1931	HSV1	Clinical isolate	UL23	G21V		Polymorphism												Non-cytopathic herpes simplex virus type-1 isolated from acyclovir-treated patients with recurrent infections	https://www.nature.com/articles/s41598-022-05188-w	doi.org/10.1038/s41598-022-05188-w	Isolated strain	PRA			01/12/2023	OJCharles			A
1932	HSV1	Clinical isolate	UL23	D162N		64												Non-cytopathic herpes simplex virus type-1 isolated from acyclovir-treated patients with recurrent infections	https://www.nature.com/articles/s41598-022-05188-w	doi.org/10.1038/s41598-022-05188-w	Isolated strain	PRA			01/12/2023	OJCharles			A
1933	HSV1	HM3PP	UL23	R212K		Resistant												Non-cytopathic herpes simplex virus type-1 isolated from acyclovir-treated patients with recurrent infections	https://www.nature.com/articles/s41598-022-05188-w	doi.org/10.1038/s41598-022-05188-w	Recombinant BAC 	PRA			01/12/2023	OJCharles		HM3PP	A
1934	HSV1	HM3PP	UL23	E225K		Resistant												Non-cytopathic herpes simplex virus type-1 isolated from acyclovir-treated patients with recurrent infections	https://www.nature.com/articles/s41598-022-05188-w	doi.org/10.1038/s41598-022-05188-w	Recombinant BAC 	PRA			01/12/2023	OJCharles		HM3PP	A
1935	HSV1		UL30	S724N		17		4.3										Sequential switching of DNA polymerase and thymidine kinase-mediated HSV-1 drug resistance in an immunocompromised child	https://journals.sagepub.com/doi/10.1177/135965350400900107	doi.org/10.1177/135965350400900107	Isolated strain	PRA			01/12/2023	OJCharles		KOS	A
1936	HSV1		UL23	R163H		12		1.1										Sequential switching of DNA polymerase and thymidine kinase-mediated HSV-1 drug resistance in an immunocompromised child	https://journals.sagepub.com/doi/10.1177/135965350400900107	doi.org/10.1177/135965350400900107	Isolated strain	PRA			01/12/2023	OJCharles		KOS	A
1937	HSV1	Strain17	UL30	V715G		4.6		3.4										Differential impact of various substitutions at codon 715 in region II of HSV-1 and HCMV DNA polymerases 	https://www.sciencedirect.com/science/article/abs/pii/S016635422100036X	doi.org/10.1016/j.antiviral.2021.105046	Recombinant BAC 	PRA			01/12/2023	OJCharles		Strain17	A
1938	HSV1	Strain17	UL30	V715M		3.4		1.5										Differential impact of various substitutions at codon 715 in region II of HSV-1 and HCMV DNA polymerases 	https://www.sciencedirect.com/science/article/abs/pii/S016635422100036X	doi.org/10.1016/j.antiviral.2021.105046	Recombinant BAC 	PRA			01/12/2023	OJCharles		Strain17	A
1939	HSV1	Strain17	UL30	V715S		9.2		5.6										Differential impact of various substitutions at codon 715 in region II of HSV-1 and HCMV DNA polymerases 	https://www.sciencedirect.com/science/article/abs/pii/S016635422100036X	doi.org/10.1016/j.antiviral.2021.105046	Recombinant BAC 	PRA			01/12/2023	OJCharles		Strain17	A
1940	HCMV	AD169	UL54	V715M	1.2			3.7										Differential impact of various substitutions at codon 715 in region II of HSV-1 and HCMV DNA polymerases 	https://www.sciencedirect.com/science/article/abs/pii/S016635422100036X	doi.org/10.1016/j.antiviral.2021.105046	Recombinant BAC 	PRA			01/12/2023	OJCharles		AD169	A
1941	HCMV	AD169	UL54	V715S	2.9			2.8										Differential impact of various substitutions at codon 715 in region II of HSV-1 and HCMV DNA polymerases 	https://www.sciencedirect.com/science/article/abs/pii/S016635422100036X	doi.org/10.1016/j.antiviral.2021.105046	Recombinant BAC 	PRA			01/12/2023	OJCharles		AD169	A