Merge pull request #380 from jodyphelan/dev

update db
jodyphelan · Jul 17, 2024 · 91dfe78 · 91dfe78
2 parents f109efd + 83e9c1c
commit 91dfe78
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Showing 3 changed files with 75 additions and 31 deletions.
diff --git a/db/tbdb.bed b/db/tbdb.bed
@@ -2,72 +2,72 @@ Chromosome	1	1524	Rv0001	dnaA	isoniazid
 Chromosome	4933	7267	Rv0005	gyrB	levofloxacin,moxifloxacin
 Chromosome	7068	9818	Rv0006	gyrA	levofloxacin,moxifloxacin
 Chromosome	13133	13911	Rv0010c	Rv0010c	isoniazid
-Chromosome	490545	491793	Rv0407	fgd1	clofazimine,pretomanid,delamanid
-Chromosome	574479	576790	Rv0486	mshA	ethionamide,isoniazid
-Chromosome	619500	620865	Rv0529	ccsA	capreomycin,amikacin,kanamycin
+Chromosome	490545	491793	Rv0407	fgd1	pretomanid,delamanid,clofazimine
+Chromosome	574479	576790	Rv0486	mshA	isoniazid,ethionamide
+Chromosome	619500	620865	Rv0529	ccsA	kanamycin,capreomycin,amikacin
 Chromosome	656010	657739	Rv0565c	Rv0565c	ethionamide
 Chromosome	731680	732406	Rv0635	hadA	isoniazid
 Chromosome	733853	734970	Rv0639	nusG	rifampicin
+Chromosome	737268	738349	Rv0643c	mmaA3	isoniazid
 Chromosome	759342	763325	Rv0667	rpoB	rifampicin
 Chromosome	763127	767320	Rv0668	rpoC	rifampicin
-Chromosome	775586	778680	Rv0676c	mmpL5	clofazimine,bedaquiline
-Chromosome	778477	779624	Rv0677c	mmpS5	clofazimine,bedaquiline
-Chromosome	778790	779487	Rv0678	mmpR5	clofazimine,bedaquiline
+Chromosome	775586	778680	Rv0676c	mmpL5	bedaquiline,clofazimine
+Chromosome	778477	779624	Rv0677c	mmpS5	bedaquiline,clofazimine
+Chromosome	778790	779487	Rv0678	mmpR5	bedaquiline,clofazimine
 Chromosome	781126	781934	Rv0682	rpsL	streptomycin
 Chromosome	800106	801462	Rv0701	rplC	linezolid
-Chromosome	1253074	1254783	Rv1129c	Rv1129c	moxifloxacin,levofloxacin,rifampicin,isoniazid
-Chromosome	1302606	1305501	Rv1173	fbiC	clofazimine,pretomanid,delamanid
+Chromosome	1253074	1254783	Rv1129c	Rv1129c	levofloxacin,moxifloxacin,isoniazid,rifampicin
+Chromosome	1302606	1305501	Rv1173	fbiC	pretomanid,delamanid,clofazimine
 Chromosome	1364162	1365186	Rv1221	sigE	pyrazinamide
-Chromosome	1406081	1407604	Rv1258c	Rv1258c	streptomycin,isoniazid,pyrazinamide
+Chromosome	1406081	1407604	Rv1258c	Rv1258c	streptomycin,pyrazinamide,isoniazid
 Chromosome	1416181	1418048	Rv1267c	embR	ethambutol
 Chromosome	1460802	1461290	Rv1305	atpE	bedaquiline
-Chromosome	1471498	1473382	EBG00000313325	rrs	streptomycin,kanamycin,capreomycin,amikacin
+Chromosome	1471498	1473382	EBG00000313325	rrs	kanamycin,capreomycin,streptomycin,amikacin
 Chromosome	1473408	1476795	EBG00000313339	rrl	capreomycin,linezolid
-Chromosome	1673148	1674183	Rv1483	fabG1	ethionamide,isoniazid
-Chromosome	1673189	1675011	Rv1484	inhA	ethionamide,isoniazid
+Chromosome	1673148	1675011	Rv1484	inhA	isoniazid,ethionamide
 Chromosome	1833247	1834987	Rv1630	rpsA	pyrazinamide
 Chromosome	1853358	1854388	Rv1644	tsnR	linezolid
 Chromosome	1917506	1918746	Rv1694	tlyA	capreomycin
-Chromosome	2062809	2065010	Rv1819c	bacA	streptomycin,kanamycin,capreomycin,amikacin
-Chromosome	2101651	2103337	Rv1854c	ndh	ethionamide,delamanid,isoniazid
+Chromosome	2062809	2065010	Rv1819c	bacA	kanamycin,capreomycin,streptomycin,amikacin
+Chromosome	2101651	2103337	Rv1854c	ndh	isoniazid,delamanid,ethionamide
 Chromosome	2153889	2156842	Rv1908c	katG	isoniazid
 Chromosome	2167649	2170934	Rv1918c	PPE35	pyrazinamide
-Chromosome	2221719	2223825	Rv1979c	Rv1979c	clofazimine,bedaquiline
+Chromosome	2221719	2223825	Rv1979c	Rv1979c	bedaquiline,clofazimine
 Chromosome	2288681	2290323	Rv2043c	pncA	pyrazinamide
 Chromosome	2517915	2519365	Rv2245	kasA	isoniazid
-Chromosome	2714124	2715832	Rv2416c	eis	amikacin,kanamycin
+Chromosome	2714124	2715832	Rv2416c	eis	kanamycin,amikacin
 Chromosome	2725899	2726780	Rv2428	ahpC	isoniazid
 Chromosome	2746135	2747798	Rv2447c	folC	para-aminosalicylic_acid
-Chromosome	2782366	2786169	Rv2477c	Rv2477c	ethambutol,moxifloxacin,streptomycin,levofloxacin,kanamycin,rifampicin,amikacin
-Chromosome	2859300	2860640	Rv2535c	pepQ	clofazimine,bedaquiline
+Chromosome	2782366	2786169	Rv2477c	Rv2477c	kanamycin,levofloxacin,moxifloxacin,streptomycin,rifampicin,ethambutol,amikacin
+Chromosome	2859300	2860640	Rv2535c	pepQ	bedaquiline,clofazimine
 Chromosome	2986639	2987615	Rv2671	ribD	para-aminosalicylic_acid
 Chromosome	2995772	2996737	Rv2680	Rv2680	capreomycin
 Chromosome	2996539	2998055	Rv2681	Rv2681	capreomycin
-Chromosome	3064515	3067372	Rv2752c	Rv2752c	ethambutol,moxifloxacin,levofloxacin,rifampicin,isoniazid
+Chromosome	3064515	3067372	Rv2752c	Rv2752c	levofloxacin,moxifloxacin,isoniazid,rifampicin,ethambutol
 Chromosome	3067193	3068161	Rv2754c	thyX	para-aminosalicylic_acid
 Chromosome	3073680	3074671	Rv2764c	thyA	para-aminosalicylic_acid
 Chromosome	3086620	3087935	Rv2780	ald	cycloserine
-Chromosome	3338868	3339762	Rv2983	fbiD	clofazimine,pretomanid,delamanid
+Chromosome	3338868	3339762	Rv2983	fbiD	pretomanid,delamanid,clofazimine
 Chromosome	3448253	3449991	Rv3083	Rv3083	ethionamide
-Chromosome	3568401	3569280	Rv3197A	whiB7	streptomycin,amikacin,kanamycin
+Chromosome	3568401	3569280	Rv3197A	whiB7	kanamycin,amikacin,streptomycin
 Chromosome	3611959	3613847	Rv3236c	Rv3236c	pyrazinamide
-Chromosome	3623159	3625110	Rv3244c	lpqB	bedaquiline,rifampicin
-Chromosome	3624910	3626860	Rv3245c	mtrB	bedaquiline,rifampicin
-Chromosome	3626663	3627924	Rv3246c	mtrA	bedaquiline,rifampicin
-Chromosome	3640207	3641538	Rv3261	fbiA	clofazimine,pretomanid,delamanid
-Chromosome	3641335	3642881	Rv3262	fbiB	clofazimine,pretomanid,delamanid
+Chromosome	3623159	3625110	Rv3244c	lpqB	rifampicin,bedaquiline
+Chromosome	3624910	3626860	Rv3245c	mtrB	rifampicin,bedaquiline
+Chromosome	3626663	3627924	Rv3246c	mtrA	rifampicin,bedaquiline
+Chromosome	3640207	3641538	Rv3261	fbiA	pretomanid,delamanid,clofazimine
+Chromosome	3641335	3642881	Rv3262	fbiB	pretomanid,delamanid,clofazimine
 Chromosome	3840194	3841620	Rv3423c	alr	cycloserine
 Chromosome	3877464	3879240	Rv3457c	rpoA	rifampicin
-Chromosome	3986612	3987299	Rv3547	ddn	delamanid,pretomanid
+Chromosome	3986612	3987299	Rv3547	ddn	pretomanid,delamanid
 Chromosome	4038158	4041013	Rv3596c	clpC1	pyrazinamide
 Chromosome	4043862	4046428	Rv3601c	panD	pyrazinamide
-Chromosome	4138202	4140002	Rv3696c	glpK	ethambutol,moxifloxacin,streptomycin,levofloxacin,rifampicin,isoniazid
+Chromosome	4138202	4140002	Rv3696c	glpK	levofloxacin,moxifloxacin,isoniazid,streptomycin,rifampicin,ethambutol
 Chromosome	4237683	4243147	Rv3793	embC	ethambutol
 Chromosome	4242947	4246517	Rv3794	embA	ethambutol
 Chromosome	4246314	4249810	Rv3795	embB	ethambutol
 Chromosome	4266953	4269124	Rv3805c	aftB	ethambutol
 Chromosome	4268925	4270084	Rv3806c	ubiA	ethambutol
 Chromosome	4326004	4330174	Rv3854c	ethA	ethionamide
 Chromosome	4327328	4328199	Rv3855	ethR	ethionamide
-Chromosome	4338171	4338961	Rv3862c	whiB6	capreomycin,amikacin,kanamycin
+Chromosome	4338171	4338961	Rv3862c	whiB6	kanamycin,capreomycin,amikacin
 Chromosome	4407528	4408481	Rv3919c	gid	streptomycin
diff --git a/db/tbdb.dr.json b/db/tbdb.dr.json
diff --git a/db/tbdb.variables.json b/db/tbdb.variables.json
@@ -1 +1,45 @@
-{"snpEff_db": "Mycobacterium_tuberculosis_h37rv", "drugs": ["rifampicin", "isoniazid", "ethambutol", "pyrazinamide", "moxifloxacin", "levofloxacin", "bedaquiline", "delamanid", "pretomanid", "linezolid", "streptomycin", "amikacin", "kanamycin", "capreomycin", "clofazimine", "ethionamide", "para-aminosalicylic_acid", "cycloserine"], "tb-profiler-version": ">=6.0.0,<7.0.0", "version": {"name": "tbdb", "commit": "82777ea", "Author": "Jody Phelan <[email protected]>", "Date": "Sun Mar 17 01:14:00 2024 +0000"}, "amplicon": false, "files": {"ref": "tbdb.fasta", "gff": "tbdb.gff", "bed": "tbdb.bed", "json_db": "tbdb.dr.json", "variables": "tbdb.variables.json", "spoligotype_spacers": "tbdb.spoligotype_spacers.txt", "spoligotype_annotations": "tbdb.spoligotype_list.csv", "bedmask": "tbdb.mask.bed", "barcode": "tbdb.barcode.bed", "rules": "tbdb.rules.txt"}}
+{
+  "db-schema-version": "1.0.0",
+  "snpEff_db": "Mycobacterium_tuberculosis_h37rv",
+  "drugs": [
+    "rifampicin",
+    "isoniazid",
+    "ethambutol",
+    "pyrazinamide",
+    "moxifloxacin",
+    "levofloxacin",
+    "bedaquiline",
+    "delamanid",
+    "pretomanid",
+    "linezolid",
+    "streptomycin",
+    "amikacin",
+    "kanamycin",
+    "capreomycin",
+    "clofazimine",
+    "ethionamide",
+    "para-aminosalicylic_acid",
+    "cycloserine"
+  ],
+  "tb-profiler-version": ">=6.0.0,<7.0.0",
+  "version": {
+    "name": "tbdb",
+    "commit": "72ef6fa",
+    "Author": "Jody Phelan <[email protected]>",
+    "Date": "Tue Jul 16 16:56:19 2024 +0100",
+    "db-schema-version": "1.0.0"
+  },
+  "amplicon": false,
+  "files": {
+    "ref": "tbdb.fasta",
+    "gff": "tbdb.gff",
+    "bed": "tbdb.bed",
+    "json_db": "tbdb.dr.json",
+    "variables": "tbdb.variables.json",
+    "spoligotype_spacers": "tbdb.spoligotype_spacers.txt",
+    "spoligotype_annotations": "tbdb.spoligotype_list.csv",
+    "bedmask": "tbdb.mask.bed",
+    "barcode": "tbdb.barcode.bed",
+    "rules": "tbdb.rules.txt"
+  }
+}