clinical-trials image-segmentation nucleus-segmentation 3d-segmentation support-vector-classifier wavelet-transform active-contour-model circulating-tumor-cells watershed-segmentation metastatic-cancer-detection microfluidic-chip hough-transform-circle prostate-specific-prostate-antigen nucleus-contour psma-segmentation psma-contour tubulin-bundling tubulin-tyrosination transcription-factor-localization multiplex-microscopy