PopED 0.5.0

• Added the ability to incorporate limit of quantification information into FIM calculations (both upper and lower limits). See the new vignette on the webpage https://andrewhooker.github.io/PopED/articles/handling_loq.html

• Adding functionality to optimize groupsize and total size of the study. See ?optimize_groupsize, ``?optimize_n_effand?optimize_n_rse`. This is also implemented in `poped_optim` through the `opt_inds=T` argument.

• Updating Vignettes, including a new one about using other tools to use as simulators for design computations. See https://andrewhooker.github.io/PopED/articles/model_def_other_pkgs.html

• Simplify RxODE syntax in the above vingette (#47, @mattfidler).

• Added the ability to predict and plot model prediction intervals by computing the expected variance (using an FO approximation) and then computing a prediction interval based on an assumption of normality. See ?model_prediciton and ?plot_model_prediction. The computation is faster but less accurate compared to using DV=TRUE (and groupsize_sim = 500) in the two functions.

• Named parameters are now passed to all calculations so that the FIM and RSE output is more readable with parameter names instead of default names.

• Allow for parallel computation in plot_efficiency_of_windows (#50).

• Make parallelization work with mrgsolve on windows (#37, #45, #46, #51, @Vincent-AC).

• Updated the function for automatic building of parameter model function (see build_sfg).

• Simplify derivative calculations (#34, @martin-gmx).

• Allow for only simulating model_switch > 1 models.

• Change the defult Ds calculation to be on log scale.

• Updated the website at https://andrewhooker.github.io/PopED

• Remove options for discontinued dplyr commands rbind_all and rbind_list.

• Minor bug fixes in shrinkage calculations (#44, #39, @martin-gmx).