CoNI is a practical R package for the unsupervised integration of numerical omics datasets. Our tool is based on partial correlations to identify putative confounding variables for a set of paired dependent variables. CoNI combines two omics datasets in an integrated, complex hypergraph-like network, represented as a weighted undirected graph, a bipartite graph, or a hypergraph structure.
Before installing CoNI a few dependencies are necessary:
dependencies<-c("igraph","doParallel","cocor","tidyverse","foreach","ggrepel","gplots","gridExtra","plyr","ppcor","tidyr","Hmisc")
`%notin%`<-Negate(`%in%`)
for(package in dependencies){
if(package %notin% rownames(installed.packages())){
install.packages(package,dependencies = TRUE)
}
}
if (!requireNamespace("BiocManager", quietly = TRUE))
install.packages("BiocManager")
BiocManager::install("genefilter")Python3 is also required to run CoNI. Make sure it is installed and in your path.