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Suggestion to update removal rules to adapt to the current mass recombinant situation #352

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aviczhl2 opened this issue Sep 30, 2023 · 0 comments

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@aviczhl2
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aviczhl2 commented Sep 30, 2023

Usher removes seqs with >5 reversions or >20 private mutations to prevent artefact.

However, recently a lot of recombinants between DV, EG, JD, GK, FL, FU,... are popping up and sometimes these recombinants are usually removed due to having too many reversions or private mutations. The number of such removal events is quite a lot now.

For example

sars-cov-2-variants/lineage-proposals#846

sars-cov-2-variants/lineage-proposals#839

sars-cov-2-variants/lineage-proposals#811

sars-cov-2-variants/lineage-proposals#674

sars-cov-2-variants/lineage-proposals#879

sars-cov-2-variants/lineage-proposals#888

And these recomb are more and more. It becomes harder and harder to separate and list every of those removed recombinants and add them back to tree.

A suggestion is that for new seqs before they are removed check for recombinants and see if it is close to any potential recomb. If it is then not remove.

Or allow manually add stationery points that prevents removal for seqs close to such points so that at least seqs for each recombinant won't be removed after the initial detection.

@aviczhl2 aviczhl2 changed the title Suggestion to update removal rules to satisfy the current mass recombinant situation Suggestion to update removal rules to adapt to the current mass recombinant situation Sep 30, 2023
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