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corrected BONUS index
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amjjbonvin committed May 21, 2024
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## BONUS 2: Does the antibody bind to a known interface of interleukin? ARCTIC-3D analysis
## BONUS 1: Does the antibody bind to a known interface of interleukin? ARCTIC-3D analysis

Gevokizumab is a highly specific antibody that targets an allosteric site of Interleukin-1β (IL-1β) in PDB file *4G6M*, thus reducing its binding affinity for its substrate, interleukin-1 receptor type I (IL-1RI). Canakinumab, another antibody binding to IL-1β, has a different mode of action, as it competes directly with IL-1RI's binding site (in PDB file *4G6J*). For more details please check [this article](https://www.sciencedirect.com/science/article/abs/pii/S0022283612007863?via%3Dihub){:target="\_blank"}.

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