analysis/KCPG/KCPG_woAR_Oncoplot.ipynb

{
 "cells": [
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "# Known Cancer Predisposition from Combined data with out autosomal recessive\n",
    "-----\n",
    "- Date : 31th May 2019\n",
    "- using R3.5 kernal\n",
    "- on 89\n",
    "-----\n",
    "- Aim : \n",
    "1. subset out the known cancer predisposition gene == known\n",
    "   - known\t290\n",
    "   - suggesting\t2726\n",
    "2. Check how many samples these variants belong to\n",
    "   - 290 variants coming from 262 Tumor_Sample_Barcode\n",
    "   - these 290 variants coming from 83 Hugo_Symbol\n",
    "3. intersect 371 Tumor_Sample_Barcode with Tumor_Sample_Barcode of clinical data\n",
    "   - out of 371 only 366 intersected \n",
    "   - why those other five samples not in clinical data\n",
    "   \n",
    "   - Rerun on 17th May 2019"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 1,
   "metadata": {},
   "outputs": [],
   "source": [
    "source(\"~/bin/da.R\")"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 2,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": [
    "suppressPackageStartupMessages({\n",
    "    library(tidyverse) \n",
    "    library(vcd)\n",
    "    library(readr)\n",
    "    library(maftools)\n",
    "    library(corrplot)\n",
    "    library(knitr)\n",
    "    library(wordcloud)\n",
    "    library(RColorBrewer)})"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 3,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "[1] ‘1.8.0’"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "packageVersion(\"maftools\")"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "## Load Mutation Data and subset"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 4,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": [
    "file_name=\"../KCPG_Variants/data/Mutation_data_cleaned_051019.xls\""
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 5,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": [
    "df = readxl::read_excel(file_name)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 6,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<ol class=list-inline>\n",
       "\t<li>3016</li>\n",
       "\t<li>84</li>\n",
       "</ol>\n"
      ],
      "text/latex": [
       "\\begin{enumerate*}\n",
       "\\item 3016\n",
       "\\item 84\n",
       "\\end{enumerate*}\n"
      ],
      "text/markdown": [
       "1. 3016\n",
       "2. 84\n",
       "\n",
       "\n"
      ],
      "text/plain": [
       "[1] 3016   84"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "df %>% dim"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 7,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "\n",
       "\n",
       "Var1     Freq\n",
       "------  -----\n",
       "CNS       613\n",
       "WLM       405\n",
       "NBL       343\n",
       "RHB       259\n",
       "OS        241\n",
       "HGG       229\n",
       "RB        221\n",
       "EWS       192\n",
       "STS       177\n",
       "GCT       139\n",
       "ACT        79\n",
       "LGG        52\n",
       "CA         35\n",
       "OST        18\n",
       "RCC         5\n",
       "GICT        2\n",
       "LMPRT       2\n",
       "PGL         2\n",
       "BCC         1\n",
       "NM          1"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "knitr::kable( sort( table(df$Tumor_types ),decreasing = T), format=\"pandoc\")"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 8,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<table>\n",
       "<tbody>\n",
       "\t<tr><th scope=row>known</th><td> 290</td></tr>\n",
       "\t<tr><th scope=row>suggesting</th><td>2726</td></tr>\n",
       "</tbody>\n",
       "</table>\n"
      ],
      "text/latex": [
       "\\begin{tabular}{r|l}\n",
       "\tknown &  290\\\\\n",
       "\tsuggesting & 2726\\\\\n",
       "\\end{tabular}\n"
      ],
      "text/markdown": [
       "\n",
       "| known |  290 |\n",
       "| suggesting | 2726 |\n",
       "\n"
      ],
      "text/plain": [
       "           [,1]\n",
       "known       290\n",
       "suggesting 2726"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "cbind( df$Known_Cancer_Predisposition_Genes %>% table )"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 9,
   "metadata": {},
   "outputs": [],
   "source": [
    "df = df[df$Known_Cancer_Predisposition_Genes == 'known',]\n",
    "df =droplevels(df)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 10,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<ol class=list-inline>\n",
       "\t<li>290</li>\n",
       "\t<li>84</li>\n",
       "</ol>\n"
      ],
      "text/latex": [
       "\\begin{enumerate*}\n",
       "\\item 290\n",
       "\\item 84\n",
       "\\end{enumerate*}\n"
      ],
      "text/markdown": [
       "1. 290\n",
       "2. 84\n",
       "\n",
       "\n"
      ],
      "text/plain": [
       "[1] 290  84"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "df%>% dim"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 11,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       ".\n",
       "   AD    AR AR/AD   XLD \n",
       "  153    92    43     2 "
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "df$Mode_of_Inheritance_abb %>% table"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 12,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "       \n",
       "        Het Hom\n",
       "  AD    153   0\n",
       "  AR     92   0\n",
       "  AR/AD  43   0\n",
       "  XLD     1   1"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "table(df$Mode_of_Inheritance_abb , df$genotype)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 13,
   "metadata": {},
   "outputs": [],
   "source": [
    "df = df[df$Mode_of_Inheritance_abb != 'AR',]\n",
    "df =droplevels(df)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 14,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<ol class=list-inline>\n",
       "\t<li>198</li>\n",
       "\t<li>84</li>\n",
       "</ol>\n"
      ],
      "text/latex": [
       "\\begin{enumerate*}\n",
       "\\item 198\n",
       "\\item 84\n",
       "\\end{enumerate*}\n"
      ],
      "text/markdown": [
       "1. 198\n",
       "2. 84\n",
       "\n",
       "\n"
      ],
      "text/plain": [
       "[1] 198  84"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "df %>% dim"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 15,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       ".\n",
       "   AD AR/AD   XLD \n",
       "  153    43     2 "
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "# sanity check\n",
    "df$Mode_of_Inheritance_abb %>% table"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 16,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "182"
      ],
      "text/latex": [
       "182"
      ],
      "text/markdown": [
       "182"
      ],
      "text/plain": [
       "[1] 182"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "len( unique(df$Tumor_Sample_Barcode) )"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 17,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "54"
      ],
      "text/latex": [
       "54"
      ],
      "text/markdown": [
       "54"
      ],
      "text/plain": [
       "[1] 54"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "len( unique(df$Hugo_Symbol) )"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### Note :\n",
    "- there are 54 genes from 182 samples and 198 variants"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "## Load Clinical Data"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 18,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": [
    "file_name_clinical = \"../KCPG_Variants/data/Combined_Clinical_Data_03.xlsx\""
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 19,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": [
    "df2 = readxl::read_excel( file_name_clinical )"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 20,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<table>\n",
       "<thead><tr><th scope=col>Tumor_Sample_Barcode</th><th scope=col>Tumor_type</th><th scope=col>Tumor_type2</th><th scope=col>Age_of_Onset</th><th scope=col>Sex</th><th scope=col>Age_group</th><th scope=col>sample_type</th><th scope=col>sequencing_type</th><th scope=col>Access_unit</th><th scope=col>Status</th><th scope=col>Ethnicity</th><th scope=col>Race</th></tr></thead>\n",
       "<tbody>\n",
       "\t<tr><td>SJACT014                          </td><td>Adrenocortical Carcinoma          </td><td>ACT                               </td><td>0.9138889                         </td><td>Female                            </td><td>Children                          </td><td>germline                          </td><td>WES                               </td><td>PCGP                              </td><td>live                              </td><td>NA                                </td><td>NA                                </td></tr>\n",
       "\t<tr><td>SJACT019118                       </td><td>Adrenocortical Carcinoma          </td><td>ACT                               </td><td>1.0200000                         </td><td>Female                            </td><td>Children                          </td><td>germline                          </td><td>WES                               </td><td>SJLIFE                            </td><td>live                              </td><td>Non Spanish speaking, Non Hispanic</td><td>NA                                </td></tr>\n",
       "\t<tr><td>SJACT025                          </td><td>Adrenocortical Carcinoma          </td><td>ACT                               </td><td>1.0833333                         </td><td>Female                            </td><td>Children                          </td><td>germline                          </td><td>WES                               </td><td>PCGP                              </td><td>live                              </td><td>NA                                </td><td>NA                                </td></tr>\n",
       "\t<tr><td>SJACT018                          </td><td>Adrenocortical Carcinoma          </td><td>ACT                               </td><td>1.0833333                         </td><td>Female                            </td><td>Children                          </td><td>germline                          </td><td>WES                               </td><td>PCGP                              </td><td>live                              </td><td>NA                                </td><td>NA                                </td></tr>\n",
       "\t<tr><td>SJACT010                          </td><td>Adrenocortical Carcinoma          </td><td>ACT                               </td><td>1.1138889                         </td><td>Male                              </td><td>Children                          </td><td>germline                          </td><td>WES                               </td><td>PCGP                              </td><td>live                              </td><td>NA                                </td><td>NA                                </td></tr>\n",
       "\t<tr><td>SJACT016                          </td><td>Adrenocortical Carcinoma          </td><td>ACT                               </td><td>1.2611111                         </td><td>Male                              </td><td>Children                          </td><td>germline                          </td><td>WES                               </td><td>PCGP                              </td><td>live                              </td><td>NA                                </td><td>NA                                </td></tr>\n",
       "</tbody>\n",
       "</table>\n"
      ],
      "text/latex": [
       "\\begin{tabular}{r|llllllllllll}\n",
       " Tumor\\_Sample\\_Barcode & Tumor\\_type & Tumor\\_type2 & Age\\_of\\_Onset & Sex & Age\\_group & sample\\_type & sequencing\\_type & Access\\_unit & Status & Ethnicity & Race\\\\\n",
       "\\hline\n",
       "\t SJACT014                           & Adrenocortical Carcinoma           & ACT                                & 0.9138889                          & Female                             & Children                           & germline                           & WES                                & PCGP                               & live                               & NA                                 & NA                                \\\\\n",
       "\t SJACT019118                        & Adrenocortical Carcinoma           & ACT                                & 1.0200000                          & Female                             & Children                           & germline                           & WES                                & SJLIFE                             & live                               & Non Spanish speaking, Non Hispanic & NA                                \\\\\n",
       "\t SJACT025                           & Adrenocortical Carcinoma           & ACT                                & 1.0833333                          & Female                             & Children                           & germline                           & WES                                & PCGP                               & live                               & NA                                 & NA                                \\\\\n",
       "\t SJACT018                           & Adrenocortical Carcinoma           & ACT                                & 1.0833333                          & Female                             & Children                           & germline                           & WES                                & PCGP                               & live                               & NA                                 & NA                                \\\\\n",
       "\t SJACT010                           & Adrenocortical Carcinoma           & ACT                                & 1.1138889                          & Male                               & Children                           & germline                           & WES                                & PCGP                               & live                               & NA                                 & NA                                \\\\\n",
       "\t SJACT016                           & Adrenocortical Carcinoma           & ACT                                & 1.2611111                          & Male                               & Children                           & germline                           & WES                                & PCGP                               & live                               & NA                                 & NA                                \\\\\n",
       "\\end{tabular}\n"
      ],
      "text/markdown": [
       "\n",
       "| Tumor_Sample_Barcode | Tumor_type | Tumor_type2 | Age_of_Onset | Sex | Age_group | sample_type | sequencing_type | Access_unit | Status | Ethnicity | Race |\n",
       "|---|---|---|---|---|---|---|---|---|---|---|---|\n",
       "| SJACT014                           | Adrenocortical Carcinoma           | ACT                                | 0.9138889                          | Female                             | Children                           | germline                           | WES                                | PCGP                               | live                               | NA                                 | NA                                 |\n",
       "| SJACT019118                        | Adrenocortical Carcinoma           | ACT                                | 1.0200000                          | Female                             | Children                           | germline                           | WES                                | SJLIFE                             | live                               | Non Spanish speaking, Non Hispanic | NA                                 |\n",
       "| SJACT025                           | Adrenocortical Carcinoma           | ACT                                | 1.0833333                          | Female                             | Children                           | germline                           | WES                                | PCGP                               | live                               | NA                                 | NA                                 |\n",
       "| SJACT018                           | Adrenocortical Carcinoma           | ACT                                | 1.0833333                          | Female                             | Children                           | germline                           | WES                                | PCGP                               | live                               | NA                                 | NA                                 |\n",
       "| SJACT010                           | Adrenocortical Carcinoma           | ACT                                | 1.1138889                          | Male                               | Children                           | germline                           | WES                                | PCGP                               | live                               | NA                                 | NA                                 |\n",
       "| SJACT016                           | Adrenocortical Carcinoma           | ACT                                | 1.2611111                          | Male                               | Children                           | germline                           | WES                                | PCGP                               | live                               | NA                                 | NA                                 |\n",
       "\n"
      ],
      "text/plain": [
       "  Tumor_Sample_Barcode Tumor_type               Tumor_type2 Age_of_Onset Sex   \n",
       "1 SJACT014             Adrenocortical Carcinoma ACT         0.9138889    Female\n",
       "2 SJACT019118          Adrenocortical Carcinoma ACT         1.0200000    Female\n",
       "3 SJACT025             Adrenocortical Carcinoma ACT         1.0833333    Female\n",
       "4 SJACT018             Adrenocortical Carcinoma ACT         1.0833333    Female\n",
       "5 SJACT010             Adrenocortical Carcinoma ACT         1.1138889    Male  \n",
       "6 SJACT016             Adrenocortical Carcinoma ACT         1.2611111    Male  \n",
       "  Age_group sample_type sequencing_type Access_unit Status\n",
       "1 Children  germline    WES             PCGP        live  \n",
       "2 Children  germline    WES             SJLIFE      live  \n",
       "3 Children  germline    WES             PCGP        live  \n",
       "4 Children  germline    WES             PCGP        live  \n",
       "5 Children  germline    WES             PCGP        live  \n",
       "6 Children  germline    WES             PCGP        live  \n",
       "  Ethnicity                          Race\n",
       "1 NA                                 NA  \n",
       "2 Non Spanish speaking, Non Hispanic NA  \n",
       "3 NA                                 NA  \n",
       "4 NA                                 NA  \n",
       "5 NA                                 NA  \n",
       "6 NA                                 NA  "
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "df2 %>% head"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 21,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<ol class=list-inline>\n",
       "\t<li>1507</li>\n",
       "\t<li>12</li>\n",
       "</ol>\n"
      ],
      "text/latex": [
       "\\begin{enumerate*}\n",
       "\\item 1507\n",
       "\\item 12\n",
       "\\end{enumerate*}\n"
      ],
      "text/markdown": [
       "1. 1507\n",
       "2. 12\n",
       "\n",
       "\n"
      ],
      "text/plain": [
       "[1] 1507   12"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "df2 %>% dim"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 22,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "182"
      ],
      "text/latex": [
       "182"
      ],
      "text/markdown": [
       "182"
      ],
      "text/plain": [
       "[1] 182"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "len( intersect( unique(df$Tumor_Sample_Barcode), unique(df2$Tumor_Sample_Barcode) ) )"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 23,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [],
      "text/latex": [],
      "text/markdown": [],
      "text/plain": [
       "character(0)"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "setdiff( df$Tumor_Sample_Barcode, df2$Tumor_Sample_Barcode )"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 24,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "\n",
       "TRUE \n",
       " 198 "
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "table( df$Tumor_Sample_Barcode %in% intersect( df$Tumor_Sample_Barcode, df2$Tumor_Sample_Barcode )) "
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 25,
   "metadata": {},
   "outputs": [],
   "source": [
    "## subset df where samples from df and df2 are same"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 26,
   "metadata": {},
   "outputs": [],
   "source": [
    "ss = df$Tumor_Sample_Barcode %in% intersect( df$Tumor_Sample_Barcode, df2$Tumor_Sample_Barcode )"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 27,
   "metadata": {},
   "outputs": [],
   "source": [
    "df_ss = df[ ss, ]"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 28,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<ol class=list-inline>\n",
       "\t<li>198</li>\n",
       "\t<li>84</li>\n",
       "</ol>\n"
      ],
      "text/latex": [
       "\\begin{enumerate*}\n",
       "\\item 198\n",
       "\\item 84\n",
       "\\end{enumerate*}\n"
      ],
      "text/markdown": [
       "1. 198\n",
       "2. 84\n",
       "\n",
       "\n"
      ],
      "text/plain": [
       "[1] 198  84"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "df_ss %>% dim"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 29,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "\n",
       " ACT  CNS  EWS  GCT  HGG  LGG  NBL   OS  OST   RB  RHB  STS  WLM <NA> \n",
       "  11   47    8    5    8    2   19   13    2   44   11    6   22    0 "
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "table(df_ss$Tumor_types, useNA = \"always\")"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 30,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "\n",
       "known  <NA> \n",
       "  198     0 "
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "table(df_ss$Known_Cancer_Predisposition_Genes, useNA = \"always\")"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 31,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<table>\n",
       "<tbody>\n",
       "\t<tr><td>198 </td><td>1507</td></tr>\n",
       "\t<tr><td> 84 </td><td>  12</td></tr>\n",
       "</tbody>\n",
       "</table>\n"
      ],
      "text/latex": [
       "\\begin{tabular}{ll}\n",
       "\t 198  & 1507\\\\\n",
       "\t  84  &   12\\\\\n",
       "\\end{tabular}\n"
      ],
      "text/markdown": [
       "\n",
       "| 198  | 1507 |\n",
       "|  84  |   12 |\n",
       "\n"
      ],
      "text/plain": [
       "     [,1] [,2]\n",
       "[1,] 198  1507\n",
       "[2,]  84    12"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "cbind(dim(df_ss), dim(df2))"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 32,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<ol class=list-inline>\n",
       "\t<li>198</li>\n",
       "\t<li>84</li>\n",
       "</ol>\n"
      ],
      "text/latex": [
       "\\begin{enumerate*}\n",
       "\\item 198\n",
       "\\item 84\n",
       "\\end{enumerate*}\n"
      ],
      "text/markdown": [
       "1. 198\n",
       "2. 84\n",
       "\n",
       "\n"
      ],
      "text/plain": [
       "[1] 198  84"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "df_ss %>% dim"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 33,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<ol class=list-inline>\n",
       "\t<li>1507</li>\n",
       "\t<li>12</li>\n",
       "</ol>\n"
      ],
      "text/latex": [
       "\\begin{enumerate*}\n",
       "\\item 1507\n",
       "\\item 12\n",
       "\\end{enumerate*}\n"
      ],
      "text/markdown": [
       "1. 1507\n",
       "2. 12\n",
       "\n",
       "\n"
      ],
      "text/plain": [
       "[1] 1507   12"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "df2 %>% dim"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 34,
   "metadata": {},
   "outputs": [],
   "source": [
    "ss2 = df2$Tumor_Sample_Barcode %in% intersect( df2$Tumor_Sample_Barcode, df$Tumor_Sample_Barcode) "
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 35,
   "metadata": {},
   "outputs": [],
   "source": [
    "df2_ss=df2[ss2,]"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 36,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<ol class=list-inline>\n",
       "\t<li>182</li>\n",
       "\t<li>12</li>\n",
       "</ol>\n"
      ],
      "text/latex": [
       "\\begin{enumerate*}\n",
       "\\item 182\n",
       "\\item 12\n",
       "\\end{enumerate*}\n"
      ],
      "text/markdown": [
       "1. 182\n",
       "2. 12\n",
       "\n",
       "\n"
      ],
      "text/plain": [
       "[1] 182  12"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "df2_ss %>% dim"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "## Sanity Check"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 37,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<ol class=list-inline>\n",
       "\t<li>198</li>\n",
       "\t<li>84</li>\n",
       "</ol>\n"
      ],
      "text/latex": [
       "\\begin{enumerate*}\n",
       "\\item 198\n",
       "\\item 84\n",
       "\\end{enumerate*}\n"
      ],
      "text/markdown": [
       "1. 198\n",
       "2. 84\n",
       "\n",
       "\n"
      ],
      "text/plain": [
       "[1] 198  84"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "df_ss %>% dim"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 38,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<ol class=list-inline>\n",
       "\t<li>182</li>\n",
       "\t<li>12</li>\n",
       "</ol>\n"
      ],
      "text/latex": [
       "\\begin{enumerate*}\n",
       "\\item 182\n",
       "\\item 12\n",
       "\\end{enumerate*}\n"
      ],
      "text/markdown": [
       "1. 182\n",
       "2. 12\n",
       "\n",
       "\n"
      ],
      "text/plain": [
       "[1] 182  12"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "df2_ss %>% dim"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "## Creating a MAF object"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 39,
   "metadata": {
    "scrolled": false
   },
   "outputs": [
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "Summarizing..\n",
      "NOTE: Mutiple reference builds found!\n",
      "37;38\n"
     ]
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "                   ID summary  Mean Median\n",
      " 1:        NCBI_Build   37;38    NA     NA\n",
      " 2:            Center    <NA>    NA     NA\n",
      " 3:           Samples     182    NA     NA\n",
      " 4:            nGenes      54    NA     NA\n",
      " 5:   Frame_Shift_Del      38 0.209      0\n",
      " 6:   Frame_Shift_Ins      17 0.093      0\n",
      " 7:      In_Frame_Del       2 0.011      0\n",
      " 8: Missense_Mutation      63 0.346      0\n",
      " 9: Nonsense_Mutation      53 0.291      0\n",
      "10:       Splice_Site      25 0.137      0\n",
      "11:             total     198 1.088      1\n"
     ]
    },
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "Gene Summary..\n"
     ]
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "    Hugo_Symbol Frame_Shift_Del Frame_Shift_Ins In_Frame_Del Missense_Mutation\n",
      " 1:         RB1               6               3            0                 2\n",
      " 2:         NF1               2               1            0                 7\n",
      " 3:       CHEK2              11               0            1                 3\n",
      " 4:        TP53               0               1            0                 5\n",
      " 5:         ATM               0               0            1                 6\n",
      " 6:      COL7A1               1               0            0                 3\n",
      " 7:       BRCA1               4               1            0                 0\n",
      " 8:        GJB2               3               1            0                 2\n",
      " 9:       BRCA2               1               1            0                 1\n",
      "10:        CDH1               1               0            0                 2\n",
      "11:      DICER1               1               2            0                 1\n",
      "12:         ALK               0               0            0                 3\n",
      "13:       FANCM               0               1            0                 0\n",
      "14:         MPL               2               0            0                 1\n",
      "15:        MSH6               2               0            0                 0\n",
      "16:       PALB2               2               0            0                 0\n",
      "17:        POLE               0               1            0                 2\n",
      "18:       RECQL               0               0            0                 1\n",
      "19:         WT1               0               1            0                 0\n",
      "20:        PMS2               0               2            0                 0\n",
      "21:          AR               0               0            0                 2\n",
      "22:      CREBBP               0               0            0                 2\n",
      "23:        HMBS               0               0            0                 1\n",
      "24:         KIT               0               0            0                 2\n",
      "25:       LZTR1               0               0            0                 1\n",
      "26:        MEN1               0               1            0                 1\n",
      "27:       NTRK1               0               0            0                 0\n",
      "28:      PTPN11               0               0            0                 2\n",
      "29:        SDHA               0               0            0                 1\n",
      "30:     SMARCA4               0               0            0                 0\n",
      "31:         ATR               0               0            0                 0\n",
      "32:        BAP1               0               0            0                 0\n",
      "33:       BARD1               0               0            0                 0\n",
      "34:      BMPR1A               0               0            0                 1\n",
      "35:       BRIP1               0               0            0                 0\n",
      "36:       CDC73               0               0            0                 1\n",
      "37:        EGFR               0               0            0                 1\n",
      "38:       EP300               0               0            0                 0\n",
      "39:       ERBB4               0               0            0                 0\n",
      "40:        EXT2               0               0            0                 1\n",
      "41:          FH               0               0            0                 1\n",
      "42:        MSH2               0               0            0                 1\n",
      "43:         NF2               0               0            0                 1\n",
      "44:        NSD1               1               0            0                 0\n",
      "45:      PDGFRA               0               0            0                 1\n",
      "46:      PHOX2B               0               0            0                 0\n",
      "47:       PTCH1               0               1            0                 0\n",
      "48:      RAD51C               1               0            0                 0\n",
      "49:      RAD51D               0               0            0                 0\n",
      "50:         RET               0               0            0                 1\n",
      "51:        SDHB               0               0            0                 1\n",
      "52:        SUFU               0               0            0                 0\n",
      "53:        TSHR               0               0            0                 1\n",
      "54:        UROD               0               0            0                 1\n",
      "    Hugo_Symbol Frame_Shift_Del Frame_Shift_Ins In_Frame_Del Missense_Mutation\n",
      "    Nonsense_Mutation Splice_Site total MutatedSamples AlteredSamples\n",
      " 1:                17           4    32             32             32\n",
      " 2:                 9           3    22             22             22\n",
      " 3:                 1           3    19             19             19\n",
      " 4:                 2           2    10             10             10\n",
      " 5:                 0           2     9              9              9\n",
      " 6:                 3           1     8              8              8\n",
      " 7:                 2           0     7              7              7\n",
      " 8:                 1           0     7              7              7\n",
      " 9:                 0           2     5              5              5\n",
      "10:                 0           1     4              4              4\n",
      "11:                 0           0     4              4              4\n",
      "12:                 0           0     3              3              3\n",
      "13:                 1           1     3              3              3\n",
      "14:                 0           0     3              3              3\n",
      "15:                 1           0     3              3              3\n",
      "16:                 1           0     3              3              3\n",
      "17:                 0           0     3              3              3\n",
      "18:                 2           0     3              3              3\n",
      "19:                 2           0     3              3              3\n",
      "20:                 1           0     3              2              2\n",
      "21:                 0           0     2              2              2\n",
      "22:                 0           0     2              2              2\n",
      "23:                 0           1     2              2              2\n",
      "24:                 0           0     2              2              2\n",
      "25:                 1           0     2              2              2\n",
      "26:                 0           0     2              2              2\n",
      "27:                 1           1     2              2              2\n",
      "28:                 0           0     2              2              2\n",
      "29:                 1           0     2              2              2\n",
      "30:                 1           1     2              2              2\n",
      "31:                 1           0     1              1              1\n",
      "32:                 1           0     1              1              1\n",
      "33:                 0           1     1              1              1\n",
      "34:                 0           0     1              1              1\n",
      "35:                 0           1     1              1              1\n",
      "36:                 0           0     1              1              1\n",
      "37:                 0           0     1              1              1\n",
      "38:                 1           0     1              1              1\n",
      "39:                 1           0     1              1              1\n",
      "40:                 0           0     1              1              1\n",
      "41:                 0           0     1              1              1\n",
      "42:                 0           0     1              1              1\n",
      "43:                 0           0     1              1              1\n",
      "44:                 0           0     1              1              1\n",
      "45:                 0           0     1              1              1\n",
      "46:                 0           1     1              1              1\n",
      "47:                 0           0     1              1              1\n",
      "48:                 0           0     1              1              1\n",
      "49:                 1           0     1              1              1\n",
      "50:                 0           0     1              1              1\n",
      "51:                 0           0     1              1              1\n",
      "52:                 1           0     1              1              1\n",
      "53:                 0           0     1              1              1\n",
      "54:                 0           0     1              1              1\n",
      "    Nonsense_Mutation Splice_Site total MutatedSamples AlteredSamples\n"
     ]
    },
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "Checking clinical data..\n",
      "Done !\n"
     ]
    }
   ],
   "source": [
    "dfx = read.maf(maf=df_ss,clinicalData = df2_ss , isTCGA = FALSE, verbose = TRUE, removeDuplicatedVariants = FALSE, useAll = TRUE )"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 40,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<table>\n",
       "<thead><tr><th scope=col>ID</th><th scope=col>summary</th><th scope=col>Mean</th><th scope=col>Median</th></tr></thead>\n",
       "<tbody>\n",
       "\t<tr><td>NCBI_Build       </td><td>37;38            </td><td>   NA            </td><td>NA               </td></tr>\n",
       "\t<tr><td>Center           </td><td>NA               </td><td>   NA            </td><td>NA               </td></tr>\n",
       "\t<tr><td>Samples          </td><td>182              </td><td>   NA            </td><td>NA               </td></tr>\n",
       "\t<tr><td>nGenes           </td><td>54               </td><td>   NA            </td><td>NA               </td></tr>\n",
       "\t<tr><td>Frame_Shift_Del  </td><td>38               </td><td>0.209            </td><td> 0               </td></tr>\n",
       "\t<tr><td>Frame_Shift_Ins  </td><td>17               </td><td>0.093            </td><td> 0               </td></tr>\n",
       "\t<tr><td>In_Frame_Del     </td><td>2                </td><td>0.011            </td><td> 0               </td></tr>\n",
       "\t<tr><td>Missense_Mutation</td><td>63               </td><td>0.346            </td><td> 0               </td></tr>\n",
       "\t<tr><td>Nonsense_Mutation</td><td>53               </td><td>0.291            </td><td> 0               </td></tr>\n",
       "\t<tr><td>Splice_Site      </td><td>25               </td><td>0.137            </td><td> 0               </td></tr>\n",
       "\t<tr><td>total            </td><td>198              </td><td>1.088            </td><td> 1               </td></tr>\n",
       "</tbody>\n",
       "</table>\n"
      ],
      "text/latex": [
       "\\begin{tabular}{r|llll}\n",
       " ID & summary & Mean & Median\\\\\n",
       "\\hline\n",
       "\t NCBI\\_Build        & 37;38               &    NA               & NA                 \\\\\n",
       "\t Center            & NA                &    NA             & NA               \\\\\n",
       "\t Samples           & 182               &    NA             & NA               \\\\\n",
       "\t nGenes            & 54                &    NA             & NA               \\\\\n",
       "\t Frame\\_Shift\\_Del   & 38                    & 0.209                 &  0                   \\\\\n",
       "\t Frame\\_Shift\\_Ins   & 17                    & 0.093                 &  0                   \\\\\n",
       "\t In\\_Frame\\_Del      & 2                     & 0.011                 &  0                   \\\\\n",
       "\t Missense\\_Mutation & 63                  & 0.346               &  0                 \\\\\n",
       "\t Nonsense\\_Mutation & 53                  & 0.291               &  0                 \\\\\n",
       "\t Splice\\_Site       & 25                  & 0.137               &  0                 \\\\\n",
       "\t total             & 198               & 1.088             &  1               \\\\\n",
       "\\end{tabular}\n"
      ],
      "text/markdown": [
       "\n",
       "| ID | summary | Mean | Median |\n",
       "|---|---|---|---|\n",
       "| NCBI_Build        | 37;38             |    NA             | NA                |\n",
       "| Center            | NA                |    NA             | NA                |\n",
       "| Samples           | 182               |    NA             | NA                |\n",
       "| nGenes            | 54                |    NA             | NA                |\n",
       "| Frame_Shift_Del   | 38                | 0.209             |  0                |\n",
       "| Frame_Shift_Ins   | 17                | 0.093             |  0                |\n",
       "| In_Frame_Del      | 2                 | 0.011             |  0                |\n",
       "| Missense_Mutation | 63                | 0.346             |  0                |\n",
       "| Nonsense_Mutation | 53                | 0.291             |  0                |\n",
       "| Splice_Site       | 25                | 0.137             |  0                |\n",
       "| total             | 198               | 1.088             |  1                |\n",
       "\n"
      ],
      "text/plain": [
       "   ID                summary Mean  Median\n",
       "1  NCBI_Build        37;38      NA NA    \n",
       "2  Center            NA         NA NA    \n",
       "3  Samples           182        NA NA    \n",
       "4  nGenes            54         NA NA    \n",
       "5  Frame_Shift_Del   38      0.209  0    \n",
       "6  Frame_Shift_Ins   17      0.093  0    \n",
       "7  In_Frame_Del      2       0.011  0    \n",
       "8  Missense_Mutation 63      0.346  0    \n",
       "9  Nonsense_Mutation 53      0.291  0    \n",
       "10 Splice_Site       25      0.137  0    \n",
       "11 total             198     1.088  1    "
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "dfx@summary"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 41,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<table>\n",
       "<thead><tr><th scope=col>Tumor_Sample_Barcode</th><th scope=col>Tumor_type</th><th scope=col>Tumor_type2</th><th scope=col>Age_of_Onset</th><th scope=col>Sex</th><th scope=col>Age_group</th><th scope=col>sample_type</th><th scope=col>sequencing_type</th><th scope=col>Access_unit</th><th scope=col>Status</th><th scope=col>Ethnicity</th><th scope=col>Race</th></tr></thead>\n",
       "<tbody>\n",
       "\t<tr><td>SJACT014                </td><td>Adrenocortical_Carcinoma</td><td>ACT                     </td><td>0.9138889               </td><td>Female                  </td><td>Children                </td><td>germline                </td><td>WES                     </td><td>PCGP                    </td><td>live                    </td><td>NA                      </td><td>NA                      </td></tr>\n",
       "\t<tr><td>SJACT025                </td><td>Adrenocortical_Carcinoma</td><td>ACT                     </td><td>1.0833333               </td><td>Female                  </td><td>Children                </td><td>germline                </td><td>WES                     </td><td>PCGP                    </td><td>live                    </td><td>NA                      </td><td>NA                      </td></tr>\n",
       "\t<tr><td>SJACT018                </td><td>Adrenocortical_Carcinoma</td><td>ACT                     </td><td>1.0833333               </td><td>Female                  </td><td>Children                </td><td>germline                </td><td>WES                     </td><td>PCGP                    </td><td>live                    </td><td>NA                      </td><td>NA                      </td></tr>\n",
       "\t<tr><td>SJACT010                </td><td>Adrenocortical_Carcinoma</td><td>ACT                     </td><td>1.1138889               </td><td>Male                    </td><td>Children                </td><td>germline                </td><td>WES                     </td><td>PCGP                    </td><td>live                    </td><td>NA                      </td><td>NA                      </td></tr>\n",
       "\t<tr><td>SJACT013                </td><td>Adrenocortical_Carcinoma</td><td>ACT                     </td><td>1.2777778               </td><td>Female                  </td><td>Children                </td><td>germline                </td><td>WES                     </td><td>PCGP                    </td><td>live                    </td><td>NA                      </td><td>NA                      </td></tr>\n",
       "\t<tr><td>SJACT015                </td><td>Adrenocortical_Carcinoma</td><td>ACT                     </td><td>1.9000000               </td><td>Male                    </td><td>Children                </td><td>germline                </td><td>WES                     </td><td>PCGP                    </td><td>live                    </td><td>NA                      </td><td>NA                      </td></tr>\n",
       "</tbody>\n",
       "</table>\n"
      ],
      "text/latex": [
       "\\begin{tabular}{r|llllllllllll}\n",
       " Tumor\\_Sample\\_Barcode & Tumor\\_type & Tumor\\_type2 & Age\\_of\\_Onset & Sex & Age\\_group & sample\\_type & sequencing\\_type & Access\\_unit & Status & Ethnicity & Race\\\\\n",
       "\\hline\n",
       "\t SJACT014                   & Adrenocortical\\_Carcinoma & ACT                        & 0.9138889                  & Female                     & Children                   & germline                   & WES                        & PCGP                       & live                       & NA                         & NA                        \\\\\n",
       "\t SJACT025                   & Adrenocortical\\_Carcinoma & ACT                        & 1.0833333                  & Female                     & Children                   & germline                   & WES                        & PCGP                       & live                       & NA                         & NA                        \\\\\n",
       "\t SJACT018                   & Adrenocortical\\_Carcinoma & ACT                        & 1.0833333                  & Female                     & Children                   & germline                   & WES                        & PCGP                       & live                       & NA                         & NA                        \\\\\n",
       "\t SJACT010                   & Adrenocortical\\_Carcinoma & ACT                        & 1.1138889                  & Male                       & Children                   & germline                   & WES                        & PCGP                       & live                       & NA                         & NA                        \\\\\n",
       "\t SJACT013                   & Adrenocortical\\_Carcinoma & ACT                        & 1.2777778                  & Female                     & Children                   & germline                   & WES                        & PCGP                       & live                       & NA                         & NA                        \\\\\n",
       "\t SJACT015                   & Adrenocortical\\_Carcinoma & ACT                        & 1.9000000                  & Male                       & Children                   & germline                   & WES                        & PCGP                       & live                       & NA                         & NA                        \\\\\n",
       "\\end{tabular}\n"
      ],
      "text/markdown": [
       "\n",
       "| Tumor_Sample_Barcode | Tumor_type | Tumor_type2 | Age_of_Onset | Sex | Age_group | sample_type | sequencing_type | Access_unit | Status | Ethnicity | Race |\n",
       "|---|---|---|---|---|---|---|---|---|---|---|---|\n",
       "| SJACT014                 | Adrenocortical_Carcinoma | ACT                      | 0.9138889                | Female                   | Children                 | germline                 | WES                      | PCGP                     | live                     | NA                       | NA                       |\n",
       "| SJACT025                 | Adrenocortical_Carcinoma | ACT                      | 1.0833333                | Female                   | Children                 | germline                 | WES                      | PCGP                     | live                     | NA                       | NA                       |\n",
       "| SJACT018                 | Adrenocortical_Carcinoma | ACT                      | 1.0833333                | Female                   | Children                 | germline                 | WES                      | PCGP                     | live                     | NA                       | NA                       |\n",
       "| SJACT010                 | Adrenocortical_Carcinoma | ACT                      | 1.1138889                | Male                     | Children                 | germline                 | WES                      | PCGP                     | live                     | NA                       | NA                       |\n",
       "| SJACT013                 | Adrenocortical_Carcinoma | ACT                      | 1.2777778                | Female                   | Children                 | germline                 | WES                      | PCGP                     | live                     | NA                       | NA                       |\n",
       "| SJACT015                 | Adrenocortical_Carcinoma | ACT                      | 1.9000000                | Male                     | Children                 | germline                 | WES                      | PCGP                     | live                     | NA                       | NA                       |\n",
       "\n"
      ],
      "text/plain": [
       "  Tumor_Sample_Barcode Tumor_type               Tumor_type2 Age_of_Onset Sex   \n",
       "1 SJACT014             Adrenocortical_Carcinoma ACT         0.9138889    Female\n",
       "2 SJACT025             Adrenocortical_Carcinoma ACT         1.0833333    Female\n",
       "3 SJACT018             Adrenocortical_Carcinoma ACT         1.0833333    Female\n",
       "4 SJACT010             Adrenocortical_Carcinoma ACT         1.1138889    Male  \n",
       "5 SJACT013             Adrenocortical_Carcinoma ACT         1.2777778    Female\n",
       "6 SJACT015             Adrenocortical_Carcinoma ACT         1.9000000    Male  \n",
       "  Age_group sample_type sequencing_type Access_unit Status Ethnicity Race\n",
       "1 Children  germline    WES             PCGP        live   NA        NA  \n",
       "2 Children  germline    WES             PCGP        live   NA        NA  \n",
       "3 Children  germline    WES             PCGP        live   NA        NA  \n",
       "4 Children  germline    WES             PCGP        live   NA        NA  \n",
       "5 Children  germline    WES             PCGP        live   NA        NA  \n",
       "6 Children  germline    WES             PCGP        live   NA        NA  "
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "dfx@clinical.data %>% head"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 42,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<table>\n",
       "<thead><tr><th scope=col>Tumor_Sample_Barcode</th><th scope=col>Project</th><th scope=col>IVA_Prediction</th><th scope=col>Hugo_Symbol</th><th scope=col>Variant_Classification2</th><th scope=col>Variant_Type</th><th scope=col>NCBI_Build</th><th scope=col>Chromosome</th><th scope=col>Start_Position</th><th scope=col>End_Position</th><th scope=col>⋯</th><th scope=col>Variant_Classification</th><th scope=col>Tumor_types</th><th scope=col>CLINVAR_ID</th><th scope=col>CLINVAR_Description</th><th scope=col>CLINVAR_ReviewStat</th><th scope=col>CLINVAR_Explanation</th><th scope=col>Mode_of_Inheritance</th><th scope=col>Mode_of_Inheritance_abb</th><th scope=col>Gene_Classification</th><th scope=col>Known_Cancer_Predisposition_Genes</th></tr></thead>\n",
       "<tbody>\n",
       "\t<tr><td>CCF11829                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               </td><td>CCF_CAYA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               </td><td>Pathogenic                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             </td><td>GJB2                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   </td><td>Frame_Shift_Del                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        </td><td>DEL                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    </td><td>37                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     </td><td>13                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     </td><td>20763686                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               </td><td>20763686                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               </td><td>⋯                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      </td><td>Frame_Shift_Del                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        </td><td>OS                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     </td><td>RCV000411531.1; RCV000623840.1; RCV000018527.39; RCV000509463.1; RCV000508139.1; RCV000146019.2; RCV000509532.1; RCV000415181.1; RCV000415175.1; RCV000415367.1; RCV000477882.1; RCV000414886.1; RCV000080373.8; RCV000018528.30; RCV000211775.2                                                                                                                                                                                                                                                                                                                                       </td><td>Pathogenic; Pathogenic; Pathogenic; not provided; Pathogenic; Pathogenic; not provided; Pathogenic; Pathogenic; Pathogenic; Pathogenic; Pathogenic; Pathogenic; Pathogenic; Pathogenic                                                                                                                                                                                                                                                                                                                                                                                                 </td><td>criteria provided, multiple submitters, no conflicts; criteria provided, single submitter; criteria provided, multiple submitters, no conflicts; no assertion provided; criteria provided, single submitter; criteria provided, multiple submitters, no conflicts; no assertion provided; criteria provided, single submitter; no assertion criteria provided; criteria provided, single submitter; no assertion criteria provided; criteria provided, single submitter; criteria provided, multiple submitters, no conflicts; no assertion criteria provided; reviewed by expert panel</td><td>[nan, nan, nan, nan, nan, nan, nan, nan, nan, nan, nan, nan, nan, nan, nan]                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            </td><td>autosomal-dominant                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     </td><td>AD                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     </td><td>Not classified                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         </td><td>known                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  </td></tr>\n",
       "\t<tr><td>CCF12237                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               </td><td>CCF_CAYA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               </td><td>Pathogenic                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             </td><td>BRCA2                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  </td><td>Frame_Shift_Ins                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        </td><td>INS                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    </td><td>37                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     </td><td>13                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     </td><td>32912770                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               </td><td>32912771                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               </td><td>⋯                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      </td><td>Frame_Shift_Ins                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        </td><td>OS                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     </td><td>RCV000031473.12; RCV000044387.10; RCV000160287.4; RCV000130074.5                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       </td><td>Pathogenic; Pathogenic; Pathogenic; Pathogenic                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         </td><td>reviewed by expert panel; criteria provided, multiple submitters, no conflicts; criteria provided, multiple submitters, no conflicts; criteria provided, multiple submitters, no conflicts                                                                                                                                                                                                                                                                                                                                                                                             </td><td>[nan, nan, nan, nan]                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   </td><td>autosomal-recessive ; autosomal-dominant                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               </td><td>AR/AD                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  </td><td>Tumor Suppressor Gene                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  </td><td>known                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  </td></tr>\n",
       "</tbody>\n",
       "</table>\n"
      ],
      "text/latex": [
       "\\begin{tabular}{r|llllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllll}\n",
       " Tumor\\_Sample\\_Barcode & Project & IVA\\_Prediction & Hugo\\_Symbol & Variant\\_Classification2 & Variant\\_Type & NCBI\\_Build & Chromosome & Start\\_Position & End\\_Position & ⋯ & Variant\\_Classification & Tumor\\_types & CLINVAR\\_ID & CLINVAR\\_Description & CLINVAR\\_ReviewStat & CLINVAR\\_Explanation & Mode\\_of\\_Inheritance & Mode\\_of\\_Inheritance\\_abb & Gene\\_Classification & Known\\_Cancer\\_Predisposition\\_Genes\\\\\n",
       "\\hline\n",
       "\t CCF11829                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                & CCF\\_CAYA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              & Pathogenic                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              & GJB2                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    & Frame\\_Shift\\_Del                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     & DEL                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     & 37                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      & 13                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      & 20763686                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                & 20763686                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                & ⋯                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       & Frame\\_Shift\\_Del                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     & OS                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      & RCV000411531.1; RCV000623840.1; RCV000018527.39; RCV000509463.1; RCV000508139.1; RCV000146019.2; RCV000509532.1; RCV000415181.1; RCV000415175.1; RCV000415367.1; RCV000477882.1; RCV000414886.1; RCV000080373.8; RCV000018528.30; RCV000211775.2                                                                                                                                                                                                                                                                                                                                        & Pathogenic; Pathogenic; Pathogenic; not provided; Pathogenic; Pathogenic; not provided; Pathogenic; Pathogenic; Pathogenic; Pathogenic; Pathogenic; Pathogenic; Pathogenic; Pathogenic                                                                                                                                                                                                                                                                                                                                                                                                  & criteria provided, multiple submitters, no conflicts; criteria provided, single submitter; criteria provided, multiple submitters, no conflicts; no assertion provided; criteria provided, single submitter; criteria provided, multiple submitters, no conflicts; no assertion provided; criteria provided, single submitter; no assertion criteria provided; criteria provided, single submitter; no assertion criteria provided; criteria provided, single submitter; criteria provided, multiple submitters, no conflicts; no assertion criteria provided; reviewed by expert panel & {[}nan, nan, nan, nan, nan, nan, nan, nan, nan, nan, nan, nan, nan, nan, nan{]}                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         & autosomal-dominant                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      & AD                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      & Not classified                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          & known                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  \\\\\n",
       "\t CCF12237                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                & CCF\\_CAYA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              & Pathogenic                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              & BRCA2                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   & Frame\\_Shift\\_Ins                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     & INS                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     & 37                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      & 13                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      & 32912770                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                & 32912771                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                & ⋯                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       & Frame\\_Shift\\_Ins                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     & OS                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      & RCV000031473.12; RCV000044387.10; RCV000160287.4; RCV000130074.5                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        & Pathogenic; Pathogenic; Pathogenic; Pathogenic                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          & reviewed by expert panel; criteria provided, multiple submitters, no conflicts; criteria provided, multiple submitters, no conflicts; criteria provided, multiple submitters, no conflicts                                                                                                                                                                                                                                                                                                                                                                                              & {[}nan, nan, nan, nan{]}                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                & autosomal-recessive ; autosomal-dominant                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                & AR/AD                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   & Tumor Suppressor Gene                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   & known                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  \\\\\n",
       "\\end{tabular}\n"
      ],
      "text/markdown": [
       "\n",
       "| Tumor_Sample_Barcode | Project | IVA_Prediction | Hugo_Symbol | Variant_Classification2 | Variant_Type | NCBI_Build | Chromosome | Start_Position | End_Position | ⋯ | Variant_Classification | Tumor_types | CLINVAR_ID | CLINVAR_Description | CLINVAR_ReviewStat | CLINVAR_Explanation | Mode_of_Inheritance | Mode_of_Inheritance_abb | Gene_Classification | Known_Cancer_Predisposition_Genes |\n",
       "|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|\n",
       "| CCF11829                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                | CCF_CAYA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                | Pathogenic                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              | GJB2                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    | Frame_Shift_Del                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         | DEL                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     | 37                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      | 13                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      | 20763686                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                | 20763686                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                | ⋯                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       | Frame_Shift_Del                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         | OS                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      | RCV000411531.1; RCV000623840.1; RCV000018527.39; RCV000509463.1; RCV000508139.1; RCV000146019.2; RCV000509532.1; RCV000415181.1; RCV000415175.1; RCV000415367.1; RCV000477882.1; RCV000414886.1; RCV000080373.8; RCV000018528.30; RCV000211775.2                                                                                                                                                                                                                                                                                                                                        | Pathogenic; Pathogenic; Pathogenic; not provided; Pathogenic; Pathogenic; not provided; Pathogenic; Pathogenic; Pathogenic; Pathogenic; Pathogenic; Pathogenic; Pathogenic; Pathogenic                                                                                                                                                                                                                                                                                                                                                                                                  | criteria provided, multiple submitters, no conflicts; criteria provided, single submitter; criteria provided, multiple submitters, no conflicts; no assertion provided; criteria provided, single submitter; criteria provided, multiple submitters, no conflicts; no assertion provided; criteria provided, single submitter; no assertion criteria provided; criteria provided, single submitter; no assertion criteria provided; criteria provided, single submitter; criteria provided, multiple submitters, no conflicts; no assertion criteria provided; reviewed by expert panel | [nan, nan, nan, nan, nan, nan, nan, nan, nan, nan, nan, nan, nan, nan, nan]                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             | autosomal-dominant                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      | AD                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      | Not classified                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          | known                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   |\n",
       "| CCF12237                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                | CCF_CAYA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                | Pathogenic                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              | BRCA2                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   | Frame_Shift_Ins                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         | INS                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     | 37                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      | 13                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      | 32912770                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                | 32912771                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                | ⋯                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       | Frame_Shift_Ins                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         | OS                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      | RCV000031473.12; RCV000044387.10; RCV000160287.4; RCV000130074.5                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        | Pathogenic; Pathogenic; Pathogenic; Pathogenic                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          | reviewed by expert panel; criteria provided, multiple submitters, no conflicts; criteria provided, multiple submitters, no conflicts; criteria provided, multiple submitters, no conflicts                                                                                                                                                                                                                                                                                                                                                                                              | [nan, nan, nan, nan]                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    | autosomal-recessive ; autosomal-dominant                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                | AR/AD                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   | Tumor Suppressor Gene                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   | known                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   |\n",
       "\n"
      ],
      "text/plain": [
       "  Tumor_Sample_Barcode Project  IVA_Prediction Hugo_Symbol\n",
       "1 CCF11829             CCF_CAYA Pathogenic     GJB2       \n",
       "2 CCF12237             CCF_CAYA Pathogenic     BRCA2      \n",
       "  Variant_Classification2 Variant_Type NCBI_Build Chromosome Start_Position\n",
       "1 Frame_Shift_Del         DEL          37         13         20763686      \n",
       "2 Frame_Shift_Ins         INS          37         13         32912770      \n",
       "  End_Position ⋯ Variant_Classification Tumor_types\n",
       "1 20763686     ⋯ Frame_Shift_Del        OS         \n",
       "2 32912771     ⋯ Frame_Shift_Ins        OS         \n",
       "  CLINVAR_ID                                                                                                                                                                                                                                      \n",
       "1 RCV000411531.1; RCV000623840.1; RCV000018527.39; RCV000509463.1; RCV000508139.1; RCV000146019.2; RCV000509532.1; RCV000415181.1; RCV000415175.1; RCV000415367.1; RCV000477882.1; RCV000414886.1; RCV000080373.8; RCV000018528.30; RCV000211775.2\n",
       "2 RCV000031473.12; RCV000044387.10; RCV000160287.4; RCV000130074.5                                                                                                                                                                                \n",
       "  CLINVAR_Description                                                                                                                                                                   \n",
       "1 Pathogenic; Pathogenic; Pathogenic; not provided; Pathogenic; Pathogenic; not provided; Pathogenic; Pathogenic; Pathogenic; Pathogenic; Pathogenic; Pathogenic; Pathogenic; Pathogenic\n",
       "2 Pathogenic; Pathogenic; Pathogenic; Pathogenic                                                                                                                                        \n",
       "  CLINVAR_ReviewStat                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     \n",
       "1 criteria provided, multiple submitters, no conflicts; criteria provided, single submitter; criteria provided, multiple submitters, no conflicts; no assertion provided; criteria provided, single submitter; criteria provided, multiple submitters, no conflicts; no assertion provided; criteria provided, single submitter; no assertion criteria provided; criteria provided, single submitter; no assertion criteria provided; criteria provided, single submitter; criteria provided, multiple submitters, no conflicts; no assertion criteria provided; reviewed by expert panel\n",
       "2 reviewed by expert panel; criteria provided, multiple submitters, no conflicts; criteria provided, multiple submitters, no conflicts; criteria provided, multiple submitters, no conflicts                                                                                                                                                                                                                                                                                                                                                                                             \n",
       "  CLINVAR_Explanation                                                        \n",
       "1 [nan, nan, nan, nan, nan, nan, nan, nan, nan, nan, nan, nan, nan, nan, nan]\n",
       "2 [nan, nan, nan, nan]                                                       \n",
       "  Mode_of_Inheritance                      Mode_of_Inheritance_abb\n",
       "1 autosomal-dominant                       AD                     \n",
       "2 autosomal-recessive ; autosomal-dominant AR/AD                  \n",
       "  Gene_Classification   Known_Cancer_Predisposition_Genes\n",
       "1 Not classified        known                            \n",
       "2 Tumor Suppressor Gene known                            "
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "dfx@data %>% head(2)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 43,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<table>\n",
       "<thead><tr><th scope=col>Var1</th><th scope=col>Freq</th></tr></thead>\n",
       "<tbody>\n",
       "\t<tr><td>Likely Pathogenic</td><td> 40              </td></tr>\n",
       "\t<tr><td>Pathogenic       </td><td>158              </td></tr>\n",
       "</tbody>\n",
       "</table>\n"
      ],
      "text/latex": [
       "\\begin{tabular}{r|ll}\n",
       " Var1 & Freq\\\\\n",
       "\\hline\n",
       "\t Likely Pathogenic &  40              \\\\\n",
       "\t Pathogenic        & 158              \\\\\n",
       "\\end{tabular}\n"
      ],
      "text/markdown": [
       "\n",
       "| Var1 | Freq |\n",
       "|---|---|\n",
       "| Likely Pathogenic |  40               |\n",
       "| Pathogenic        | 158               |\n",
       "\n"
      ],
      "text/plain": [
       "  Var1              Freq\n",
       "1 Likely Pathogenic  40 \n",
       "2 Pathogenic        158 "
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "data.frame( table(dfx@data$IVA_Prediction) )"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 44,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<table>\n",
       "<thead><tr><th scope=col>Hugo_Symbol</th><th scope=col>Frame_Shift_Del</th><th scope=col>Frame_Shift_Ins</th><th scope=col>In_Frame_Del</th><th scope=col>Missense_Mutation</th><th scope=col>Nonsense_Mutation</th><th scope=col>Splice_Site</th><th scope=col>total</th><th scope=col>MutatedSamples</th><th scope=col>AlteredSamples</th></tr></thead>\n",
       "<tbody>\n",
       "\t<tr><td>RB1   </td><td> 6    </td><td>3     </td><td>0     </td><td>2     </td><td>17    </td><td>4     </td><td>32    </td><td>32    </td><td>32    </td></tr>\n",
       "\t<tr><td>NF1   </td><td> 2    </td><td>1     </td><td>0     </td><td>7     </td><td> 9    </td><td>3     </td><td>22    </td><td>22    </td><td>22    </td></tr>\n",
       "\t<tr><td>CHEK2 </td><td>11    </td><td>0     </td><td>1     </td><td>3     </td><td> 1    </td><td>3     </td><td>19    </td><td>19    </td><td>19    </td></tr>\n",
       "\t<tr><td>TP53  </td><td> 0    </td><td>1     </td><td>0     </td><td>5     </td><td> 2    </td><td>2     </td><td>10    </td><td>10    </td><td>10    </td></tr>\n",
       "\t<tr><td>ATM   </td><td> 0    </td><td>0     </td><td>1     </td><td>6     </td><td> 0    </td><td>2     </td><td> 9    </td><td> 9    </td><td> 9    </td></tr>\n",
       "\t<tr><td>COL7A1</td><td> 1    </td><td>0     </td><td>0     </td><td>3     </td><td> 3    </td><td>1     </td><td> 8    </td><td> 8    </td><td> 8    </td></tr>\n",
       "</tbody>\n",
       "</table>\n"
      ],
      "text/latex": [
       "\\begin{tabular}{r|llllllllll}\n",
       " Hugo\\_Symbol & Frame\\_Shift\\_Del & Frame\\_Shift\\_Ins & In\\_Frame\\_Del & Missense\\_Mutation & Nonsense\\_Mutation & Splice\\_Site & total & MutatedSamples & AlteredSamples\\\\\n",
       "\\hline\n",
       "\t RB1    &  6     & 3      & 0      & 2      & 17     & 4      & 32     & 32     & 32    \\\\\n",
       "\t NF1    &  2     & 1      & 0      & 7      &  9     & 3      & 22     & 22     & 22    \\\\\n",
       "\t CHEK2  & 11     & 0      & 1      & 3      &  1     & 3      & 19     & 19     & 19    \\\\\n",
       "\t TP53   &  0     & 1      & 0      & 5      &  2     & 2      & 10     & 10     & 10    \\\\\n",
       "\t ATM    &  0     & 0      & 1      & 6      &  0     & 2      &  9     &  9     &  9    \\\\\n",
       "\t COL7A1 &  1     & 0      & 0      & 3      &  3     & 1      &  8     &  8     &  8    \\\\\n",
       "\\end{tabular}\n"
      ],
      "text/markdown": [
       "\n",
       "| Hugo_Symbol | Frame_Shift_Del | Frame_Shift_Ins | In_Frame_Del | Missense_Mutation | Nonsense_Mutation | Splice_Site | total | MutatedSamples | AlteredSamples |\n",
       "|---|---|---|---|---|---|---|---|---|---|\n",
       "| RB1    |  6     | 3      | 0      | 2      | 17     | 4      | 32     | 32     | 32     |\n",
       "| NF1    |  2     | 1      | 0      | 7      |  9     | 3      | 22     | 22     | 22     |\n",
       "| CHEK2  | 11     | 0      | 1      | 3      |  1     | 3      | 19     | 19     | 19     |\n",
       "| TP53   |  0     | 1      | 0      | 5      |  2     | 2      | 10     | 10     | 10     |\n",
       "| ATM    |  0     | 0      | 1      | 6      |  0     | 2      |  9     |  9     |  9     |\n",
       "| COL7A1 |  1     | 0      | 0      | 3      |  3     | 1      |  8     |  8     |  8     |\n",
       "\n"
      ],
      "text/plain": [
       "  Hugo_Symbol Frame_Shift_Del Frame_Shift_Ins In_Frame_Del Missense_Mutation\n",
       "1 RB1          6              3               0            2                \n",
       "2 NF1          2              1               0            7                \n",
       "3 CHEK2       11              0               1            3                \n",
       "4 TP53         0              1               0            5                \n",
       "5 ATM          0              0               1            6                \n",
       "6 COL7A1       1              0               0            3                \n",
       "  Nonsense_Mutation Splice_Site total MutatedSamples AlteredSamples\n",
       "1 17                4           32    32             32            \n",
       "2  9                3           22    22             22            \n",
       "3  1                3           19    19             19            \n",
       "4  2                2           10    10             10            \n",
       "5  0                2            9     9              9            \n",
       "6  3                1            8     8              8            "
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "dfx@gene.summary %>% head"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "# Number of unique genes after making MAF file"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 45,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<ol class=list-inline>\n",
       "\t<li>54</li>\n",
       "\t<li>10</li>\n",
       "</ol>\n"
      ],
      "text/latex": [
       "\\begin{enumerate*}\n",
       "\\item 54\n",
       "\\item 10\n",
       "\\end{enumerate*}\n"
      ],
      "text/markdown": [
       "1. 54\n",
       "2. 10\n",
       "\n",
       "\n"
      ],
      "text/plain": [
       "[1] 54 10"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "dfx@gene.summary %>% dim"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 46,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<table>\n",
       "<thead><tr><th scope=col>Tumor_Sample_Barcode</th><th scope=col>Frame_Shift_Del</th><th scope=col>Frame_Shift_Ins</th><th scope=col>In_Frame_Del</th><th scope=col>Missense_Mutation</th><th scope=col>Nonsense_Mutation</th><th scope=col>Splice_Site</th><th scope=col>total</th></tr></thead>\n",
       "<tbody>\n",
       "\t<tr><td>SJACT028   </td><td>0          </td><td>0          </td><td>0          </td><td>0          </td><td>2          </td><td>1          </td><td>3          </td></tr>\n",
       "\t<tr><td>SJCNS042493</td><td>0          </td><td>0          </td><td>0          </td><td>2          </td><td>1          </td><td>0          </td><td>3          </td></tr>\n",
       "\t<tr><td>CCF12237   </td><td>0          </td><td>1          </td><td>0          </td><td>0          </td><td>1          </td><td>0          </td><td>2          </td></tr>\n",
       "\t<tr><td>SJCNS018601</td><td>1          </td><td>0          </td><td>0          </td><td>0          </td><td>1          </td><td>0          </td><td>2          </td></tr>\n",
       "\t<tr><td>SJGCT018639</td><td>1          </td><td>0          </td><td>0          </td><td>1          </td><td>0          </td><td>0          </td><td>2          </td></tr>\n",
       "\t<tr><td>SJHGG034   </td><td>1          </td><td>0          </td><td>0          </td><td>1          </td><td>0          </td><td>0          </td><td>2          </td></tr>\n",
       "</tbody>\n",
       "</table>\n"
      ],
      "text/latex": [
       "\\begin{tabular}{r|llllllll}\n",
       " Tumor\\_Sample\\_Barcode & Frame\\_Shift\\_Del & Frame\\_Shift\\_Ins & In\\_Frame\\_Del & Missense\\_Mutation & Nonsense\\_Mutation & Splice\\_Site & total\\\\\n",
       "\\hline\n",
       "\t SJACT028    & 0           & 0           & 0           & 0           & 2           & 1           & 3          \\\\\n",
       "\t SJCNS042493 & 0           & 0           & 0           & 2           & 1           & 0           & 3          \\\\\n",
       "\t CCF12237    & 0           & 1           & 0           & 0           & 1           & 0           & 2          \\\\\n",
       "\t SJCNS018601 & 1           & 0           & 0           & 0           & 1           & 0           & 2          \\\\\n",
       "\t SJGCT018639 & 1           & 0           & 0           & 1           & 0           & 0           & 2          \\\\\n",
       "\t SJHGG034    & 1           & 0           & 0           & 1           & 0           & 0           & 2          \\\\\n",
       "\\end{tabular}\n"
      ],
      "text/markdown": [
       "\n",
       "| Tumor_Sample_Barcode | Frame_Shift_Del | Frame_Shift_Ins | In_Frame_Del | Missense_Mutation | Nonsense_Mutation | Splice_Site | total |\n",
       "|---|---|---|---|---|---|---|---|\n",
       "| SJACT028    | 0           | 0           | 0           | 0           | 2           | 1           | 3           |\n",
       "| SJCNS042493 | 0           | 0           | 0           | 2           | 1           | 0           | 3           |\n",
       "| CCF12237    | 0           | 1           | 0           | 0           | 1           | 0           | 2           |\n",
       "| SJCNS018601 | 1           | 0           | 0           | 0           | 1           | 0           | 2           |\n",
       "| SJGCT018639 | 1           | 0           | 0           | 1           | 0           | 0           | 2           |\n",
       "| SJHGG034    | 1           | 0           | 0           | 1           | 0           | 0           | 2           |\n",
       "\n"
      ],
      "text/plain": [
       "  Tumor_Sample_Barcode Frame_Shift_Del Frame_Shift_Ins In_Frame_Del\n",
       "1 SJACT028             0               0               0           \n",
       "2 SJCNS042493          0               0               0           \n",
       "3 CCF12237             0               1               0           \n",
       "4 SJCNS018601          1               0               0           \n",
       "5 SJGCT018639          1               0               0           \n",
       "6 SJHGG034             1               0               0           \n",
       "  Missense_Mutation Nonsense_Mutation Splice_Site total\n",
       "1 0                 2                 1           3    \n",
       "2 2                 1                 0           3    \n",
       "3 0                 1                 0           2    \n",
       "4 0                 1                 0           2    \n",
       "5 1                 0                 0           2    \n",
       "6 1                 0                 0           2    "
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "dfx@variant.classification.summary %>% head"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### Samples with top variants"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 47,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "\n",
       "\n",
       "Tumor_Sample_Barcode    DEL   INS   SNP   total\n",
       "---------------------  ----  ----  ----  ------\n",
       "SJACT028                  0     0     3       3\n",
       "SJCNS042493               0     0     3       3\n",
       "CCF12237                  0     1     1       2\n",
       "SJCNS018601               1     0     1       2\n",
       "SJGCT018639               1     0     1       2\n",
       "SJHGG034                  1     0     1       2"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "knitr::kable( dfx@variant.type.summary %>% head,format = \"pandoc\")"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 48,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "\n",
       "\n",
       "Tumor_Sample_Barcode    Variants\n",
       "---------------------  ---------\n",
       "SJACT028                       3\n",
       "SJCNS042493                    3\n",
       "CCF12237                       2\n",
       "SJCNS018601                    2\n",
       "SJGCT018639                    2\n",
       "SJHGG034                       2"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "knitr::kable( dfx@variants.per.sample %>% head,format = \"pandoc\")"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 49,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "30"
      ],
      "text/latex": [
       "30"
      ],
      "text/markdown": [
       "30"
      ],
      "text/plain": [
       "[1] 30"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "gs = as.data.frame( dfx@gene.summary )  \n",
    "gf_sx = nrow( gs[ gs$MutatedSamples >= 2,] )\n",
    "gf_sx"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 50,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<table>\n",
       "<thead><tr><th scope=col>Hugo_Symbol</th><th scope=col>Frame_Shift_Del</th><th scope=col>Frame_Shift_Ins</th><th scope=col>In_Frame_Del</th><th scope=col>Missense_Mutation</th><th scope=col>Nonsense_Mutation</th><th scope=col>Splice_Site</th><th scope=col>total</th><th scope=col>MutatedSamples</th><th scope=col>AlteredSamples</th></tr></thead>\n",
       "<tbody>\n",
       "\t<tr><td>RB1   </td><td> 6    </td><td>3     </td><td>0     </td><td>2     </td><td>17    </td><td>4     </td><td>32    </td><td>32    </td><td>32    </td></tr>\n",
       "\t<tr><td>NF1   </td><td> 2    </td><td>1     </td><td>0     </td><td>7     </td><td> 9    </td><td>3     </td><td>22    </td><td>22    </td><td>22    </td></tr>\n",
       "\t<tr><td>CHEK2 </td><td>11    </td><td>0     </td><td>1     </td><td>3     </td><td> 1    </td><td>3     </td><td>19    </td><td>19    </td><td>19    </td></tr>\n",
       "\t<tr><td>TP53  </td><td> 0    </td><td>1     </td><td>0     </td><td>5     </td><td> 2    </td><td>2     </td><td>10    </td><td>10    </td><td>10    </td></tr>\n",
       "\t<tr><td>ATM   </td><td> 0    </td><td>0     </td><td>1     </td><td>6     </td><td> 0    </td><td>2     </td><td> 9    </td><td> 9    </td><td> 9    </td></tr>\n",
       "\t<tr><td>COL7A1</td><td> 1    </td><td>0     </td><td>0     </td><td>3     </td><td> 3    </td><td>1     </td><td> 8    </td><td> 8    </td><td> 8    </td></tr>\n",
       "\t<tr><td>BRCA1 </td><td> 4    </td><td>1     </td><td>0     </td><td>0     </td><td> 2    </td><td>0     </td><td> 7    </td><td> 7    </td><td> 7    </td></tr>\n",
       "\t<tr><td>GJB2  </td><td> 3    </td><td>1     </td><td>0     </td><td>2     </td><td> 1    </td><td>0     </td><td> 7    </td><td> 7    </td><td> 7    </td></tr>\n",
       "\t<tr><td>BRCA2 </td><td> 1    </td><td>1     </td><td>0     </td><td>1     </td><td> 0    </td><td>2     </td><td> 5    </td><td> 5    </td><td> 5    </td></tr>\n",
       "\t<tr><td>CDH1  </td><td> 1    </td><td>0     </td><td>0     </td><td>2     </td><td> 0    </td><td>1     </td><td> 4    </td><td> 4    </td><td> 4    </td></tr>\n",
       "</tbody>\n",
       "</table>\n"
      ],
      "text/latex": [
       "\\begin{tabular}{r|llllllllll}\n",
       " Hugo\\_Symbol & Frame\\_Shift\\_Del & Frame\\_Shift\\_Ins & In\\_Frame\\_Del & Missense\\_Mutation & Nonsense\\_Mutation & Splice\\_Site & total & MutatedSamples & AlteredSamples\\\\\n",
       "\\hline\n",
       "\t RB1    &  6     & 3      & 0      & 2      & 17     & 4      & 32     & 32     & 32    \\\\\n",
       "\t NF1    &  2     & 1      & 0      & 7      &  9     & 3      & 22     & 22     & 22    \\\\\n",
       "\t CHEK2  & 11     & 0      & 1      & 3      &  1     & 3      & 19     & 19     & 19    \\\\\n",
       "\t TP53   &  0     & 1      & 0      & 5      &  2     & 2      & 10     & 10     & 10    \\\\\n",
       "\t ATM    &  0     & 0      & 1      & 6      &  0     & 2      &  9     &  9     &  9    \\\\\n",
       "\t COL7A1 &  1     & 0      & 0      & 3      &  3     & 1      &  8     &  8     &  8    \\\\\n",
       "\t BRCA1  &  4     & 1      & 0      & 0      &  2     & 0      &  7     &  7     &  7    \\\\\n",
       "\t GJB2   &  3     & 1      & 0      & 2      &  1     & 0      &  7     &  7     &  7    \\\\\n",
       "\t BRCA2  &  1     & 1      & 0      & 1      &  0     & 2      &  5     &  5     &  5    \\\\\n",
       "\t CDH1   &  1     & 0      & 0      & 2      &  0     & 1      &  4     &  4     &  4    \\\\\n",
       "\\end{tabular}\n"
      ],
      "text/markdown": [
       "\n",
       "| Hugo_Symbol | Frame_Shift_Del | Frame_Shift_Ins | In_Frame_Del | Missense_Mutation | Nonsense_Mutation | Splice_Site | total | MutatedSamples | AlteredSamples |\n",
       "|---|---|---|---|---|---|---|---|---|---|\n",
       "| RB1    |  6     | 3      | 0      | 2      | 17     | 4      | 32     | 32     | 32     |\n",
       "| NF1    |  2     | 1      | 0      | 7      |  9     | 3      | 22     | 22     | 22     |\n",
       "| CHEK2  | 11     | 0      | 1      | 3      |  1     | 3      | 19     | 19     | 19     |\n",
       "| TP53   |  0     | 1      | 0      | 5      |  2     | 2      | 10     | 10     | 10     |\n",
       "| ATM    |  0     | 0      | 1      | 6      |  0     | 2      |  9     |  9     |  9     |\n",
       "| COL7A1 |  1     | 0      | 0      | 3      |  3     | 1      |  8     |  8     |  8     |\n",
       "| BRCA1  |  4     | 1      | 0      | 0      |  2     | 0      |  7     |  7     |  7     |\n",
       "| GJB2   |  3     | 1      | 0      | 2      |  1     | 0      |  7     |  7     |  7     |\n",
       "| BRCA2  |  1     | 1      | 0      | 1      |  0     | 2      |  5     |  5     |  5     |\n",
       "| CDH1   |  1     | 0      | 0      | 2      |  0     | 1      |  4     |  4     |  4     |\n",
       "\n"
      ],
      "text/plain": [
       "   Hugo_Symbol Frame_Shift_Del Frame_Shift_Ins In_Frame_Del Missense_Mutation\n",
       "1  RB1          6              3               0            2                \n",
       "2  NF1          2              1               0            7                \n",
       "3  CHEK2       11              0               1            3                \n",
       "4  TP53         0              1               0            5                \n",
       "5  ATM          0              0               1            6                \n",
       "6  COL7A1       1              0               0            3                \n",
       "7  BRCA1        4              1               0            0                \n",
       "8  GJB2         3              1               0            2                \n",
       "9  BRCA2        1              1               0            1                \n",
       "10 CDH1         1              0               0            2                \n",
       "   Nonsense_Mutation Splice_Site total MutatedSamples AlteredSamples\n",
       "1  17                4           32    32             32            \n",
       "2   9                3           22    22             22            \n",
       "3   1                3           19    19             19            \n",
       "4   2                2           10    10             10            \n",
       "5   0                2            9     9              9            \n",
       "6   3                1            8     8              8            \n",
       "7   2                0            7     7              7            \n",
       "8   1                0            7     7              7            \n",
       "9   0                2            5     5              5            \n",
       "10  0                1            4     4              4            "
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "gs %>% head(10)"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "#### Note : there are only gf_sx genes with 2 or more mutations"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### plotmafSummary\n",
    "to plot the summary of the maf file, which displays number of variants in each sample as a stacked barplot and variant types as a boxplot summarized by Variant_Classification."
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 51,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<strong>png:</strong> 2"
      ],
      "text/latex": [
       "\\textbf{png:} 2"
      ],
      "text/markdown": [
       "**png:** 2"
      ],
      "text/plain": [
       "png \n",
       "  2 "
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    },
    {
     "data": {
      "image/png": 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MiQY3u4HTt2xGKxZs2aHdthAQDg+GnXrl3sYPLy8sre8dVXX030nDFjRvmUClCi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\n3nvv448/3r17d//+/bOzs6dPn/7YY4+FEJYtW1Z631WrVuXm5qa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s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\n67Wo7f3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      "text/plain": [
       "Plot with title “Top 30\n",
       "mutated genes”"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "options(repr.plot.width=12, repr.plot.height=10)\n",
    "plotmafSummary(maf = dfx, rmOutlier = FALSE ,dashboard = TRUE,addStat = 'median', textSize = 2, top = gf_sx, showBarcodes=F )\n",
    "svg(\"../KCPG_Variants/plots/KCGP/plotmafsummary_01.svg\", height=10, width=12)\n",
    "plotmafSummary(maf = dfx, rmOutlier = FALSE ,dashboard = TRUE,addStat = 'median', textSize = 2, top = gf_sx, showBarcodes=F )\n",
    "dev.off()"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### Oncoplots or waterfall plots\n",
    "- Adding Clinical Data on oncoplot"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### Make Oncoplots with the total genes from the gene summary"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 63,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "'Saving : ../KCPG_Variants/plots/KCGP/oncoplot_31stMay_01.svg'"
      ],
      "text/latex": [
       "'Saving : ../KCPG\\_Variants/plots/KCGP/oncoplot\\_31stMay\\_01.svg'"
      ],
      "text/markdown": [
       "'Saving : ../KCPG_Variants/plots/KCGP/oncoplot_31stMay_01.svg'"
      ],
      "text/plain": [
       "[1] \"Saving : ../KCPG_Variants/plots/KCGP/oncoplot_31stMay_01.svg\""
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    },
    {
     "data": {
      "text/html": [
       "<strong>png:</strong> 2"
      ],
      "text/latex": [
       "\\textbf{png:} 2"
      ],
      "text/markdown": [
       "**png:** 2"
      ],
      "text/plain": [
       "png \n",
       "  2 "
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    },
    {
     "data": {
      "image/png": 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      "text/plain": [
       "plot without title"
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     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "total_genes = len( unique(rownames(gs)))\n",
    "options(repr.plot.width=28, repr.plot.height=8)\n",
    "oncoplot(maf = dfx,bgCol = \"white\",\n",
    "        top = 30,\n",
    "        \n",
    "        fontSize = 14,\n",
    "        SampleNamefontSize = 32,\n",
    "        titleFontSize = 12,\n",
    "        legendFontSize = 14,\n",
    "        annotationTitleFontSize = 22,\n",
    "        annotationFontSize = 9,\n",
    "        \n",
    "        drawColBar = TRUE,\n",
    "        drawRowBar = TRUE,\n",
    "        showTumorSampleBarcodes = F,\n",
    "        sortByAnnotation = TRUE,\n",
    "        writeMatrix = FALSE,\n",
    "        clinicalFeatures = c(\"Age_group\",\"Sex\"))\n",
    "\n",
    "out_svg = paste0('../KCPG_Variants/plots/KCGP/oncoplot_31stMay_01.svg')\n",
    "paste0(\"Saving : \", out_svg)\n",
    "svg(out_svg, width=18, height=8)\n",
    "oncoplot(maf = dfx,bgCol = \"white\",\n",
    "        top = total_genes,\n",
    "        \n",
    "        fontSize = 14,\n",
    "        SampleNamefontSize = 32,\n",
    "        titleFontSize = 12,\n",
    "        legendFontSize = 14,\n",
    "        annotationTitleFontSize = 22,\n",
    "        annotationFontSize = 9,\n",
    "        \n",
    "        drawColBar = TRUE,\n",
    "        drawRowBar = TRUE,\n",
    "        showTumorSampleBarcodes = F,\n",
    "        sortByAnnotation = TRUE,\n",
    "        writeMatrix = FALSE,\n",
    "        clinicalFeatures = c(\"Age_group\",\"Sex\"))\n",
    "dev.off()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 71,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "'Saving : ../KCPG_Variants/plots/KCGP/oncoplot_31stMay_01.pdf'"
      ],
      "text/latex": [
       "'Saving : ../KCPG\\_Variants/plots/KCGP/oncoplot\\_31stMay\\_01.pdf'"
      ],
      "text/markdown": [
       "'Saving : ../KCPG_Variants/plots/KCGP/oncoplot_31stMay_01.pdf'"
      ],
      "text/plain": [
       "[1] \"Saving : ../KCPG_Variants/plots/KCGP/oncoplot_31stMay_01.pdf\""
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    },
    {
     "data": {
      "text/html": [
       "<strong>png:</strong> 2"
      ],
      "text/latex": [
       "\\textbf{png:} 2"
      ],
      "text/markdown": [
       "**png:** 2"
      ],
      "text/plain": [
       "png \n",
       "  2 "
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    },
    {
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      "text/plain": [
       "plot without title"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "total_genes = len( unique(rownames(gs)))\n",
    "options(repr.plot.width=28, repr.plot.height=8)\n",
    "oncoplot(maf = dfx,bgCol = \"white\",\n",
    "        top = 30,\n",
    "        \n",
    "        fontSize = 14,\n",
    "        SampleNamefontSize = 0,\n",
    "        titleFontSize = 2,\n",
    "        legendFontSize = 0,\n",
    "        annotationTitleFontSize = 0,\n",
    "        annotationFontSize = 0,\n",
    "        \n",
    "        drawColBar = TRUE,\n",
    "        drawRowBar = TRUE,\n",
    "        showTumorSampleBarcodes = F,\n",
    "        sortByAnnotation = TRUE,\n",
    "        writeMatrix = FALSE,\n",
    "        clinicalFeatures = c(\"Age_group\",\"Sex\"))\n",
    "\n",
    "out_img = paste0('../KCPG_Variants/plots/KCGP/oncoplot_31stMay_01.pdf')\n",
    "paste0(\"Saving : \", out_img)\n",
    "pdf(out_img, width=18, height=8)\n",
    "oncoplot(maf = dfx,bgCol = \"white\",\n",
    "        top = total_genes,\n",
    "        \n",
    "        fontSize = 14,\n",
    "        SampleNamefontSize = 0,\n",
    "        titleFontSize = 2,\n",
    "        legendFontSize = 0,\n",
    "        annotationTitleFontSize = 0,\n",
    "        annotationFontSize = 0,\n",
    "        \n",
    "        drawColBar = TRUE,\n",
    "        drawRowBar = TRUE,\n",
    "        showTumorSampleBarcodes = F,\n",
    "        sortByAnnotation = TRUE,\n",
    "        writeMatrix = FALSE,\n",
    "        clinicalFeatures = c(\"Age_group\",\"Sex\"))\n",
    "dev.off()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": []
  }
 ],
 "metadata": {
  "kernelspec": {
   "display_name": "p3_R_3.5.0",
   "language": "R",
   "name": "ir3.5.0"
  },
  "language_info": {
   "codemirror_mode": "r",
   "file_extension": ".r",
   "mimetype": "text/x-r-source",
   "name": "R",
   "pygments_lexer": "r",
   "version": "3.5.0"
  },
  "toc": {
   "nav_menu": {},
   "number_sections": true,
   "sideBar": true,
   "skip_h1_title": false,
   "title_cell": "Table of Contents",
   "title_sidebar": "Contents",
   "toc_cell": true,
   "toc_position": {},
   "toc_section_display": true,
   "toc_window_display": false
  },
  "varInspector": {
   "cols": {
    "lenName": 16,
    "lenType": 16,
    "lenVar": 40
   },
   "kernels_config": {
    "python": {
     "delete_cmd_postfix": "",
     "delete_cmd_prefix": "del ",
     "library": "var_list.py",
     "varRefreshCmd": "print(var_dic_list())"
    },
    "r": {
     "delete_cmd_postfix": ") ",
     "delete_cmd_prefix": "rm(",
     "library": "var_list.r",
     "varRefreshCmd": "cat(var_dic_list()) "
    }
   },
   "types_to_exclude": [
    "module",
    "function",
    "builtin_function_or_method",
    "instance",
    "_Feature"
   ],
   "window_display": false
  }
 },
 "nbformat": 4,
 "nbformat_minor": 2
}