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MatLab ToolBox for integration of multiple omic sources to a genome-scale metabolic model

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gibbslab/GEM-multiomic-integrator

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This repo contains a conglomerate of scripts to integrate proteomic and transcriptomic data based on a genome-scale metabolic model.

How to use

Here we have two use cases:

  1. astrocyte_contextualization.m integrates the data to contextualize the Osorio model.
  2. astrocyte_reconstruction.m recontructs a context-specific model of an astrocyte using Recon3D as the base.

Articles

Multi-omics integrative analysis coupled to control theory and computational simulation of a genome-scale metabolic model reveal controlling biological switches in human astrocytes under palmitic acid-induced lipotoxicity. (submitted)

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MatLab ToolBox for integration of multiple omic sources to a genome-scale metabolic model

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