How to generate ExAC pickle file

Generate population site pickle file

This file is not required. This is used by deTiN to update the prior on the somatic status of specific sites. I.e. sites of common population variants are less likely to be true somatic events.

If you want to use a version of this file for HG38 you can generate a new version of the file using the latest Gnomad exome VCF. Next you will want to filter that VCF for 1% allele frequency variants using VCFTools for example. Finally call the deTiN function deTiN_utilities.build_exac_pickle(vcf) with your vcf file.