UpdateSymbolList generates wrong symbols

[apredeus]

Dear Seurat team,

It seems like UpdateSymbolList uses a logic that results in erroneous changes to some gene symbols.

There are quite a few genes for which official HGNC symbol co-insides with a symbol that was used for another gene in the past. The function automatically changes these. For example, HBM is a current name for "hemoglobin subunit mu", and an old name for "LDL receptor related protein 5", which are two totally different genes (https://www.genenames.org/tools/search/#!/?query=HBM). The function, however, converts HBM to LRP5. Similar thing happens to HBG1 and quite a few other genes.

I think there needs to be a check if gene symbol exists in the newest version - and if it does, the symbol should not be changed.

[andrewwbutler]

Hi,

Thanks for reporting! We've made some fixes/updates to this function which hopefully resolve this problem. Please try installing the develop branch (instructions here) and see if that fixes the issue for you.

[no-response]

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